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This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early po... See more...
Aliases for NTF4 Gene
Aliases for NTF4 Gene
External Ids for NTF4 Gene
- HGNC: 8024
- NCBI Entrez Gene: 4909
- Ensembl: ENSG00000225950
- OMIM®: 162662
- UniProtKB/Swiss-Prot: P34130
Previous HGNC Symbols for NTF4 Gene
- NTF5
Previous GeneCards Identifiers for NTF4 Gene
- GC19M054257
- GC19M049564
- GC19M045941
- GC19M049565
- GC19M049055
- GC19M049061
- GC19M049073
- GC19M049082
Summaries for NTF4 Gene
-
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]
GeneCards Summary for NTF4 Gene
NTF4 (Neurotrophin 4) is a Protein Coding gene. Diseases associated with NTF4 include Glaucoma 1, Open Angle, O and Hypochondriasis. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and neurotrophin p75 receptor binding. An important paralog of this gene is NTF3.
UniProtKB/Swiss-Prot Summary for NTF4 Gene
-
Target-derived survival factor for peripheral sensory sympathetic neurons.
Additional gene information for NTF4 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NTF4 Gene
Genomics for NTF4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NTF4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NTF4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NTF4
- Top Transcription factor binding sites by QIAGEN in the NTF4 gene promoter:
-
- Brachyury
- CBF(2)
- CBF-A
- CBF-B
- CP1A
- Egr-4
- NF-Y
- NF-YA
- NF-YB
- p53
Genomic Locations for NTF4 Gene
Latest Assembly
- chr19:49,058,284-49,065,076
- (GRCh38/hg38)
- Size:
- 6,793 bases
- Orientation:
- Minus strand
Previous Assembly
- chr19:49,564,397-49,567,124
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 2,728 bases
- Orientation:
- Minus strand
Genomic View for NTF4 Gene
Genes around NTF4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
NTF4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NTF4 Gene
Proteins for NTF4 Gene
-
Protein details for NTF4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P34130-NTF4_HUMAN
- Recommended name:
- Neurotrophin-4
- Protein Accession:
- P34130
- Q6FH56
Protein attributes for NTF4 Gene
- Size:
- 210 amino acids
- Molecular mass:
- 22427 Da
- Quaternary structure:
- No Data Available
Protein Expression for NTF4 Gene
Post-translational modifications for NTF4 Gene
Other Protein References for NTF4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for NTF4
-
Abcam antibodies for NTF4
- Invitrogen Antibodies for NTF4 (AFLGC-NTF4)
- antibodies-online: Show 51 available Neurotrophin 4 Antibodies ranked by validation data
- Compare Top Neurotrophin 4 Antibodies
-
Recommended
- 131 WB Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 29 WB Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 36 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
-
Santa Cruz Biotechnology (SCBT) Antibodies for NTF4
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for NTF4
- Origene Custom Protein Services for NTF4
- Sino Biological Recombinant Proteins for NTF4
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for NTF4
-
ProSci Proteins for NTF4
-
Abcam proteins for NTF4
Assay products for research
- RayBiotech Human NT-4 ELISA
-
Custom Assay ServicesOriGene ELISA Kits for NTF4
- Novus Biologicals ELISA Kits for NTF4
- antibodies-online: Show 81 available Neurotrophin 4 Elisa Kits ranked by validation data
- Compare Top Neurotrophin 4 Elisa Kits
-
Quality Products:
- ABIN1116176
- ABIN1706065
- ABIN365304
- ABIN414911
- ABIN625066
- ABIN4993186
- ABIN1029391
- ABIN5522178
- ABIN2708342
- ABIN6719849
- ABIN1116178
- ABIN424195
- ABIN1029392
- ABIN5522179
- ABIN2685113
- ABIN5669966
- ABIN365362
- ABIN773504
- ABIN773473
- ABIN5657347
- ABIN1116177
- ABIN365378
- ABIN416257
- ABIN1571614
- ABIN5522180
- ABIN2685112
- ABIN5670629
- ABIN578889
- ABIN5593019
- ABIN772130
- ABIN775294
- ABIN1564650
-
Boster Bio ELISA Kits for NTF4
No data available for DME Specific Peptides for NTF4 Gene
Domains & Families for NTF4 Gene
Gene Families for NTF4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted secreted proteins
Protein Domains for NTF4 Gene
- InterPro:
- Blocks:
-
- Nerve growth factor
Suggested Antigen Peptide Sequences for NTF4 Gene
- GenScript: Design optimal peptide antigens:
-
- Neutrophic factor 4 (NTF4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P34130- Family:
-
- Belongs to the NGF-beta family.
