Aliases for NTN5 Gene

Aliases for NTN5 Gene

  • Netrin 5 2 3 5
  • Netrin-5 2 3 4
  • Netrin-1-Like Protein 3 4

External Ids for NTN5 Gene

Previous GeneCards Identifiers for NTN5 Gene

  • GC19M053857
  • GC19M049164
  • GC19M045544

Summaries for NTN5 Gene

GeneCards Summary for NTN5 Gene

NTN5 (Netrin 5) is a Protein Coding gene. An important paralog of this gene is NTN3.

UniProtKB/Swiss-Prot Summary for NTN5 Gene

  • Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube.

Additional gene information for NTN5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NTN5 Gene

Genomics for NTN5 Gene

GeneHancer (GH) Regulatory Elements for NTN5 Gene

Promoters and enhancers for NTN5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J048673 Enhancer 0.3 Ensembl CraniofacialAtlas 759.9 +0.6 609 0.5 NTN5 lnc-CA11-1 piR-33270-017 NONHSAG026179.2 SEC1P RF00017-3045
GH19J048672 Promoter 0.3 EPDnew 750.6 -0.2 -206 0.1 NTN5 lnc-CA11-1 LOC105372431 NONHSAG026179.2 SEC1P RF00017-3045
GH19J048676 Enhancer 0.2 Ensembl 759.4 -0.5 -519 0.4 NTN5 lnc-CA11-1 LOC105372431 NONHSAG026179.2 SEC1P RF00017-3045
GH19J048674 Enhancer 0.2 ENCODE 750.6 -1.5 -1528 0 NTN5 lnc-CA11-1 FUT2 MAMSTR DBP SEC1P RASIP1 IZUMO1 LOC105372431 NONHSAG026179.2
GH19J048168 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 18.3 +502.5 502503 3.2 ZNF785 SIN3A ZBTB40 SIX5 POLR2A CREB1 HCFC1 ZNF133 MYC NFYC ZSWIM9 LIG1 NONHSAG026155.2 lnc-CARD8-3 BICRA SNRNP70 EHD2 NOP53-AS1 GRWD1 CA11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NTN5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NTN5 gene promoter:
  • AhR
  • Bach1
  • E47
  • Elk-1
  • HTF
  • Max
  • p53
  • Spz1
  • SRY
  • Tal-1

Genomic Locations for NTN5 Gene

Genomic Locations for NTN5 Gene
chr19:48,661,407-48,673,081
(GRCh38/hg38)
Size:
11,675 bases
Orientation:
Minus strand
chr19:49,164,664-49,176,338
(GRCh37/hg19)
Size:
11,675 bases
Orientation:
Minus strand

Genomic View for NTN5 Gene

Genes around NTN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTN5 Gene

Proteins for NTN5 Gene

  • Protein details for NTN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTR8-NET5_HUMAN
    Recommended name:
    Netrin-5
    Protein Accession:
    Q8WTR8
    Secondary Accessions:
    • Q8N4X9
    • Q8WU63

    Protein attributes for NTN5 Gene

    Size:
    489 amino acids
    Molecular mass:
    53174 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NTN5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NTN5 Gene

Post-translational modifications for NTN5 Gene

  • Glycosylation at Asn62
  • Modification sites at PhosphoSitePlus

Other Protein References for NTN5 Gene

No data available for DME Specific Peptides for NTN5 Gene

Domains & Families for NTN5 Gene

Gene Families for NTN5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for NTN5 Gene

Suggested Antigen Peptide Sequences for NTN5 Gene

GenScript: Design optimal peptide antigens:
  • Netrin-1-like protein (NET5_HUMAN)
genes like me logo Genes that share domains with NTN5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NTN5 Gene

Function for NTN5 Gene

Molecular function for NTN5 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube.

