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Aliases for NTMT1 Gene

Aliases for NTMT1 Gene

  • N-Terminal Xaa-Pro-Lys N-Methyltransferase 1 2 3 5
  • X-Pro-Lys N-Terminal Protein Methyltransferase 1A 3 4
  • Alpha N-Terminal Protein Methyltransferase 1A 3 4
  • Methyltransferase-Like Protein 11A 3 4
  • N-Terminal RCC1 Methyltransferase 3 4
  • METTL11A 3 4
  • C9orf32 3 4
  • NRMT1 3 4
  • NTM1A 3 4
  • NRMT 3 4
  • Chromosome 9 Open Reading Frame 32 2
  • Methyltransferase Like 11A 2
  • EC 2.1.1.244 4
  • AD-003 3
  • HOMT1A 3

External Ids for NTMT1 Gene

Previous HGNC Symbols for NTMT1 Gene

  • C9orf32
  • METTL11A

Previous GeneCards Identifiers for NTMT1 Gene

  • GC09P132372

Summaries for NTMT1 Gene

Entrez Gene Summary for NTMT1 Gene

  • The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]

GeneCards Summary for NTMT1 Gene

NTMT1 (N-Terminal Xaa-Pro-Lys N-Methyltransferase 1) is a Protein Coding gene. Among its related pathways are DNA Damage. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and O-methyltransferase activity. An important paralog of this gene is METTL11B.

UniProtKB/Swiss-Prot for NTMT1 Gene

  • Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.

Additional gene information for NTMT1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTMT1 Gene

Genomics for NTMT1 Gene

GeneHancer (GH) Regulatory Elements for NTMT1 Gene

Promoters and enhancers for NTMT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I129605 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 555.9 0.0 -1 5.8 CLOCK FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF548 MCM3 SP3 NTMT1 NUP188 LOC101929314 SPOUT1 FUBP3 PKN3 C9orf50 NCS1 MIGA2 USP20
GH09I129623 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 556.7 +17.8 17840 6.7 PKNOX1 CLOCK SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B NTMT1 NUP188 FUBP3 PKN3 SPOUT1 PRRX2 TOR1B ENSG00000234055 LOC101929314 C9orf50
GH09I129619 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 557.2 +11.4 11366 1.1 RB1 ZFP64 SIN3A ZBTB40 RFX5 ZNF335 GLIS2 EGR1 HSF1 CREM NTMT1 C9orf50
GH09I129457 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -149.0 -149036 4.4 HDGF FOXA2 ARID4B SIN3A YBX1 DMAP1 YY1 ZNF766 ZNF143 FOS LOC101929314 SPOUT1 LOC101929270 NTMT1 C9orf50 NUP188 LINC00963 USP20 C9orf106 ASB6
GH09I129566 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -39.6 -39586 5.8 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A ZBTB7B YY1 ZNF766 E2F8 C9orf50 NTMT1 LOC105376292 NCS1 IER5L CRAT PTPA LINC00963
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NTMT1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NTMT1 Gene

Genomic Locations for NTMT1 Gene
chr9:129,608,884-129,636,131
(GRCh38/hg38)
Size:
27,248 bases
Orientation:
Plus strand
chr9:132,371,163-132,398,209
(GRCh37/hg19)

Genomic View for NTMT1 Gene

Genes around NTMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTMT1 Gene

Proteins for NTMT1 Gene

  • Protein details for NTMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV86-NTM1A_HUMAN
    Recommended name:
    N-terminal Xaa-Pro-Lys N-methyltransferase 1
    Protein Accession:
    Q9BV86
    Secondary Accessions:
    • A8K4J2
    • A8K8G7
    • Q5SZB9
    • Q9UI28

    Protein attributes for NTMT1 Gene

    Size:
    223 amino acids
    Molecular mass:
    25387 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NTMT1 Gene

    Alternative splice isoforms for NTMT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NTMT1 Gene

Post-translational modifications for NTMT1 Gene

  • Ubiquitination at isoforms=259 and Lys101
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NTMT1 Gene

Domains & Families for NTMT1 Gene

Gene Families for NTMT1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NTMT1 Gene

Suggested Antigen Peptide Sequences for NTMT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BV86

UniProtKB/Swiss-Prot:

NTM1A_HUMAN :
  • Belongs to the methyltransferase superfamily. NTM1 family.
Family:
  • Belongs to the methyltransferase superfamily. NTM1 family.
genes like me logo Genes that share domains with NTMT1: view

Function for NTMT1 Gene

Molecular function for NTMT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein].
UniProtKB/Swiss-Prot CatalyticActivity:
2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] = 2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein].
UniProtKB/Swiss-Prot Function:
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.

