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Aliases for NSA2 Gene

Aliases for NSA2 Gene

  • NSA2, Ribosome Biogenesis Homolog 2 3 5
  • Hairy Cell Leukemia Protein 1 2 3 4
  • TGF Beta-Inducible Nuclear Protein 1 2 3
  • TINP1 3 4
  • NSA2 Ribosome Biogenesis Homolog (S. Cerevisiae) 2
  • Ribosome Biogenesis Protein NSA2 Homolog 3
  • TGF-Beta-Inducible Nuclear Protein 1 4
  • TGF-Beta Inducible Nuclear Protein 3
  • HUSSY-29 3
  • HUSSY29 3
  • CDK105 3
  • HCL-G1 3
  • HCLG1 3

External Ids for NSA2 Gene

Previous GeneCards Identifiers for NSA2 Gene

  • GC05P074099
  • GC05P074062
  • GC05P069268

Summaries for NSA2 Gene

Entrez Gene Summary for NSA2 Gene

  • This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]

GeneCards Summary for NSA2 Gene

NSA2 (NSA2, Ribosome Biogenesis Homolog) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NSA2 Gene

  • Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).

Gene Wiki entry for NSA2 Gene

Additional gene information for NSA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSA2 Gene

Genomics for NSA2 Gene

GeneHancer (GH) Regulatory Elements for NSA2 Gene

Promoters and enhancers for NSA2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J074764 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 767.7 +1.1 1107 3.9 ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZC3H11A MEF2D NSA2 GFM2 RPS26P26 POLK POC5 ENSG00000272040 RNU6-658P FAM169A
GH05J074864 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 79.4 +102.1 102141 6.2 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ETS1 GLIS2 ATF7 FAM169A LOC441086 NSA2 RPS26P26 GFM2 GC05M074884
GH05J074849 Enhancer 1 Ensembl ENCODE 89.5 +85.7 85662 3.6 ELF3 DMAP1 YY1 SCRT2 CEBPB KAT8 NFIL3 SP1 ATF4 RCOR2 NSA2 RNU6-1330P FAM169A GC05M074847 LOC441086
GH05J074761 Enhancer 0.8 ENCODE dbSUPER 95.3 -2.6 -2641 3.3 CTCF JUN CEBPB EP300 THRB RFX5 HIC1 ZFP69B FOSL1 JUND NSA2 RNU6-658P GFM2 GC05M074726
GH05J074815 Enhancer 0.5 ENCODE 89.5 +51.7 51671 3.4 SRF NANOG RNF2 POU5F1 ETS1 NSA2 LOC260421 GC05P074837 FAM169A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NSA2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NSA2 Gene

Genomic Locations for NSA2 Gene
14,685 bases
Plus strand
9,921 bases
Plus strand

Genomic View for NSA2 Gene

Genes around NSA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NSA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NSA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSA2 Gene

Proteins for NSA2 Gene

  • Protein details for NSA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosome biogenesis protein NSA2 homolog
    Protein Accession:

    Protein attributes for NSA2 Gene

    260 amino acids
    Molecular mass:
    30065 Da
    Quaternary structure:
    • Component of the pre-66S ribosomal particle.

neXtProt entry for NSA2 Gene

Post-translational modifications for NSA2 Gene

  • Ubiquitination at Lys201 and isoforms=189
  • Modification sites at PhosphoSitePlus

Other Protein References for NSA2 Gene

No data available for DME Specific Peptides for NSA2 Gene

Domains & Families for NSA2 Gene

Gene Families for NSA2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for NSA2 Gene

Suggested Antigen Peptide Sequences for NSA2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
  • Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
genes like me logo Genes that share domains with NSA2: view

Function for NSA2 Gene

Molecular function for NSA2 Gene

UniProtKB/Swiss-Prot Function:
Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).

Gene Ontology (GO) - Molecular Function for NSA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with NSA2: view
genes like me logo Genes that share phenotypes with NSA2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NSA2 Gene

Localization for NSA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NSA2 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NSA2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NSA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IBA --
GO:0030687 preribosome, large subunit precursor IBA --
genes like me logo Genes that share ontologies with NSA2: view

Pathways & Interactions for NSA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NSA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000460 maturation of 5.8S rRNA IBA --
GO:0000470 maturation of LSU-rRNA IBA --
GO:0006364 rRNA processing IEA --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with NSA2: view

No data available for Pathways by source and SIGNOR curated interactions for NSA2 Gene

