Aliases for NRON Gene

Subcategory (RNA class) for NRON Gene

lncRNA

Aliases for NRON Gene

External Ids for NRON Gene

Previous GeneCards Identifiers for NRON Gene

  • GC00U921663
  • GC09U901411
  • GC09M129172
  • GC09M129175
  • GC09M129178

Summaries for NRON Gene

GeneCards Summary for NRON Gene

NRON (Non-Coding Repressor Of NFAT) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with NRON include Inflammatory Bowel Disease and Down Syndrome.

Rfam classification for NRON Gene

  • ncRNA Repressor of NFAT (nuclear factor of activated T cells)

Additional gene information for NRON Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for NRON Gene

Genomics for NRON Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NRON Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J126410 Enhancer 0.8 ENCODE dbSUPER 250.7 -0.8 -779 1.8 BCL11A SIN3A PRDM6 CBFB IKZF1 NR2F1 ATF2 JUNB ZNF217 ARID3A NRON MVB12B ENSG00000252985 LMX1B
GH09J126405 Enhancer 0.7 Ensembl CraniofacialAtlas dbSUPER 0.7 +3.5 3470 2.9 BHLHE40 EZH2 MVB12B NRON RF00017-7913 LMX1B
GH09J126388 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 +17.0 17031 10.8 BCL11A DEK CTCF ZIC2 REST IRF4 TRIM22 RXRA MIER3 EBF1 MVB12B ENSG00000252985 RF00017-7913 NRON LMX1B
GH09J126413 Enhancer 0.5 FANTOM5 0.7 -2.7 -2676 0.4 ZNF316 NFE2 MAFG ZSCAN4 MAFK EMSY MVB12B ZBTB34 NRON ENSG00000252985 LMX1B
GH09J126400 Enhancer 0.8 Ensembl dbSUPER 0.4 +8.4 8402 2.9 CEBPB GABPA ZNF589 CEBPG ATF4 ZNF584 MEIS2 ATF3 CREB1 POLR2A MVB12B ENSG00000252985 NRON RF00017-7913 LMX1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRON on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for NRON Gene

Latest Assembly
chr9:126,407,773-126,410,831
(GRCh38/hg38)
Size:
3,059 bases
Orientation:
Minus strand

Previous Assembly
chr9:129,170,054-129,172,783
(GRCh37/hg19 by Entrez Gene)
Size:
2,730 bases
Orientation:
Minus strand

chr9:129,170,320-129,170,689
(GRCh37/hg19 by Ensembl)
Size:
370 bases
Orientation:
Minus strand

Genomic View for NRON Gene

Genes around NRON on UCSC Golden Path with GeneCards custom track
NRON in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
NRON Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRON Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRON Gene

Proteins for NRON Gene

Post-translational modifications for NRON Gene

No Post-translational modifications

No data available for DME Specific Peptides for NRON Gene

Domains & Families for NRON Gene

Gene Families for NRON Gene

genes like me logo Genes that share domains with NRON: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NRON Gene

Function for NRON Gene

Phenotypes From GWAS Catalog for NRON Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NRON Gene

Localization for NRON Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRON gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NRON Gene

Pathways & Interactions for NRON Gene

PathCards logo

SuperPathways for NRON Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRON Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for NRON Gene

Drugs & Compounds for NRON Gene

No Compound Related Data Available

Transcripts for NRON Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for NRON Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000067DD11_9606 lncRNA 371 4

Ensembl: ENST00000517270 (view in UCSC) ,

LncBook: HSALNT0155428,

LNCipedia: lnc-ANGPTL2-10:3,

Rfam: RF00636,

URS000075EE86_9606 lncRNA 2730 3

RefSeq: NR_045006,

LNCipedia: lnc-ANGPTL2-10:2,

NONCODE: NONHSAT134764.2,

URS0000D5CC82_9606 lncRNA 2731 2

LncBook: HSALNT0289382,

LNCipedia: lnc-ANGPTL2-10:1,

URS0001BF273E_9606 lncRNA 2985 1

LncBook: HSALNT0155427,

URS0001BF10E6_9606 lncRNA 2730 1

LncBook: HSALNT0289382,

NRON in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for NRON Gene

No ASD Table

Relevant External Links for NRON Gene

GeneLoc Exon Structure for
NRON

No data available for mRNA/cDNA for NRON Gene

Expression for NRON Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NRON Gene

SOURCE GeneReport for Unigene cluster for NRON Gene:

Hs.742606
genes like me logo Genes that share expression patterns with NRON: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRON Gene

Orthologs for NRON Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRON Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NRON 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia NRON 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia NRON 31
  • 96 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NRON 31 31
  • 94 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Nron 31
  • 94 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NRON 31
  • 92 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NRON 31
  • 83 (a)
OneToOne
Species where no ortholog for NRON was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NRON Gene

ENSEMBL:
Gene Tree for NRON (if available)
TreeFam:
Gene Tree for NRON (if available)

Paralogs for NRON Gene

No data available for Paralogs for NRON Gene

Variants for NRON Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NRON Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NRON Gene

Variant ID Type Subtype PubMed ID
esv3621766 CNV gain 21293372

Additional Variant Information for NRON Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRON

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for NRON Gene

Disorders for NRON Gene

MalaCards: The human disease database

(4) MalaCards diseases for NRON Gene - From: LNC, COP, and GCD

Disorder Aliases PubMed IDs
inflammatory bowel disease
  • inflammatory bowel diseases
down syndrome
  • trisomy 21
acquired immunodeficiency syndrome
  • acquired immune deficiency
heart disease
  • congenital heart disease
- elite association - COSMIC cancer census association via MalaCards
Search NRON in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRON

genes like me logo Genes that share disorders with NRON: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRON Gene

Publications for NRON Gene

  1. A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. (PMID: 16141075) Willingham AT … Schultz PG (Science (New York, N.Y.) 2005) 2 3 74
  2. The kinase LRRK2 is differently expressed in chronic rhinosinusitis with and without nasal polyps. (PMID: 29545945) Ma Y … Shi L (Clinical and translational allergy 2018) 2 3
  3. Circulating long non-coding RNAs NRON and MHRT as novel predictive biomarkers of heart failure. (PMID: 28296001) Xuan L … Yang BF (Journal of cellular and molecular medicine 2017) 3 74
  4. The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins. (PMID: 25728138) Imam H … Jameel S (Scientific reports 2015) 3 74
  5. The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. (PMID: 21983832) Liu Z … Lenardo MJ (Nature immunology 2011) 3 74

Products for NRON Gene

Sources for NRON Gene