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This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
NTN4 (Netrin 4) is a Protein Coding gene. Among its related pathways are Developmental Biology and MET promotes cell motility. Gene Ontology (GO) annotations related to this gene include laminin-1 binding. An important paralog of this gene is LAMB1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 21516116 |
GO:0043237 | laminin-1 binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005604 | basement membrane | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0043256 | laminin complex | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Developmental Biology |
.51
|
|
2 | Axon guidance | ||
3 | Degradation of the extracellular matrix | ||
4 | Netrin-1 signaling | ||
5 | MET promotes cell motility |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007411 | axon guidance | TAS | -- |
GO:0009887 | animal organ morphogenesis | IBA | 21873635 |
GO:0009888 | tissue development | IBA | 21873635 |
GO:0016322 | neuron remodeling | IEA | -- |
GO:0016477 | cell migration | IBA | 21873635 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | NTN4 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | NTN4 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | NTN4 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Ntn4 32 |
|
||
mouse (Mus musculus) |
Mammalia | Ntn4 17 33 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | NTN4 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | NTN4 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | NTN4 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | NTN4 33 |
|
OneToOne | |
African clawed frog (Xenopus laevis) |
Amphibia | Xl.32478 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | ntn4 33 32 |
|
OneToOne |
SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs193920922 | uncertain-significance, Malignant tumor of prostate | 95,737,907(-) | G/A | coding_sequence_variant, missense_variant | |
rs1000018974 | -- | 95,736,441(-) | A/T | intron_variant | |
rs1000036802 | -- | 95,737,387(-) | C/T | intron_variant | |
rs1000055589 | -- | 95,780,202(-) | A/G | intron_variant | |
rs1000079648 | -- | 95,691,114(-) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3549615 | CNV | deletion | 23714750 |
esv3580380 | CNV | loss | 25503493 |
esv3630436 | CNV | loss | 21293372 |
nsv1052350 | CNV | gain | 25217958 |
nsv455692 | CNV | gain | 19166990 |
nsv526022 | CNV | loss | 19592680 |
nsv559831 | CNV | gain | 21841781 |
nsv7234 | OTHER | inversion | 18451855 |
nsv833 | CNV | insertion | 18451855 |
nsv975524 | CNV | duplication | 23825009 |
No disorders were found for NTN4 Gene.