Aliases for NT5C2 Gene
Aliases for NT5C2 Gene
External Ids for NT5C2 Gene
- HGNC: 8022
- Entrez Gene: 22978
- Ensembl: ENSG00000076685
- OMIM: 600417
- UniProtKB: P49902
Previous HGNC Symbols for NT5C2 Gene
- NT5B
Previous GeneCards Identifiers for NT5C2 Gene
- GC10M103741
- GC10M104081
- GC10M104979
- GC10M104512
- GC10M104837
- GC10M098480
Summaries for NT5C2 Gene
-
This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011]
-
This gene, when mutated to be over-active, has been linked to chemotherapy resistance in relapsed T-cell Acute Lymphoblastic Leukemia.
GeneCards Summary for NT5C2 Gene
NT5C2 (5'-Nucleotidase, Cytosolic II) is a Protein Coding gene. Diseases associated with NT5C2 include Spastic Paraplegia 45, Autosomal Recessive and Sphenoid Sinusitis. Among its related pathways are NAD metabolism and Metabolism of nucleotides. Gene Ontology (GO) annotations related to this gene include nucleotide binding and nucleoside phosphotransferase activity. An important paralog of this gene is NT5DC4.
UniProtKB/Swiss-Prot for NT5C2 Gene
-
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
Additional gene information for NT5C2 Gene
- Monarch Initiative
- Search for NT5C2 at DataMed
- Search for NT5C2 at HumanCyc
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5C2 Gene
Genomics for NT5C2 Gene
GeneHancer (GH) Regulatory Elements for NT5C2 Gene
Promoters and enhancers for NT5C2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NT5C2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NT5C2 gene promoter:
-
- E2F
- E2F-1
- Egr-3
- En-1
- MRF-2
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
Genomic Locations for NT5C2 Gene
Genomic Locations for NT5C2 Gene
- chr10:103,088,017-103,193,306
- (GRCh38/hg38)
- Size:
- 105,290 bases
- Orientation:
- Minus strand
- chr10:104,845,940-104,953,056
- (GRCh37/hg19)
- Size:
- 107,117 bases
- Orientation:
- Minus strand
Genomic View for NT5C2 Gene
Genes around NT5C2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q24.32-q24.33 by HGNC
- 10q24.32-q24.33 by Entrez Gene
- 10q24.33 by Ensembl
NT5C2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NT5C2 Gene
Proteins for NT5C2 Gene
-
Protein details for NT5C2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P49902-5NTC_HUMAN
- Recommended name:
- Cytosolic purine 5'-nucleotidase
- Protein Accession:
- P49902
- B7Z382
- D3DR91
- Q5JUV5
Protein attributes for NT5C2 Gene
- Size:
- 561 amino acids
- Molecular mass:
- 64970 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Homotetramer.
Three dimensional structures from OCA and Proteopedia for NT5C2 Gene
Protein Expression for NT5C2 Gene
Selected DME Specific Peptides for NT5C2 Gene
- P49902:
-
- LTRSISEIKPPNLFP
- YFDLILVDARKPLFFGEGTVLRQVDT
- EVGKVFL
- TSWSDRLQNAAD
- GFKDGDLFMS
- KLPLLLSRM
- KKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYA
- RFYILNTLFNLPETYLLACLVDFFTNC
- FGFDMDYTLAVY
- TGKLKIGTYTGPLQHGIVYSGGSSD
- PHGPKPGSSHR
- LVCAHGFNF
- LYIGDHIF
- ATRNRTSVDFKD
- LTVERLVSIGYP
- TVERLVS
- RSMFQDVRDAVDWVHYKGSLKEKT
- QYPNKFIQRDDT
- KVDAYGN
- TNSDYKYT
- KIMTYLFD
Post-translational modifications for NT5C2 Gene
Other Protein References for NT5C2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_016871463.1
- XP_016871436.1
- XP_016871456.1
- XP_006717786.1
- XP_005269702.1
- XP_024303675.1
- XP_024303672.1
- NP_001338123.1
- NP_001338103.1
- NP_001338113.1
- NP_001338098.1
- NP_001338124.1
- NP_001338104.1
- NP_001338114.1
- XP_024303669.1
- XP_024303679.1
- XP_006717784.1
- NP_001338108.1
- NP_001338118.1
- XP_024303677.1
- XP_024303671.1
- XP_005269694.1
- NP_001338125.1
- NP_001338105.1
- NP_001338115.1
- XP_024303678.1
- NP_001338126.1
- NP_001338106.1
- NP_001338116.1
- NP_001338099.1
- NP_001338120.1
- NP_001338100.1
- NP_001338110.1
- XP_016871455.1
- NP_001338109.1
- NP_001338119.1
- XP_024303676.1
- NP_001127845.1
- XP_024303673.1
- NP_001338107.1
- NP_001338117.1
- XP_024303670.1
- XP_005269703.1
