This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-span... See more...

Aliases for NRP1 Gene

Aliases for NRP1 Gene

  • Neuropilin 1 2 3 5
  • Vascular Endothelial Cell Growth Factor 165 Receptor 3 4
  • Neuropilin-1 3 4
  • VEGF165R 3 4
  • NRP 3 4
  • Transmembrane Receptor 3
  • CD304 Antigen 4
  • BDCA4 3
  • CD304 3
  • NP1 3

External Ids for NRP1 Gene

Previous GeneCards Identifiers for NRP1 Gene

  • GC10M033216
  • GC10M033616
  • GC10M033470
  • GC10M033506
  • GC10M033466

Summaries for NRP1 Gene

Entrez Gene Summary for NRP1 Gene

  • This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NRP1 Gene

NRP1 (Neuropilin 1) is a Protein Coding gene. Diseases associated with NRP1 include Angiomatous Meningioma and Acute Hemorrhagic Leukoencephalitis. Among its related pathways are p70S6K Signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include heparin binding and growth factor binding. An important paralog of this gene is NRP2.

UniProtKB/Swiss-Prot Summary for NRP1 Gene

  • The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulate VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
  • The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Gene Wiki entry for NRP1 Gene

Additional gene information for NRP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRP1 Gene

Genomics for NRP1 Gene

GeneHancer (GH) Regulatory Elements for NRP1 Gene

Promoters and enhancers for NRP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NRP1 gene promoter:
  • CREB
  • MyoD
  • STAT5A

Genomic Locations for NRP1 Gene

Genomic Locations for NRP1 Gene
chr10:33,177,491-33,336,262
(GRCh38/hg38)
Size:
158,772 bases
Orientation:
Minus strand
chr10:33,466,419-33,625,190
(GRCh37/hg19)
Size:
158,772 bases
Orientation:
Minus strand

Genomic View for NRP1 Gene

Genes around NRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRP1 Gene

Proteins for NRP1 Gene

  • Protein details for NRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14786-NRP1_HUMAN
    Recommended name:
    Neuropilin-1
    Protein Accession:
    O14786
    Secondary Accessions:
    • B0LPG9
    • O60461
    • Q5T7F1
    • Q5T7F2
    • Q5T7F3
    • Q86T59
    • Q96I90
    • Q96IH5

    Protein attributes for NRP1 Gene

    Size:
    923 amino acids
    Molecular mass:
    103134 Da
    Quaternary structure:
    • Homodimer, and heterodimer with NRP2. Interacts with FER (By similarity). Binds PLXNB1. Interacts with VEGFA (PubMed:26503042).

    Three dimensional structures from OCA and Proteopedia for NRP1 Gene

    Alternative splice isoforms for NRP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRP1 Gene

Post-translational modifications for NRP1 Gene

  • Glycosylation at Asn150, Asn261, Asn300, Asn522, Ser612, Thr827, Ser829, Thr830, Asn842, Ser844, and Asn892
  • Ubiquitination at Lys53 and Lys106
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Antibody Products

No data available for DME Specific Peptides for NRP1 Gene

Domains & Families for NRP1 Gene

Gene Families for NRP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for NRP1 Gene

GenScript: Design optimal peptide antigens:
  • Vascular endothelial cell growth factor 165 receptor (NRP1_HUMAN)
  • Neuropilin 1 (Q5JWQ0_HUMAN)
  • Neuropilin 1 (Q5JWQ1_HUMAN)
  • Neuropilin 1 (Q5JWQ2_HUMAN)
  • Neuropilin 1 (Q5JWQ4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14786

UniProtKB/Swiss-Prot:

NRP1_HUMAN :
  • The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
  • Belongs to the neuropilin family.
Domain:
  • The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
Family:
  • Belongs to the neuropilin family.
genes like me logo Genes that share domains with NRP1: view

Function for NRP1 Gene

Molecular function for NRP1 Gene

UniProtKB/Swiss-Prot Function:
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulate VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
UniProtKB/Swiss-Prot Function:
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
GENATLAS Biochemistry:
neuropilin 1,cell surface glycoprotein,expressed by the developing nervous system, complexing with plexin 1(PLXN1),implicated in repulsive axon guidance,also expressed by endothelial and tumor cells,vascular endothelial growth factor-165 receptor,with dominant negative form resulting from the deletion of an extracellular domain,necessary component of receptor complexes for some,but not all,secreted semaphorin family members

Phenotypes From GWAS Catalog for NRP1 Gene

Gene Ontology (GO) - Molecular Function for NRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005021 vascular endothelial growth factor-activated receptor activity NAS,IEA 19909241
GO:0005096 GTPase activator activity IMP 26051942
GO:0005515 protein binding IPI 16763549
GO:0008201 heparin binding IEA --
GO:0015026 coreceptor activity TAS 21245381
genes like me logo Genes that share ontologies with NRP1: view
genes like me logo Genes that share phenotypes with NRP1: view

Animal Models for NRP1 Gene

MGI Knock Outs for NRP1:
  • Nrp1 Nrp1<tm1Hfu>
  • Nrp1 Nrp1<tm2.1Ddg>
  • Nrp1 Nrp1<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRP1 Gene

Localization for NRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRP1 Gene

Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRP1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 4
cytoskeleton 3
endosome 3
mitochondrion 2
endoplasmic reticulum 2
nucleus 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002116 semaphorin receptor complex NAS 19909241
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space HDA 16502470
GO:0005769 early endosome ISS 23639442
GO:0005829 cytosol IDA 21245381
genes like me logo Genes that share ontologies with NRP1: view

Pathways & Interactions for NRP1 Gene

PathCards logo

SuperPathways for NRP1 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.62
.61
.60
.57
2 Semaphorin interactions
3 VEGF Pathway (Qiagen)
.66
4 CREB Pathway
.68
.63
5 PAK Pathway
.56
.56
genes like me logo Genes that share pathways with NRP1: view

Pathways by source for NRP1 Gene

26 Qiagen pathways for NRP1 Gene
  • Actin-Based Motility by Rho Family GTPases
  • Activation of PKC through GPCR
  • Antioxidant Action of Vitamin-C
  • Apoptotic Pathways in Synovial Fibroblasts
  • Breast Cancer Regulation by Stathmin1
1 Cell Signaling Technology pathway for NRP1 Gene

SIGNOR curated interactions for NRP1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS 24401374
GO:0001569 branching involved in blood vessel morphogenesis ISS 24401374
GO:0001764 neuron migration ISS --
GO:0001938 positive regulation of endothelial cell proliferation TAS 21245381
GO:0002040 sprouting angiogenesis ISS 24401374
genes like me logo Genes that share ontologies with NRP1: view

Drugs & Compounds for NRP1 Gene

(28) Drugs for NRP1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palifermin Approved Pharma Target, binder 0
pegaptanib Approved, Investigational Pharma Target 0
Ranibizumab Approved Pharma 532
Angiogenesis Inhibitors Pharma 4808
Antibodies Pharma 8378

(27) Additional Compounds for NRP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for NRP1 Gene

Compound Action Cas Number
EG00229 Nrp1 inhibitor 1210945-69-9
genes like me logo Genes that share compounds with NRP1: view

Transcripts for NRP1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6: - - - - - -
SP7: - - -
SP8: - - - -
SP9: - - - - -
SP10:
SP11:

ExUns: 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for NRP1 Gene

GeneLoc Exon Structure for
NRP1
ECgene alternative splicing isoforms for
NRP1

Expression for NRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NRP1 Gene

This gene is overexpressed in Amniocyte (14.5), Serum (11.7), and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NRP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of NRP1 Gene:

NRP1

SOURCE GeneReport for Unigene cluster for NRP1 Gene:

Hs.131704

mRNA Expression by UniProt/SwissProt for NRP1 Gene:

O14786-NRP1_HUMAN
Tissue specificity: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.

Evidence on tissue expression from TISSUES for NRP1 Gene

  • Kidney(4.6)
  • Muscle(4.5)
  • Liver(4.4)
  • Bone marrow(4.3)
  • Nervous system(4.3)
  • Heart(3.2)
  • Lung(3.1)
  • Spleen(2.9)
  • Lymph node(2.6)
  • Blood(2.2)
  • Eye(2)
genes like me logo Genes that share expression patterns with NRP1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRP1 Gene

Orthologs for NRP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRP1 33 32
  • 99.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NRP1 33 32
  • 91.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NRP1 33 32
  • 90.58 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRP1 33
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrp1 32
  • 87.74 (n)
mouse
(Mus musculus)
Mammalia Nrp1 17 33 32
  • 87.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NRP1 33
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRP1 33 32
  • 78.21 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRP1 33
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrp1 32
  • 71.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397804 32
zebrafish
(Danio rerio)
Actinopterygii nrp1a 33 32
  • 66.25 (n)
OneToMany
nrp1b 33
  • 51 (a)
OneToMany
nrp1 32
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7396 33
  • 23 (a)
OneToMany
Species where no ortholog for NRP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRP1 Gene

ENSEMBL:
Gene Tree for NRP1 (if available)
TreeFam:
Gene Tree for NRP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NRP1: view image

Paralogs for NRP1 Gene

(32) SIMAP similar genes for NRP1 Gene using alignment to 19 proteins:

  • NRP1_HUMAN
  • E7EX60_HUMAN
  • E9PEP6_HUMAN
  • H0Y4A0_HUMAN
  • H0Y4N6_HUMAN
  • H0Y7Z2_HUMAN
  • Q5JWQ2_HUMAN
  • Q5JWQ4_HUMAN
  • Q5JWQ6_HUMAN
  • Q5T7F0_HUMAN
  • Q6X907_HUMAN
  • Q71SW6_HUMAN
  • Q7Z5M2_HUMAN
  • Q9H2D7_HUMAN
  • Q9H2D8_HUMAN
  • Q9H2D9_HUMAN
  • Q9H2E0_HUMAN
  • Q9H2E1_HUMAN
  • V9GYL7_HUMAN
genes like me logo Genes that share paralogs with NRP1: view

Variants for NRP1 Gene

Sequence variations from dbSNP and Humsavar for NRP1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs875989818 uncertain-significance, not provided 33,330,706(-) A/C splice_donor_variant
rs1000002801 -- 33,293,342(-) G/A intron_variant
rs1000016611 -- 33,266,124(-) C/T intron_variant
rs1000025753 -- 33,270,918(-) A/G intron_variant
rs1000049792 -- 33,322,709(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NRP1 Gene

Variant ID Type Subtype PubMed ID
dgv393n106 CNV deletion 24896259
esv2662402 CNV deletion 23128226
esv2678844 CNV deletion 23128226
esv27085 CNV loss 19812545
esv2735262 CNV deletion 23290073
esv3546134 CNV deletion 23714750
esv3622850 CNV loss 21293372
esv4611 CNV loss 18987735
esv8432 CNV loss 19470904
nsv1068297 CNV deletion 25765185
nsv1133985 CNV deletion 24896259
nsv24782 CNV deletion 16902084
nsv528133 CNV loss 19592680
nsv6299 CNV insertion 18451855
nsv825336 CNV loss 20364138
nsv831829 CNV loss 17160897

Variation tolerance for NRP1 Gene

Residual Variation Intolerance Score: 9.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.75; 78.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRP1 Gene

Human Gene Mutation Database (HGMD)
NRP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRP1 Gene

Disorders for NRP1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for NRP1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NRP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NRP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRP1 Gene

Publications for NRP1 Gene

  1. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. (PMID: 9529250) Soker S … Klagsbrun M (Cell 1998) 2 3 4 23 56
  2. Exploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes. (PMID: 18785001) Schneider BP … Sledge GW (Breast cancer research and treatment 2009) 3 23 43 56
  3. The altered expression of syndecan 4 in the uninvolved skin of venous leg ulcer patients may predispose to venous leg ulcer. (PMID: 18638267) Nagy N … Széll M (Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2008) 3 23 43 56
  4. DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population. (PMID: 21682944) Alkelai A … Lerer B (The international journal of neuropsychopharmacology 2012) 3 43 56
  5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 43 56

Products for NRP1 Gene