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Aliases for NSUN6 Gene

Aliases for NSUN6 Gene

  • NOP2/Sun RNA Methyltransferase Family Member 6 2 3 5
  • NOL1/NOP2/Sun And PUA Domain-Containing Protein 1 3 4
  • NOL1/NOP2/Sun Domain Family, Member 6 2 3
  • NOP2/Sun Domain Family, Member 6 2 3
  • ARL5B Antisense RNA 1 2 3
  • NOPD1 3 4
  • Nucleolar Protein (NOL1/NOP2/Sun) And PUA Domains 1 3
  • NOL1/NOP2/Sun Domain Family Member 6 4
  • Putative Methyltransferase NSUN6 3
  • 4933414E04Rik 3
  • EC 56
  • EC 2.1.1.- 4
  • ARL5B-AS1 3
  • EC 2.1.1 56

External Ids for NSUN6 Gene

Previous HGNC Symbols for NSUN6 Gene

  • NOPD1
  • ARL5B-AS1

Previous GeneCards Identifiers for NSUN6 Gene

  • GC10M018874
  • GC10M018499

Summaries for NSUN6 Gene

GeneCards Summary for NSUN6 Gene

NSUN6 (NOP2/Sun RNA Methyltransferase Family Member 6) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include RNA binding and methyltransferase activity. An important paralog of this gene is NOP2.

UniProtKB/Swiss-Prot for NSUN6 Gene

  • May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

Additional gene information for NSUN6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSUN6 Gene

Genomics for NSUN6 Gene

GeneHancer (GH) Regulatory Elements for NSUN6 Gene

Promoters and enhancers for NSUN6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I018657 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 570.1 -0.3 -349 4.8 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 NSUN6 ARL5B ENSG00000240291 LOC105376438 GC10P018678
GH10I018649 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 583.9 +8.3 8297 3.6 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B NSUN6 ENSG00000240291 LOC105376438 ARL5B
GH10I018626 Enhancer 1.1 Ensembl ENCODE 44.5 +31.6 31630 1.6 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B GLIS2 ZNF143 KLF7 NSUN6 ENSG00000240291 ARL5B
GH10I018609 Enhancer 1.2 Ensembl ENCODE 20.2 +48.2 48175 2.6 PKNOX1 FOXA2 MLX ARID4B NEUROD1 SIN3A FEZF1 ZNF48 ETS1 YY1 NSUN6 ARL5B ENSG00000240291
GH10I018607 Enhancer 1.2 FANTOM5 Ensembl ENCODE 20.2 +51.2 51235 1.7 SMAD1 ZSCAN26 ZBTB6 NFIB JUN ZNF529 ZNF195 FOSL1 ZNF335 LCORL ARL5B NSUN6 ENSG00000240291
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NSUN6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NSUN6 gene promoter:

Genomic Locations for NSUN6 Gene

Genomic Locations for NSUN6 Gene
114,103 bases
Minus strand

Genomic View for NSUN6 Gene

Genes around NSUN6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NSUN6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NSUN6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSUN6 Gene

Proteins for NSUN6 Gene

  • Protein details for NSUN6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative methyltransferase NSUN6
    Protein Accession:
    Secondary Accessions:
    • B0YJ54

    Protein attributes for NSUN6 Gene

    469 amino acids
    Molecular mass:
    51770 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NSUN6 Gene

neXtProt entry for NSUN6 Gene

Selected DME Specific Peptides for NSUN6 Gene


Post-translational modifications for NSUN6 Gene

  • Ubiquitination at isoforms=419
  • Modification sites at PhosphoSitePlus

Domains & Families for NSUN6 Gene

Gene Families for NSUN6 Gene

Suggested Antigen Peptide Sequences for NSUN6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
genes like me logo Genes that share domains with NSUN6: view

Function for NSUN6 Gene

Molecular function for NSUN6 Gene

UniProtKB/Swiss-Prot Function:
May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

Enzyme Numbers (IUBMB) for NSUN6 Gene

Phenotypes From GWAS Catalog for NSUN6 Gene

Gene Ontology (GO) - Molecular Function for NSUN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IDA 26160102
GO:0003723 RNA binding IEA --
GO:0008168 methyltransferase activity IEA --
GO:0016428 tRNA (cytosine-5-)-methyltransferase activity IDA 26160102
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with NSUN6: view
genes like me logo Genes that share phenotypes with NSUN6: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NSUN6 Gene

Localization for NSUN6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NSUN6 gene
Compartment Confidence
cytosol 5
golgi apparatus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NSUN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 26160102
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NSUN6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NSUN6 Gene

Pathways & Interactions for NSUN6 Gene

genes like me logo Genes that share pathways with NSUN6: view

Pathways by source for NSUN6 Gene

Gene Ontology (GO) - Biological Process for NSUN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification TAS --
GO:0030488 tRNA methylation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with NSUN6: view

No data available for SIGNOR curated interactions for NSUN6 Gene

Drugs & Compounds for NSUN6 Gene

(1) Additional Compounds for NSUN6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  • 2-S-Adenosyl-L-methionine
  • 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  • 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  • Active methionine
genes like me logo Genes that share compounds with NSUN6: view

Transcripts for NSUN6 Gene

Unigene Clusters for NSUN6 Gene

NOP2/Sun domain family, member 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NSUN6 Gene

No ASD Table

Relevant External Links for NSUN6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NSUN6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NSUN6 Gene

mRNA differential expression in normal tissues according to GTEx for NSUN6 Gene

This gene is overexpressed in Liver (x4.5).

