Aliases for NT5C Gene
External Ids for NT5C Gene
Previous HGNC Symbols for NT5C Gene
Previous GeneCards Identifiers for NT5C Gene
This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for NT5C Gene
NT5C (5', 3'-Nucleotidase, Cytosolic) is a Protein Coding gene. Diseases associated with NT5C include Localized Chondrosarcoma and Autoimmune Lymphoproliferative Syndrome. Among its related pathways are NAD metabolism and Metabolism of nucleotides. Gene Ontology (GO) annotations related to this gene include phosphatase activity and nucleotidase activity. An important paralog of this gene is NT5M.
UniProtKB/Swiss-Prot Summary for NT5C Gene
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.