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Aliases for NT5DC2 Gene

Aliases for NT5DC2 Gene

  • 5'-Nucleotidase Domain Containing 2 2
  • 5-Nucleotidase Domain Containing 2 2 3 5
  • EC 3.1.3.- 4

External Ids for NT5DC2 Gene

Summaries for NT5DC2 Gene

GeneCards Summary for NT5DC2 Gene

NT5DC2 (5'-Nucleotidase Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity and 5-nucleotidase activity. An important paralog of this gene is NT5DC3.

Additional gene information for NT5DC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5DC2 Gene

Genomics for NT5DC2 Gene

GeneHancer (GH) Regulatory Elements for NT5DC2 Gene

Promoters and enhancers for NT5DC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I052528 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 574.7 +1.4 1424 9.6 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 NT5DC2 SMIM4 PBRM1 STAB1 ITIH4 ITIH1 GNL3 NEK4 RPL29 PIR41495
GH03I052044 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.6 +483.5 483455 14 HDGF PKNOX1 CLOCK ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF416 ZNF207 DUSP7 DCAF1 GPR62 RAD54L2 PHF7 NT5DC2 RPL29 PCBP4 WDR82 SFMBT1
GH03I053345 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 9.9 -812.2 -812248 2.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 DCP1A NISCH PBRM1 ENSG00000271976 RFT1 PHF7 ENSG00000212608 PRKCD NEK4 ACTR8
GH03I052452 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 9.7 +80.3 80293 5.5 PKNOX1 ATF1 MLX ARNT ZFP64 ZNF133 ARID4B DMAP1 GLI4 ZNF48 NISCH TNNC1 PPM1M NT5DC2 PBRM1 ITIH3 SFMBT1
GH03I052466 Enhancer 1 VISTA FANTOM5 dbSUPER 22.1 +66.9 66896 3 ZNF121 ATF4 POLR2A MNT PRDM1 NR2F2 NT5DC2 SEMA3G STAB1 SMIM4 RNU6-856P RNU6ATAC16P PBRM1 GNL3 ENSG00000252787 SNORD19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NT5DC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NT5DC2 gene promoter:

Genomic Locations for NT5DC2 Gene

Genomic Locations for NT5DC2 Gene
10,709 bases
Minus strand

Genomic View for NT5DC2 Gene

Genes around NT5DC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5DC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5DC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5DC2 Gene

Proteins for NT5DC2 Gene

  • Protein details for NT5DC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5-nucleotidase domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • C9JTZ6
    • E9PAL9
    • O95888
    • Q96C80
    • Q9H9Z8

    Protein attributes for NT5DC2 Gene

    520 amino acids
    Molecular mass:
    60719 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH14550.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14064.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NT5DC2 Gene


neXtProt entry for NT5DC2 Gene

Post-translational modifications for NT5DC2 Gene

  • Ubiquitination at isoforms=2102
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NT5DC2 Gene

Domains & Families for NT5DC2 Gene

Gene Families for NT5DC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NT5DC2 Gene

Suggested Antigen Peptide Sequences for NT5DC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 5(3)-deoxyribonucleotidase family.
  • Belongs to the 5(3)-deoxyribonucleotidase family.
genes like me logo Genes that share domains with NT5DC2: view

Function for NT5DC2 Gene

Enzyme Numbers (IUBMB) for NT5DC2 Gene

Phenotypes From GWAS Catalog for NT5DC2 Gene

Gene Ontology (GO) - Molecular Function for NT5DC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008253 5-nucleotidase activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NT5DC2: view
genes like me logo Genes that share phenotypes with NT5DC2: view

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NT5DC2 Gene

Localization for NT5DC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NT5DC2 gene
Compartment Confidence
mitochondrion 2
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NT5DC2 Gene

Pathways & Interactions for NT5DC2 Gene

SuperPathways for NT5DC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NT5DC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with NT5DC2: view

No data available for Pathways by source and SIGNOR curated interactions for NT5DC2 Gene

Drugs & Compounds for NT5DC2 Gene

No Compound Related Data Available

Transcripts for NT5DC2 Gene

Unigene Clusters for NT5DC2 Gene

5-nucleotidase domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NT5DC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5: -
SP7: -
SP8: -
SP9: - - - -
SP10: - - - - -
SP11: -
SP15: -

ExUns: 19a · 19b

Relevant External Links for NT5DC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NT5DC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NT5DC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NT5DC2 Gene

This gene is overexpressed in Breast (20.7), Salivary gland (15.7), and Fetal heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NT5DC2 Gene

Protein tissue co-expression partners for NT5DC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NT5DC2 Gene:


SOURCE GeneReport for Unigene cluster for NT5DC2 Gene:


Evidence on tissue expression from TISSUES for NT5DC2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with NT5DC2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NT5DC2 Gene

Orthologs for NT5DC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NT5DC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NT5DC2 33 34
  • 98.83 (n)
(Bos Taurus)
Mammalia NT5DC2 33 34
  • 91.74 (n)
(Canis familiaris)
Mammalia NT5DC2 33 34
  • 90.82 (n)
(Mus musculus)
Mammalia Nt5dc2 33 16 34
  • 90.09 (n)
(Rattus norvegicus)
Mammalia Nt5dc2 33
  • 90.02 (n)
(Ornithorhynchus anatinus)
Mammalia NT5DC2 34
  • 79 (a)
(Monodelphis domestica)
Mammalia NT5DC2 34
  • 74 (a)
(Gallus gallus)
Aves NT5DC2 33 34
  • 74.74 (n)
(Anolis carolinensis)
Reptilia NT5DC2 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nt5dc2 33
  • 69.9 (n)
Str.295 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53840 33
(Danio rerio)
Actinopterygii nt5dc2 33 34
  • 69.95 (n)
wufb83e03 33
fruit fly
(Drosophila melanogaster)
Insecta CG1814 34
  • 40 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G23890 33
  • 47.59 (n)
(Oryza sativa)
Liliopsida Os09g0424600 33
  • 48.4 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
Species where no ortholog for NT5DC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NT5DC2 Gene

Gene Tree for NT5DC2 (if available)
Gene Tree for NT5DC2 (if available)

Paralogs for NT5DC2 Gene

Paralogs for NT5DC2 Gene

(1) SIMAP similar genes for NT5DC2 Gene using alignment to 5 proteins: Pseudogenes for NT5DC2 Gene

genes like me logo Genes that share paralogs with NT5DC2: view

Variants for NT5DC2 Gene

Sequence variations from dbSNP and Humsavar for NT5DC2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000039280 -- 52,536,808(-) A/G upstream_transcript_variant
rs1000449787 -- 52,531,698(-) G/A intron_variant
rs1000810387 -- 52,525,412(-) G/A intron_variant
rs1000859453 -- 52,527,112(-) C/T intron_variant
rs1001051732 -- 52,533,104(-) C/A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NT5DC2 Gene

Variant ID Type Subtype PubMed ID
dgv8326n54 CNV loss 21841781
esv27812 CNV loss 19812545
esv3596160 CNV gain 21293372
nsv1072693 CNV deletion 25765185
nsv3820 CNV insertion 18451855
nsv834697 CNV loss 17160897
nsv954862 CNV deletion 24416366

Variation tolerance for NT5DC2 Gene

Residual Variation Intolerance Score: 8.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.51; 85.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NT5DC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NT5DC2 Gene

Disorders for NT5DC2 Gene

Additional Disease Information for NT5DC2

No disorders were found for NT5DC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NT5DC2 Gene

Publications for NT5DC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 58
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for NT5DC2 Gene

Sources for NT5DC2 Gene

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