- NP_001338121.1
- NP_001338101.1
- NP_001338111.1
- XP_011537839.1
- NP_001338122.1
- NP_001338102.1
- NP_001338112.1
- NP_036361.1
Antibody Products
- Atlas Antibodies Anti-NT5C2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for NT5C2
- Novus Biologicals Antibodies for NT5C2
-
Abcam antibodies for NT5C2
- Invitrogen Antibodies for NT5C2 (AFLGC-NT5C2)
-
Biorbyt antibodies for NT5C2
-
Santa Cruz Biotechnology (SCBT) Antibodies for NT5C2
Protein Products
- Atlas Antibodies PrEST Antigen NT5C2
- Search Origene for MassSpec and Protein Over-expression Lysates for NT5C2
- Origene Custom Protein Services for NT5C2
- ProSpec Recombinant Proteins for NT5C2
-
Abcam proteins for NT5C2
Assay Products
- antibodies-online: Search results for 2 available NT5C2 Elisa Kits ranked by validation data
- Compare Top NT5C2 Elisa Kits
-
Quality Products:
Domains & Families for NT5C2 Gene
Gene Families for NT5C2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for NT5C2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NT5C2 Gene
- GenScript: Design optimal peptide antigens:
-
- Cytosolic 5'-nucleotidase II (5NTC_HUMAN)
- cDNA FLJ53335, highly similar to Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (B7Z382_HUMAN)
- 5'-nucleotidase, cytosolic II (Q5JUV3_HUMAN)
- 5'-nucleotidase, cytosolic II (Q5JUV6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P49902- Family:
-
- Belongs to the 5'(3')-deoxyribonucleotidase family.
Function for NT5C2 Gene
Molecular function for NT5C2 Gene
- UniProtKB/Swiss-Prot Function:
- May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate; Xref=Rhea:RHEA:12484, ChEBI:CHEBI:15377, ChEBI:CHEBI:18254, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043; EC=3.1.3.5;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Allosterically activated by various compounds, including ATP.
Enzyme Numbers (IUBMB) for NT5C2 Gene
Phenotypes From GWAS Catalog for NT5C2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008253 | 5'-nucleotidase activity | IBA,TAS | 21873635 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for NT5C2 Gene
- MGI mutant phenotypes for NT5C2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NT5C2:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability after Maraba virus infection
- Increased viability with SS1P at EC90
- shRNA abundance <= 50%
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NT5C2
-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NT5C2 - Now 50% OFF >
- * NT5C2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * NT5C2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for NT5C2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NT5C2
- genomics-online: gRNA clones - Search results for available NT5C2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for NT5C2
miRNA for NT5C2 Gene
- miRTarBase miRNAs that target NT5C2
-
- hsa-mir-375 (MIRT020065)
- hsa-mir-34a-5p (MIRT025290)
- hsa-mir-21-5p (MIRT031022)
- hsa-mir-193b-3p (MIRT041471)
- hsa-mir-5089-5p (MIRT517057)
- hsa-mir-7151-3p (MIRT517058)
- hsa-mir-5095 (MIRT517059)
- hsa-mir-550a-5p (MIRT517060)
- hsa-mir-550a-3-5p (MIRT517061)
- hsa-mir-1271-3p (MIRT517062)
- hsa-mir-661 (MIRT517063)
- hsa-mir-3116 (MIRT517064)
- hsa-mir-4537 (MIRT517065)
- hsa-mir-1254 (MIRT517066)
- hsa-mir-6506-5p (MIRT517067)
- hsa-mir-619-5p (MIRT517068)
- hsa-mir-3922-3p (MIRT517069)
- hsa-mir-3176 (MIRT517070)
- hsa-mir-6504-3p (MIRT517071)
- hsa-mir-6746-3p (MIRT517072)
- hsa-mir-4438 (MIRT517073)
- hsa-mir-6869-5p (MIRT646865)
- hsa-mir-4279 (MIRT646866)
- hsa-mir-1200 (MIRT646867)
- hsa-mir-6829-3p (MIRT646868)
- hsa-mir-6791-3p (MIRT646869)
- hsa-mir-1976 (MIRT646870)
- hsa-mir-3653-5p (MIRT646871)
- hsa-mir-6747-3p (MIRT646872)
- hsa-mir-6727-3p (MIRT646873)
- hsa-mir-4722-3p (MIRT646874)
- hsa-mir-544b (MIRT646875)
- hsa-mir-4324 (MIRT646876)
- hsa-mir-660-3p (MIRT646877)
- hsa-mir-5571-5p (MIRT646878)
- hsa-mir-498 (MIRT673359)