Phenotypes From GWAS Catalog for NTN5 Gene

genes like me logo Genes that share phenotypes with NTN5: view

Animal Models for NTN5 Gene

MGI Knock Outs for NTN5:
  • Ntn5 Ntn5<tm1.1Rwb>

Animal Model Products

  • Taconic Biosciences Mouse Models for NTN5

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NTN5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NTN5 Gene

Localization for NTN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTN5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NTN5 gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for NTN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005604 basement membrane IBA 21873635
genes like me logo Genes that share ontologies with NTN5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NTN5 Gene

Pathways & Interactions for NTN5 Gene

PathCards logo

SuperPathways for NTN5 Gene

No Data Available

Interacting Proteins for NTN5 Gene

Gene Ontology (GO) - Biological Process for NTN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0009887 animal organ morphogenesis IBA 21873635
GO:0009888 tissue development IBA 21873635
GO:0016477 cell migration IBA 21873635
genes like me logo Genes that share ontologies with NTN5: view

No data available for Pathways by source and SIGNOR curated interactions for NTN5 Gene

Drugs & Compounds for NTN5 Gene

No Compound Related Data Available

Transcripts for NTN5 Gene

mRNA/cDNA for NTN5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NTN5

Alternative Splicing Database (ASD) splice patterns (SP) for NTN5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for NTN5 Gene

GeneLoc Exon Structure for
NTN5
ECgene alternative splicing isoforms for
NTN5

Expression for NTN5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NTN5 Gene

mRNA differential expression in normal tissues according to GTEx for NTN5 Gene

This gene is overexpressed in Pituitary (x5.9).

Protein differential expression in normal tissues from HIPED for NTN5 Gene

This gene is overexpressed in Frontal cortex (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NTN5 Gene



Protein tissue co-expression partners for NTN5 Gene

NURSA nuclear receptor signaling pathways regulating expression of NTN5 Gene:

NTN5

SOURCE GeneReport for Unigene cluster for NTN5 Gene:

Hs.326217

Evidence on tissue expression from TISSUES for NTN5 Gene

  • Muscle(4.2)
genes like me logo Genes that share expression patterns with NTN5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NTN5 Gene

Orthologs for NTN5 Gene

This gene was present in the common ancestor of animals.

Orthologs for NTN5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTN5 33 32
  • 99.32 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NTN5 33
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NTN5 33 32
  • 84.9 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ntn5 17 33 32
  • 79.47 (n)
rat
(Rattus norvegicus)
Mammalia Ntn5 32
  • 78.46 (n)
oppossum
(Monodelphis domestica)
Mammalia NTN5 33
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NTN5 33
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 33
  • 8 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia NTN5 33
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii NTN5 33
  • 22 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NetA 33
  • 25 (a)
ManyToMany
NetB 33
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea unc-6 33
  • 29 (a)
OneToMany
Species where no ortholog for NTN5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NTN5 Gene

ENSEMBL:
Gene Tree for NTN5 (if available)
TreeFam:
Gene Tree for NTN5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NTN5: view image

Paralogs for NTN5 Gene

(1) SIMAP similar genes for NTN5 Gene using alignment to 2 proteins:

  • NET5_HUMAN
  • M0QXZ9_HUMAN
genes like me logo Genes that share paralogs with NTN5: view

Variants for NTN5 Gene

Sequence variations from dbSNP and Humsavar for NTN5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000063861 -- 48,665,096(-) G/A/T intron_variant
rs1000497603 -- 48,669,056(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000678040 -- 48,674,393(-) C/T upstream_transcript_variant
rs1000713613 -- 48,674,388(-) G/T upstream_transcript_variant
rs1000733024 -- 48,674,660(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NTN5 Gene

Variant ID Type Subtype PubMed ID
esv2718679 CNV deletion 23290073
esv2718680 CNV deletion 23290073
esv2718681 CNV deletion 23290073
nsv954676 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for NTN5 Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NTN5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NTN5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTN5 Gene

Disorders for NTN5 Gene

Additional Disease Information for NTN5

No disorders were found for NTN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NTN5 Gene

Publications for NTN5 Gene

  1. Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse. (PMID: 26858598) Garrett AM … Burgess RW (Frontiers in molecular neuroscience 2016) 2 3 56
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  3. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) Psychiatric GWAS Consortium Bipolar Disorder Working Group (Nature genetics 2011) 3 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56

Products for NTN5 Gene

Sources for NTN5 Gene