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Aliases for NRN1L Gene

Aliases for NRN1L Gene

  • Neuritin 1 Like 2 3 5
  • Neuritin-Like Protein 3 4
  • MRCC2446 3
  • UNQ2446 3
  • Cpg15-2 3

External Ids for NRN1L Gene

Previous GeneCards Identifiers for NRN1L Gene

  • GC16P066478
  • GC16P067918
  • GC16P053791

Summaries for NRN1L Gene

Entrez Gene Summary for NRN1L Gene

  • The protein encoded by this gene is extracellular and enhances both neurite growth and neuronal survival. The encoded protein is found both as a GPI anchored membrane-bound form and as a secreted form. This activity-related ligand functions as a homodimer or heterodimer. [provided by RefSeq, Feb 2017]

GeneCards Summary for NRN1L Gene

NRN1L (Neuritin 1 Like) is a Protein Coding gene. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins and Metabolism of proteins. An important paralog of this gene is NRN1.

Additional gene information for NRN1L Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRN1L Gene

Genomics for NRN1L Gene

GeneHancer (GH) Regulatory Elements for NRN1L Gene

Promoters and enhancers for NRN1L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J067880 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 600.7 -1.5 -1468 6.8 CC2D1A CTCF SP1 SP5 KLF14 PRDM1 RAD21 ZNF560 ARID2 PRDM10 NRN1L GC16P067885 GC16P067884 ENSG00000263126 DUS2 CENPT THAP11 TSNAXIP1 RANBP10 DPEP3
GH16J067934 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.5 +51.4 51362 4.1 ZNF652 ZFX SP1 ELF3 MNT CBFA2T2 ZNF148 NKRF POLR2A MLLT1 ENSG00000261884 GC16P067936 PSMB10 EDC4 E2F4 NFATC3 RANBP10 ENSG00000263276 ENSG00000260891 ENSG00000270165
GH16J067854 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 11.7 -27.7 -27711 4.4 SP1 ELF3 MNT CBFA2T2 ZNF121 CEBPG ZSCAN21 NCOA3 PPARG SP5 ENSG00000262141 RANBP10 ACD NFATC3 NRN1L TSNAXIP1 DUS2 PSKH1 E2F4 SLC12A4
GH16J067942 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 10.8 +58.9 58941 3.3 CC2D1A ELF3 CTCF POLR2A CEBPG RERE SP1 PPARG SP5 RAD21 GC16M067943 LCAT SLC12A4 DUS2 DPEP3 RNU6-359P PSKH1 C16orf86 ENKD1 NRN1L
GH16J067860 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.7 -22.6 -22573 4.1 ZNF121 NCOA3 FOSL2 ZNF600 ZNF629 SCRT2 KLF4 PKNOX1 SCRT1 FOSL1 NRN1L THAP11 PSKH1 RANBP10 TSNAXIP1 RIPOR1 PRMT7 ACD PARD6A CARMIL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRN1L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NRN1L gene promoter:
  • CUTL1
  • E47
  • Hand1
  • HEN1
  • NF-1
  • NF-1/L
  • PPAR-alpha
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for NRN1L Gene

Genomic Locations for NRN1L Gene
chr16:67,884,878-67,888,855
(GRCh38/hg38)
Size:
3,978 bases
Orientation:
Plus strand
chr16:67,918,708-67,922,758
(GRCh37/hg19)
Size:
4,051 bases
Orientation:
Plus strand

Genomic View for NRN1L Gene

Genes around NRN1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRN1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRN1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRN1L Gene

Proteins for NRN1L Gene

  • Protein details for NRN1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q496H8-NRN1L_HUMAN
    Recommended name:
    Neuritin-like protein
    Protein Accession:
    Q496H8
    Secondary Accessions:
    • Q6UWH7

    Protein attributes for NRN1L Gene

    Size:
    165 amino acids
    Molecular mass:
    17786 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NRN1L Gene

Post-translational modifications for NRN1L Gene

No Post-translational modifications

Other Protein References for NRN1L Gene

No data available for DME Specific Peptides for NRN1L Gene

Domains & Families for NRN1L Gene

Gene Families for NRN1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for NRN1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NRN1L Gene

GenScript: Design optimal peptide antigens:
  • Neuritin-like protein (NRN1L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q496H8

