This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth fac... See more...

Aliases for NRP2 Gene

Aliases for NRP2 Gene

  • Neuropilin 2 2 3 5
  • Vascular Endothelial Cell Growth Factor 165 Receptor 2 3 4
  • Neuropilin-2 3 4
  • VEGF165R2 3 4
  • Receptor For VEGF165 And Semaphorins Class3 3
  • Neuropilin-2a(17) 3
  • Neuropilin-2a(22) 3
  • Neuropilin-2b(0) 3
  • PRO2714 3
  • NPN2 3
  • NP2 3

External Ids for NRP2 Gene

Previous GeneCards Identifiers for NRP2 Gene

  • GC02P204763
  • GC02P205271
  • GC02P206510
  • GC02P206749
  • GC02P206372
  • GC02P206254
  • GC02P198397

Summaries for NRP2 Gene

Entrez Gene Summary for NRP2 Gene

  • This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NRP2 Gene

NRP2 (Neuropilin 2) is a Protein Coding gene. Diseases associated with NRP2 include Wallerian Degeneration and Hirschsprung Disease 1. Among its related pathways are p70S6K Signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include growth factor binding. An important paralog of this gene is NRP1.

UniProtKB/Swiss-Prot Summary for NRP2 Gene

  • High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
  • (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells.

Gene Wiki entry for NRP2 Gene

Additional gene information for NRP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRP2 Gene

Genomics for NRP2 Gene

GeneHancer (GH) Regulatory Elements for NRP2 Gene

Promoters and enhancers for NRP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J205678 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 765.3 +1.8 1848 11.4 SIN3A CTCF ZBTB6 POLR2A RAD21 SP1 SP7 ELF1 ZSCAN21 PRDM1 NRP2 lnc-INO80D-8 ENSG00000225216 HSALNG0021744
GH02J205711 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.8 +32.0 32011 6 ZNF24 HDAC2 RELA RAD21 NKRF MLLT1 ZNF687 CREM ZBED1 IKZF1 NRP2 ENSG00000225216 INO80D HSALNG0021744
GH02J205705 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 17 +25.5 25497 4.3 SP1 ETV6 HLF MAX RELA POLR2A MLLT1 ZNF687 CREM ZBTB33 NRP2 ENSG00000225216 INO80D HSALNG0021744
GH02J205729 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.3 +50.0 50020 6.8 MAFK BACH1 POLR2A NFE2L2 FOXA2 REST ZNF316 NFE2 ATF3 EZH2 ENSG00000225216 NRP2 ADAM23 HSALNG0021744
GH02J205751 Enhancer 1 Ensembl ENCODE dbSUPER 16.1 +73.2 73210 8.8 NR2F6 RXRA CEBPB RCOR1 ATF3 SP1 ESRRA FOS TCF7L2 NR2F2 NRP2 ENSG00000225216 HSALNG0021744
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NRP2 gene promoter:
  • aMEF-2
  • Cdc5
  • CREB
  • MEF-2A
  • Msx-1
  • PPAR-gamma1
  • PPAR-gamma2
  • USF-1
  • USF-1:USF-2
  • USF1

Genomic Locations for NRP2 Gene

Genomic Locations for NRP2 Gene
chr2:205,681,990-205,798,133
(GRCh38/hg38)
Size:
116,144 bases
Orientation:
Plus strand
chr2:206,546,714-206,662,857
(GRCh37/hg19)
Size:
116,144 bases
Orientation:
Plus strand

Genomic View for NRP2 Gene

Genes around NRP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRP2 Gene

Proteins for NRP2 Gene

  • Protein details for NRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60462-NRP2_HUMAN
    Recommended name:
    Neuropilin-2
    Protein Accession:
    O60462
    Secondary Accessions:
    • A0A024R3W6
    • A0A024R412
    • E9PF66
    • O14820
    • O14821
    • Q53TQ4
    • Q53TS3
    • Q7LBX6
    • Q7LBX7
    • Q9H2D4
    • Q9H2D5
    • Q9H2E2
    • Q9H2E3
    • Q9H2E4
    • X5D2Q8

    Protein attributes for NRP2 Gene

    Size:
    931 amino acids
    Molecular mass:
    104831 Da
    Quaternary structure:
    • Heterodimer with NRP1. Binds PLXNB1.
    • (Microbial infection) Interacts with human cytomegalovirus proteins gL, UL128, UL130 and UL131A.

    Three dimensional structures from OCA and Proteopedia for NRP2 Gene

    Alternative splice isoforms for NRP2 Gene

neXtProt entry for NRP2 Gene

Post-translational modifications for NRP2 Gene

  • Glycosylation at Asn152, Asn157, Thr595, Thr600, Thr603, Thr607, Asn629, Ser672, and Asn839
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for NRP2
  • Boster Bio Antibodies for NRP2

No data available for DME Specific Peptides for NRP2 Gene

Domains & Families for NRP2 Gene

Gene Families for NRP2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for NRP2 Gene

GenScript: Design optimal peptide antigens:
  • Neuropilin 2 (B7ZL68_HUMAN)
  • Vascular endothelial cell growth factor 165 receptor 2 (NRP2_HUMAN)
  • Neuropilin-2a(17) (Q7LBX6_HUMAN)
  • Neuropilin-2a(22) (Q7LBX7_HUMAN)
  • Neuropilin-2 soluble isoform 9 (Q9H2E2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60462

UniProtKB/Swiss-Prot:

NRP2_HUMAN :
  • The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
  • Belongs to the neuropilin family.
Domain:
  • The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
Family:
  • Belongs to the neuropilin family.
genes like me logo Genes that share domains with NRP2: view

Function for NRP2 Gene

Molecular function for NRP2 Gene

UniProtKB/Swiss-Prot Function:
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells.
GENATLAS Biochemistry:
neuropilin 2,cell surface glycoprotein expressed by the developing nervous system,semaphorin 3C and 3F receptor,implicated in repulsive axon guidance,also expressed by endothelial and tumor cells,vascular endothelial growth factor-165 receptor

Phenotypes From GWAS Catalog for NRP2 Gene

Gene Ontology (GO) - Molecular Function for NRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005021 vascular endothelial growth factor-activated receptor activity NAS,TAS 11112349
GO:0005515 protein binding IPI 25752543
GO:0008201 heparin binding IEA --
GO:0017154 semaphorin receptor activity NAS 11112349
GO:0019838 growth factor binding TAS 21245381
genes like me logo Genes that share ontologies with NRP2: view
genes like me logo Genes that share phenotypes with NRP2: view

Animal Models for NRP2 Gene

MGI Knock Outs for NRP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRP2 Gene

Localization for NRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRP2 Gene

Membrane; Single-pass type I membrane protein.
Isoform s9: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRP2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
peroxisome 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002116 semaphorin receptor complex NAS 19909241
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 9288754
GO:0016021 integral component of membrane NAS 11112349
genes like me logo Genes that share ontologies with NRP2: view

Pathways & Interactions for NRP2 Gene

PathCards logo

SuperPathways for NRP2 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.62
.61
.60
.57
2 CREB Pathway
.68
.63
3 PAK Pathway
.56
.56
4 p70S6K Signaling
.60
.60
5 Phospholipase-C Pathway
.56
.56
genes like me logo Genes that share pathways with NRP2: view

Pathways by source for NRP2 Gene

1 R&D Systems pathway for NRP2 Gene
23 Qiagen pathways for NRP2 Gene
  • Actin-Based Motility by Rho Family GTPases
  • Activation of PKC through GPCR
  • Antioxidant Action of Vitamin-C
  • Apoptotic Pathways in Synovial Fibroblasts
  • Breast Cancer Regulation by Stathmin1
2 Cell Signaling Technology pathways for NRP2 Gene

SIGNOR curated interactions for NRP2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis NAS 11112349
GO:0001755 neural crest cell migration IEA --
GO:0001764 neuron migration IEA --
GO:0001938 positive regulation of endothelial cell proliferation TAS 21245381
GO:0003148 outflow tract septum morphogenesis ISS --
genes like me logo Genes that share ontologies with NRP2: view

Drugs & Compounds for NRP2 Gene

(3) Drugs for NRP2 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Daunorubicin Approved Pharma DNA topoisomerase II inhibitor 354

(1) Additional Compounds for NRP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NRP2: view

Transcripts for NRP2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRP2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for NRP2 Gene

GeneLoc Exon Structure for
NRP2
ECgene alternative splicing isoforms for
NRP2

Expression for NRP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRP2 Gene

This gene is overexpressed in Esophagus - Muscularis (x4.6), Colon - Sigmoid (x4.3), and Esophagus - Gastroesophageal Junction (x4.2).

Protein differential expression in normal tissues from HIPED for NRP2 Gene

This gene is overexpressed in Serum (28.7) and Uterus (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NRP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of NRP2 Gene:

NRP2

SOURCE GeneReport for Unigene cluster for NRP2 Gene:

Hs.471200

Evidence on tissue expression from TISSUES for NRP2 Gene

  • Nervous system(4.7)
  • Lung(2.8)
  • Skin(2.6)
  • Eye(2.5)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with NRP2: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRP2 Gene

Orthologs for NRP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRP2 33 32
  • 99.42 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NRP2 33 32
  • 91.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NRP2 33 32
  • 90.82 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nrp2 17 33 32
  • 89.01 (n)
rat
(Rattus norvegicus)
Mammalia Nrp2 32
  • 87.93 (n)
oppossum
(Monodelphis domestica)
Mammalia NRP2 33
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRP2 33
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRP2 33 32
  • 75.69 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRP2 33
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrp2 32
  • 70.72 (n)
Str.14279 32
zebrafish
(Danio rerio)
Actinopterygii nrp2b 33 32
  • 64.65 (n)
OneToMany
nrp2a 33
  • 55 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5393 32
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7396 33
  • 22 (a)
OneToMany
Species where no ortholog for NRP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRP2 Gene

ENSEMBL:
Gene Tree for NRP2 (if available)
TreeFam:
Gene Tree for NRP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NRP2: view image

Paralogs for NRP2 Gene

(29) SIMAP similar genes for NRP2 Gene using alignment to 7 proteins:

  • NRP2_HUMAN
  • B7ZL68_HUMAN
  • C9JH98_HUMAN
  • F5H1G4_HUMAN
  • F5H2X3_HUMAN
  • Q7LBX6_HUMAN
  • Q96GU8_HUMAN
genes like me logo Genes that share paralogs with NRP2: view

Variants for NRP2 Gene

Sequence variations from dbSNP and Humsavar for NRP2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs114144673 uncertain-significance, Hirschsprung disease 1, - 205,727,900(+) C/A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs779617179 likely-pathogenic, Inborn genetic diseases 205,763,747(+) T/ coding_sequence_variant, frameshift, genic_downstream_transcript_variant, intron_variant
rs200483574 benign, not specified 205,776,522(+) /A coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, stop_gained
rs1000014176 -- 205,752,934(+) C/G/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000070137 -- 205,794,601(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NRP2 Gene

Variant ID Type Subtype PubMed ID
esv25775 CNV gain 19812545
nsv3123 CNV insertion 18451855
nsv460021 CNV gain 19166990
nsv524370 CNV loss 19592680
nsv526779 CNV loss 19592680
nsv584246 CNV gain 21841781
nsv834514 CNV gain 17160897

Variation tolerance for NRP2 Gene

Residual Variation Intolerance Score: 27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 47.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRP2 Gene

Human Gene Mutation Database (HGMD)
NRP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRP2 Gene

Disorders for NRP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NRP2 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
wallerian degeneration
  • wallerian degeneration of the pyramidal tract
hirschsprung disease 1
  • hirschsprung disease, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search NRP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NRP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRP2 Gene

Publications for NRP2 Gene

  1. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. (PMID: 9331348) Chen H … Tessier-Lavigne M (Neuron 1997) 2 3 4 23 56
  2. Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population. (PMID: 17427189) Wu S … Zhang D (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 23 43 56
  3. Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms. (PMID: 11112349) Rossignol M … Klagsbrun M (Genomics 2000) 3 4 23 56
  4. Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]. (PMID: 10748121) Gluzman-Poltorak Z … Neufeld G (The Journal of biological chemistry 2000) 3 4 23 56
  5. An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor. (PMID: 30057110) Martinez-Martin N … Ciferri C (Cell 2018) 3 4 56

Products for NRP2 Gene

Sources for NRP2 Gene