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Aliases for NTF3 Gene

Aliases for NTF3 Gene

  • Neurotrophin 3 2 3 5
  • Nerve Growth Factor 2 3 4
  • Neurotrophic Factor 3 4
  • Neurotrophin-3 3 4
  • NGF-2 3 4
  • HDNF 3 4
  • NT-3 3 4
  • NGF2 3
  • NT3 3

External Ids for NTF3 Gene

Previous GeneCards Identifiers for NTF3 Gene

  • GC12U990064
  • GC12P005487
  • GC12P005420
  • GC12P005473
  • GC12P005541

Summaries for NTF3 Gene

Entrez Gene Summary for NTF3 Gene

  • The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]

GeneCards Summary for NTF3 Gene

NTF3 (Neurotrophin 3) is a Protein Coding gene. Diseases associated with NTF3 include Hypochondriasis and Diabetic Polyneuropathy. Among its related pathways are GPCR Pathway and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and chemoattractant activity. An important paralog of this gene is BDNF.

UniProtKB/Swiss-Prot for NTF3 Gene

  • Seems to promote the survival of visceral and proprioceptive sensory neurons.

Gene Wiki entry for NTF3 Gene

Additional gene information for NTF3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTF3 Gene

Genomics for NTF3 Gene

GeneHancer (GH) Regulatory Elements for NTF3 Gene

Promoters and enhancers for NTF3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J005429 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 616.5 +0.1 90 6 SP1 YY1 PRDM1 GLIS2 RXRA ZNF600 PRDM10 ZIC2 ZSCAN4 POLR2A NTF3 KCNA5 GC12M005446
GH12J004537 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.6 -893.1 -893107 3.6 SP1 CC2D1A ELF3 MNT NKRF POLR2A NFRKB YY1 ELF1 SP7 RAD51AP1 C12orf4 NTF3 GC12M004550
GH12J006166 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +736.0 735982 3.9 SP1 ZKSCAN8 CBFA2T2 MLLT1 GTF2F1 BACH1 TRIM24 SP7 CREM PRDM1 PIR38862 CD9 VWF ATN1 NTF3 TNFRSF1A TAPBPL VAMP1 PIR39839 LOC105369623
GH12J005455 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 13.5 +24.9 24911 2.8 RFX1 BMI1 ZBTB33 NTF3 GC12M005446 GC12P006205
GH12J005496 Enhancer 1 Ensembl ENCODE dbSUPER 11.2 +66.8 66768 4.9 SP1 RXRA JUND FOS YY1 ZBTB33 GABPA HNF4A EZH2 MAX NTF3 GC12M005501 GC12M005461
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NTF3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NTF3 gene promoter:
  • AP-1
  • ATF-2
  • c-Ets-1
  • c-Jun
  • CREB
  • deltaCREB
  • GR
  • GR-alpha
  • LyF-1

Genomic Locations for NTF3 Gene

Genomic Locations for NTF3 Gene
89,429 bases
Plus strand
89,425 bases
Plus strand

Genomic View for NTF3 Gene

Genes around NTF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTF3 Gene

Proteins for NTF3 Gene

  • Protein details for NTF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B7Z1T5
    • Q6FH50

    Protein attributes for NTF3 Gene

    257 amino acids
    Molecular mass:
    29355 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NTF3 Gene

    Alternative splice isoforms for NTF3 Gene


neXtProt entry for NTF3 Gene

Post-translational modifications for NTF3 Gene

  • Glycosylation at isoforms=2131
  • Modification sites at PhosphoSitePlus

Other Protein References for NTF3 Gene

Antibody Products

No data available for DME Specific Peptides for NTF3 Gene

Domains & Families for NTF3 Gene

Gene Families for NTF3 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for NTF3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54849, highly similar to Neurotrophin-3 (B7Z1T5_HUMAN)
  • Neurotrophic factor (NTF3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NGF-beta family.
  • Belongs to the NGF-beta family.
genes like me logo Genes that share domains with NTF3: view

Function for NTF3 Gene

Molecular function for NTF3 Gene

UniProtKB/Swiss-Prot Function:
Seems to promote the survival of visceral and proprioceptive sensory neurons.
GENATLAS Biochemistry:
neurotrophic factor (neurotrophin) 3,29.3kDa,ligand for NTRK3 (TRKC),expressed in retina and the anterior segment of the developing eye

Phenotypes From GWAS Catalog for NTF3 Gene

Gene Ontology (GO) - Molecular Function for NTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 2236018
GO:0005165 neurotrophin receptor binding IEA --
GO:0005515 protein binding IPI 18596692
GO:0008083 growth factor activity IDA 23027130
GO:0042056 chemoattractant activity IDA 23027130
genes like me logo Genes that share ontologies with NTF3: view
genes like me logo Genes that share phenotypes with NTF3: view

Animal Models for NTF3 Gene

MGI Knock Outs for NTF3:

Animal Model Products

CRISPR Products

miRNA for NTF3 Gene

miRTarBase miRNAs that target NTF3

Clone Products

  • Applied Biological Materials (abm): Clones for NTF3 - Now 50% OFF >
  • * NTF3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NTF3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for NTF3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NTF3 Gene

Localization for NTF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTF3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NTF3 gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0008021 synaptic vesicle IBA 21873635
GO:0030424 axon IBA 21873635
GO:0030425 dendrite IBA 21873635
genes like me logo Genes that share ontologies with NTF3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NTF3 Gene

