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Aliases for NT5C1B-RDH14 Gene

Aliases for NT5C1B-RDH14 Gene

  • NT5C1B-RDH14 Readthrough 2 3 5 13
  • NT5C1B-RDH14 Read-Through Transcript 3
  • Cytosolic 5'-Nucleotidase 1B 3
  • Cytosolic 5'-Nucleotidase IB 3
  • NT5C1B-RDH14 Protein 3
  • NT5C1B 3
  • CN-IB 3
  • AIRP 3
  • CN1B 3

External Ids for NT5C1B-RDH14 Gene

Previous GeneCards Identifiers for NT5C1B-RDH14 Gene

  • GC02U902251
  • GC02M018737

Summaries for NT5C1B-RDH14 Gene

Entrez Gene Summary for NT5C1B-RDH14 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring NT5C1B (5'-nucleotidase, cytosolic IB) and RDH14 (retinol dehydrogenase 14) genes on chromosome 2. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for NT5C1B-RDH14 Gene

NT5C1B-RDH14 (NT5C1B-RDH14 Readthrough) is a Protein Coding gene. Among its related pathways are Metabolism of nucleotides and NAD metabolism. Gene Ontology (GO) annotations related to this gene include nucleotide binding and magnesium ion binding. An important paralog of this gene is NT5C1B.

Additional gene information for NT5C1B-RDH14 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5C1B-RDH14 Gene

Genomics for NT5C1B-RDH14 Gene

GeneHancer (GH) Regulatory Elements for NT5C1B-RDH14 Gene

Promoters and enhancers for NT5C1B-RDH14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J018589 Promoter 0.7 EPDnew 600.7 0.0 -4 0.1 ATF7 ATF2 NT5C1B NT5C1B-RDH14 GC02M018608 LOC105373456
GH02J018559 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.6 +29.3 29279 3 ZNF652 SP1 ZFX ELF3 MNT SIX5 CBFA2T2 ZNF148 NKRF POLR2A RDH14 NT5C1B NT5C1B-RDH14 ENSG00000260331
GH02J018479 Enhancer 1 UCNEbase Ensembl ENCODE 10 +109.3 109327 1.1 ZIC2 ZFHX2 FEZF1 NT5C1B NT5C1B-RDH14 GC02M018508 LOC105373454
GH02J018611 Enhancer 0.8 Ensembl ENCODE 11.5 -21.8 -21811 0.6 SP1 RXRA ZIC2 ZNF7 FOXA2 JUND FOS ATF3 ZBTB33 RAD21 GC02M018608 NT5C1B RNU6-1215P NT5C1B-RDH14 LOC105373456 ENSG00000224626
GH02J018518 Enhancer 0.9 Ensembl ENCODE 10.3 +69.6 69579 4 ZNF652 CC2D1A CTCF RAD21 PKNOX1 RXRA ARID2 REST TRIM22 GTF2F1 RNU6-1215P NT5C1B NT5C1B-RDH14 GC02M018508 ENSG00000260331
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NT5C1B-RDH14 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NT5C1B-RDH14 Gene

Genomic Locations for NT5C1B-RDH14 Gene
34,858 bases
Minus strand
34,858 bases
Minus strand

Genomic View for NT5C1B-RDH14 Gene

Genes around NT5C1B-RDH14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5C1B-RDH14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5C1B-RDH14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5C1B-RDH14 Gene

Proteins for NT5C1B-RDH14 Gene

  • Protein details for NT5C1B-RDH14 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    NT5C1B-RDH14 readthrough
    Protein Accession:

    Protein attributes for NT5C1B-RDH14 Gene

    533 amino acids
    Molecular mass:
    60169 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NT5C1B-RDH14 Gene

Post-translational modifications for NT5C1B-RDH14 Gene

No Post-translational modifications

Other Protein References for NT5C1B-RDH14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NT5C1B-RDH14 Gene

Domains & Families for NT5C1B-RDH14 Gene

Gene Families for NT5C1B-RDH14 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NT5C1B-RDH14 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NT5C1B-RDH14: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NT5C1B-RDH14 Gene

Function for NT5C1B-RDH14 Gene

Phenotypes From GWAS Catalog for NT5C1B-RDH14 Gene

Gene Ontology (GO) - Molecular Function for NT5C1B-RDH14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0008253 5'-nucleotidase activity IBA --
genes like me logo Genes that share ontologies with NT5C1B-RDH14: view

