Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
NT5C (5', 3'-Nucleotidase, Cytosolic) is a Protein Coding gene. Diseases associated with NT5C include Trichostrongylosis and Trichostrongyloidiasis. Among its related pathways are Metabolism of nucleotides and NAD metabolism. Gene Ontology (GO) annotations related to this gene include phosphatase activity and nucleotidase activity. An important paralog of this gene is NT5M.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0008252 | nucleotidase activity | IDA | 10681516 |
GO:0008253 | 5'-nucleotidase activity | IEA,IBA | 21873635 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0016791 | phosphatase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 10681516 |
GO:0005737 | cytoplasm | IEA,IDA | 10681516 |
GO:0005829 | cytosol | IDA,TAS | -- |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism of nucleotides | ||
2 | Metabolism |
.40
|
|
3 | NAD metabolism |
NAD metabolism
.53
|
|
4 | Gemcitabine Pathway, Pharmacokinetics/Pharmacodynamics | ||
5 | Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006195 | purine nucleotide catabolic process | TAS | -- |
GO:0006204 | IMP catabolic process | IEA | -- |
GO:0009117 | nucleotide metabolic process | IEA | -- |
GO:0009223 | pyrimidine deoxyribonucleotide catabolic process | IBA,IDA | 10681516 |
GO:0009264 | deoxyribonucleotide catabolic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Lamivudine | Approved, Investigational | Pharma | Enzyme, substrate | Nucleoside analog reverse transcriptase inhibitor | 724 | |
Adenosine | Approved, Investigational | Pharma | 659 | |||
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
Water | Approved | Pharma | 0 | |||
Adenosine monophosphate | Approved, Investigational | Nutra | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
deoxyadenosine |
|
958-09-8 |
|
|||
Deoxyadenosine monophosphate |
|
653-63-4 |
|
|||
deoxyguanosine |
|
961-07-9 |
|
|||
Nicotinamide ribotide |
|
75414-16-3 |
|
|||
Nicotinic acid mononucleotide |
|
321-02-8 |
|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | · | 5g |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||
SP7: | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NT5C 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NT5C 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NT5C 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Nt5c 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nt5c 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | NT5C 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NT5C 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11541956 | - |
p.Pro68Leu |
Disorder | Aliases | PubMed IDs |
---|---|---|
trichostrongylosis |
|
|
trichostrongyloidiasis |
|
|
paramyotonia congenita of von eulenburg |
|
|