- hsa-mir-23b-5p (MIRT677061)
- hsa-mir-23a-5p (MIRT677062)
- hsa-mir-550b-2-5p (MIRT693874)
- hsa-mir-6514-3p (MIRT693875)
- hsa-mir-6894-3p (MIRT693876)
- hsa-mir-6811-3p (MIRT693877)
- hsa-mir-214-5p (MIRT693878)
- hsa-mir-6889-3p (MIRT693879)
- hsa-mir-1914-5p (MIRT693880)
- hsa-mir-6752-3p (MIRT693881)
- hsa-mir-6729-3p (MIRT693882)
- hsa-mir-6848-3p (MIRT706299)
- hsa-mir-6843-3p (MIRT706300)
- hsa-mir-6131 (MIRT706301)
- hsa-mir-4454 (MIRT706302)
- hsa-mir-3663-5p (MIRT706303)
- hsa-mir-5699-3p (MIRT706304)
- hsa-mir-4421 (MIRT706305)
- hsa-mir-4485-5p (MIRT706306)
- hsa-mir-3934-5p (MIRT706307)
- hsa-mir-764 (MIRT706308)
- hsa-mir-125a-3p (MIRT706309)
- hsa-mir-3148 (MIRT784660)
- hsa-mir-4477b (MIRT785974)
- hsa-mir-651-3p (MIRT788326)
- hsa-mir-7856-5p (MIRT789615)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for NT5C2
- Browse OriGene Inhibitory RNA Products For NT5C2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NT5C2
- genomics-online: shRNA clones - Search results for available NT5C2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for NT5C2 - Now 50% OFF >
- * NT5C2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * NT5C2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG208873
- MG217314
- MG218651
- MR208873
- MR208873L1
- MR208873L1V
- MR208873L2
- MR208873L2V
- MR208873L3
- MR208873L3V
- MR208873L4
- MR208873L4V
- MR217314
- MR217314L1
- MR217314L1V
- MR217314L2
- MR217314L2V
- MR217314L3
- MR217314L3V
- MR217314L4
- MR217314L4V
- MR218651
- MR218651L1
- MR218651L1V
- MR218651L2
- MR218651L2V
- MR218651L3
- MR218651L3V
- MR218651L4
- MR218651L4V
- RC200194
- RC200194L1
- RC200194L1V
- RC200194L2
- RC200194L2V
- RC200194L3
- RC200194L3V
- RC200194L4
- RC200194L4V
- RC225961
- RC225961L1
- RC225961L1V
- RC225961L2
- RC225961L2V
- RC225961L3
- RC225961L3V
- RC225961L4
- RC225961L4V
- RC500194
- RG200194
- RG225961
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NT5C2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NT5C2
- genomics-online: cdna clones - Search results for available NT5C2 gene related products
- orf clones - Search results for available NT5C2 gene related products
Cell Line Products
-
Horizon Cell Lines for NT5C2
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for NT5C2 Gene
Localization for NT5C2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NT5C2 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 2 |
| nucleus | 2 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NT5C2 Gene
Pathways & Interactions for NT5C2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism of nucleotides | ||
| 2 | Metabolism |
.40
|
|
| 3 | NAD metabolism |
.42
|
|
| 4 | Abacavir transport and metabolism | ||
| 5 | Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics | ||
Pathways by source for NT5C2 Gene
4 BioSystems pathways for NT5C2 Gene
6 Reactome pathways for NT5C2 Gene
1 PharmGKB pathway for NT5C2 Gene
4 KEGG pathways for NT5C2 Gene
2 GeneGo (Thomson Reuters) pathways for NT5C2 Gene
Interacting Proteins for NT5C2 Gene
Selected Interacting proteins:
P49902-5NTC_HUMAN
ENSP00000339479
for NT5C2 Gene via
UniProtKB
STRING
IID
MINT
GPS-Prot Interaction Network for NT5C2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006195 | purine nucleotide catabolic process | TAS | -- |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0009117 | nucleotide metabolic process | IEA | -- |
| GO:0016311 | dephosphorylation | IEA | -- |
| GO:0017144 | drug metabolic process | TAS | -- |
No data available for SIGNOR curated interactions for NT5C2 Gene
Drugs & Compounds for NT5C2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ribavirin | Approved | Pharma | Target, inducer | 1042 | ||
| Didanosine | Approved | Pharma | 152 | |||
| Gemcitabine | Approved | Pharma | Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs | 2309 | ||
| Adenosine | Approved, Investigational | Pharma | Agonist, Channel blocker | 599 | ||
