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This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth fac... See more...
Aliases for NRP2 Gene
Aliases for NRP2 Gene
External Ids for NRP2 Gene
- HGNC: 8005
- Entrez Gene: 8828
- Ensembl: ENSG00000118257
- OMIM: 602070
- UniProtKB: O60462
Previous GeneCards Identifiers for NRP2 Gene
- GC02P204763
- GC02P205271
- GC02P206510
- GC02P206749
- GC02P206372
- GC02P206254
- GC02P198397
Summaries for NRP2 Gene
-
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for NRP2 Gene
NRP2 (Neuropilin 2) is a Protein Coding gene. Diseases associated with NRP2 include Wallerian Degeneration and Exudative Vitreoretinopathy 1. Among its related pathways are Neuroscience and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include growth factor binding. An important paralog of this gene is NRP1.
UniProtKB/Swiss-Prot Summary for NRP2 Gene
-
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
-
(Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells.
Additional gene information for NRP2 Gene
- HGNC(8005)
- Entrez Gene(8828)
- Ensembl(ENSG00000118257)
- OMIM(602070)
- UniProtKB(O60462)
- Open Targets Platform(ENSG00000118257)
- Search for NRP2 at DataMed
- Search for NRP2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRP2 Gene
Genomics for NRP2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NRP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NRP2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRP2
- Top Transcription factor binding sites by QIAGEN in the NRP2 gene promoter:
-
- aMEF-2
- Cdc5
- CREB
- MEF-2A
- Msx-1
- PPAR-gamma1
- PPAR-gamma2
- USF-1
- USF-1:USF-2
- USF1
Genomic Locations for NRP2 Gene
Genomic Locations for NRP2 Gene
- chr2:205,681,990-205,798,133
- (GRCh38/hg38)
- Size:
- 116,144 bases
- Orientation:
- Plus strand
- chr2:206,546,714-206,662,857
- (GRCh37/hg19)
- Size:
- 116,144 bases
- Orientation:
- Plus strand
Genomic View for NRP2 Gene
Genes around NRP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q33.3 by HGNC
- 2q33.3 by Entrez Gene
- 2q33.3 by Ensembl
NRP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NRP2 Gene
Proteins for NRP2 Gene
-
Protein details for NRP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60462-NRP2_HUMAN
- Recommended name:
- Neuropilin-2
- Protein Accession:
- O60462
- A0A024R3W6
- A0A024R412
- E9PF66
- O14820
- O14821
- Q53TQ4
- Q53TS3
- Q7LBX6
- Q7LBX7
- Q9H2D4
- Q9H2D5
- Q9H2E2
- Q9H2E3
- Q9H2E4
- X5D2Q8
Protein attributes for NRP2 Gene
- Size:
- 931 amino acids
- Molecular mass:
- 104831 Da
- Quaternary structure:
-
- Heterodimer with NRP1. Binds PLXNB1.
- (Microbial infection) Interacts with human cytomegalovirus proteins gL, UL128, UL130 and UL131A.
Three dimensional structures from OCA and Proteopedia for NRP2 Gene
Protein Expression for NRP2 Gene
Post-translational modifications for NRP2 Gene
Other Protein References for NRP2 Gene
Antibody Products
- G Biosciences Immunotag™ Neuropilin-2 Antibody and Immunotag™ NRP2 Antibody
- Alomone Labs, Ltd. Anti-Neuropilin-2 (NRP2) (extracellular)-FITC Antibody
- GeneTex Anti-NRP2 antibody [N2N3]
- Novus Biologicals Antibodies for NRP2
-
Abcam antibodies for NRP2
- Invitrogen Antibodies for NRP2 (AFLGC-NRP2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for NRP2
- Sino Biological Antibodies for NRP2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for NRP2
- Origene Custom Protein Services for NRP2
- Sino Biological Recombinant Proteins for NRP2
- Sino Biological Cell Lysates for NRP2
-
Abcam proteins for NRP2
Assay Products
- RayBiotech Human Neuropilin-2 ELISA
- Novus Biologicals ELISA Kits for NRP2
- antibodies-online: Show 30 available NRP2 Elisa Kits ranked by validation data
- Compare Top NRP2 Elisa Kits
-
Quality Products:
- ABIN415192
- ABIN846051
- ABIN1884446
- ABIN3198600
- ABIN2212650
- ABIN1571592
- ABIN6384875
- ABIN5657330
- ABIN2537168
- ABIN4971539
- ABIN2859217
- ABIN2685101
- ABIN6719876
- ABIN2748890
- ABIN6206412
