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This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
NTM (Neurotrimin) is a Protein Coding gene. Diseases associated with NTM include Jacobsen Syndrome and Connective Tissue Disease. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is OPCML.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 21982860 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031225 | anchored component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007155 | cell adhesion | NAS,IEA | -- |
GO:0008038 | neuron recognition | TAS | 7891157 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NTM 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NTM 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NTM 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ntm 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | NTM 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ntm 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NTM 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NTM 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NTM 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ntm 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.26284 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | opcml 31 |
|
OneToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG31708 30 31 |
|
ManyToMany | |
CG11320 31 |
|
ManyToMany | |||
CG40378 31 |
|
ManyToMany | |||
CG14521 31 |
|
ManyToMany | |||
Ama 31 |
|
ManyToMany | |||
CG42368 31 |
|
ManyToMany | |||
CG14010 31 |
|
ManyToMany | |||
Lac 31 |
|
ManyToMany | |||
CG34391 31 |
|
ManyToMany | |||
CG42343 31 |
|
ManyToMany | |||
CG31646 31 |
|
ManyToMany | |||
CG7166 31 |
|
ManyToMany | |||
CG32791 31 |
|
ManyToMany | |||
CG31814 31 |
|
ManyToMany | |||
CG34353 31 |
|
ManyToMany | |||
klg 31 |
|
ManyToMany | |||
wrapper 31 |
|
ManyToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009965 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | rig-5 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs139579932 | Likely Benign: Connective tissue disease | 132,335,082(+) |
C/T NM_001352005.2(NTM):c.1004C>T (p.Ser335Leu) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
rs190818488 | Benign: not provided | 132,146,402(+) |
G/A NM_001144058.1(NTM):c.288G>A (p.Thr96=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
rs201653643 | Likely Benign: Connective tissue disease; not provided | 132,330,155(+) |
G/A NM_001352005.2(NTM):c.937G>A (p.Val313Met) |
MISSENSE_VARIANT,INTRON | |
rs375999981 | Likely Benign: Connective tissue disease | 132,307,685(+) |
G/A NM_001352005.2(NTM):c.527-4G>A |
INTRON | |
rs75710163 | Benign: not provided | 131,911,625(+) |
G/T NM_001144058.1(NTM):c.144G>T (p.Arg48=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS |
Disorder | Aliases | PubMed IDs |
---|---|---|
jacobsen syndrome |
|
|
connective tissue disease |
|
|