Pathways & Interactions for NTF3 Gene

genes like me logo Genes that share pathways with NTF3: view

SIGNOR curated interactions for NTF3 Gene


Gene Ontology (GO) - Biological Process for NTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 23027130
GO:0002092 positive regulation of receptor internalization IDA 23027130
GO:0007165 signal transduction TAS 2236018
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IDA 23027130
GO:0007267 cell-cell signaling TAS 2236018
genes like me logo Genes that share ontologies with NTF3: view

Drugs & Compounds for NTF3 Gene

(47) Drugs for NTF3 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4-des-dimethylaminotetracycline Pharma 15

(28) Additional Compounds for NTF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NTF3: view

Transcripts for NTF3 Gene

mRNA/cDNA for NTF3 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for NTF3 Gene

Neurotrophin 3:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for NTF3 - Now 50% OFF >
  • * NTF3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NTF3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for NTF3

Alternative Splicing Database (ASD) splice patterns (SP) for NTF3 Gene

No ASD Table

Relevant External Links for NTF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NTF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NTF3 Gene

mRNA differential expression in normal tissues according to GTEx for NTF3 Gene

This gene is overexpressed in Artery - Tibial (x8.1), Artery - Aorta (x6.2), and Artery - Coronary (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NTF3 Gene

NURSA nuclear receptor signaling pathways regulating expression of NTF3 Gene:


SOURCE GeneReport for Unigene cluster for NTF3 Gene:


mRNA Expression by UniProt/SwissProt for NTF3 Gene:

Tissue specificity: Brain and peripheral tissues.

Evidence on tissue expression from TISSUES for NTF3 Gene

  • Nervous system(4.7)
  • Blood(4.2)
  • Muscle(2.3)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with NTF3: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NTF3 Gene

Orthologs for NTF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NTF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NTF3 35 34
  • 98.7 (n)
(Monodelphis domestica)
Mammalia NTF3 35
  • 93 (a)
(Canis familiaris)
Mammalia NTF3 35 34
  • 92.1 (n)
(Rattus norvegicus)
Mammalia Ntf3 34
  • 90.62 (n)
(Mus musculus)
Mammalia Ntf3 17 35 34
  • 90 (n)
(Bos Taurus)
Mammalia NTF3 35 34
  • 89.68 (n)
(Ornithorhynchus anatinus)
Mammalia NT-3 35
  • 88 (a)
(Gallus gallus)
Aves NTF3 35 34
  • 78.89 (n)
(Anolis carolinensis)
Reptilia NTF3 35
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ntf3 34
  • 73.28 (n)
Str.3752 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1074 34
(Danio rerio)
Actinopterygii ntf3 35 34
  • 59.48 (n)
Species where no ortholog for NTF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTF3 Gene

Gene Tree for NTF3 (if available)
Gene Tree for NTF3 (if available)
Evolutionary constrained regions (ECRs) for NTF3: view image

Paralogs for NTF3 Gene

Paralogs for NTF3 Gene

(3) SIMAP similar genes for NTF3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NTF3: view

Variants for NTF3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NTF3 Gene

Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of schizophrenia. This does not seem to be the case.

Sequence variations from dbSNP and Humsavar for NTF3 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs540320780 uncertain-significance, Hirschsprung disease 1 5,494,440(+) G/A coding_sequence_variant, missense_variant
rs1000021071 -- 5,453,330(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000075380 -- 5,460,408(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000114211 -- 5,474,007(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000135888 -- 5,469,381(+) C/G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NTF3 Gene

Variant ID Type Subtype PubMed ID
dgv1348n100 CNV gain 25217958
esv2559368 CNV insertion 19546169
esv3358188 CNV duplication 20981092
nsv1040098 CNV gain 25217958
nsv1051126 CNV gain 25217958
nsv1110206 CNV duplication 24896259
nsv1152910 CNV duplication 26484159
nsv468988 CNV gain 19166990
nsv470262 CNV gain 18288195
nsv473788 CNV novel sequence insertion 20440878
nsv478052 CNV novel sequence insertion 20440878
nsv513347 CNV insertion 21212237
nsv523152 CNV gain 19592680
nsv524170 CNV gain 19592680
nsv557155 CNV gain 21841781
nsv592 CNV insertion 18451855

Variation tolerance for NTF3 Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.35; 70.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NTF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

SNP Genotyping and Copy Number Assay Products

Disorders for NTF3 Gene

MalaCards: The human disease database

(24) MalaCards diseases for NTF3 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • hypochondria
diabetic polyneuropathy
  • diabetes mellitus with polyneuropathy
demyelinating disease
  • demyelinating disorder
diabetic autonomic neuropathy
  • diabetic neuropathies
diabetic neuropathy
  • diabetic neuropathies
- elite association - COSMIC cancer census association via MalaCards
Search NTF3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NTF3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NTF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NTF3 Gene

Publications for NTF3 Gene

  1. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. (PMID: 1889806) Maisonpierre PC … Yancopoulos GD (Genomics 1991) 2 3 4 23 58
  2. Association of neurotrophin-3 gene variant with severe forms of schizophrenia. (PMID: 7733919) Hattori M … Nanko S (Biochemical and biophysical research communications 1995) 3 4 45 58
  3. NT-3 gene modified Schwann cells promote TrkC gene modified mesenchymal stem cells to differentiate into neuron-like cells in vitro. (PMID: 19680743) Zhang YQ … Zeng YS (Anatomical science international 2010) 3 23 58
  4. Increased neurotrophin-3 in drug-free subjects with bipolar disorder during manic and depressive episodes. (PMID: 20060128) Fernandes BS … Kapczinski F (Journal of psychiatric research 2010) 3 23 58
  5. Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease. (PMID: 20219210) Gratacòs M … Estivill X (Journal of psychiatric research 2010) 3 45 58

Products for NTF3 Gene

Sources for NTF3 Gene

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