Phenotypes for NT5C1B-RDH14 Gene

genes like me logo Genes that share phenotypes with NT5C1B-RDH14: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NT5C1B-RDH14 Gene

Localization for NT5C1B-RDH14 Gene

Gene Ontology (GO) - Cellular Components for NT5C1B-RDH14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with NT5C1B-RDH14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for NT5C1B-RDH14 Gene

Pathways & Interactions for NT5C1B-RDH14 Gene

PathCards logo

SuperPathways for NT5C1B-RDH14 Gene

genes like me logo Genes that share pathways with NT5C1B-RDH14: view

Pathways by source for NT5C1B-RDH14 Gene

Interacting Proteins for NT5C1B-RDH14 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
Selected Interacting proteins: ENSP00000433415 for NT5C1B-RDH14 Gene via STRING

GPS-Prot Interaction Network for NT5C1B-RDH14

Gene Ontology (GO) - Biological Process for NT5C1B-RDH14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009117 nucleotide metabolic process IEA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with NT5C1B-RDH14: view

No data available for SIGNOR curated interactions for NT5C1B-RDH14 Gene

Drugs & Compounds for NT5C1B-RDH14 Gene

No Compound Related Data Available

Transcripts for NT5C1B-RDH14 Gene

mRNA/cDNA for NT5C1B-RDH14 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NT5C1B-RDH14 Gene

No ASD Table

Relevant External Links for NT5C1B-RDH14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NT5C1B-RDH14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NT5C1B-RDH14 Gene

genes like me logo Genes that share expression patterns with NT5C1B-RDH14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NT5C1B-RDH14 Gene

Orthologs for NT5C1B-RDH14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NT5C1B-RDH14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NT5C1B-RDH14 35
  • 98 (a)
(Mus musculus)
Mammalia Nt5c1b 35
  • 71 (a)
(Bos Taurus)
Mammalia -- 35
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 55 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 53 (a)
(Canis familiaris)
Mammalia -- 35
  • 52 (a)
(Gallus gallus)
Aves -- 35
  • 68 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 67 (a)
(Danio rerio)
Actinopterygii nt5c1bb 35
  • 62 (a)
nt5c1ba 35
  • 57 (a)
CABZ01003826.1 35
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
Species where no ortholog for NT5C1B-RDH14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NT5C1B-RDH14 Gene

Gene Tree for NT5C1B-RDH14 (if available)
Gene Tree for NT5C1B-RDH14 (if available)
Evolutionary constrained regions (ECRs) for NT5C1B-RDH14: view image

Paralogs for NT5C1B-RDH14 Gene

Paralogs for NT5C1B-RDH14 Gene

(5) SIMAP similar genes for NT5C1B-RDH14 Gene using alignment to 1 proteins:

  • C9J2C7_HUMAN
genes like me logo Genes that share paralogs with NT5C1B-RDH14: view

Variants for NT5C1B-RDH14 Gene

Sequence variations from dbSNP and Humsavar for NT5C1B-RDH14 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000006558 -- 18,570,024(-) G/A intron_variant
rs1000043575 -- 18,581,243(-) A/G intron_variant
rs1000108601 -- 18,562,599(-) G/A intron_variant
rs1000203703 -- 18,587,250(-) CCCCCC/CCCCCCC intron_variant
rs1000247039 -- 18,588,162(-) A/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NT5C1B-RDH14 Gene

Variant ID Type Subtype PubMed ID
esv2229780 CNV deletion 18987734
esv2751837 CNV gain 17911159
esv3589966 CNV loss 21293372
esv3589967 CNV loss 21293372
nsv2624 CNV insertion 18451855
nsv519085 CNV loss 19592680
nsv581114 CNV gain 21841781

Variation tolerance for NT5C1B-RDH14 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NT5C1B-RDH14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NT5C1B-RDH14 Gene

Disorders for NT5C1B-RDH14 Gene

Additional Disease Information for NT5C1B-RDH14

No disorders were found for NT5C1B-RDH14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NT5C1B-RDH14 Gene

Publications for NT5C1B-RDH14 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 13 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for NT5C1B-RDH14 Gene

Sources for NT5C1B-RDH14 Gene

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