Aliases for NSD3 Gene
External Ids for NSD3 Gene
Previous HGNC Symbols for NSD3 Gene
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]
GeneCards Summary for NSD3 Gene
NSD3 (Nuclear Receptor Binding SET Domain Protein 3) is a Protein Coding gene. Diseases associated with NSD3 include Wolf-Hirschhorn Syndrome and Nut Midline Carcinoma. Among its related pathways are PKMTs methylate histone lysines and Chromatin organization. An important paralog of this gene is NSD2.
UniProtKB/Swiss-Prot Summary for NSD3 Gene
Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.