- ABIN1144957
- ABIN819129
- ABIN2859218
- ABIN5676205
- ABIN2685102
- ABIN2748427
- ABIN6384876
- ABIN6719877
- ABIN2748891
- ABIN6206413
- ABIN6206414
-
Signalway ELISA kits for NRP2
-
Abcam assays for NRP2
- Sino Biological Assays for NRP2
No data available for DME Specific Peptides for NRP2 Gene
Domains & Families for NRP2 Gene
Gene Families for NRP2 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for NRP2 Gene
- InterPro:
- Blocks:
-
- Coagulation factor 5/8 type C domain (FA58C)
- CUB domain
- MAM domain signature
- ProtoNet:
Suggested Antigen Peptide Sequences for NRP2 Gene
- GenScript: Design optimal peptide antigens:
-
- Neuropilin 2 (B7ZL68_HUMAN)
- Vascular endothelial cell growth factor 165 receptor 2 (NRP2_HUMAN)
- Neuropilin-2a(17) (Q7LBX6_HUMAN)
- Neuropilin-2a(22) (Q7LBX7_HUMAN)
- Neuropilin-2 soluble isoform 9 (Q9H2E2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60462UniProtKB/Swiss-Prot:
NRP2_HUMAN :- The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
- Belongs to the neuropilin family.
- Domain:
-
- The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
- Family:
-
- Belongs to the neuropilin family.
Function for NRP2 Gene
Molecular function for NRP2 Gene
- UniProtKB/Swiss-Prot Function:
- High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells.
- GENATLAS Biochemistry:
- neuropilin 2,cell surface glycoprotein expressed by the developing nervous system,semaphorin 3C and 3F receptor,implicated in repulsive axon guidance,also expressed by endothelial and tumor cells,vascular endothelial growth factor-165 receptor
Phenotypes From GWAS Catalog for NRP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005021 | vascular endothelial growth factor-activated receptor activity | TAS,NAS | 11112349 |
| GO:0005515 | protein binding | IPI | 25752543 |
| GO:0008201 | heparin binding | IEA | -- |
| GO:0017154 | semaphorin receptor activity | NAS | 11112349 |
| GO:0019838 | growth factor binding | TAS | 21245381 |
Phenotypes for NRP2 Gene
- MGI mutant phenotypes for NRP2:
-
inferred from 6 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- reproductive system phenotype
- vision/eye phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for NRP2:
-
- no effect
- Decreased viability
- Increased viability
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased shRNA abundance (Z-score < -2)
- Increased HPV18 LCR reporter activity
- Increased shRNA abundance (Z-score > 2)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased peripheral FA formation
Animal Models for NRP2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NRP2 - Select products 50% OFF >
- * NRP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NRP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRP2
miRNA for NRP2 Gene
- miRTarBase miRNAs that target NRP2
-
- mmu-let-7b-5p (MIRT012179)
- mmu-miR-24-3p (MIRT013910)
- mmu-miR-149-5p (MIRT014739)
- hsa-miR-335-5p (MIRT017537)
- hsa-miR-331-3p (MIRT019236)
- hsa-miR-10b-5p (MIRT025587)
- hsa-miR-196a-5p (MIRT437981)
- mmu-miR-362-3p (MIRT577192)
- mmu-miR-329-3p (MIRT577193)
- mmu-miR-23b-3p (MIRT577194)
- mmu-miR-23a-3p (MIRT577195)
- mmu-miR-466f-3p (MIRT582114)
- mmu-miR-466i-3p (MIRT582115)
- mmu-miR-3082-5p (MIRT589389)
- mmu-miR-1894-3p (MIRT589390)
- mmu-miR-700-3p (MIRT589391)
- mmu-miR-5122 (MIRT589392)
- mmu-miR-146a-5p (MIRT589393)
- mmu-miR-146b-5p (MIRT589394)
- mmu-miR-466l-3p (MIRT593208)
- hsa-miR-486-5p (MIRT733005)
- hsa-miR-3163 (MIRT784711)
- hsa-miR-369-3p (MIRT785288)
- hsa-miR-374a-5p (MIRT785353)
- hsa-miR-374b-5p (MIRT785359)
- hsa-miR-374c-5p (MIRT785363)
- hsa-miR-5692b (MIRT787783)
- hsa-miR-5692c (MIRT787786)
- hsa-miR-655-3p (MIRT788389)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NRP2
- Browse OriGene Inhibitory RNA Products For NRP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRP2
Clone Products
- Applied Biological Materials (abm): Clones for NRP2 - Select products 50% OFF >
