This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 k... See more...

Aliases for NSD2 Gene

Aliases for NSD2 Gene

  • Nuclear Receptor Binding SET Domain Protein 2 2 3 5
  • Histone-Lysine N-Methyltransferase NSD2 3 4
  • Nuclear SET Domain-Containing Protein 2 3 4
  • Wolf-Hirschhorn Syndrome Candidate 1 2 3
  • EC 2.1.1.43 4 54
  • WHSC1 3 4
  • MMSET 3 4
  • TRX5 3 4
  • Multiple Myeloma SET Domain Containing Protein Type III 3
  • Probable Histone-Lysine N-Methyltransferase NSD2 3
  • Multiple Myeloma SET Domain-Containing Protein 4
  • Multiple Myeloma SET Domain Containing Protein 2
  • Wolf-Hirschhorn Syndrome Candidate 1 Protein 4
  • IL5 Promoter REII Region-Binding Protein 3
  • Trithorax/Ash1-Related Protein 5 3
  • Protein Trithorax-5 4
  • KIAA1090 4
  • REIIBP 3
  • KMT3F 3
  • KMT3G 3
  • WHS 3

External Ids for NSD2 Gene

Previous HGNC Symbols for NSD2 Gene

  • WHSC1

Summaries for NSD2 Gene

Entrez Gene Summary for NSD2 Gene

  • This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq, Jul 2008]

GeneCards Summary for NSD2 Gene

NSD2 (Nuclear Receptor Binding SET Domain Protein 2) is a Protein Coding gene. Diseases associated with NSD2 include Wolf-Hirschhorn Syndrome and Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1. Among its related pathways are DNA Double-Strand Break Repair and PKMTs methylate histone lysines. An important paralog of this gene is NSD3.

UniProtKB/Swiss-Prot Summary for NSD2 Gene

  • Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.

Gene Wiki entry for NSD2 Gene

Additional gene information for NSD2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NSD2 Gene

Genomics for NSD2 Gene

GeneHancer (GH) Regulatory Elements for NSD2 Gene

Promoters and enhancers for NSD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J001867 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 752.8 -0.2 -203 7 ZBTB40 ZBTB6 RBPJ POLR2A MYC CC2D1A NFYC ELF1 L3MBTL2 MAX NSD2 RF00017-4245 lnc-LETM1-1 FAM193A RNF4 HAUS3 NELFA UVSSA GAK MAEA
GH04J001854 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.4 -15.1 -15149 4.5 SP1 ZBTB40 SIX5 ZBTB6 RBPJ SMARCE1 POLR2A HCFC1 MYC NFYC LETM1 lnc-TMEM129-3 NSD2 FAM193A HAUS3 NELFA RNF4 ENSG00000270195 GAK UVSSA
GH04J001885 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 750.4 +16.9 16907 6.2 MAX DACH1 SMARCA4 ZNF680 PKNOX1 ZNF24 POLR2A FOSL1 BCOR DPF2 NSD2 RF00017-4246
GH04J002007 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 12 +137.6 137608 3.6 ZBTB40 CTCF SIX5 ZBTB6 RBPJ POLR2A TCF7L2 NR2F1 NR2F6 ATF1 NELFA lnc-NSD2-1 RNF4 FAM193A HAUS3 NOP14-AS1 CTBP1-DT UVSSA MFSD10 ENSG00000244459
GH04J001907 Enhancer 0.8 Ensembl ENCODE dbSUPER 12 +36.9 36893 1 CREB1 SCRT2 KLF4 ESRRA FOS NSD2 LETM1 RF00017-4246
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NSD2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NSD2 Gene

Genomic Locations for NSD2 Gene
chr4:1,871,393-1,982,207
(GRCh38/hg38)
Size:
110,815 bases
Orientation:
Plus strand
chr4:1,873,123-1,983,934
(GRCh37/hg19)
Size:
110,812 bases
Orientation:
Plus strand

Genomic View for NSD2 Gene

Genes around NSD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NSD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NSD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSD2 Gene

