Aliases for NRSN2 Gene

Aliases for NRSN2 Gene

  • Neurensin 2 2 3 5
  • Neurensin-2 3 4
  • C20orf98 3 4
  • Chromosome 20 Open Reading Frame 98 2
  • DJ1103G7.6 3

External Ids for NRSN2 Gene

Previous HGNC Symbols for NRSN2 Gene

  • C20orf98

Previous GeneCards Identifiers for NRSN2 Gene

  • GC20P000276
  • GC20P000327

Summaries for NRSN2 Gene

GeneCards Summary for NRSN2 Gene

NRSN2 (Neurensin 2) is a Protein Coding gene. An important paralog of this gene is NRSN1.

UniProtKB/Swiss-Prot Summary for NRSN2 Gene

Gene Wiki entry for NRSN2 Gene

Additional gene information for NRSN2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRSN2 Gene

Genomics for NRSN2 Gene

GeneHancer (GH) Regulatory Elements for NRSN2 Gene

Promoters and enhancers for NRSN2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRSN2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRSN2

Top Transcription factor binding sites by QIAGEN in the NRSN2 gene promoter:
  • AML1a
  • C/EBPalpha
  • CHOP-10
  • E47
  • FOXI1
  • HFH-3
  • Olf-1
  • Spz1
  • Tal-1

Genomic Locations for NRSN2 Gene

Genomic Locations for NRSN2 Gene
chr20:346,726-359,660
(GRCh38/hg38)
Size:
12,935 bases
Orientation:
Plus strand
chr20:327,370-340,304
(GRCh37/hg19)
Size:
12,935 bases
Orientation:
Plus strand

Genomic View for NRSN2 Gene

Genes around NRSN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRSN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRSN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRSN2 Gene

Proteins for NRSN2 Gene

  • Protein details for NRSN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZP1-NRSN2_HUMAN
    Recommended name:
    Neurensin-2
    Protein Accession:
    Q9GZP1
    Secondary Accessions:
    • A8K3B2
    • Q6FII5
    • Q9NUD3

    Protein attributes for NRSN2 Gene

    Size:
    204 amino acids
    Molecular mass:
    21983 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NRSN2 Gene

Post-translational modifications for NRSN2 Gene

  • Ubiquitination at Lys21
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NRSN2 Gene

Domains & Families for NRSN2 Gene

Gene Families for NRSN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for NRSN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NRSN2 Gene

GenScript: Design optimal peptide antigens:
  • Neurensin-2 (NRSN2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZP1

UniProtKB/Swiss-Prot:

NRSN2_HUMAN :
  • Belongs to the VMP family.
Family:
  • Belongs to the VMP family.
genes like me logo Genes that share domains with NRSN2: view

Function for NRSN2 Gene

Molecular function for NRSN2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in maintenance and/or transport of vesicles.

Phenotypes From GWAS Catalog for NRSN2 Gene

Gene Ontology (GO) - Molecular Function for NRSN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NRSN2: view
genes like me logo Genes that share phenotypes with NRSN2: view

miRNA for NRSN2 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRSN2 Gene

Localization for NRSN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRSN2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRSN2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRSN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030133 transport vesicle IBA,ISS --
GO:0031410 cytoplasmic vesicle IBA 21873635
genes like me logo Genes that share ontologies with NRSN2: view

Pathways & Interactions for NRSN2 Gene

PathCards logo

SuperPathways for NRSN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRSN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IBA 21873635
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NRSN2: view

No data available for Pathways by source and SIGNOR curated interactions for NRSN2 Gene

Drugs & Compounds for NRSN2 Gene

No Compound Related Data Available

Transcripts for NRSN2 Gene

mRNA/cDNA for NRSN2 Gene

8 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRSN2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - -
SP9: -
SP10: - -

Relevant External Links for NRSN2 Gene

GeneLoc Exon Structure for
NRSN2

Expression for NRSN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NRSN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRSN2 Gene

This gene is overexpressed in Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for NRSN2 Gene

This gene is overexpressed in Frontal cortex (22.0), Testis (20.5), Retina (15.6), and Pancreas (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NRSN2 Gene



Protein tissue co-expression partners for NRSN2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRSN2

SOURCE GeneReport for Unigene cluster for NRSN2 Gene:

Hs.416024

Evidence on tissue expression from TISSUES for NRSN2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with NRSN2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRSN2 Gene

Orthologs for NRSN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRSN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRSN2 31 30
  • 99.35 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NRSN2 31 30
  • 88.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NRSN2 31 30
  • 86.8 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrsn2 30
  • 70.69 (n)
mouse
(Mus musculus)
Mammalia Nrsn2 17 31 30
  • 69.85 (n)
oppossum
(Monodelphis domestica)
Mammalia NRSN2 31
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRSN2 31
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRSN2 31
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii NRSN2 31
  • 26 (a)
OneToOne
Species where no ortholog for NRSN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRSN2 Gene

ENSEMBL:
Gene Tree for NRSN2 (if available)
TreeFam:
Gene Tree for NRSN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NRSN2: view image

Paralogs for NRSN2 Gene

Paralogs for NRSN2 Gene

(1) SIMAP similar genes for NRSN2 Gene using alignment to 6 proteins:

  • NRSN2_HUMAN
  • V9GY99_HUMAN
  • V9GYN1_HUMAN
  • V9GYV8_HUMAN
  • V9GYY0_HUMAN
  • V9GZ28_HUMAN
genes like me logo Genes that share paralogs with NRSN2: view

Variants for NRSN2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRSN2 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
728810 Benign: not provided 353,212(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
774529 Benign: not provided 353,227(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
777514 Benign: not provided 353,383(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT
782662 Benign: not provided 353,498(+) G/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
786966 Benign: not provided 349,673(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for NRSN2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NRSN2 Gene

Variant ID Type Subtype PubMed ID
dgv4219n100 CNV gain 25217958
dgv771e214 CNV gain 21293372
esv3893263 CNV loss 25118596
nsv458838 CNV loss 19166990
nsv585168 CNV loss 21841781

Variation tolerance for NRSN2 Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.10; 75.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRSN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRSN2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRSN2 Gene

Disorders for NRSN2 Gene

Additional Disease Information for NRSN2

No disorders were found for NRSN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRSN2 Gene

Publications for NRSN2 Gene

  1. Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma. (PMID: 26055238) Wang X … Xia Q (Digestive diseases and sciences 2015) 2 3 54
  2. Molecular characterization of a transport vesicle protein Neurensin-2, a homologue of Neurensin-1, expressed in neural cells. (PMID: 16527258) Nakanishi K … Taketani S (Brain research 2006) 2 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 54

Products for NRSN2 Gene

Sources for NRSN2 Gene