UniProtKB/Swiss-Prot:

NRN1L_HUMAN :
  • Belongs to the neuritin family.
Family:
  • Belongs to the neuritin family.
genes like me logo Genes that share domains with NRN1L: view

Function for NRN1L Gene

Phenotypes From GWAS Catalog for NRN1L Gene

Gene Ontology (GO) - Molecular Function for NRN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with NRN1L: view
genes like me logo Genes that share phenotypes with NRN1L: view

Animal Models for NRN1L Gene

MGI Knock Outs for NRN1L:
  • Nrn1l Nrn1l<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for NRN1L

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRN1L

Clone Products

  • Applied Biological Materials (abm): Clones for NRN1L - Now 50% OFF >
  • * NRN1L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NRN1L tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NRN1L Gene

Localization for NRN1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRN1L Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRN1L gene
Compartment Confidence
extracellular 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for NRN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with NRN1L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NRN1L Gene

Pathways & Interactions for NRN1L Gene

genes like me logo Genes that share pathways with NRN1L: view

Interacting Proteins for NRN1L Gene

Gene Ontology (GO) - Biological Process for NRN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
GO:1990138 neuron projection extension IEA --
genes like me logo Genes that share ontologies with NRN1L: view

No data available for SIGNOR curated interactions for NRN1L Gene

Drugs & Compounds for NRN1L Gene

No Compound Related Data Available

Transcripts for NRN1L Gene

mRNA/cDNA for NRN1L Gene

Unigene Clusters for NRN1L Gene

Neuritin 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRN1L

Clone Products

  • Applied Biological Materials (abm): Clones for NRN1L - Now 50% OFF >
  • * NRN1L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NRN1L tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for NRN1L Gene

No ASD Table

Relevant External Links for NRN1L Gene

GeneLoc Exon Structure for
NRN1L
ECgene alternative splicing isoforms for
NRN1L

Expression for NRN1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRN1L Gene

NURSA nuclear receptor signaling pathways regulating expression of NRN1L Gene:

NRN1L

SOURCE GeneReport for Unigene cluster for NRN1L Gene:

Hs.435464
genes like me logo Genes that share expression patterns with NRN1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRN1L Gene

Orthologs for NRN1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRN1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRN1L 35 34
  • 98.92 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrn1l 34
  • 83.16 (n)
mouse
(Mus musculus)
Mammalia Nrn1l 17 35 34
  • 82.49 (n)
dog
(Canis familiaris)
Mammalia NRN1L 34
  • 74.3 (n)
chicken
(Gallus gallus)
Aves -- 35
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia NRN1L 35
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nrn1lb 35
  • 35 (a)
OneToMany
nrn1la 35
  • 34 (a)
OneToMany
Species where no ortholog for NRN1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRN1L Gene

ENSEMBL:
Gene Tree for NRN1L (if available)
TreeFam:
Gene Tree for NRN1L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NRN1L: view image

Paralogs for NRN1L Gene

Paralogs for NRN1L Gene

(1) SIMAP similar genes for NRN1L Gene using alignment to 3 proteins:

  • NRN1L_HUMAN
  • I3L2K6_HUMAN
  • J3QS81_HUMAN
genes like me logo Genes that share paralogs with NRN1L: view

Variants for NRN1L Gene

Sequence variations from dbSNP and Humsavar for NRN1L Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1001308848 -- 67,883,857(+) C/T upstream_transcript_variant
rs1002574737 -- 67,887,555(+) C/G genic_downstream_transcript_variant, intron_variant
rs1002623305 -- 67,887,066(+) G/A genic_downstream_transcript_variant, intron_variant
rs1002830792 -- 67,888,816(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1003218996 -- 67,887,052(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NRN1L Gene

Variant ID Type Subtype PubMed ID
nsv1844 CNV deletion 18451855
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680

Variation tolerance for NRN1L Gene

Residual Variation Intolerance Score: 93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.18; 80.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRN1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRN1L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRN1L Gene

Disorders for NRN1L Gene

Additional Disease Information for NRN1L

No disorders were found for NRN1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRN1L Gene

Publications for NRN1L Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 58
  3. cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. (PMID: 18265009) Fujino T … Nedivi E (The Journal of comparative neurology 2008) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for NRN1L Gene

Sources for NRN1L Gene

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