- * NRP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223542
- MG223547
- MG223943
- MG223953
- MG224748
- MG224751
- MR223542
- MR223542L3
- MR223542L4
- MR223547
- MR223547L3
- MR223547L4
- MR223943
- MR223943L3
- MR223943L4
- MR223953
- MR223953L3
- MR223953L4
- MR224748
- MR224748L3
- MR224748L4
- MR224751
- MR224751L3
- MR224751L4
- RC210928
- RC210928L1
- RC210928L2
- RC210928L3
- RC210928L4
- RC213830
- RC213830L3
- RC213830L4
- RC214608
- RC214608L3
- RC214608L4
- RC220706
- RC220706L1
- RC220706L2
- RC220706L3
- RC220706L4
- RC220920
- RC220920L1
- RC220920L2
- RC220920L3
- RC220920L4
- RC221028
- RC221028L3
- RC221028L4
- RG210928
- RG213830
- RG214608
- RG220706
- RG220920
- RG221028
- RR202885
- RR202885L3
- RR202885L4
- MR223542L3V
- MR223542L4V
- MR223547L3V
- MR223547L4V
- MR223943L3V
- MR223943L4V
- MR223953L3V
- MR223953L4V
- MR224748L3V
- MR224748L4V
- MR224751L3V
- MR224751L4V
- RC210928L1V
- RC210928L2V
- RC210928L3V
- RC210928L4V
- RC213830L3V
- RC213830L4V
- RC214608L3V
- RC214608L4V
- RC220706L1V
- RC220706L2V
- RC220706L3V
- RC220706L4V
- RC220920L1V
- RC220920L2V
- RC220920L3V
- RC220920L4V
- RC221028L3V
- RC221028L4V
- RR202885L3V
- RR202885L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NRP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRP2
Cell Line Products
-
Horizon Cell Lines for NRP2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRP2 Gene
Localization for NRP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NRP2 Gene
- Membrane. Single-pass type I membrane protein.
- [Isoform s9]: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Plasma membrane (3)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002116 | semaphorin receptor complex | NAS | 19909241 |
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | TAS | -- |
| GO:0016021 | integral component of membrane | NAS | 11112349 |
Pathways & Interactions for NRP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
|
PPAR Pathway
.66
Rac1 Pathway
.65
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Nuclear Receptor Activation by Vitamin-A
.57
|
| 2 | CREB Pathway |
CREB Pathway
.68
|
Activation of PKC through GPCR
.63
|
| 3 | PAK Pathway |
Antioxidant Action of Vitamin-C
.56
|
PAK Pathway
.56
|
| 4 | p70S6K Signaling |
p70S6K Signaling
.60
|
Renin-Angiotensin Pathway
.60
|
| 5 | Phospholipase-C Pathway |
Phospholipase-C Pathway
.56
|
PTEN Pathway
.56
|
Pathways by source for NRP2 Gene
2 BioSystems pathways for NRP2 Gene
7 Reactome pathways for NRP2 Gene
1 GeneGo (Thomson Reuters) pathway for NRP2 Gene
- Development VEGF-family signaling
1 R&D Systems pathway for NRP2 Gene
23 Qiagen pathways for NRP2 Gene
- Actin-Based Motility by Rho Family GTPases
- Activation of PKC through GPCR
- Antioxidant Action of Vitamin-C
- Apoptotic Pathways in Synovial Fibroblasts
- Breast Cancer Regulation by Stathmin1
2 Cell Signaling Technology pathways for NRP2 Gene
Interacting Proteins for NRP2 Gene
Selected Interacting proteins:
O60462-NRP2_HUMAN
ENSP00000353582
for NRP2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for NRP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | NAS | 11112349 |
| GO:0001755 | neural crest cell migration | IEA | -- |
| GO:0001764 | neuron migration | IEA | -- |
| GO:0001938 | positive regulation of endothelial cell proliferation | TAS | 21245381 |
| GO:0003148 | outflow tract septum morphogenesis | ISS | -- |
Drugs & Compounds for NRP2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Daunorubicin | Approved | Pharma | DNA topoisomerase II inhibitor | 383 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for NRP2 Gene
mRNA/cDNA for NRP2 Gene
- 6 REFSEQ mRNAs :
- 26 NCBI additional mRNA sequence :
- 17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000272849 5909 nts (view in UCSC)
- ENST00000357118 3367 nts (view in UCSC)
- ENST00000357785 2926 nts (view in UCSC)
- ENST00000360409 6662 nts (view in UCSC)
- ENST00000412873 2730 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NRP2 - Select products 50% OFF >
