Aliases for NTN1 Gene
External Ids for NTN1 Gene
Previous GeneCards Identifiers for NTN1 Gene
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]
GeneCards Summary for NTN1 Gene
NTN1 (Netrin 1) is a Protein Coding gene. Diseases associated with NTN1 include Mirror Movements 4 and Mirror Movements 1. Among its related pathways are Notch Signaling Pathway (WikiPathways) and Netrin-1 signaling. An important paralog of this gene is NTN3.
UniProtKB/Swiss-Prot Summary for NTN1 Gene
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335).