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Aliases for NT5DC4 Gene

Aliases for NT5DC4 Gene

  • 5'-Nucleotidase Domain Containing 4 2 3 5
  • 5'-Nucleotidase Domain-Containing Protein 4 3 4
  • EC 56

External Ids for NT5DC4 Gene

Previous GeneCards Identifiers for NT5DC4 Gene

  • GC02U900803
  • GC02P113196
  • GC02P113465
  • GC02P105933
  • GC02P112721
  • GC02P113964
  • GC02P112722
  • GC02P112869
  • GC02P112919
  • GC02P113139
  • GC02P113364
  • GC02P113604
  • GC02P113831

Summaries for NT5DC4 Gene

GeneCards Summary for NT5DC4 Gene

NT5DC4 (5'-Nucleotidase Domain Containing 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity and 5'-nucleotidase activity. An important paralog of this gene is NT5C2.

Additional gene information for NT5DC4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5DC4 Gene

Genomics for NT5DC4 Gene

GeneHancer (GH) Regulatory Elements for NT5DC4 Gene

Promoters and enhancers for NT5DC4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NT5DC4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NT5DC4 gene promoter:
  • AREB6
  • FOXC1
  • HEN1
  • Pax-4a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • SRF
  • SRF (504 AA)

Genomic Locations for NT5DC4 Gene

Genomic Locations for NT5DC4 Gene
22,070 bases
Plus strand
21,394 bases
Plus strand

Genomic View for NT5DC4 Gene

Genes around NT5DC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5DC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5DC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5DC4 Gene

Proteins for NT5DC4 Gene

  • Protein details for NT5DC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5'-nucleotidase domain-containing protein 4
    Protein Accession:

    Protein attributes for NT5DC4 Gene

    428 amino acids
    Molecular mass:
    48951 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH41437.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NT5DC4 Gene

Selected DME Specific Peptides for NT5DC4 Gene


Post-translational modifications for NT5DC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NT5DC4 Gene

Gene Families for NT5DC4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NT5DC4 Gene

Suggested Antigen Peptide Sequences for NT5DC4 Gene

GenScript: Design optimal peptide antigens:
  • 5'-nucleotidase domain-containing protein 4 (NT5D4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 5'(3')-deoxyribonucleotidase family.
  • Belongs to the 5'(3')-deoxyribonucleotidase family.
genes like me logo Genes that share domains with NT5DC4: view

Function for NT5DC4 Gene

Enzyme Numbers (IUBMB) for NT5DC4 Gene

Gene Ontology (GO) - Molecular Function for NT5DC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008253 5'-nucleotidase activity IBA 21873635
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NT5DC4: view

Animal Model Products

Clone Products

  • Applied Biological Materials (abm): Clones for NT5DC4 - Now 50% OFF >
  • * NT5DC4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NT5DC4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NT5DC4 Gene

Localization for NT5DC4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NT5DC4 gene
Compartment Confidence
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
lysosome 0
golgi apparatus 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NT5DC4 Gene

Pathways & Interactions for NT5DC4 Gene

PathCards logo

SuperPathways for NT5DC4 Gene

No Data Available

Interacting Proteins for NT5DC4 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
Selected Interacting proteins: ENSP00000330247 Q86YG4-NT5D4_HUMAN for NT5DC4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for NT5DC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with NT5DC4: view

No data available for Pathways by source and SIGNOR curated interactions for NT5DC4 Gene

Drugs & Compounds for NT5DC4 Gene

No Compound Related Data Available

Transcripts for NT5DC4 Gene

mRNA/cDNA for NT5DC4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for NT5DC4 Gene

5'-nucleotidase domain containing 4:
Representative Sequences:

Clone Products

  • Applied Biological Materials (abm): Clones for NT5DC4 - Now 50% OFF >
  • * NT5DC4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NT5DC4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for NT5DC4 Gene

No ASD Table

Relevant External Links for NT5DC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NT5DC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NT5DC4 Gene

mRNA differential expression in normal tissues according to GTEx for NT5DC4 Gene

This gene is overexpressed in Testis (x22.3), Whole Blood (x15.3), and Spleen (x5.1).

Protein differential expression in normal tissues from HIPED for NT5DC4 Gene

This gene is overexpressed in Salivary gland (43.0) and Testis (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NT5DC4 Gene

Protein tissue co-expression partners for NT5DC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of NT5DC4 Gene:


SOURCE GeneReport for Unigene cluster for NT5DC4 Gene:


Evidence on tissue expression from TISSUES for NT5DC4 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with NT5DC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NT5DC4 Gene

Orthologs for NT5DC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NT5DC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NT5DC4 35
  • 97 (a)
(Monodelphis domestica)
Mammalia NT5DC4 35
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 74 (a)
-- 35
  • 65 (a)
(Bos Taurus)
Mammalia NT5DC4 35
  • 66 (a)
(Gallus gallus)
Aves -- 35
  • 72 (a)
-- 35
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 22 (a)
(Danio rerio)
Actinopterygii nt5c2l1 35
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32549 35
  • 30 (a)
(Caenorhabditis elegans)
Secernentea Y71H10B.1 35
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9662 35
  • 39 (a)
Species where no ortholog for NT5DC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NT5DC4 Gene

Gene Tree for NT5DC4 (if available)
Gene Tree for NT5DC4 (if available)
Evolutionary constrained regions (ECRs) for NT5DC4: view image

Paralogs for NT5DC4 Gene

Paralogs for NT5DC4 Gene

(1) SIMAP similar genes for NT5DC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NT5DC4: view

Variants for NT5DC4 Gene

Sequence variations from dbSNP and Humsavar for NT5DC4 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000099265 -- 112,729,739(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000155036 -- 112,726,133(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000165157 -- 112,728,542(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000209677 -- 112,730,513(+) A/C/G genic_downstream_transcript_variant, intron_variant
rs1000240737 -- 112,730,205(+) C/T genic_downstream_transcript_variant, intron_variant

Variation tolerance for NT5DC4 Gene

Gene Damage Index Score: 5.51; 71.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NT5DC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NT5DC4 Gene

Disorders for NT5DC4 Gene

Additional Disease Information for NT5DC4

No disorders were found for NT5DC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NT5DC4 Gene

Publications for NT5DC4 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58
  2. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for NT5DC4 Gene

Sources for NT5DC4 Gene

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