Function for NTF4 Gene
Molecular function for NTF4 Gene
- UniProtKB/Swiss-Prot Function:
- Target-derived survival factor for peripheral sensory sympathetic neurons.
LifeMap Function Summary for NTF4 Gene
NTF4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Brain
Phenotypes From GWAS Catalog for NTF4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IEA | -- |
| GO:0005163 | nerve growth factor receptor binding | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 10631974 |
| GO:0008083 | growth factor activity | IEA,IBA | 21873635 |
Phenotypes for NTF4 Gene
- MGI mutant phenotypes for NTF4:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for NTF4:
Animal Models for NTF4 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NTF4 - Starting at $85 >
- * NTF4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NTF4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NTF4
-
Santa Cruz Biotechnology (SCBT) CRISPR for NTF4
miRNA for NTF4 Gene
- miRTarBase miRNAs that target NTF4
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NTF4
- Browse OriGene Inhibitory RNA Products For NTF4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NTF4
Clone products for research
- Applied Biological Materials (abm): Clones for NTF4 - Starting at $45 >
- * NTF4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for NTF4
- Sino Biological Human cDNA Clone for NTF4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NTF4
Cell Lines for research
-
Horizon Cell Lines for NTF4
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NTF4 Gene
Localization for NTF4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NTF4 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 3 |
| cytosol | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Golgi apparatus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0008021 | synaptic vesicle | IBA | 21873635 |
| GO:0030424 | axon | IBA | 21873635 |
| GO:0030425 | dendrite | IBA | 21873635 |
Pathways & Interactions for NTF4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
| 3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 4 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
|
| 5 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.61
Nanog in Mammalian ESC Pluripotency
.61
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
Pathways by source for NTF4 Gene
4 BioSystems pathways for NTF4 Gene
4 KEGG pathways for NTF4 Gene
2 GeneGo (Thomson Reuters) pathways for NTF4 Gene
- Development MAG-dependent inhibition of neurite outgrowth
- Development Neurotrophin family signaling
2 R&D Systems pathways for NTF4 Gene
56 Qiagen pathways for NTF4 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
Interacting Proteins for NTF4 Gene
Selected Interacting proteins:
P34130-NTF4_HUMAN
ENSP00000469455
for NTF4 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for NTF4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA | 21873635 |
| GO:0007202 | activation of phospholipase C activity | TAS | -- |
| GO:0007402 | ganglion mother cell fate determination | ISS | 10681461 |
| GO:0007422 | peripheral nervous system development | IBA | 21873635 |
Transcripts for NTF4 Gene
mRNA/cDNA for NTF4 Gene
- 1 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000593537 932 nts (view in UCSC)
- ENST00000594938 278 nts (view in UCSC)
- ENST00000595857 813 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NTF4 - Starting at $85 >
- * NTF4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NTF4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NTF4
-
Santa Cruz Biotechnology (SCBT) CRISPR for NTF4
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NTF4
- Browse OriGene Inhibitory RNA Products For NTF4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NTF4
Clone products for research
- Applied Biological Materials (abm): Clones for NTF4 - Starting at $45 >
- * NTF4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for NTF4
- Sino Biological Human cDNA Clone for NTF4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NTF4
Relevant External Links for NTF4 Gene
- GeneLoc Exon Structure for
- NTF4
Expression for NTF4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells
-
Ovary (Reproductive System)
- Ovarian Somatic Cells Ovigerous Cord
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Motor Neurons (Nervous System)
- Neurons
- Spinal Cord (Nervous System)
mRNA differential expression in normal tissues according to GTEx for NTF4 Gene
This gene is overexpressed in Prostate (x7.3), Skin - Not Sun Exposed (Suprapubic) (x7.1), Skin - Sun Exposed (Lower leg) (x5.7), Esophagus - Mucosa (x5.0), Muscle - Skeletal (x4.4), Vagina (x4.2), and Bladder (x4.1).