- * NRP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NRP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NRP2
- Browse OriGene Inhibitory RNA Products For NRP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRP2
Clone Products
- Applied Biological Materials (abm): Clones for NRP2 - Select products 50% OFF >
- * NRP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223542
- MG223547
- MG223943
- MG223953
- MG224748
- MG224751
- MR223542
- MR223542L3
- MR223542L4
- MR223547
- MR223547L3
- MR223547L4
- MR223943
- MR223943L3
- MR223943L4
- MR223953
- MR223953L3
- MR223953L4
- MR224748
- MR224748L3
- MR224748L4
- MR224751
- MR224751L3
- MR224751L4
- RC210928
- RC210928L1
- RC210928L2
- RC210928L3
- RC210928L4
- RC213830
- RC213830L3
- RC213830L4
- RC214608
- RC214608L3
- RC214608L4
- RC220706
- RC220706L1
- RC220706L2
- RC220706L3
- RC220706L4
- RC220920
- RC220920L1
- RC220920L2
- RC220920L3
- RC220920L4
- RC221028
- RC221028L3
- RC221028L4
- RG210928
- RG213830
- RG214608
- RG220706
- RG220920
- RG221028
- RR202885
- RR202885L3
- RR202885L4
- MR223542L3V
- MR223542L4V
- MR223547L3V
- MR223547L4V
- MR223943L3V
- MR223943L4V
- MR223953L3V
- MR223953L4V
- MR224748L3V
- MR224748L4V
- MR224751L3V
- MR224751L4V
- RC210928L1V
- RC210928L2V
- RC210928L3V
- RC210928L4V
- RC213830L3V
- RC213830L4V
- RC214608L3V
- RC214608L4V
- RC220706L1V
- RC220706L2V
- RC220706L3V
- RC220706L4V
- RC220920L1V
- RC220920L2V
- RC220920L3V
- RC220920L4V
- RC221028L3V
- RC221028L4V
- RR202885L3V
- RR202885L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NRP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRP2
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||
| SP2: | |||||||||||||
| SP3: | |||||||||||||
| SP4: | |||||||||||||
| SP5: | |||||||||||||
| SP6: | |||||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: | |||||||||||||
| SP10: | |||||||||||||
| SP11: |
Relevant External Links for NRP2 Gene
- GeneLoc Exon Structure for
- NRP2
Expression for NRP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Endothelium (Cardiovascular System)
- Angioblasts Embryonic Capillary Plexus
- Extraembryonic Angioblasts Extraembryonic Blood Islands
- Lymphatic Endothelial Cells Lymphatic Vessels
- Angioblasts Embryonic Blood Islands
- Venous Endothelial Cells Cardinal Veins
-
Neural Crest (Gastrulation Derivatives)
- Cardiac Neural Crest Cells "Branchial Arch 3,4,6"
- Neural Crest Outflow Tract Cells Outflow Tract
- Cranial Neural Crest Cells Branchial Arch 2
- Cranial Neural Crest Cells Branchial Arch 1
- Cardiac Neural Crest Cells Cardiac Neural Crest
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
- nGnG Amacrine Cells Inner Nuclear Layer
- Adult Dopaminergic Neurons Ventral Tegmental Area
-
Head Mesenchyme (Muscoskeletal System)
- Cardiac Neural Crest Cells "Branchial Arch 3,4,6"
- Cranial Neural Crest Cells Branchial Arch 2
- Cranial Neural Crest Cells Branchial Arch 1
-
Brain (Nervous System)
- Adult Dopaminergic Neurons Ventral Tegmental Area
- Hypothalamus
- Thalamus
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Angioblasts Embryonic Capillary Plexus
- Angioblasts Embryonic Blood Islands
- Angioblasts Proepicardium
- Neural Tube (Nervous System)
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
- nGnG Amacrine Cells Inner Nuclear Layer
-
Heart (Cardiovascular System)
- Neural Crest Outflow Tract Cells Outflow Tract
- Venous Endothelial Cells Cardinal Veins
-
Tooth (Integumentary System)
- Dental Papilla Cells Dental Papilla
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Blood Islands
-
Lymph (Hematopoietic System)
- Lymphatic Endothelial Cells Lymphatic Vessels
- Bone (Muscoskeletal System)
-
Placenta (Extraembryonic Tissues)
-
Spinal Cord (Nervous System)
mRNA differential expression in normal tissues according to GTEx for NRP2 Gene
This gene is overexpressed in Esophagus - Muscularis (x4.6), Colon - Sigmoid (x4.3), and Esophagus - Gastroesophageal Junction (x4.2).