Protein differential expression in normal tissues from HIPED for NSUN6 Gene

This gene is overexpressed in Breast (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NSUN6 Gene

Protein tissue co-expression partners for NSUN6 Gene

NURSA nuclear receptor signaling pathways regulating expression of NSUN6 Gene:


SOURCE GeneReport for Unigene cluster for NSUN6 Gene:

genes like me logo Genes that share expression patterns with NSUN6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NSUN6 Gene

Orthologs for NSUN6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NSUN6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NSUN6 33 34
  • 99.08 (n)
(Canis familiaris)
Mammalia NSUN6 33
  • 88.84 (n)
-- 34
  • 88 (a)
(Bos Taurus)
Mammalia -- 34
  • 88 (a)
NSUN6 33
  • 87.72 (n)
(Mus musculus)
Mammalia Nsun6 33 16 34
  • 81.73 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 81 (a)
(Rattus norvegicus)
Mammalia Nsun6 33
  • 80.95 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
(Gallus gallus)
Aves NSUN6 33
  • 73.88 (n)
-- 34
  • 73 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nsun6 33
  • 69.31 (n)
Str.11935 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16793 33
(Danio rerio)
Actinopterygii LOC100149557 33
  • 59.46 (n)
NSUN6 34
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11109 33 34
  • 49.37 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP2 34
  • 18 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06560 33
  • 51.11 (n)
(Oryza sativa)
Liliopsida Os08g0365900 33
  • 52.82 (n)
Os.21286 33
Species where no ortholog for NSUN6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NSUN6 Gene

Gene Tree for NSUN6 (if available)
Gene Tree for NSUN6 (if available)

Paralogs for NSUN6 Gene

Paralogs for NSUN6 Gene

genes like me logo Genes that share paralogs with NSUN6: view

Variants for NSUN6 Gene

Sequence variations from dbSNP and Humsavar for NSUN6 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1012448367 uncertain-significance, Brugada syndrome 18,540,319(-) C/A genic_downstream_transcript_variant, intron_variant
rs1027091807 uncertain-significance, Brugada syndrome 18,541,343(-) T/C genic_downstream_transcript_variant, intron_variant
rs1039406883 uncertain-significance, Brugada syndrome 4 18,539,273(-) G/A genic_downstream_transcript_variant, intron_variant
rs1060504914 likely-benign, Brugada syndrome 4 18,539,538(-) C/T genic_downstream_transcript_variant, intron_variant
rs1060504915 likely-benign, Brugada syndrome 4 18,538,341(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NSUN6 Gene

Variant ID Type Subtype PubMed ID
dgv370n106 CNV duplication 24896259
dgv3e19 OTHER inversion 19470904
dgv971n54 CNV gain 21841781
dgv972n54 CNV gain+loss 21841781
dgv973n54 CNV gain 21841781
dgv974n54 CNV gain 21841781
dgv975n54 CNV gain 21841781
dgv976n54 CNV gain+loss 21841781
dgv977n54 CNV loss 21841781
dgv978n54 CNV loss 21841781
dgv979n54 CNV gain 21841781
dgv980n54 CNV gain 21841781
dgv981n54 CNV loss 21841781
dgv982n54 CNV gain 21841781
dgv983n54 CNV loss 21841781
dgv984n54 CNV gain 21841781
esv1520077 CNV deletion 17803354
esv2294866 CNV deletion 18987734
esv2446416 CNV deletion 19546169
esv25204 CNV loss 19812545
esv2661238 CNV deletion 23128226
esv2664218 CNV deletion 23128226
esv2667049 CNV deletion 23128226
esv2670942 CNV deletion 23128226
esv2733739 CNV deletion 23290073
esv2759736 CNV gain 17122850
esv34545 CNV gain 17911159
esv3622509 CNV loss 21293372
esv3622510 CNV gain 21293372
esv3622511 CNV loss 21293372
esv3622512 CNV gain 21293372
esv3622513 CNV loss 21293372
esv6083 OTHER inversion 19470904
nsv1042073 CNV gain 25217958
nsv1069460 CNV deletion 25765185
nsv1077317 CNV duplication 25765185
nsv1120045 OTHER inversion 24896259
nsv1133974 CNV deletion 24896259
nsv1141167 CNV duplication 24896259
nsv1148802 CNV duplication 26484159
nsv1153075 CNV duplication 26484159
nsv466760 CNV loss 19166990
nsv466762 CNV gain 19166990
nsv511455 CNV loss 21212237
nsv512150 CNV loss 21212237
nsv550042 CNV gain 21841781
nsv550043 CNV gain 21841781
nsv550044 CNV loss 21841781
nsv550067 CNV loss 21841781
nsv550087 CNV gain+loss 21841781
nsv550098 CNV loss 21841781
nsv550100 CNV loss 21841781
nsv550109 CNV loss 21841781
nsv550118 CNV loss 21841781
nsv550121 CNV gain 21841781

Variation tolerance for NSUN6 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NSUN6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NSUN6 Gene

Disorders for NSUN6 Gene

Additional Disease Information for NSUN6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NSUN6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NSUN6 Gene

Publications for NSUN6 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6. (PMID: 28531330) Liu RJ … Wang ED (Nucleic acids research 2017) 3 58

Products for NSUN6 Gene

Sources for NSUN6 Gene

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