Enzyme Numbers (IUBMB) for NTMT1 Gene

Phenotypes From GWAS Catalog for NTMT1 Gene

Gene Ontology (GO) - Molecular Function for NTMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20668449
GO:0008168 methyltransferase activity IEA --
GO:0008276 protein methyltransferase activity IEA,IDA 20481588
GO:0016740 transferase activity IEA --
GO:0042054 histone methyltransferase activity IDA 26543159
genes like me logo Genes that share ontologies with NTMT1: view
genes like me logo Genes that share phenotypes with NTMT1: view

Animal Models for NTMT1 Gene

MGI Knock Outs for NTMT1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NTMT1

Clone Products

  • Addgene plasmids for NTMT1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NTMT1 Gene

Localization for NTMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTMT1 Gene

Nucleus. Note=Predominantly nuclear (PubMed:24090352).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NTMT1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NTMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 20668449
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with NTMT1: view

Pathways & Interactions for NTMT1 Gene

SuperPathways for NTMT1 Gene

SuperPathway Contained pathways
1 DNA Damage
genes like me logo Genes that share pathways with NTMT1: view

Pathways by source for NTMT1 Gene

1 Cell Signaling Technology pathway for NTMT1 Gene

Gene Ontology (GO) - Biological Process for NTMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006480 N-terminal protein amino acid methylation IEA --
GO:0007051 spindle organization IMP 20668449
GO:0007059 chromosome segregation IMP 20668449
GO:0016571 histone methylation IDA 26543159
GO:0018011 N-terminal peptidyl-alanine methylation IBA --
genes like me logo Genes that share ontologies with NTMT1: view

No data available for SIGNOR curated interactions for NTMT1 Gene

Drugs & Compounds for NTMT1 Gene

(1) Drugs for NTMT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(1) Additional Compounds for NTMT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  • 2-S-Adenosyl-L-methionine
  • 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  • 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  • Active methionine
29908-03-0
genes like me logo Genes that share compounds with NTMT1: view

Transcripts for NTMT1 Gene

Unigene Clusters for NTMT1 Gene

N-terminal Xaa-Pro-Lys N-methyltransferase 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for NTMT1

Alternative Splicing Database (ASD) splice patterns (SP) for NTMT1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5:

Relevant External Links for NTMT1 Gene

GeneLoc Exon Structure for
NTMT1
ECgene alternative splicing isoforms for
NTMT1

Expression for NTMT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NTMT1 Gene

Protein differential expression in normal tissues from HIPED for NTMT1 Gene

This gene is overexpressed in Adipocyte (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NTMT1 Gene



Protein tissue co-expression partners for NTMT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NTMT1 Gene:

NTMT1

SOURCE GeneReport for Unigene cluster for NTMT1 Gene:

Hs.744027

Evidence on tissue expression from TISSUES for NTMT1 Gene

  • Adrenal gland(4.3)
  • Skin(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NTMT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NTMT1 Gene

Orthologs for NTMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NTMT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL11A 34
  • 100 (a)
OneToOne
NTMT1 33
  • 99.4 (n)
mouse
(Mus musculus)
Mammalia Ntmt1 33 16 34
  • 89.99 (n)
rat
(Rattus norvegicus)
Mammalia Ntmt1 33
  • 88.79 (n)
dog
(Canis familiaris)
Mammalia NTMT1 33 34
  • 88.49 (n)
cow
(Bos Taurus)
Mammalia NTMT1 33 34
  • 87.89 (n)
oppossum
(Monodelphis domestica)
Mammalia NTMT1 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves METTL11A 33 34
  • 79.82 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ntmt1 33
  • 71.15 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25348 33
zebrafish
(Danio rerio)
Actinopterygii ntmt1 33 34
  • 71.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ntmt 33 34
  • 50.62 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010397 33
  • 50.08 (n)
worm
(Caenorhabditis elegans)
Secernentea homt-1 33 34
  • 45.51 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR615W 33
  • 52.7 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F02101g 33
  • 49.76 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAE1 33 34 36 36
  • 47.58 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G44450 33
  • 48.13 (n)
rice
(Oryza sativa)
Liliopsida Os03g0780900 33
  • 49.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01114 33
  • 49.51 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tae1 33
  • 46.76 (n)
Species where no ortholog for NTMT1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NTMT1 Gene

ENSEMBL:
Gene Tree for NTMT1 (if available)
TreeFam:
Gene Tree for NTMT1 (if available)

Paralogs for NTMT1 Gene

Paralogs for NTMT1 Gene

(1) SIMAP similar genes for NTMT1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NTMT1: view

Variants for NTMT1 Gene

Sequence variations from dbSNP and Humsavar for NTMT1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000035606 -- 129,635,170(+) G/A intron_variant
rs1000043386 -- 129,608,086(+) G/A upstream_transcript_variant
rs1000132120 -- 129,629,356(+) G/A intron_variant
rs1000259437 -- 129,625,360(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000319099 -- 129,619,251(+) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NTMT1 Gene

Variant ID Type Subtype PubMed ID
esv2669087 CNV deletion 23128226
esv3621837 CNV loss 21293372
nsv1046477 CNV gain 25217958
nsv469901 CNV loss 18288195
nsv831731 CNV gain+loss 17160897
nsv951783 CNV deletion 24416366
nsv951784 CNV deletion 24416366

Variation tolerance for NTMT1 Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NTMT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NTMT1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTMT1 Gene

Disorders for NTMT1 Gene

Additional Disease Information for NTMT1

No disorders were found for NTMT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NTMT1 Gene

Publications for NTMT1 Gene

  1. Identification of protein N-terminal methyltransferases in yeast and humans. (PMID: 20481588) Webb KJ … Clarke SG (Biochemistry 2010) 2 3 4 58
  2. Molecular basis for histone N-terminal methylation by NRMT1. (PMID: 26543159) Wu R … Li H (Genes & development 2015) 3 4 58
  3. NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1. (PMID: 24090352) Petkowski JJ … Schaner Tooley CE (The Biochemical journal 2013) 3 4 58
  4. NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. (PMID: 20668449) Tooley CE … Macara IG (Nature 2010) 3 4 58
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58

Products for NTMT1 Gene

  • Addgene plasmids for NTMT1

Sources for NTMT1 Gene

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