NRP2 Gene (Protein Coding)

Neuropilin 2

GC02P205681
GIFtS:
44
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth fac... See more...

Aliases for NRP2 Gene

Aliases for NRP2 Gene

  • Neuropilin 2 2 3 5
  • VEGF165R2 2 3 4
  • Vascular Endothelial Cell Growth Factor 165 Receptor 2 3 4
  • Neuropilin-2 3 4
  • Receptor For VEGF165 And Semaphorins Class3 3
  • Neuropilin-2a(17) 3
  • Neuropilin-2a(22) 3
  • Neuropilin-2b(0) 3
  • PRO2714 3
  • NPN2 3
  • NRP2 5
  • NP2 3

External Ids for NRP2 Gene

Previous GeneCards Identifiers for NRP2 Gene

  • GC02P204763
  • GC02P205271
  • GC02P206510
  • GC02P206749
  • GC02P206372
  • GC02P206254
  • GC02P198397

Summaries for NRP2 Gene

Entrez Gene Summary for NRP2 Gene

  • This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NRP2 Gene

NRP2 (Neuropilin 2) is a Protein Coding gene. Diseases associated with NRP2 include Wallerian Degeneration and Exudative Vitreoretinopathy 1. Among its related pathways are L1CAM interactions and Development VEGF signaling via VEGFR2 - generic cascades. Gene Ontology (GO) annotations related to this gene include growth factor binding. An important paralog of this gene is NRP1.

UniProtKB/Swiss-Prot Summary for NRP2 Gene

  • High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
  • (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells.

Gene Wiki entry for NRP2 Gene

Additional gene information for NRP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRP2 Gene

Genomics for NRP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NRP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J205681 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 265.3 +3.5 3473 8.1 ZNF600 ZIC2 POLR2A ZBTB10 YY1 ETS1 FEZF1 ZNF341 ZNF217 SIN3A NRP2 ENSG00000225216 lnc-INO80D-8 HSALNG0021744 INO80D
GH02J205711 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.8 +31.9 31911 5.8 BCLAF1 NFIC BCL11A ZNF592 CTCF EBF1 SMARCA5 TAL1 BHLHE40 BATF NRP2 ENSG00000225216 INO80D HSALNG0021744
GH02J205705 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 17 +25.5 25497 4.3 BCLAF1 SP1 ZNF207 JUND POLR2A ZNF592 EBF1 CBFB MAX ASH2L HSALNG0021744 NRP2 ENSG00000225216 INO80D
GH02J205768 Enhancer 1.1 Ensembl ENCODE dbSUPER 16.2 +90.3 90261 8.7 CEBPA CHD4 CTCF REST MAFF SMAD4 SMC3 YY1 JUND RAD21 NRP2 ENSG00000225216 lnc-PARD3B-4 INO80D
GH02J205678 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 13.9 -2.3 -2292 3.1 ZNF654 ZNF580 TRIM22 FEZF1 ZFP64 CTCF ZNF513 ELF1 RAD21 SMC3 NRP2 lnc-INO80D-8 piR-52079-120
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRP2

Top Transcription factor binding sites by QIAGEN in the NRP2 gene promoter:
  • aMEF-2
  • Cdc5
  • CREB
  • MEF-2A
  • Msx-1
  • PPAR-gamma1
  • PPAR-gamma2
  • USF-1
  • USF-1:USF-2
  • USF1

Genomic Locations for NRP2 Gene

Latest Assembly
chr2:205,681,990-205,798,133
(GRCh38/hg38)
Size:
116,144 bases
Orientation:
Plus strand

Previous Assembly
chr2:206,547,225-206,662,855
(GRCh37/hg19 by Entrez Gene)
Size:
115,631 bases
Orientation:
Plus strand

chr2:206,546,714-206,662,857
(GRCh37/hg19 by Ensembl)
Size:
116,144 bases
Orientation:
Plus strand

Genomic View for NRP2 Gene

Genes around NRP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRP2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NRP2 Gene

Proteins for NRP2 Gene

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  • Protein details for NRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60462-NRP2_HUMAN
    Recommended name:
    Neuropilin-2
    Protein Accession:
    O60462
    Secondary Accessions:
    • A0A024R3W6
    • A0A024R412
    • E9PF66
    • O14820
    • O14821
    • Q53TQ4
    • Q53TS3
    • Q7LBX6
    • Q7LBX7
    • Q9H2D4
    • Q9H2D5
    • Q9H2E2
    • Q9H2E3
    • Q9H2E4
    • X5D2Q8

    Protein attributes for NRP2 Gene

    Size:
    931 amino acids
    Molecular mass:
    104831 Da
    Quaternary structure:
    • Heterodimer with NRP1. Binds PLXNB1.
    • (Microbial infection) Interacts with human cytomegalovirus proteins gL, UL128, UL130 and UL131A.