This gene is overexpressed in Breast (46.1) and Pancreatic juice (21.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NTF4 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NTF4
SOURCE GeneReport for Unigene cluster for NTF4 Gene:
Hs.266902mRNA Expression by UniProt/SwissProt for NTF4 Gene:
P34130-NTF4_HUMAN
Tissue specificity:
Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
Evidence on tissue expression from TISSUES for NTF4 Gene
- Nervous system(3.8)
- Adrenal gland(2.5)
- Muscle(2.5)
- Skin(2.4)
- Kidney(2.2)
- Eye(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for NTF4 Gene
Germ Layers:
- ectoderm
Systems:
- nervous
Regions:
Head and neck:
- eye
- head
Primer products for research
-
OriGene qPCR primer pairs for NTF4
-
OriGene qPCR primer pairs and template standards for NTF4
Gene Expression Assays for research
Orthologs for NTF4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NTF4 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NTF4 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NTF4 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ntf4 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ntf5 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | NTF4 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NTF4 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ntf4 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | NTF4 30 |
|
OneToOne |
- Species where no ortholog for NTF4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for NTF4 Gene
- ENSEMBL:
- Gene Tree for NTF4 (if available)
- TreeFam:
- Gene Tree for NTF4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NTF4: view image
- Alliance of Genome Resources:
- Additional Orthologs for NTF4
Paralogs for NTF4 Gene
(3) SIMAP similar genes for NTF4 Gene using alignment to 4 proteins:
- NTF4_HUMAN
- E7EP46_HUMAN
- M0QZQ0_HUMAN
- M0R0X2_HUMAN
Pseudogenes.org Pseudogenes for NTF4 Gene
Variants for NTF4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NTF4 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs121918427 | Conflicting Interpretations: Glaucoma 1, open angle, O. Glaucoma 1, open angle, O (GLC1O) [MIM:613100] | 49,061,382(-) |
G/Ap.Arg206Trp NM_006179.4(NTF4):c.616C>T (p.Arg206Trp) |
MISSENSE | |
| rs121918428 | Pathogenic: Glaucoma 1, open angle, O. Glaucoma 1, open angle, O (GLC1O) [MIM:613100] | 49,061,381(-) |
C/Tp.Arg206Gln NM_006179.4(NTF4):c.617G>A (p.Arg206Gln) |
MISSENSE | |
| rs200675509 | Glaucoma 1, open angle, O (GLC1O) [MIM:613100] |
p.Arg209Gly |
|||
| rs200786116 | Benign: not provided | 49,061,795(-) |
C/T NM_006179.4(NTF4):c.203G>A (p.Arg68Gln) |
MISSENSE | |
| rs61732310 | Likely Benign: Mental retardation, X-linked 99; Glaucoma 1, open angle, O | 49,061,735(-) |
G/Ap.Ala88Val NM_006179.4(NTF4):c.263C>T (p.Ala88Val) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.00;
74.88% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NTF4 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTF4 Gene
Disorders for NTF4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| glaucoma 1, open angle, o |
|
|
| hypochondriasis |
|
|
| open-angle glaucoma |
|
|
| mental retardation, x-linked 99 |
|
|
| trichothiodystrophy 7, nonphotosensitive |
|
|
Search NTF4 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
NTF4_HUMAN- Glaucoma 1, open angle, O (GLC1O) [MIM:613100]: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. {ECO:0000269 PubMed:19765683, ECO:0000269 PubMed:20215012}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.