Drugs & Compounds for NSA2 Gene

No Compound Related Data Available

Transcripts for NSA2 Gene

Unigene Clusters for NSA2 Gene

NSA2 ribosome biogenesis homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NSA2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: - -
SP4: - - - -

Relevant External Links for NSA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NSA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NSA2 Gene

Protein differential expression in normal tissues from HIPED for NSA2 Gene

This gene is overexpressed in Lung (35.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NSA2 Gene

Protein tissue co-expression partners for NSA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NSA2 Gene:


SOURCE GeneReport for Unigene cluster for NSA2 Gene:


Evidence on tissue expression from TISSUES for NSA2 Gene

  • Muscle(4.5)
  • Spleen(2.4)
  • Heart(2.3)
  • Kidney(2.2)
  • Liver(2.2)
  • Lung(2.2)
  • Intestine(2.1)
  • Nervous system(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with NSA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NSA2 Gene

Orthologs for NSA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NSA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia NSA2 34
  • 100 (a)
(Pan troglodytes)
Mammalia NSA2 34 33
  • 99.87 (n)
(Bos Taurus)
Mammalia NSA2 34 33
  • 93.33 (n)
(Canis familiaris)
Mammalia NSA2 34 33
  • 92.69 (n)
(Rattus norvegicus)
Mammalia Nsa2 33
  • 88.59 (n)
(Mus musculus)
Mammalia Nsa2 16 34 33
  • 88.08 (n)
(Ornithorhynchus anatinus)
Mammalia NSA2 34
  • 84 (a)
(Gallus gallus)
Aves NSA2 34 33
  • 83.21 (n)
(Anolis carolinensis)
Reptilia NSA2 34
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nsa2 33
  • 82.82 (n)
Str.79 33
(Danio rerio)
Actinopterygii nsa2 34 33
  • 76.41 (n)
wufb34b10 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.360 33
fruit fly
(Drosophila melanogaster)
Insecta Ip259 34 33
  • 66.8 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008001 33
  • 64.99 (n)
(Caenorhabditis elegans)
Secernentea W09C5.1 34
  • 70 (a)
CELE_W09C5.1 33
  • 68.22 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13619g 33
  • 62.56 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NSA2 36 34 33
  • 61.41 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL050W 33
  • 57.44 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G06360 33
  • 65.9 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10191 33
(Glycine max)
eudicotyledons Gma.7693 33
(Oryza sativa)
Liliopsida Os07g0673100 33
  • 66.54 (n)
Os.10094 33
(Hordeum vulgare)
Liliopsida Hv.499 33
(Zea mays)
Liliopsida Zm.3343 33
(Triticum aestivum)
Liliopsida Ta.14408 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCP1E11.08 33
  • 63.97 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00981 33
  • 58.46 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.406 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.406 33
Species where no ortholog for NSA2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NSA2 Gene

Gene Tree for NSA2 (if available)
Gene Tree for NSA2 (if available)
Evolutionary constrained regions (ECRs) for NSA2: view image

Paralogs for NSA2 Gene

(1) SIMAP similar genes for NSA2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NSA2: view

No data available for Paralogs for NSA2 Gene

Variants for NSA2 Gene

Sequence variations from dbSNP and Humsavar for NSA2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs79992455 benign, not specified 74,763,700(+) T/C upstream_transcript_variant
rs1000131685 -- 74,776,343(+) C/A/G genic_downstream_transcript_variant, intron_variant
rs1000271888 -- 74,770,026(+) T/G intron_variant
rs1000289844 -- 74,770,500(+) G/A intron_variant
rs1000441223 -- 74,763,867(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NSA2 Gene

Variant ID Type Subtype PubMed ID
nsv598653 CNV loss 21841781
nsv968947 CNV duplication 23825009
nsv968948 CNV duplication 23825009

Variation tolerance for NSA2 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NSA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NSA2 Gene

Disorders for NSA2 Gene

Additional Disease Information for NSA2

No disorders were found for NSA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NSA2 Gene

Publications for NSA2 Gene

  1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F … Valle G (Yeast (Chichester, England) 2001) 2 3 4 58
  2. Molecular analysis of the human chromosome 5q13.3 region in patients with hairy cell leukemia and identification of tumor suppressor gene candidates. (PMID: 10486207) Wu X … Einhorn S (Genomics 1999) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 58
  5. Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage. (PMID: 28031328) An H … Sun FL (Molecular and cellular biology 2017) 3 58

Products for NSA2 Gene

Sources for NSA2 Gene

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