Aliases for NT5E Gene
External Ids for NT5E Gene
Previous HGNC Symbols for NT5E Gene
Previous GeneCards Identifiers for NT5E Gene
The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
GeneCards Summary for NT5E Gene
NT5E (5'-Nucleotidase Ecto) is a Protein Coding gene. Diseases associated with NT5E include Calcification Of Joints And Arteries and Intestinal Tuberculosis. Among its related pathways are NAD metabolism and Pyrimidine metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include nucleotide binding and hydrolase activity, acting on ester bonds.
UniProtKB/Swiss-Prot for NT5E Gene
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.