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This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
NRP2 (Neuropilin 2) is a Protein Coding gene. Diseases associated with NRP2 include Wallerian Degeneration and Exudative Vitreoretinopathy 1. Among its related pathways are Neuroscience and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include growth factor binding. An important paralog of this gene is NRP1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005021 | vascular endothelial growth factor-activated receptor activity | TAS,NAS | 11112349 |
GO:0005515 | protein binding | IPI | 25752543 |
GO:0008201 | heparin binding | IEA | -- |
GO:0017154 | semaphorin receptor activity | NAS | 11112349 |
GO:0019838 | growth factor binding | TAS | 21245381 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002116 | semaphorin receptor complex | NAS | 19909241 |
GO:0005576 | extracellular region | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | TAS | -- |
GO:0016021 | integral component of membrane | NAS | 11112349 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
|
PPAR Pathway
.66
Rac1 Pathway
.65
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Nuclear Receptor Activation by Vitamin-A
.57
|
2 | CREB Pathway |
CREB Pathway
.68
|
Activation of PKC through GPCR
.63
|
3 | PAK Pathway |
Antioxidant Action of Vitamin-C
.56
|
PAK Pathway
.56
|
4 | p70S6K Signaling |
p70S6K Signaling
.60
|
Renin-Angiotensin Pathway
.60
|
5 | Phospholipase-C Pathway |
Phospholipase-C Pathway
.56
|
PTEN Pathway
.56
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | NAS | 11112349 |
GO:0001755 | neural crest cell migration | IEA | -- |
GO:0001764 | neuron migration | IEA | -- |
GO:0001938 | positive regulation of endothelial cell proliferation | TAS | 21245381 |
GO:0003148 | outflow tract septum morphogenesis | ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Daunorubicin | Approved | Pharma | DNA topoisomerase II inhibitor | 383 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: |
ExUns: | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||
SP2: | |||||||||||||
SP3: | |||||||||||||
SP4: | |||||||||||||
SP5: | |||||||||||||
SP6: | |||||||||||||
SP7: | |||||||||||||
SP8: | |||||||||||||
SP9: | |||||||||||||
SP10: | |||||||||||||
SP11: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NRP2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NRP2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NRP2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Nrp2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nrp2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | NRP2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NRP2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NRP2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NRP2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nrp2 30 |
|
||
Str.14279 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | nrp2b 30 31 |
|
OneToMany | |
nrp2a 31 |
|
OneToMany | |||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5393 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7396 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
717718 | Likely Benign: not provided | 205,725,930(+) | C/T | MISSENSE_VARIANT | |
717896 | Likely Benign: not provided | 205,743,244(+) | A/C | MISSENSE_VARIANT | |
719903 | Benign: not provided | 205,794,956(+) | C/T | SYNONYMOUS_VARIANT | |
721609 | Likely Benign: not provided | 205,722,603(+) | A/G | MISSENSE_VARIANT | |
724326 | Benign: not provided | 205,743,360(+) | C/T | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
wallerian degeneration |
|
|
exudative vitreoretinopathy 1 |
|
|
breast cancer |
|
|
hirschsprung disease 1 |
|
|
autism |
|
|