Proteins for NSD2 Gene

  • Protein details for NSD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96028-NSD2_HUMAN
    Recommended name:
    Histone-lysine N-methyltransferase NSD2
    Protein Accession:
    O96028
    Secondary Accessions:
    • A2A2T2
    • A2A2T3
    • A2A2T4
    • A7MCZ1
    • D3DVQ2
    • O96031
    • Q4VBY8
    • Q672J1
    • Q6IS00
    • Q86V01
    • Q9BZB4
    • Q9UI92
    • Q9UPR2

    Protein attributes for NSD2 Gene

    Size:
    1365 amino acids
    Molecular mass:
    152258 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA83042.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NSD2 Gene

    Alternative splice isoforms for NSD2 Gene

neXtProt entry for NSD2 Gene

Selected DME Specific Peptides for NSD2 Gene

O96028:
  • RFMNHSC
  • ELTFNYN
  • GKWECPWH
  • KGEFVNEYVGELIDEEEC
  • RCPVAYH
  • CGKFYHE
  • IIDAGPKGN

Post-translational modifications for NSD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NSD2 Gene

Gene Families for NSD2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for NSD2 Gene

GenScript: Design optimal peptide antigens:
  • Wolf-Hirschhorn syndrome candidate 1 (A2A2T2_HUMAN)
  • Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP (B3VCH6_HUMAN)
  • Wolf-Hirschhorn syndrome candidate 1 protein (NSD2_HUMAN)
  • WHSC1 protein (Q05CW4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O96028

UniProtKB/Swiss-Prot:

NSD2_HUMAN :
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
genes like me logo Genes that share domains with NSD2: view

Function for NSD2 Gene

Molecular function for NSD2 Gene

UniProtKB/Swiss-Prot Function:
Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43; Evidence=. ;.

Enzyme Numbers (IUBMB) for NSD2 Gene

Phenotypes From GWAS Catalog for NSD2 Gene

Gene Ontology (GO) - Molecular Function for NSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 19481544
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with NSD2: view
genes like me logo Genes that share phenotypes with NSD2: view

Human Phenotype Ontology for NSD2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NSD2 Gene

MGI Knock Outs for NSD2:
  • Nsd2 Nsd2<tm1Ykan>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for NSD2

No data available for Transcription Factor Targets and HOMER Transcription for NSD2 Gene

Localization for NSD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NSD2 Gene

Nucleus. Chromosome.
Isoform 4: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NSD2 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA 21873635
GO:0005634 nucleus IDA,IBA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NSD2: view

Pathways & Interactions for NSD2 Gene

genes like me logo Genes that share pathways with NSD2: view

SIGNOR curated interactions for NSD2 Gene

Activates:

Gene Ontology (GO) - Biological Process for NSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0003149 membranous septum morphogenesis IEA --
GO:0003289 atrial septum primum morphogenesis IEA --
GO:0003290 atrial septum secundum morphogenesis IEA --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
genes like me logo Genes that share ontologies with NSD2: view

Drugs & Compounds for NSD2 Gene

(2) Drugs for NSD2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D-Lysine Approved, Experimental Nutra Full agonist, Agonist 0
s-adenosylhomocysteine Experimental Pharma 0

(1) Additional Compounds for NSD2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
485-80-3
genes like me logo Genes that share compounds with NSD2: view

Transcripts for NSD2 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for NSD2

Alternative Splicing Database (ASD) splice patterns (SP) for NSD2 Gene

No ASD Table

Relevant External Links for NSD2 Gene

GeneLoc Exon Structure for
NSD2
ECgene alternative splicing isoforms for
NSD2

Expression for NSD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of NSD2 Gene:

NSD2

mRNA Expression by UniProt/SwissProt for NSD2 Gene:

O96028-NSD2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for NSD2 Gene

  • Nervous system(4.8)
  • Spleen(4.2)
  • Bone marrow(2.8)
  • Blood(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NSD2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • outer ear
  • scalp
  • skull
  • tooth
Thorax:
  • chest wall
  • clavicle
  • diaphragm
  • esophagus
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • intestine
  • kidney
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
Pelvis:
  • fallopian tube
  • ovary
  • pelvis
  • penis
  • prostate
  • testicle
  • urethra
  • uterus
  • vagina
  • vas deferens
  • vulva
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • hair
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with NSD2: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NSD2 Gene

