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Aliases for NT5C1B Gene

Aliases for NT5C1B Gene

  • 5'-Nucleotidase, Cytosolic IB 2
  • 5-Nucleotidase, Cytosolic IB 2 3 5
  • Autoimmune Infertility-Related Protein 3 4
  • CN-IB 3 4
  • CN1B 3 4
  • AIRP 3 4
  • Testicular Tissue Protein Li 1 3
  • Cytosolic 5-Nucleotidase 1B 3
  • Cytosolic 5-Nucleotidase IB 4
  • EC 4

External Ids for NT5C1B Gene

Previous GeneCards Identifiers for NT5C1B Gene

  • GC02M018630
  • GC02M018711
  • GC02M018728
  • GC02M018657
  • GC02M018665
  • GC02M018599
  • GC02M018607
  • GC02M018744

Summaries for NT5C1B Gene

Entrez Gene Summary for NT5C1B Gene

  • Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse physiologic processes (Sala-Newby and Newby, 2001 [PubMed 11690631]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NT5C1B Gene

NT5C1B (5'-Nucleotidase, Cytosolic IB) is a Protein Coding gene. Diseases associated with NT5C1B include Tracheal Cancer and Coenurosis. Among its related pathways are Pyrimidine metabolism (KEGG) and Metabolism. Gene Ontology (GO) annotations related to this gene include nucleotide binding and 5-nucleotidase activity. An important paralog of this gene is NT5C1B-RDH14.

UniProtKB/Swiss-Prot for NT5C1B Gene

  • Dephosphorylates the 5 and 2(3)-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).

Additional gene information for NT5C1B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5C1B Gene

Genomics for NT5C1B Gene

GeneHancer (GH) Regulatory Elements for NT5C1B Gene

Promoters and enhancers for NT5C1B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I018589 Promoter 0.7 EPDnew 550.8 0.0 -4 0.1 ATF7 ATF2 NT5C1B NT5C1B-RDH14 GC02M018608 LOC105373456
GH02I018625 Enhancer 0.6 FANTOM5 ENCODE 18.3 -37.0 -37006 2 JUND POLR2A NT5C1B NT5C1B-RDH14 RNU6-1215P OSR1 GC02M018608 GC02P018659 LOC105373456
GH02I018519 Enhancer 0.9 Ensembl ENCODE 10.3 +68.9 68934 2.2 CTCF PKNOX1 ZNF654 KLF6 TRIM22 REST RAD21 CC2D1A ARID2 ZNF143 RNU6-1215P NT5C1B NT5C1B-RDH14 GC02M018508 ENSG00000260331
GH02I018800 Enhancer 0.9 ENCODE 10.1 -211.1 -211110 0 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 TCF12 SLC30A9 ATF7 GC02P018799 RNU6-1215P NT5C1B GC02P018896 LOC105373456
GH02I018479 Enhancer 0.8 UCNEbase ENCODE 10.2 +109.3 109327 1.1 ZFHX2 FEZF1 ZIC2 NT5C1B NT5C1B-RDH14 GC02M018508 LOC105373454
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NT5C1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NT5C1B gene promoter:

Genomic Locations for NT5C1B Gene

Genomic Locations for NT5C1B Gene
26,710 bases
Minus strand

Genomic View for NT5C1B Gene

Genes around NT5C1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5C1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5C1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5C1B Gene

Proteins for NT5C1B Gene

  • Protein details for NT5C1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytosolic 5-nucleotidase 1B
    Protein Accession:
    Secondary Accessions:
    • B5MCR0
    • B7ZVX7
    • Q53RX2
    • Q8N9W3
    • Q8NA26
    • Q96DU5
    • Q96KE6
    • Q96M25
    • Q96SA3

    Protein attributes for NT5C1B Gene

    610 amino acids
    Molecular mass:
    68804 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • Sequence=AAK39108.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK83285.1; Type=Frameshift; Positions=320; Evidence={ECO:0000305}; Sequence=BAC04103.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC44363.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NT5C1B Gene


neXtProt entry for NT5C1B Gene

Post-translational modifications for NT5C1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NT5C1B Gene

Domains & Families for NT5C1B Gene

Gene Families for NT5C1B Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NT5C1B Gene


Suggested Antigen Peptide Sequences for NT5C1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 5-nucleotidase type 3 family.
  • Belongs to the 5-nucleotidase type 3 family.
genes like me logo Genes that share domains with NT5C1B: view

Function for NT5C1B Gene

Molecular function for NT5C1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A 5-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by ADP.
UniProtKB/Swiss-Prot Function:
Dephosphorylates the 5 and 2(3)-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).

Enzyme Numbers (IUBMB) for NT5C1B Gene

Phenotypes From GWAS Catalog for NT5C1B Gene

Gene Ontology (GO) - Molecular Function for NT5C1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IEA --
GO:0008253 5-nucleotidase activity TAS,IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NT5C1B: view
genes like me logo Genes that share phenotypes with NT5C1B: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NT5C1B Gene

Localization for NT5C1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NT5C1B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NT5C1B gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for NT5C1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA,IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NT5C1B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NT5C1B Gene

Pathways & Interactions for NT5C1B Gene

genes like me logo Genes that share pathways with NT5C1B: view

Pathways by source for NT5C1B Gene

2 GeneGo (Thomson Reuters) pathways for NT5C1B Gene

Interacting Proteins for NT5C1B Gene

Gene Ontology (GO) - Biological Process for NT5C1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006195 purine nucleotide catabolic process TAS --
GO:0009117 nucleotide metabolic process IEA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with NT5C1B: view

