External Ids for NRN1 Gene
Previous GeneCards Identifiers for NRN1 Gene
This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for NRN1 Gene
NRN1 (Neuritin 1) is a Protein Coding gene. Diseases associated with NRN1 include Megalencephalic Leukoencephalopathy With Subcortical Cysts 1 and Spinal Muscular Atrophy. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is NRN1L.
UniProtKB/Swiss-Prot Summary for NRN1 Gene
Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.