Orthologs for NSD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NSD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WHSC1 33 32
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia WHSC1 33 32
  • 88.39 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Whsc1 33 32
  • 87.39 (n)
OneToOne
Nsd2 17
rat
(Rattus norvegicus)
Mammalia Whsc1 32
  • 86.85 (n)
oppossum
(Monodelphis domestica)
Mammalia WHSC1 33
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WHSC1 33 32
  • 82.91 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WHSC1 33
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves WHSC1 33 32
  • 76.93 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WHSC1 33
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia whsc1 32
  • 68.29 (n)
zebrafish
(Danio rerio)
Actinopterygii whsc1 33 32
  • 67.56 (n)
OneToOne
wufc12c04 32
fruit fly
(Drosophila melanogaster)
Insecta Mes-4 33
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea set-23 33
  • 33 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9549 33
  • 53 (a)
OneToMany
Species where no ortholog for NSD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NSD2 Gene

ENSEMBL:
Gene Tree for NSD2 (if available)
TreeFam:
Gene Tree for NSD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NSD2: view image

Paralogs for NSD2 Gene

Pseudogenes.org Pseudogenes for NSD2 Gene

genes like me logo Genes that share paralogs with NSD2: view

Variants for NSD2 Gene

Sequence variations from dbSNP and Humsavar for NSD2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs10019502 benign, 4p partial monosomy syndrome 1,893,735(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs10034373 benign, 4p partial monosomy syndrome 1,980,928(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs111668967 likely-benign, 4p partial monosomy syndrome 1,979,994(+) A/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs112014939 likely-benign, 4p partial monosomy syndrome 1,918,543(+) A/G coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs112146288 likely-benign, 4p partial monosomy syndrome 1,979,433(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NSD2 Gene

Variant ID Type Subtype PubMed ID
dgv8903n54 CNV gain 21841781
dgv8904n54 CNV gain+loss 21841781
dgv8905n54 CNV gain+loss 21841781
dgv8906n54 CNV loss 21841781
esv27096 CNV loss 19812545
esv2726833 CNV deletion 23290073
esv2726834 CNV deletion 23290073
nsv1073290 CNV deletion 25765185
nsv1144066 CNV deletion 24896259
nsv478611 CNV novel sequence insertion 20440878
nsv593340 CNV gain 21841781
nsv593346 CNV loss 21841781
nsv593347 CNV gain 21841781
nsv593348 CNV gain 21841781
nsv593349 CNV gain+loss 21841781
nsv593361 CNV gain 21841781
nsv593364 CNV gain+loss 21841781
nsv819354 CNV gain 19587683
nsv829836 CNV loss 17160897

Variation tolerance for NSD2 Gene

Residual Variation Intolerance Score: 1.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NSD2 Gene

Human Gene Mutation Database (HGMD)
NSD2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NSD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NSD2 Gene

Disorders for NSD2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for NSD2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NSD2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NSD2_HUMAN
  • Note=A chromosomal aberration involving NSD2 is a cause of multiple myeloma tumors. Translocation t(4;14)(p16.3;q32.3) with IgH.
  • Note=NSD2 is located in the Wolf-Hirschhorn syndrome (WHS) critical region. WHS results from by sub-telomeric deletions in the short arm of chromosome 4. NSD2 is deleted in every case, however deletion of linked genes contributes to both the severity of the core characteristics and the presence of the additional syndromic problems.

Additional Disease Information for NSD2

genes like me logo Genes that share disorders with NSD2: view

No data available for Genatlas for NSD2 Gene

Publications for NSD2 Gene

  1. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. (PMID: 9787135) Chesi M … Bergsagel PL (Blood 1998) 2 3 4 23 56
  2. WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma. (PMID: 9618163) Stec I … den Dunnen JT (Human molecular genetics 1998) 2 3 4 23 56
  3. Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity. (PMID: 18172012) Kim JY … Seo SB (Molecular and cellular biology 2008) 3 4 23 56
  4. Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients. (PMID: 15677557) Keats JJ … Pilarski LM (Blood 2005) 3 4 23 56
  5. Transcription repression activity is associated with the type I isoform of the MMSET gene involved in t(4;14) in multiple myeloma. (PMID: 16197452) Todoerti K … Neri A (British journal of haematology 2005) 3 4 23 56

Products for NSD2 Gene

Sources for NSD2 Gene