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Aliases for NRON Gene

Subcategory (RNA class) for NRON Gene

lncRNA

Quality Score for this RNA gene is

14

Aliases for NRON Gene

  • Non-Coding Repressor Of NFAT 2 3 5
  • Non-Protein Coding RNA, Repressor Of NFAT 2 3
  • Noncoding Repressor Of NFAT 2 3
  • Non-Protein Coding RNA 194 2
  • NCRNA00194 3

External Ids for NRON Gene

ORGUL Members for NRON Gene

Previous GeneCards Identifiers for NRON Gene

  • GC00U921663
  • GC09U901411
  • GC09M129172
  • GC09M129175
  • GC09M129178

Summaries for NRON Gene

GeneCards Summary for NRON Gene

NRON (Non-Coding Repressor Of NFAT) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with NRON include Down Syndrome and Inflammatory Bowel Disease.

fRNAdb sequence ontologies for NRON Gene

  • ncRNA: An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

Additional gene information for NRON Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for NRON Gene

Genomics for NRON Gene

GeneHancer (GH) Regulatory Elements for NRON Gene

Promoters and enhancers for NRON Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J126410 Enhancer 0.9 ENCODE dbSUPER 600.7 -1.1 -1106 1.8 RELA IKZF1 IKZF2 PKNOX1 CBFB PAX8 DPF2 RUNX3 BCL11A NR2F1 NRON MVB12B GC09P126427
GH09J126424 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -11.7 -11697 5.6 FOSL2 ZBTB33 ZIC2 POLR2A ZSCAN5C ZKSCAN1 FOXA2 FOS DPF2 FOXA1 MVB12B ZBTB34 GC09P126427 NRON
GH09J126373 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.3 +34.4 34383 10.2 ELF3 CEBPG AHR HNF1A PPARG SP5 ZNF644 HMG20B RXRA PRDM10 MVB12B ENSG00000252985 NRON
GH09J126398 Enhancer 1 ENCODE dbSUPER 0.4 +11.8 11837 0.2 CTCF RAD21 ARID2 ZBTB33 GATAD2A ZNF143 REST LARP7 TRIM22 CTBP1 ENSG00000252985 MVB12B NRON
GH09J126413 Enhancer 0.6 FANTOM5 0.7 -3.0 -3003 0.4 MAFK ZSCAN4 ZNF316 NFE2 MAFG EMSY MVB12B ZBTB34 NRON GC09P126427
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRON on UCSC Golden Path with GeneCards custom track

Genomic Locations for NRON Gene

Genomic Locations for NRON Gene
chr9:126,407,775-126,410,504
(GRCh38/hg38)
Size:
2,730 bases
Orientation:
Minus strand
chr9:129,170,320-129,170,689
(GRCh37/hg19)
Size:
370 bases
Orientation:
Minus strand

Genomic View for NRON Gene

Genes around NRON on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRON Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRON Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRON Gene

ORGUL Member Location for NRON Gene

ORGUL Member Location for NRON gene

Proteins for NRON Gene

No data available for DME Specific Peptides for NRON Gene

Domains & Families for NRON Gene

Gene Families for NRON Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NRON: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NRON Gene

Function for NRON Gene

Phenotypes From GWAS Catalog for NRON Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NRON Gene

Localization for NRON Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRON gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NRON Gene

Pathways & Interactions for NRON Gene

PathCards logo

SuperPathways for NRON Gene

No Data Available

Interacting Proteins for NRON Gene

Gene Ontology (GO) - Biological Process for NRON Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NRON Gene

Drugs & Compounds for NRON Gene

No Compound Related Data Available

Transcripts for NRON Gene

mRNA/cDNA for NRON Gene

(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNA Central transcripts :

Unigene Clusters for NRON Gene

Non-protein coding RNA, repressor of NFAT:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRON Gene

No ASD Table

Relevant External Links for NRON Gene

GeneLoc Exon Structure for
NRON
ECgene alternative splicing isoforms for
NRON

Expression for NRON Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRON Gene

NURSA nuclear receptor signaling pathways regulating expression of NRON Gene:

NRON

SOURCE GeneReport for Unigene cluster for NRON Gene:

Hs.742606
genes like me logo Genes that share expression patterns with NRON: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRON Gene

Orthologs for NRON Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRON Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRON 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRON 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRON 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRON 35 35
  • 94 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nron 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRON 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRON 35
  • 83 (a)
OneToOne
Species where no ortholog for NRON was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NRON Gene

ENSEMBL:
Gene Tree for NRON (if available)
TreeFam:
Gene Tree for NRON (if available)

Paralogs for NRON Gene

No data available for Paralogs for NRON Gene

Variants for NRON Gene

Sequence variations from dbSNP and Humsavar for NRON Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001179961 -- 126,411,274(-) T/A upstream_transcript_variant
rs1001413419 -- 126,411,782(-) A/G upstream_transcript_variant
rs1001466712 -- 126,411,410(-) A/T upstream_transcript_variant
rs1001494243 -- 126,407,493(-) G/A downstream_transcript_variant
rs1001990752 -- 126,407,479(-) C/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NRON Gene

Variant ID Type Subtype PubMed ID
esv3621766 CNV gain 21293372

Additional Variant Information for NRON Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRON

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NRON Gene

Disorders for NRON Gene

MalaCards: The human disease database

(4) MalaCards diseases for NRON Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
down syndrome
  • trisomy 21
inflammatory bowel disease
  • inflammatory bowel diseases
acquired immunodeficiency syndrome
  • aids
congestive heart failure
  • cardiac failure congestive
- elite association - COSMIC cancer census association via MalaCards
Search NRON in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRON

genes like me logo Genes that share disorders with NRON: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRON Gene

Publications for NRON Gene

  1. A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. (PMID: 16141075) Willingham AT … Schultz PG (Science (New York, N.Y.) 2005) 1 2 3 58
  2. The kinase LRRK2 is differently expressed in chronic rhinosinusitis with and without nasal polyps. (PMID: 29545945) Ma Y … Shi L (Clinical and translational allergy 2018) 2 3 58
  3. Long non-coding and endogenous retroviral RNA levels are associated with proinflammatory cytokine mRNA expression in peripheral blood cells: Implications for schizophrenia. (PMID: 28942956) Melbourne JK … Sharma RP (Psychiatry research 2018) 3 58
  4. Long non-coding RNA NRON is downregulated in HCC and suppresses tumour cell proliferation and metastasis. (PMID: 29772429) Yao Z … Deng M (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3 58
  5. Circulating long non-coding RNAs NRON and MHRT as novel predictive biomarkers of heart failure. (PMID: 28296001) Xuan L … Yang BF (Journal of cellular and molecular medicine 2017) 3 58

Products for NRON Gene

Sources for NRON Gene

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