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This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015]
NTNG1 (Netrin G1) is a Protein Coding gene. Diseases associated with NTNG1 include Rett Syndrome and Non-Specific Syndromic Intellectual Disability. Among its related pathways are Metabolism of proteins and Axon guidance. An important paralog of this gene is NTNG2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J107138 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE CraniofacialAtlas | 250.7 | +0.8 | 806 | 4.4 | ETS1 CTCF ZIC2 SIN3A TRIM22 MAFF ZNF341 SMC3 RAD21 ZNF316 | HSALNG0005772 NTNG1 lnc-PRMT6-5 VAV3 | |
GH01J107139 | Enhancer | 0.3 | ENCODE | 250.7 | -1.6 | -1633 | 0.1 | CEBPB | NTNG1 HSALNG0005771 PRMT6 | |
GH01J107055 | Promoter/Enhancer | 1.7 | Ensembl ENCODE CraniofacialAtlas | 15.9 | -82.6 | -82648 | 3.3 | TBP ZBTB10 SIX5 NR2C1 MNT IKZF1 SMAD5 ETS1 MBD2 POLR2A | PRMT6 HSALNG0005767 lnc-VAV3-11 NTNG1 HSALNG0005769 | |
GH01J107076 | Enhancer | 0.6 | Ensembl ENCODE | 11.3 | -62.9 | -62860 | 0.9 | ZFX EP300 CEBPB | NTNG1 HSALNG0005770 PRMT6 HSALNG0005771 | |
GH01J106956 | Enhancer | 0.5 | ENCODE | 8.9 | -183.0 | -183049 | 1.3 | SIX4 BATF YBX1 GATAD2B ATF7 RUNX3 PPP1R10 | NTNG1 HSALNG0005762 piR-58297-019 PRMT6 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 14595443 |
GO:0050839 | cell adhesion molecule binding | IPI | 23986473 |
GO:0098632 | cell-cell adhesion mediator activity | IGI | 23986473 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031225 | anchored component of membrane | IEA | -- |
GO:0043256 | laminin complex | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism of proteins | ||
2 | Axon guidance | ||
3 | Cell adhesion molecules | ||
4 | Post-translational modification- synthesis of GPI-anchored proteins |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007275 | multicellular organism development | IEA | -- |
GO:0007399 | nervous system development | IEA | -- |
GO:0007409 | axonogenesis | ISS | -- |
GO:0009887 | animal organ morphogenesis | IBA | 21873635 |
GO:0009888 | tissue development | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Allopurinol | Approved | Pharma | 182 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NTNG1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MGC139448 31 |
|
OneToOne | |
NTNG1 30 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Ntng1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ntng1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NTNG1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NTNG1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NTNG1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NTNG1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NTNG1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ntng1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ntng1a 31 |
|
OneToMany | |
vav3b 31 |
|
OneToMany | |||
ntng1 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | NetA 31 |
|
ManyToMany | |
NetB 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | unc-6 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
930831 | Uncertain Significance: See cases | 107,430,737(+) |
T/A NM_001113226.3(NTNG1):c.1088-13T>A |
INTRON | |
rs143347360 | Benign: not provided | 107,324,416(+) |
C/G NM_014917.4(NTNG1):c.381C>G (p.Pro127=) |
SYNONYMOUS | |
rs144330931 | Benign: not provided | 107,324,443(+) |
G/A NM_014917.4(NTNG1):c.408G>A (p.Leu136=) |
SYNONYMOUS | |
rs151288291 | Benign: not provided | 107,324,465(+) |
C/T NM_014917.4(NTNG1):c.430C>T (p.Leu144=) |
SYNONYMOUS | |
rs1570946113 | Uncertain Significance: not provided | 107,430,900(+) |
A/T NM_014917.4(NTNG1):c.1087+23192A>T |
MISSENSE_VARIANT,INTRON |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv248n100 | CNV | gain | 25217958 |
esv2674592 | CNV | deletion | 23128226 |
esv2676966 | CNV | deletion | 23128226 |
esv2678975 | CNV | deletion | 23128226 |
esv2758957 | CNV | loss | 17122850 |
esv3587104 | CNV | gain | 21293372 |
esv3587106 | CNV | loss | 21293372 |
esv3587107 | CNV | loss | 21293372 |
esv3587108 | CNV | loss | 21293372 |
esv3893978 | CNV | loss | 25118596 |
nsv1001678 | CNV | loss | 25217958 |
nsv1133885 | CNV | deletion | 24896259 |
nsv1142066 | CNV | tandem duplication | 24896259 |
nsv1142765 | CNV | deletion | 24896259 |
nsv477247 | CNV | novel sequence insertion | 20440878 |
nsv478792 | CNV | novel sequence insertion | 20440878 |
nsv508033 | OTHER | sequence alteration | 20534489 |
nsv521184 | CNV | loss | 19592680 |
nsv547330 | CNV | gain | 21841781 |
nsv830982 | CNV | gain | 17160897 |
nsv830993 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
rett syndrome |
|
|
non-specific syndromic intellectual disability |
|
|
partial fetal alcohol syndrome |
|
|
st. louis encephalitis |
|
|
alcohol-related birth defect |
|
|