    Three dimensional structures from OCA and Proteopedia for NRP2 Gene

    Alternative splice isoforms for NRP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRP2 Gene

Protein Expression for NRP2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NRP2 Gene

  • Glycosylation at Asn152, Asn157, Thr595, Thr600, Thr603, Thr607, Asn629, Ser672, and Asn839
  • Modification sites at PhosphoSitePlus

Other Protein References for NRP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NRP2 Gene

Domains & Families for NRP2 Gene

Gene Families for NRP2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for NRP2 Gene

InterPro:
Blocks:
  • Coagulation factor 5/8 type C domain (FA58C)
  • CUB domain
  • MAM domain signature

Suggested Antigen Peptide Sequences for NRP2 Gene

GenScript: Design optimal peptide antigens:
  • Neuropilin 2 (B7ZL68_HUMAN)
  • Vascular endothelial cell growth factor 165 receptor 2 (NRP2_HUMAN)
  • Neuropilin-2a(17) (Q7LBX6_HUMAN)
  • Neuropilin-2a(22) (Q7LBX7_HUMAN)
  • Neuropilin-2 soluble isoform 9 (Q9H2E2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60462

UniProtKB/Swiss-Prot:

NRP2_HUMAN :
  • The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
  • Belongs to the neuropilin family.
Domain:
  • The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
Family:
  • Belongs to the neuropilin family.
genes like me logo Genes that share domains with NRP2: view

Function for NRP2 Gene

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Molecular function for NRP2 Gene

UniProtKB/Swiss-Prot Function:
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells.
GENATLAS Biochemistry:
neuropilin 2,cell surface glycoprotein expressed by the developing nervous system,semaphorin 3C and 3F receptor,implicated in repulsive axon guidance,also expressed by endothelial and tumor cells,vascular endothelial growth factor-165 receptor

Phenotypes From GWAS Catalog for NRP2 Gene

Gene Ontology (GO) - Molecular Function for NRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005021 vascular endothelial growth factor-activated receptor activity TAS,NAS 11112349
GO:0005515 protein binding IPI 25752543
GO:0008201 heparin binding IEA --
GO:0017154 semaphorin receptor activity NAS 11112349
GO:0019838 growth factor binding TAS 21245381
genes like me logo Genes that share ontologies with NRP2: view
genes like me logo Genes that share phenotypes with NRP2: view

Animal Models for NRP2 Gene

MGI Knock Outs for NRP2:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRP2

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRP2 Gene

Localization for NRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRP2 Gene

Membrane. Single-pass type I membrane protein.
[Isoform s9]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRP2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 2
peroxisome 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002116 semaphorin receptor complex NAS 19909241
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS --
GO:0016021 integral component of membrane NAS 11112349
genes like me logo Genes that share ontologies with NRP2: view

Pathways & Interactions for NRP2 Gene

PathCards logo

SuperPathways for NRP2 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
Rac1 Pathway
.65
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Nuclear Receptor Activation by Vitamin-A
.57
2 CREB Pathway
CREB Pathway
.68
Activation of PKC through GPCR
.63
3 PAK Pathway
Antioxidant Action of Vitamin-C
.56
PAK Pathway
.56
4 p70S6K Signaling
p70S6K Signaling
.60
Renin-Angiotensin Pathway
.60
5 Phospholipase-C Pathway
Phospholipase-C Pathway
.56
PTEN Pathway
.56
genes like me logo Genes that share pathways with NRP2: view

Pathways by source for NRP2 Gene

1 GeneGo (Thomson Reuters) pathway for NRP2 Gene
  • Development VEGF-family signaling
1 R&D Systems pathway for NRP2 Gene
23 Qiagen pathways for NRP2 Gene
  • Actin-Based Motility by Rho Family GTPases
  • Activation of PKC through GPCR
  • Antioxidant Action of Vitamin-C
  • Apoptotic Pathways in Synovial Fibroblasts
  • Breast Cancer Regulation by Stathmin1
2 Cell Signaling Technology pathways for NRP2 Gene

SIGNOR curated interactions for NRP2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis NAS 11112349
GO:0001755 neural crest cell migration IEA --
GO:0001764 neuron migration IEA --
GO:0001938 positive regulation of endothelial cell proliferation TAS 21245381
GO:0003148 outflow tract septum morphogenesis ISS --
genes like me logo Genes that share ontologies with NRP2: view

Drugs & Compounds for NRP2 Gene

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(4) Drugs for NRP2 Gene - From: DrugBank, PharmGKB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Daunorubicin Approved Pharma DNA topoisomerase II inhibitor 399
ATYR1923 Investigational Pharma Target, modulator 0

(1) Additional Compounds for NRP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NRP2: view

Transcripts for NRP2 Gene

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mRNA/cDNA for NRP2 Gene

6 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRP2

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for NRP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for NRP2 Gene

GeneLoc Exon Structure for
NRP2

Expression for NRP2 Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NRP2 Gene

mRNA expression in normal human tissues for NRP2 Gene
mRNA expression by GTEx for NRP2 GenemRNA expression by BioGPS for NRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRP2 Gene

This gene is overexpressed in Esophagus - Muscularis (x4.6), Colon - Sigmoid (x4.3), and Esophagus - Gastroesophageal Junction (x4.2).

