Aliases for NTAN1 Gene
External Ids for NTAN1 Gene
Previous GeneCards Identifiers for NTAN1 Gene
The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
GeneCards Summary for NTAN1 Gene
NTAN1 (N-Terminal Asparagine Amidase) is a Protein Coding gene. Diseases associated with NTAN1 include Diabetes Mellitus, Insulin-Dependent, 21 and Secondary Progressive Multiple Sclerosis. Gene Ontology (GO) annotations related to this gene include protein-N-terminal asparagine amidohydrolase activity.
UniProtKB/Swiss-Prot Summary for NTAN1 Gene
N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn.