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Aliases for NT5C1B-RDH14 Gene

Aliases for NT5C1B-RDH14 Gene

  • NT5C1B-RDH14 Readthrough 2 3 5

External Ids for NT5C1B-RDH14 Gene

Previous GeneCards Identifiers for NT5C1B-RDH14 Gene

  • GC02U902251
  • GC02M018737

Summaries for NT5C1B-RDH14 Gene

Entrez Gene Summary for NT5C1B-RDH14 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring NT5C1B (5'-nucleotidase, cytosolic IB) and RDH14 (retinol dehydrogenase 14) genes on chromosome 2. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for NT5C1B-RDH14 Gene

NT5C1B-RDH14 (NT5C1B-RDH14 Readthrough) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and NAD metabolism. Gene Ontology (GO) annotations related to this gene include nucleotide binding and magnesium ion binding. An important paralog of this gene is NT5C1B.

Additional gene information for NT5C1B-RDH14 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5C1B-RDH14 Gene

Genomics for NT5C1B-RDH14 Gene

GeneHancer (GH) Regulatory Elements for NT5C1B-RDH14 Gene

Promoters and enhancers for NT5C1B-RDH14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I018589 Promoter 0.7 EPDnew 550.8 0.0 -4 0.1 ATF7 ATF2 NT5C1B NT5C1B-RDH14 GC02M018608 LOC105373456
GH02I018519 Enhancer 0.9 Ensembl ENCODE 10.3 +68.9 68934 2.2 CTCF PKNOX1 ZNF654 KLF6 TRIM22 REST RAD21 CC2D1A ARID2 ZNF143 RNU6-1215P NT5C1B NT5C1B-RDH14 GC02M018508 ENSG00000260331
GH02I018479 Enhancer 0.8 UCNEbase ENCODE 10 +109.3 109327 1.1 ZFHX2 FEZF1 ZIC2 NT5C1B NT5C1B-RDH14 GC02M018508 LOC105373454
GH02I018611 Enhancer 0.6 ENCODE 11.4 -21.8 -21825 0.6 FOXA2 RXRA MAX ZNF384 REST ZIC2 RAD21 JUND ATF3 ZBTB33 GC02M018608 NT5C1B RNU6-1215P NT5C1B-RDH14 LOC105373456 GC02P018659
GH02I018472 Enhancer 0.7 Ensembl ENCODE 9.7 +116.0 116049 1.4 ZFHX2 JUND EGR1 PRDM10 FOS EGR2 ZBTB17 NT5C1B NT5C1B-RDH14 LOC105373454 GC02M018508
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NT5C1B-RDH14 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NT5C1B-RDH14 Gene

Genomic Locations for NT5C1B-RDH14 Gene
chr2:18,554,723-18,589,580
(GRCh38/hg38)
Size:
34,858 bases
Orientation:
Minus strand
chr2:18,735,989-18,770,846
(GRCh37/hg19)

Genomic View for NT5C1B-RDH14 Gene

Genes around NT5C1B-RDH14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5C1B-RDH14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5C1B-RDH14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5C1B-RDH14 Gene

Proteins for NT5C1B-RDH14 Gene

  • Protein details for NT5C1B-RDH14 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    C9J2C7
    Recommended name:
    NT5C1B-RDH14 readthrough
    Protein Accession:
    C9J2C7

    Protein attributes for NT5C1B-RDH14 Gene

    Size:
    533 amino acids
    Molecular mass:
    60169 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NT5C1B-RDH14 Gene

Post-translational modifications for NT5C1B-RDH14 Gene

No Post-translational modifications

Other Protein References for NT5C1B-RDH14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NT5C1B-RDH14 Gene

Domains & Families for NT5C1B-RDH14 Gene

Gene Families for NT5C1B-RDH14 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NT5C1B-RDH14 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NT5C1B-RDH14: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NT5C1B-RDH14 Gene

Function for NT5C1B-RDH14 Gene

Gene Ontology (GO) - Molecular Function for NT5C1B-RDH14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0008253 5-nucleotidase activity IEA --
genes like me logo Genes that share ontologies with NT5C1B-RDH14: view

Phenotypes for NT5C1B-RDH14 Gene

genes like me logo Genes that share phenotypes with NT5C1B-RDH14: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NT5C1B-RDH14 Gene

Localization for NT5C1B-RDH14 Gene

Gene Ontology (GO) - Cellular Components for NT5C1B-RDH14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NT5C1B-RDH14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for NT5C1B-RDH14 Gene

Pathways & Interactions for NT5C1B-RDH14 Gene

genes like me logo Genes that share pathways with NT5C1B-RDH14: view

Pathways by source for NT5C1B-RDH14 Gene

Interacting Proteins for NT5C1B-RDH14 Gene

Gene Ontology (GO) - Biological Process for NT5C1B-RDH14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009117 nucleotide metabolic process IEA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with NT5C1B-RDH14: view

No data available for SIGNOR curated interactions for NT5C1B-RDH14 Gene

Drugs & Compounds for NT5C1B-RDH14 Gene

No Compound Related Data Available

Transcripts for NT5C1B-RDH14 Gene

mRNA/cDNA for NT5C1B-RDH14 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for NT5C1B-RDH14 Gene

No ASD Table

Relevant External Links for NT5C1B-RDH14 Gene

GeneLoc Exon Structure for
NT5C1B-RDH14
ECgene alternative splicing isoforms for
NT5C1B-RDH14

Expression for NT5C1B-RDH14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NT5C1B-RDH14 Gene

genes like me logo Genes that share expression patterns with NT5C1B-RDH14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NT5C1B-RDH14 Gene

Orthologs for NT5C1B-RDH14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NT5C1B-RDH14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NT5C1B-RDH14 34
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nt5c1b 34
  • 71 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 53 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 68 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 67 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nt5c1bb 34
  • 62 (a)
ManyToMany
nt5c1ba 34
  • 57 (a)
ManyToMany
CABZ01003826.1 34
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToMany
Species where no ortholog for NT5C1B-RDH14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NT5C1B-RDH14 Gene

ENSEMBL:
Gene Tree for NT5C1B-RDH14 (if available)
TreeFam:
Gene Tree for NT5C1B-RDH14 (if available)

Paralogs for NT5C1B-RDH14 Gene

Paralogs for NT5C1B-RDH14 Gene

(5) SIMAP similar genes for NT5C1B-RDH14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NT5C1B-RDH14: view

Variants for NT5C1B-RDH14 Gene

Sequence variations from dbSNP and Humsavar for NT5C1B-RDH14 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000006558 -- 18,570,024(-) G/A intron_variant
rs1000043575 -- 18,581,243(-) A/G intron_variant
rs1000108601 -- 18,562,599(-) G/A intron_variant
rs1000203703 -- 18,587,250(-) CCCCCC/CCCCCCC intron_variant
rs1000247039 -- 18,588,162(-) A/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NT5C1B-RDH14 Gene

Variant ID Type Subtype PubMed ID
nsv581114 CNV gain 21841781
nsv519085 CNV loss 19592680
nsv2624 CNV insertion 18451855
esv3589967 CNV loss 21293372
esv3589966 CNV loss 21293372
esv2751837 CNV gain 17911159
esv2229780 CNV deletion 18987734

Variation tolerance for NT5C1B-RDH14 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NT5C1B-RDH14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NT5C1B-RDH14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NT5C1B-RDH14 Gene

Disorders for NT5C1B-RDH14 Gene

Additional Disease Information for NT5C1B-RDH14

No disorders were found for NT5C1B-RDH14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NT5C1B-RDH14 Gene

Publications for NT5C1B-RDH14 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for NT5C1B-RDH14 Gene

Sources for NT5C1B-RDH14 Gene

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