Aliases for NSG2 Gene

Aliases for NSG2 Gene

  • Neuronal Vesicle Trafficking Associated 2 2 3 5
  • Neuronal Vesicle Trafficking-Associated Protein 2 3 4
  • Neuron-Specific Protein Family Member 2 3 4
  • Calcyon Family Member 3 2 3
  • Protein P19 3 4
  • CALY3 3 4
  • Hypothalamus Golgi Apparatus Expressed 19 KDa Protein 3
  • P19 Protein 3
  • HMP19 3
  • Hmp19 4

External Ids for NSG2 Gene

Summaries for NSG2 Gene

GeneCards Summary for NSG2 Gene

NSG2 (Neuronal Vesicle Trafficking Associated 2) is a Protein Coding gene. Diseases associated with NSG2 include 3-Methylglutaconic Aciduria, Type I. An important paralog of this gene is NSG1.

Additional gene information for NSG2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NSG2 Gene

Genomics for NSG2 Gene

GeneHancer (GH) Regulatory Elements for NSG2 Gene

Promoters and enhancers for NSG2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J174045 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 500.7 +0.6 585 1.2 ZNF217 EP300 CTCF ZIC2 REST ZNF263 AFF1 ZBTB26 ZBTB25 CHD1 NSG2 RF00017-5120
GH05J173883 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.9 -155.7 -155670 13.7 RXRA ZBTB40 ZNF217 EP300 SIN3A MYC NRF1 USF1 POLR2G SP1 CPEB4 HSALNG0046732 BOD1 NSG2 CREBRF
GH05J174311 Promoter/Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas 16.4 +266.4 266419 0.4 RXRA CTCF GABPA ZBTB26 REST RAD21 SMC3 RBM14 TCF12 MXI1 NSG2 ENSG00000253244 BOD1 ENSG00000253447 ENSG00000249722 HSALNG0046749
GH05J173940 Enhancer 1.1 ENCODE dbSUPER 19.7 -101.1 -101122 7 EP300 FOXK2 TCF12 TEAD4 KDM6A TCF7 FOXA1 ZBTB25 TGIF2 SKI NSG2 C5orf47 BOD1 ENSG00000253244 LINC01485 RF00017-5119 HSALNG0046732 CPEB4
GH05J173917 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.9 -126.0 -126041 4.8 FOXK2 CTCF TCF12 SIN3A SP1 BCLAF1 JUND PHF8 SIX5 ZNF639 BOD1 C5orf47 NSG2 HSALNG0046732 CPEB4 RF00017-5119
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NSG2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NSG2

Genomic Locations for NSG2 Gene

Genomic Locations for NSG2 Gene
197,898 bases
Plus strand
197,898 bases
Plus strand

Genomic View for NSG2 Gene

Genes around NSG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NSG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NSG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSG2 Gene

Proteins for NSG2 Gene

  • Protein details for NSG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal vesicle trafficking-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R5Y0
    • D3DQN0
    • Q9UHX8

    Protein attributes for NSG2 Gene

    171 amino acids
    Molecular mass:
    19085 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NSG2 Gene

Post-translational modifications for NSG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NSG2 Gene

No data available for DME Specific Peptides for NSG2 Gene

Domains & Families for NSG2 Gene

Gene Families for NSG2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NSG2 Gene

  • D1 dopamine receptor-interacting

Suggested Antigen Peptide Sequences for NSG2 Gene

GenScript: Design optimal peptide antigens:
  • Protein p19 (NSG2_HUMAN)
  • HMP19 protein (Q6IAL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NSG family.
  • Belongs to the NSG family.
genes like me logo Genes that share domains with NSG2: view

Function for NSG2 Gene

Phenotypes From GWAS Catalog for NSG2 Gene

Gene Ontology (GO) - Molecular Function for NSG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032051 clathrin light chain binding IBA 21873635
genes like me logo Genes that share ontologies with NSG2: view
genes like me logo Genes that share phenotypes with NSG2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NSG2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NSG2 Gene

Localization for NSG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NSG2 Gene