Protein differential expression in normal tissues from HIPED for NRP2 Gene

This gene is overexpressed in Serum (28.7) and Uterus (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NRP2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRP2

SOURCE GeneReport for Unigene cluster for NRP2 Gene:

Hs.471200

Evidence on tissue expression from TISSUES for NRP2 Gene

  • Nervous system(4.7)
  • Skin(3.1)
  • Lung(3.1)
  • Eye(2.9)
  • Heart(2.4)
  • Intestine(2.3)
  • Lymph node(2.1)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with NRP2: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRP2 Gene

Orthologs for NRP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia NRP2 29 30
  • 99.42 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia NRP2 29 30
  • 91.37 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia NRP2 29 30
  • 90.82 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Nrp2 29 16 30
  • 89.01 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Nrp2 29
  • 87.93 (n)
Oppossum
(Monodelphis domestica)
 Mammalia NRP2 30
  • 86 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia NRP2 30
  • 83 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves NRP2 29 30
  • 75.69 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia NRP2 30
  • 76 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia nrp2 29
  • 70.72 (n)
Str.14279 29
Zebrafish
(Danio rerio)
 Actinopterygii nrp2b 29 30
  • 64.65 (n)
 OneToMany
nrp2a 30
  • 55 (a)
 OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.5393 29
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.7396 30
  • 22 (a)
 OneToMany
Species where no ortholog for NRP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NRP2 Gene

ENSEMBL:
Gene Tree for NRP2 (if available)
TreeFam:
Gene Tree for NRP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NRP2: view image
Alliance of Genome Resources:
Additional Orthologs for NRP2

Paralogs for NRP2 Gene

Paralogs for NRP2 Gene

(29) SIMAP similar genes for NRP2 Gene using alignment to 7 proteins:

  • NRP2_HUMAN
  • B7ZL68_HUMAN
  • C9JH98_HUMAN
  • F5H1G4_HUMAN
  • F5H2X3_HUMAN
  • Q7LBX6_HUMAN
  • Q96GU8_HUMAN
genes like me logo Genes that share paralogs with NRP2: view

Variants for NRP2 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRP2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
777569 Benign: not provided 205,743,315(+) T/.
NM_003872.3(NRP2):c.1404= (p.Val468=) 		SYNONYMOUS_VARIANT,NO_SEQUENCE_ALTERATION
rs114144673 Uncertain Significance: Hirschsprung disease 1 205,727,900(+) C/Tp.Arg334Cys
NM_003872.3(NRP2):c.1000C>T (p.Arg334Cys) 		MISSENSE
rs114305456 Benign: not provided 205,725,952(+) G/A
NM_003872.3(NRP2):c.860G>A (p.Arg287Gln) 		MISSENSE
rs114848039 Likely Benign: not provided 205,749,769(+) G/A
NM_003872.3(NRP2):c.1831G>A (p.Glu611Lys) 		MISSENSE
rs1180835963 Likely Benign: not provided 205,766,827(+) A/T
NM_003872.3(NRP2):c.2425+24A>T 		INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NRP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NRP2 Gene

Variant ID Type Subtype PubMed ID
esv25775 CNV gain 19812545
nsv3123 CNV insertion 18451855
nsv460021 CNV gain 19166990
nsv524370 CNV loss 19592680
nsv526779 CNV loss 19592680
nsv584246 CNV gain 21841781
nsv834514 CNV gain 17160897

Variation tolerance for NRP2 Gene

Residual Variation Intolerance Score: 27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 47.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRP2 Gene

Human Gene Mutation Database (HGMD)
NRP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRP2
Leiden Open Variation Database (LOVD)
NRP2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRP2 Gene

Disorders for NRP2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NRP2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
wallerian degeneration
  • wallerian degeneration of the pyramidal tract
exudative vitreoretinopathy 1
  • evr1
breast cancer
  • breast cancer, familial
hirschsprung disease 1
  • hirschsprung disease, susceptibility to, 1
autism
  • autistic disorder
- elite association - COSMIC cancer census association via MalaCards
Search NRP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRP2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NRP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRP2 Gene

Publications for NRP2 Gene

  1. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. (PMID: 9331348) Chen H … Tessier-Lavigne M (Neuron 1997) 2 3 4 22
  2. Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population. (PMID: 17427189) Wu S … Zhang D (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 22 40
  3. Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms. (PMID: 11112349) Rossignol M … Klagsbrun M (Genomics 2000) 3 4 22
  4. Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]. (PMID: 10748121) Gluzman-Poltorak Z … Neufeld G (The Journal of biological chemistry 2000) 3 4 22
  5. An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor. (PMID: 30057110) Martinez-Martin N … Ciferri C (Cell 2018) 3 4

ExternalLinks

View latest publications for NRP2 gene in Mastermind

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