Additional Disease Information for NTF4
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for NTF4 Gene
Publications for NTF4 Gene
- Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. (PMID: 19765683) Pasutto F … Reis A (American journal of human genetics 2009) 3 4 22 72
- The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site. (PMID: 10631974) Robinson RC … Jones EY (Protein science : a publication of the Protein Society 1999) 3 4 22
- Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. (PMID: 1313578) Ip NY … Squinto SP (Proceedings of the National Academy of Sciences of the United States of America 1992) 3 4 22
- Human chromosome 19 contains the neurotrophin-5 gene locus and three related genes that may encode novel acidic neurotrophins. (PMID: 1496419) Berkemeier LR … Rosenthal A (Somatic cell and molecular genetics 1992) 2 3 22
- No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma. (PMID: 20215012) Liu Y … Hauser MA (American journal of human genetics 2010) 3 4
ExternalLinks
Products for NTF4 Gene
- View all 8 R&D Systems NTF4 (NT-4) Products
- View all R&D Systems NTF4 (NT-4) Proteins and Enzymes
- View all 5 R&D Systems NTF4 (NT-4) Primary Antibodies
- View all R&D Systems NTF4 (NT-4) ELISAs
- View all R&D Systems NTF4 (NT-4) Luminex Assays
- Learn more about R&D Systems custom NTF4 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for NTF4
- Custom Assay ServicesOriGene ELISA Kits for NTF4
- Search Origene for MassSpec and Protein Over-expression Lysates for NTF4
- Origene Custom Protein Services for NTF4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NTF4
- Browse OriGene Inhibitory RNA Products For NTF4
- OriGene qPCR primer pairs for NTF4
- OriGene qPCR primer pairs and template standards for NTF4
- OriGene CRISPR knockouts for NTF4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NTF4
- Sino Biological Human cDNA Clone for NTF4
- Sino Biological Human cDNA Clone for NTF4
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- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for NTF4
- Novus Biologicals proteins and lysates for NTF4
- Novus Biologicals ELISA Kits for NTF4
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for NTF4
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- VectorBuilder Custom and pre-made DNA vectors for NTF4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for NTF4 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for NTF4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for NTF4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for NTF4
- antibodies-online: Show 51 available Neurotrophin 4 Antibodies ranked by validation data
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- Recommended
- 131 WB Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 29 WB Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 36 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- antibodies-online: Show 81 available Neurotrophin 4 Elisa Kits ranked by validation data
- Compare Top Neurotrophin 4 Elisa Kits
- Quality Products:
- ABIN1116176
- ABIN1706065
- ABIN365304
- ABIN414911
- ABIN625066
- ABIN4993186
- ABIN1029391
- ABIN5522178
- ABIN2708342
- ABIN6719849
- ABIN1116178
- ABIN424195
- ABIN1029392
- ABIN5522179
- ABIN2685113
- ABIN5669966
- ABIN365362
- ABIN773504
- ABIN773473
- ABIN5657347
- ABIN1116177
- ABIN365378
- ABIN416257
- ABIN1571614
- ABIN5522180
- ABIN2685112
- ABIN5670629
- ABIN578889
- ABIN5593019
- ABIN772130
- ABIN775294
- ABIN1564650
- antibodies-online: Show 38 available Neurotrophin 4 Proteins ranked by validation data
- Compare Top Neurotrophin 4 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for NTF4
- Search Santa Cruz Biotechnology (SCBT) for NTF4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NTF4
- Horizon Cell Lines for NTF4
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NTF4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NTF4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NTF4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NTF4
Sources for NTF4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources