Aliases for NT5DC2 Gene

Aliases for NT5DC2 Gene

  • 5'-Nucleotidase Domain Containing 2 2 3 5
  • 5'-Nucleotidase Domain-Containing Protein 2 3 4
  • EC 3.1.3.- 4

External Ids for NT5DC2 Gene

Previous GeneCards Identifiers for NT5DC2 Gene

  • GC03M052534

Summaries for NT5DC2 Gene

GeneCards Summary for NT5DC2 Gene

NT5DC2 (5'-Nucleotidase Domain Containing 2) is a Protein Coding gene. Diseases associated with NT5DC2 include Acute Contagious Conjunctivitis and Acute Conjunctivitis. Gene Ontology (GO) annotations related to this gene include hydrolase activity and 5'-nucleotidase activity. An important paralog of this gene is NT5DC3.

Additional gene information for NT5DC2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NT5DC2 Gene

Genomics for NT5DC2 Gene

GeneHancer (GH) Regulatory Elements for NT5DC2 Gene

Promoters and enhancers for NT5DC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NT5DC2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NT5DC2

Top Transcription factor binding sites by QIAGEN in the NT5DC2 gene promoter:
  • E2F
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GATA-2

Genomic Locations for NT5DC2 Gene

Genomic Locations for NT5DC2 Gene
chr3:52,524,369-52,535,077
(GRCh38/hg38)
Size:
10,709 bases
Orientation:
Minus strand
chr3:52,558,385-52,569,093
(GRCh37/hg19)
Size:
10,709 bases
Orientation:
Minus strand

Genomic View for NT5DC2 Gene

Genes around NT5DC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5DC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5DC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5DC2 Gene

Proteins for NT5DC2 Gene

  • Protein details for NT5DC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H857-NT5D2_HUMAN
    Recommended name:
    5'-nucleotidase domain-containing protein 2
    Protein Accession:
    Q9H857
    Secondary Accessions:
    • C9JTZ6
    • E9PAL9
    • O95888
    • Q96C80
    • Q9H9Z8

    Protein attributes for NT5DC2 Gene

    Size:
    520 amino acids
    Molecular mass:
    60719 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14550.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14064.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for NT5DC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NT5DC2 Gene

Post-translational modifications for NT5DC2 Gene

  • Ubiquitination at Lys102
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NT5DC2 Gene

Domains & Families for NT5DC2 Gene

Gene Families for NT5DC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NT5DC2 Gene

Blocks:
  • Beta and gamma crystallin
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NT5DC2 Gene

GenScript: Design optimal peptide antigens:
  • 5'-nucleotidase domain-containing protein 2 (NT5D2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H857

UniProtKB/Swiss-Prot:

NT5D2_HUMAN :
  • Belongs to the 5'(3')-deoxyribonucleotidase family.
Family:
  • Belongs to the 5'(3')-deoxyribonucleotidase family.
genes like me logo Genes that share domains with NT5DC2: view

Function for NT5DC2 Gene

Enzyme Numbers (IUBMB) for NT5DC2 Gene

Phenotypes From GWAS Catalog for NT5DC2 Gene

Gene Ontology (GO) - Molecular Function for NT5DC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008253 5'-nucleotidase activity IBA 21873635
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NT5DC2: view
genes like me logo Genes that share phenotypes with NT5DC2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NT5DC2 Gene

Localization for NT5DC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NT5DC2 gene
Compartment Confidence
mitochondrion 2
extracellular 1
cytosol 1
nucleus 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NT5DC2 Gene

Pathways & Interactions for NT5DC2 Gene

PathCards logo

SuperPathways for NT5DC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NT5DC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with NT5DC2: view

No data available for Pathways by source and SIGNOR curated interactions for NT5DC2 Gene

Drugs & Compounds for NT5DC2 Gene

No Compound Related Data Available

Transcripts for NT5DC2 Gene

mRNA/cDNA for NT5DC2 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NT5DC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5: -
SP6:
SP7: -
SP8: -
SP9: - - - -
SP10: - - - - -
SP11: -
SP12:
SP13:
SP14:
SP15: -

ExUns: 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for NT5DC2 Gene

GeneLoc Exon Structure for
NT5DC2

Expression for NT5DC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NT5DC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NT5DC2 Gene

This gene is overexpressed in Breast (20.7), Salivary gland (15.7), and Fetal heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NT5DC2 Gene



Protein tissue co-expression partners for NT5DC2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NT5DC2

SOURCE GeneReport for Unigene cluster for NT5DC2 Gene:

Hs.84753

Evidence on tissue expression from TISSUES for NT5DC2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with NT5DC2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NT5DC2 Gene

Orthologs for NT5DC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NT5DC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NT5DC2 31 30
  • 98.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NT5DC2 31 30
  • 91.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NT5DC2 31 30
  • 90.82 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nt5dc2 17 31 30
  • 90.09 (n)
rat
(Rattus norvegicus)
Mammalia Nt5dc2 30
  • 90.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NT5DC2 31
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NT5DC2 31
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves NT5DC2 31 30
  • 74.74 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NT5DC2 31
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nt5dc2 30
  • 69.9 (n)
Str.295 30
African clawed frog
(Xenopus laevis)
Amphibia MGC53840 30
zebrafish
(Danio rerio)
Actinopterygii nt5dc2 31 30
  • 69.95 (n)
OneToOne
wufb83e03 30
fruit fly
(Drosophila melanogaster)
Insecta CG1814 31
  • 40 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G23890 30
  • 47.59 (n)
rice
(Oryza sativa)
Liliopsida Os09g0424600 30
  • 48.4 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 42 (a)
OneToMany
Species where no ortholog for NT5DC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NT5DC2 Gene

ENSEMBL:
Gene Tree for NT5DC2 (if available)
TreeFam:
Gene Tree for NT5DC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NT5DC2: view image

Paralogs for NT5DC2 Gene

Paralogs for NT5DC2 Gene

(1) SIMAP similar genes for NT5DC2 Gene using alignment to 5 proteins:

  • NT5D2_HUMAN
  • C9J036_HUMAN
  • F8WEY1_HUMAN
  • H7C4G8_HUMAN
  • H7C519_HUMAN

Pseudogenes.org Pseudogenes for NT5DC2 Gene

genes like me logo Genes that share paralogs with NT5DC2: view

Variants for NT5DC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NT5DC2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs35920544 - p.Ser91Arg

Additional dbSNP identifiers (rs#s) for NT5DC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NT5DC2 Gene

Variant ID Type Subtype PubMed ID
dgv8326n54 CNV loss 21841781
esv27812 CNV loss 19812545
esv3596160 CNV gain 21293372
nsv1072693 CNV deletion 25765185
nsv3820 CNV insertion 18451855
nsv834697 CNV loss 17160897
nsv954862 CNV deletion 24416366

Variation tolerance for NT5DC2 Gene

Residual Variation Intolerance Score: 8.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.51; 85.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NT5DC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NT5DC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NT5DC2 Gene

Disorders for NT5DC2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NT5DC2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acute contagious conjunctivitis
  • contagious opthalmia
acute conjunctivitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NT5DC2

genes like me logo Genes that share disorders with NT5DC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NT5DC2 Gene

Publications for NT5DC2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 54
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 54
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54

Products for NT5DC2 Gene

Sources for NT5DC2 Gene