Aliases for NTMT1 Gene
External Ids for NTMT1 Gene
Previous HGNC Symbols for NTMT1 Gene
Previous GeneCards Identifiers for NTMT1 Gene
The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]
GeneCards Summary for NTMT1 Gene
NTMT1 (N-Terminal Xaa-Pro-Lys N-Methyltransferase 1) is a Protein Coding gene. Diseases associated with NTMT1 include Retinitis Pigmentosa 42. Among its related pathways are DNA Damage. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and O-methyltransferase activity. An important paralog of this gene is METTL11B.
UniProtKB/Swiss-Prot Summary for NTMT1 Gene
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.