This gene is overexpressed in Serum (28.7) and Uterus (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NRP2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRP2
SOURCE GeneReport for Unigene cluster for NRP2 Gene:
Hs.471200Evidence on tissue expression from TISSUES for NRP2 Gene
- Nervous system(4.7)
- Skin(3.2)
- Lung(3.2)
- Eye(3)
- Heart(2.6)
- Intestine(2.4)
- Lymph node(2.3)
- Blood(2.3)
- Muscle(2.1)
- Kidney(2)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for NRP2
Gene Expression Assay Products
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRP2 Gene
Orthologs for NRP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NRP2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NRP2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NRP2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Nrp2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Nrp2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | NRP2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NRP2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | NRP2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NRP2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nrp2 30 |
|
||
| Str.14279 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | nrp2b 30 31 |
|
OneToMany | |
| nrp2a 31 |
|
OneToMany | |||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5393 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7396 31 |
|
OneToMany |
- Species where no ortholog for NRP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for NRP2 Gene
- ENSEMBL:
- Gene Tree for NRP2 (if available)
- TreeFam:
- Gene Tree for NRP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NRP2: view image
Paralogs for NRP2 Gene
Paralogs for NRP2 Gene
- NRP1 5
- F8 5
- HEPHL1 5
- F5 5
- HEPH 5
- NRXN3 5
- NRXN2 5
- CNTNAP2 5
- CNTNAP3B 5
- CNTNAP5 5
- CNTNAP4 5
- ENSG00000287694 5
- NRXN1 5
- CP 5
- CNTNAP3 5
- CNTNAP1 5
- EDIL3 5
- MEP1B 5
- CUBN 5
- MEP1A 5
- TLL1 5
- MFGE8 5
- BMP1 5
- TLL2 5
- CUZD1 5
- DCBLD2 5
- CDCP2 5
- CNTNAP3C 5
- NETO1 5
- NETO2 5
- ASTL 5
- MFRP 5
- PDGFC 5
- PDGFD 5
- PCOLCE 5
- PCOLCE2 5
- ENSG00000286088 5
(29) SIMAP similar genes for NRP2 Gene using alignment to 7 proteins:
- NRP2_HUMAN
- B7ZL68_HUMAN
- C9JH98_HUMAN
- F5H1G4_HUMAN
- F5H2X3_HUMAN
- Q7LBX6_HUMAN
- Q96GU8_HUMAN
Variants for NRP2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRP2 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 717718 | Likely Benign: not provided | 205,725,930(+) | C/T | MISSENSE_VARIANT | |
| 717896 | Likely Benign: not provided | 205,743,244(+) | A/C | MISSENSE_VARIANT | |
| 719903 | Benign: not provided | 205,794,956(+) | C/T | SYNONYMOUS_VARIANT | |
| 721609 | Likely Benign: not provided | 205,722,603(+) | A/G | MISSENSE_VARIANT | |
| 724326 | Benign: not provided | 205,743,360(+) | C/T | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.84;
47.94% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NRP2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRP2 Gene
Disorders for NRP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| wallerian degeneration |
|
|
| exudative vitreoretinopathy 1 |
|
|
| breast cancer |
|
|
| hirschsprung disease 1 |
|
|
| autism |
|
|
Search NRP2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NRP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for NRP2 Gene
Publications for NRP2 Gene
- Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. (PMID: 9331348) Chen H … Tessier-Lavigne M (Neuron 1997) 2 3 4 23
- Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population. (PMID: 17427189) Wu S … Zhang D (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 23 41
- Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]. (PMID: 10748121) Gluzman-Poltorak Z … Neufeld G (The Journal of biological chemistry 2000) 3 4 23
- Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms. (PMID: 11112349) Rossignol M … Klagsbrun M (Genomics 2000) 3 4 23
- An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor. (PMID: 30057110) Martinez-Martin N … Ciferri C (Cell 2018) 3 4
ExternalLinks
Products for NRP2 Gene
- View all 17 R&D Systems NRP2 (Neuropilin-2) Products
- View all R&D Systems NRP2 (Neuropilin-2) Proteins and Enzymes
- View all 15 R&D Systems NRP2 (Neuropilin-2) Primary Antibodies
- View all R&D Systems NRP2 (Neuropilin-2) cDNA Clones
- Learn more about R&D Systems custom NRP2 antibody, protein, and immunoassay development services
- Custom Antibody Services
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for NRP2