Membrane; Single-pass type II membrane protein. Golgi apparatus, trans-Golgi network membrane. Cell projection, dendrite. Endosome membrane. Early endosome membrane. Late endosome membrane. Lysosome lumen. Cytoplasmic vesicle membrane. Golgi apparatus, Golgi stack membrane. Endosome, multivesicular body membrane. Note=Endocytosed from the cell surface, thus entered into early endosomes, trafficks to late endosomes and degradates in lysosomes (By similarity). Mainly Golgi stack, but also found in small vacuolar organelles and multivesicular bodies. Found in both stationary and motile endosomes (By similarity). {ECO:0000250 UniProtKB:P47759, ECO:0000250 UniProtKB:Q3KR51}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NSG2 gene
Compartment Confidence
endosome 4
golgi apparatus 4
lysosome 3
extracellular 2
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NSG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA,ISS --
GO:0005769 early endosome ISS --
GO:0005770 late endosome ISS --
GO:0005794 Golgi apparatus IDA,IEA --
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with NSG2: view

Pathways & Interactions for NSG2 Gene

PathCards logo

SuperPathways for NSG2 Gene

No Data Available

Interacting Proteins for NSG2 Gene


Gene Ontology (GO) - Biological Process for NSG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007212 dopamine receptor signaling pathway IEA --
GO:0016197 endosomal transport IBA 21873635
GO:0048268 clathrin coat assembly IBA 21873635
genes like me logo Genes that share ontologies with NSG2: view

No data available for Pathways by source and SIGNOR curated interactions for NSG2 Gene

Drugs & Compounds for NSG2 Gene

No Compound Related Data Available

Transcripts for NSG2 Gene

mRNA/cDNA for NSG2 Gene

16 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NSG2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NSG2 Gene

No ASD Table

Relevant External Links for NSG2 Gene

GeneLoc Exon Structure for

Expression for NSG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NSG2

Evidence on tissue expression from TISSUES for NSG2 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with NSG2: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NSG2 Gene

Orthologs for NSG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NSG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 31
  • 100 (a)
LOC462279 30
  • 100 (n)
(Canis familiaris)
Mammalia -- 31
  • 100 (a)
HMP19 30
  • 94.35 (n)
(Bos Taurus)
Mammalia NSG2 31
  • 99 (a)
HMP19 30
  • 93.76 (n)
(Mus musculus)
Mammalia Nsg2 17 31 30
  • 91.03 (n)
(Rattus norvegicus)
Mammalia Nsg2 30
  • 90.64 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 70 (a)
(Gallus gallus)
Aves -- 31
  • 78 (a)
LOC416212 30
  • 76.22 (n)
(Anolis carolinensis)
Reptilia -- 31
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hmp19 30
  • 73.92 (n)
(Danio rerio)
Actinopterygii hmp19 31 30
  • 72.9 (n)
zgc73142 30
Species where no ortholog for NSG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NSG2 Gene

Gene Tree for NSG2 (if available)
Gene Tree for NSG2 (if available)

Paralogs for NSG2 Gene

Paralogs for NSG2 Gene

(4) SIMAP similar genes for NSG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NSG2: view

Variants for NSG2 Gene

Additional dbSNP identifiers (rs#s) for NSG2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NSG2 Gene

Variant ID Type Subtype PubMed ID
dgv113n17 CNV loss 16327808
esv1477078 CNV deletion 17803354
esv2731129 CNV deletion 23290073
esv2731130 CNV deletion 23290073
esv2731131 CNV deletion 23290073
esv3413399 CNV duplication 20981092
esv990876 CNV deletion 20482838
nsv5137 CNV deletion 18451855
nsv600298 CNV gain 21841781

Variation tolerance for NSG2 Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NSG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NSG2 Gene

Disorders for NSG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NSG2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
3-methylglutaconic aciduria, type i
  • mgca1
- elite association - COSMIC cancer census association via MalaCards
Search NSG2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NSG2

genes like me logo Genes that share disorders with NSG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NSG2 Gene

Publications for NSG2 Gene

  1. Complementary roles of the neuron-enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking. (PMID: 25376768) Muthusamy N … Bergson C (Journal of neurochemistry 2015) 2 3 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. (PMID: 15383276) Goehler H … Wanker EE (Molecular cell 2004) 2 3 54
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu RM … Chen JL (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 54
  5. A 19-kDa protein belonging to a new family is expressed in the Golgi apparatus of neural cells. (PMID: 7829526) Sabéran-Djoneidi D … Lévi-Strauss M (The Journal of biological chemistry 1995) 2 3 54

Products for NSG2 Gene

Sources for NSG2 Gene