No data available for SIGNOR curated interactions for NT5C1B Gene

Drugs & Compounds for NT5C1B Gene

(18) Drugs for NT5C1B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine Approved, Investigational Pharma Agonist 551
Inosine Approved, Investigational Pharma 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0

(13) Additional Compounds for NT5C1B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-nicotinamide D-ribonucleotide
  • 1-(6-Amino-9H-purin-9-yl)-1,2-dideoxy-b-D-Ribofuranose
  • 1-(6-Amino-9H-purin-9-yl)-1,2-dideoxy-beta-D-Ribofuranose
  • 1-(6-Amino-9H-purin-9-yl)-1,2-dideoxy-beta-delta-Ribofuranose
  • 2'-Deoxyadenosine
  • 2-Deoxyadenosine
Deoxyadenosine monophosphate
  • 2'-dAMP
  • 2'-Deoxy-5'-adenylate
  • 2'-Deoxy-5'-adenylic acid
  • 2'-Deoxy-Adenosine 5'-phosphorate
  • 2'-Deoxy-Adenosine 5'-phosphoric acid
  • 2'-Deoxy-Guanosine
  • 2'-Deoxyguanosine
  • 2-Deoxyguanosine
  • 9-(2-Deoxy-b-D-erythro-pentofuranosyl)-Guanine
  • 9-(2-Deoxy-b-D-erythro-pentofuranosyl)guanine
Nicotinamide riboside
  • 1-(beta-D-Ribofuranosyl)nicotinamide
  • 1-b-D-Ribosyl-3-Pyridinecarboxamide
  • 1-beta-D-Ribosyl-3-Pyridinecarboxamide
  • 1-beta-delta-Ribosyl-3-Pyridinecarboxamide
  • 3-(Aminocarbonyl)-1-beta-D-ribofuranosyl-Pyridinium
genes like me logo Genes that share compounds with NT5C1B: view

Transcripts for NT5C1B Gene

Unigene Clusters for NT5C1B Gene

5-nucleotidase, cytosolic IB:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NT5C1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for NT5C1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NT5C1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NT5C1B Gene

mRNA differential expression in normal tissues according to GTEx for NT5C1B Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for NT5C1B Gene

This gene is overexpressed in Serum (38.9) and Plasma (27.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NT5C1B Gene

Protein tissue co-expression partners for NT5C1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NT5C1B Gene:


SOURCE GeneReport for Unigene cluster for NT5C1B Gene:


mRNA Expression by UniProt/SwissProt for NT5C1B Gene:

Tissue specificity: Highly expressed in testis, placenta and pancreas. Detected at lower levels in heart, kidney, liver and lung.
genes like me logo Genes that share expression patterns with NT5C1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NT5C1B Gene

Orthologs for NT5C1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for NT5C1B Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia NT5C1B 33
  • 86.26 (n)
-- 34
  • 53 (a)
(Bos Taurus)
Mammalia NT5C1B 33
  • 81.67 (n)
-- 34
  • 70 (a)
(Mus musculus)
Mammalia Nt5c1b 33 16 34
  • 77.42 (n)
(Rattus norvegicus)
Mammalia Nt5c1b 33
  • 76.7 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 58 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 54 (a)
(Gallus gallus)
Aves NT5C1B 33
  • 75.08 (n)
-- 34
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nt5c1a 33
  • 68.73 (n)
(Danio rerio)
Actinopterygii nt5c1bb 33 34
  • 66.05 (n)
nt5c1ba 34
  • 59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12354 33
Species where no ortholog for NT5C1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NT5C1B Gene

Gene Tree for NT5C1B (if available)
Gene Tree for NT5C1B (if available)

Paralogs for NT5C1B Gene

Paralogs for NT5C1B Gene

(2) SIMAP similar genes for NT5C1B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NT5C1B: view

Variants for NT5C1B Gene

Sequence variations from dbSNP and Humsavar for NT5C1B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000006558 -- 18,570,024(-) G/A intron_variant
rs1000043575 -- 18,581,243(-) A/G intron_variant
rs1000108601 -- 18,562,599(-) G/A downstream_transcript_variant
rs1000203703 -- 18,587,250(-) CCCCCC/CCCCCCC intron_variant
rs1000247039 -- 18,588,162(-) A/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NT5C1B Gene

Variant ID Type Subtype PubMed ID
esv2229780 CNV deletion 18987734
esv2751837 CNV gain 17911159
esv3589967 CNV loss 21293372
nsv2624 CNV insertion 18451855
nsv519085 CNV loss 19592680
nsv581114 CNV gain 21841781

Variation tolerance for NT5C1B Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NT5C1B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NT5C1B Gene

Disorders for NT5C1B Gene

MalaCards: The human disease database

(11) MalaCards diseases for NT5C1B Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
tracheal cancer
  • ca trachea
  • coenuriasis
pulmonary alveolar microlithiasis
  • pam
urogenital tuberculosis
  • genitourinary tuberculosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NT5C1B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NT5C1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NT5C1B Gene

Publications for NT5C1B Gene

  1. Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. (PMID: 11690631) Sala-Newby GB … Newby AC (Biochimica et biophysica acta 2001) 2 3 4 58
  2. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli ET … Goldstein DB (European journal of human genetics : EJHG 2010) 3 44 58
  3. Contribution of adenosine related genes to the risk of depression with disturbed sleep. (PMID: 20392501) Gass N … Paunio T (Journal of affective disorders 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan JA … Goldberg AL (The EMBO journal 2013) 3 58

Products for NT5C1B Gene

Sources for NT5C1B Gene

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