- Origene Custom Protein Services for NRP2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NRP2
- Browse OriGene Inhibitory RNA Products For NRP2
- OriGene qPCR primer pairs for NRP2
- OriGene CRISPR knockouts for NRP2
- MG223542
- MG223547
- MG223943
- MG223953
- MG224748
- MG224751
- MR223542
- MR223542L3
- MR223542L4
- MR223547
- MR223547L3
- MR223547L4
- MR223943
- MR223943L3
- MR223943L4
- MR223953
- MR223953L3
- MR223953L4
- MR224748
- MR224748L3
- MR224748L4
- MR224751
- MR224751L3
- MR224751L4
- RC210928
- RC210928L1
- RC210928L2
- RC210928L3
- RC210928L4
- RC213830
- RC213830L3
- RC213830L4
- RC214608
- RC214608L3
- RC214608L4
- RC220706
- RC220706L1
- RC220706L2
- RC220706L3
- RC220706L4
- RC220920
- RC220920L1
- RC220920L2
- RC220920L3
- RC220920L4
- RC221028
- RC221028L3
- RC221028L4
- RG210928
- RG213830
- RG214608
- RG220706
- RG220920
- RG221028
- RR202885
- RR202885L3
- RR202885L4
- MR223542L3V
- MR223542L4V
- MR223547L3V
- MR223547L4V
- MR223943L3V
- MR223943L4V
- MR223953L3V
- MR223953L4V
- MR224748L3V
- MR224748L4V
- MR224751L3V
- MR224751L4V
- RC210928L1V
- RC210928L2V
- RC210928L3V
- RC210928L4V
- RC213830L3V
- RC213830L4V
- RC214608L3V
- RC214608L4V
- RC220706L1V
- RC220706L2V
- RC220706L3V
- RC220706L4V
- RC220920L1V
- RC220920L2V
- RC220920L3V
- RC220920L4V
- RC221028L3V
- RC221028L4V
- RR202885L3V
- RR202885L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NRP2
- Sino Biological Human cDNA Clone for NRP2
- Sino Biological Recombinant Proteins for NRP2
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- Sino Biological Antibodies for NRP2
- Sino Biological Assays for NRP2
- Browse Recombinant Proteins
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- Novus Biologicals proteins and lysates for NRP2
- Novus Biologicals ELISA Kits for NRP2
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for NRP2
- Abcam proteins for NRP2
- Abcam assays for NRP2
- Find your target
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- Invitrogen Antibodies for NRP2 (AFLGC-NRP2)
- VectorBuilder Custom and pre-made DNA vectors for NRP2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for NRP2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for NRP2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for NRP2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for NRP2
- antibodies-online: Show 34 available NRP2 Antibodies ranked by validation data
- Compare Top NRP2 Antibodies
- antibodies-online: Show 30 available NRP2 Elisa Kits ranked by validation data
- Compare Top NRP2 Elisa Kits
- Quality Products:
- ABIN415192
- ABIN846051
- ABIN1884446
- ABIN3198600
- ABIN2212650
- ABIN1571592
- ABIN6384875
- ABIN5657330
- ABIN2537168
- ABIN4971539
- ABIN2859217
- ABIN2685101
- ABIN6719876
- ABIN2748890
- ABIN6206412
- ABIN1144957
- ABIN819129
- ABIN2859218
- ABIN5676205
- ABIN2685102
- ABIN2748427
- ABIN6384876
- ABIN6719877
- ABIN2748891
- ABIN6206413
- ABIN6206414
- antibodies-online: Show 12 available NRP2 Proteins ranked by validation data
- Compare Top NRP2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for NRP2
- Search Santa Cruz Biotechnology (SCBT) for NRP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NRP2
- Horizon Cell Lines for NRP2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRP2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NRP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRP2
- Signalway ELISA kits for NRP2
Sources for NRP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
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- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
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- (100) DGIdb
- (101) ClinicalTrials
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- (104) diseasecard
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- (133) TISSUES
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- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
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- (143) Applied Biosystems
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- (152) DiseaseEnhancer
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- (155) Biocompare
- (156) Mastermind
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- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
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- (163) LncBase
- (164) LncBook
- (165) LNCipedia
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