| Cytarabine | Approved, Experimental, Investigational | Pharma | 1267 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| beta-nicotinamide D-ribonucleotide |
|
|
||||
| deoxyadenosine |
|
958-09-8 |
|
|||
| Deoxyadenosine monophosphate |
|
653-63-4 |
|
|||
| deoxyguanosine |
|
961-07-9 |
|
|||
| nicotinate beta-D-ribonucleotide |
|
|
Drug Products
- Atlas Antibodies PrEST Antigen NT5C2
Transcripts for NT5C2 Gene
mRNA/cDNA for NT5C2 Gene
- (31) REFSEQ mRNAs :
- (38) Additional mRNA sequences :
- (248) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000404739 3365 bps (ENST00000404739.7)
- ENST00000369857 2625 bps (ENST00000369857.8)
- ENST00000421281 440 bps (ENST00000421281.1)
- ENST00000469228 495 bps (ENST00000469228.1)
- ENST00000452156 856 bps (ENST00000452156.5)
Unigene Clusters for NT5C2 Gene
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NT5C2 - Now 50% OFF >
- * NT5C2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * NT5C2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for NT5C2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NT5C2
- genomics-online: gRNA clones - Search results for available NT5C2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for NT5C2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for NT5C2
- Browse OriGene Inhibitory RNA Products For NT5C2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NT5C2
- genomics-online: shRNA clones - Search results for available NT5C2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for NT5C2 - Now 50% OFF >
- * NT5C2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * NT5C2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG208873
- MG217314
- MG218651
- MR208873
- MR208873L1
- MR208873L1V
- MR208873L2
- MR208873L2V
- MR208873L3
- MR208873L3V
- MR208873L4
- MR208873L4V
- MR217314
- MR217314L1
- MR217314L1V
- MR217314L2
- MR217314L2V
- MR217314L3
- MR217314L3V
- MR217314L4
- MR217314L4V
- MR218651
- MR218651L1
- MR218651L1V
- MR218651L2
- MR218651L2V
- MR218651L3
- MR218651L3V
- MR218651L4
- MR218651L4V
- RC200194
- RC200194L1
- RC200194L1V
- RC200194L2
- RC200194L2V
- RC200194L3
- RC200194L3V
- RC200194L4
- RC200194L4V
- RC225961
- RC225961L1
- RC225961L1V
- RC225961L2
- RC225961L2V
- RC225961L3
- RC225961L3V
- RC225961L4
- RC225961L4V
- RC500194
- RG200194
- RG225961
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NT5C2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NT5C2
- genomics-online: cdna clones - Search results for available NT5C2 gene related products
- orf clones - Search results for available NT5C2 gene related products
Expression for NT5C2 Gene
This gene is overexpressed in Salivary gland (15.6), Skin (7.7), and Testis (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NT5C2 Gene
NURSA nuclear receptor signaling pathways regulating expression of NT5C2 Gene:
NT5C2SOURCE GeneReport for Unigene cluster for NT5C2 Gene:
Hs.97439Evidence on tissue expression from TISSUES for NT5C2 Gene
- Nervous system(5)
- Blood(2.4)
- Bone marrow(2.1)
- Kidney(2.1)
- Thyroid gland(2.1)
- Heart(2)
- Muscle(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for NT5C2 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cranial nerve
- eye
- head
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- peripheral nerve
- peripheral nervous system
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for NT5C2
-
OriGene qPCR primer pairs and template standards for NT5C2
- genomics-online: primer clones - Search results for available NT5C2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NT5C2 Gene
Orthologs for NT5C2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NT5C2 35 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | NT5C2 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NT5C2 35 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NT5C2 35 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Nt5c2 17 35 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100363253 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | NT5C2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NT5C2 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NT5C2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nt5c2 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.9923 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | nt5c2a 35 |
|
OneToMany | |
| nt5c2b 35 34 |
|
OneToMany | |||
| wufc45b10 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000380 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG32549 35 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | Y71H10B.1 35 34 |
|
OneToMany | |
| Y71H10B.1b 36 |
|
|
|||
| Y71H10B.1a 36 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G75210 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os03g0774300 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9662 35 |
|
OneToMany | |
| Cin.1884 34 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.1884 34 |
|
- Species where no ortholog for NT5C2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for NT5C2 Gene
- ENSEMBL:
- Gene Tree for NT5C2 (if available)
- TreeFam:
- Gene Tree for NT5C2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NT5C2: view image
Paralogs for NT5C2 Gene
(1) SIMAP similar genes for NT5C2 Gene using alignment to 8 proteins:
- 5NTC_HUMAN
- B7Z382_HUMAN
- H0YHR8_HUMAN
- Q5JUV3_HUMAN
- Q5JUV4_HUMAN
- Q5JUV6_HUMAN
- S4R3A6_HUMAN
- S4R3E7_HUMAN
Pseudogenes.org Pseudogenes for NT5C2 Gene
Variants for NT5C2 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1057519866 | not-provided, Leukemia-Lymphoma, Adult T-Cell | 103,093,198(-) | C/T | coding_sequence_variant, intron_variant, missense_variant | |
| rs1057519867 | not-provided, Leukemia-Lymphoma, Adult T-Cell, Lymphoblastic leukemia, acute, with lymphomatous features | 103,093,223(-) | T/G | coding_sequence_variant, intron_variant, missense_variant | |
| rs1057519868 | not-provided, Leukemia-Lymphoma, Adult T-Cell | 103,090,988(-) | T/G | coding_sequence_variant, missense_variant | |
| rs10883841 | benign, not specified, - | 103,174,952(-) | T/C/G | 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant | |
| rs11598702 | drug-response, gemcitabine response - Other | 103,138,228(-) | T/C/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3624406 | CNV | gain | 21293372 |
| esv3624407 | CNV | loss | 21293372 |
| nsv7528 | CNV | deletion | 18451855 |
| nsv948173 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
19.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.97;
68.14% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NT5C2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NT5C2 Gene
Disorders for NT5C2 Gene
(7) MalaCards diseases for NT5C2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spastic paraplegia 45, autosomal recessive |
|
|
| sphenoid sinusitis |
|
|
| molybdenum cofactor deficiency, complementation group a |
|
|
| orbital cellulitis |
|
|
| acute orbital inflammation |
|
|
Search NT5C2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
5NTC_HUMAN- Spastic paraplegia 45, autosomal recessive (SPG45) [MIM:613162]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Some SPG45 patients manifest mental retardation, contractures and learning disability. {ECO:0000269 PubMed:24482476, ECO:0000269 PubMed:28884889}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for NT5C2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for NT5C2 Gene
Publications for NT5C2 Gene
- Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. (PMID: 24482476) Novarino G … Gleeson JG (Science (New York, N.Y.) 2014) 2 3 4 58
- Molecular cloning of human cytosolic purine 5'-nucleotidase. (PMID: 7999131) Oka J … Inoue S (Biochemical and biophysical research communications 1994) 2 3 4 58
- Novel homozygous missense mutation in NT5C2 underlying hereditary spastic paraplegia SPG45. (PMID: 28884889) Straussberg R … McGrath JA (American journal of medical genetics. Part A 2017) 3 4 58
- Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. (PMID: 21572416) Kato N … He J (Nature genetics 2011) 3 45 58
- Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain LV … van Duijn CM (Nature genetics 2011) 3 45 58
ExternalLinks
Products for NT5C2 Gene
- Custom Antibody ServicesOriGene Antibodies for NT5C2
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- MG208873
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- RC200194
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- RC225961
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- RC225961L3
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- RC500194
- RG200194
- RG225961
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NT5C2
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Cyagen custom Knockout/knockin (KOKI) mouse models for NT5C2
- antibodies-online: Search results for 56 available NT5C2 Antibodies ranked by validation data
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- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for NT5C2
- Search Santa Cruz Biotechnology (SCBT) for NT5C2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NT5C2
- Horizon Cell Lines for NT5C2
- genomics-online: cdna clones - Search results for available NT5C2 gene related products
- orf clones - Search results for available NT5C2 gene related products
- genomics-online: gRNA clones - Search results for available NT5C2 gene related products
- genomics-online: primer clones - Search results for available NT5C2 gene related products
- genomics-online: shRNA clones - Search results for available NT5C2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NT5C2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NT5C2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NT5C2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NT5C2
- Biorbyt antibodies for NT5C2
Sources for NT5C2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) HGMD
- (45) GAD
- (46) BGMUT
- (47) HuGE
- (48) Atlas
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) OCA
- (69) Proteopedia
- (70) MOPED
- (71) neXtProt
- (72) Reactome
- (73) GeneGo (Thomson Reuters)
- (74) fRNAdb
- (75) DISEASES
- (76) SIMAP
- (77) GenomeRNAi
- (78) LifeMap
- (79) miRTarBase
- (80) MalaCards
- (81) Invitrogen
- (82) BitterDB
- (83) ESI-BIO
- (84) RefSeq
- (85) BioSystems
- (86) MaxQB
- (87) IUPHAR
- (88) BioGPS
- (89) Illumina
- (90) COMPARTMENTS
- (91) HOMER
- (92) PaxDb
- (93) ApexBio
- (94) Addgene
- (95) antibodies-online
- (96) CYP
- (97) NONCODE
- (98) SwitchGear Genomics
- (99) TreeFam
- (100) PathCards
- (101) GeneReviews
- (102) GeneTex
- (103) Taconic Biosciences
- (104) GTEx
- (105) ProteomicsDB
- (106) SCBT
- (107) DGIdb
- (108) ClinicalTrials
- (109) FDA Approved Drugs
- (110) RVIS
- (111) SIGNOR
- (112) diseasecard
- (113) NIH Rare Diseases
- (114) Orphanet
- (115) UMLS
- (116) GTR
- (117) Disease Ontology
- (118) Genetics Home Reference
- (119) MeSH
- (120) MedlinePlus
- (121) CDC
- (122) NINDS
- (123) NCBI Bookshelf
- (124) ClinVar
- (125) Gene Damage Index
- (126) ViGene Biosciences
- (127) HPO
- (128) UDN
- (129) VISTA
- (130) FANTOM5
- (131) ENCODE
- (132) ProSci
- (133) Horizon
- (134) NURSA
- (135) IID
- (136) Cyagen
- (137) VectorBuilder
- (138) SNPedia
- (139) BRCA Exchange
- (140) St John's Lab
- (141) CIViC
- (142) ProteoGenix
- (143) dbSUPER
- (144) TISSUES
- (145) Gene ORGANizer
- (146) abm
- (147) CrownBio
- (148) Human Protein Atlas
- (149) GWAS Catalog
- (150) Monarch Initiative
- (151) DataMed
- (152) HumanCyc
- (153) genomics-online
- (154) UCNEbase
- (155) EPDnew
- (156) Applied Biosystems
- (157) GlyConnect
- (158) Aminode
- (159) GeneCopoeia
- (160) GPS-Prot
- (161) RNACentral
- (162) LncRNADisease
- (163) LOVD
- (164) miR2Disease
- (165) DiseaseEnhancer
- (166) Boster Bio
- (167) Biorbyt
- (168) Biocompare
- (169) Mastermind