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Aliases for NRM Gene

Aliases for NRM Gene

  • Nurim 2 3 3 5
  • Nurim (Nuclear Envelope Membrane Protein) 2 3
  • Nuclear Rim Protein 3 4
  • NRM29 3 4
  • Nuclear Envelope Membrane Protein 4

External Ids for NRM Gene

Previous GeneCards Identifiers for NRM Gene

  • GC06M030711
  • GC06M030426
  • GC06M030761
  • GC06M030763

Summaries for NRM Gene

Entrez Gene Summary for NRM Gene

  • The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for NRM Gene

NRM (Nurim) is a Protein Coding gene.

Additional gene information for NRM Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRM Gene

Genomics for NRM Gene

GeneHancer (GH) Regulatory Elements for NRM Gene

Promoters and enhancers for NRM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I030678 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 582.7 +6.1 6094 13.5 MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 NRM PPP1R10 DHX16 MDC1 DDX39B TRIM39 LY6G5B IER3 TRIM26 PAIP1P1
GH06I031538 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 80 -849.7 -849719 4.9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 DDX39B DDX39B-AS1 GC06M031542 GC06M031543 GC06M031550 GC06M031555 GC06M031573 GC06M031965 GC06M031970 PIR32498
GH06I030611 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 63.8 +75.9 75868 8.7 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPP1R10 MRPS18B DDX39B MDC1 TRIM39 ABCF1 NRM DHX16 ZNRD1 TRIM26
GH06I030715 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 61.6 -28.1 -28106 7.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 MDC1 TUBB DDX39B TRIM39 DHX16 LY6G5B PPP1R10 ZNRD1 PAIP1P1 NRM
GH06I031650 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 45.2 -961.0 -961045 3.3 CLOCK MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D SSRP1 BAG6 APOM ATF6B DDX39B LY6G5B MDC1 LSM2 DHX16 PBX2 NRM
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NRM on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NRM gene promoter:

Genomic Locations for NRM Gene

Genomic Locations for NRM Gene
chr6:30,688,047-30,691,420
(GRCh38/hg38)
Size:
3,374 bases
Orientation:
Minus strand
chr6:30,655,824-30,659,197
(GRCh37/hg19)

Genomic View for NRM Gene

Genes around NRM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for NRM Gene

  • Protein details for NRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXM6-NRM_HUMAN
    Recommended name:
    Nurim
    Protein Accession:
    Q8IXM6
    Secondary Accessions:
    • B0S7R0
    • B0S7R1
    • I3XIE2
    • I3XIE3
    • Q5JP57
    • Q5JP58
    • Q5JP59
    • Q5JP60
    • Q8WU45
    • Q9BSX3
    • Q9UN92

    Protein attributes for NRM Gene

    Size:
    262 amino acids
    Molecular mass:
    29379 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NRM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRM Gene

Post-translational modifications for NRM Gene

  • Ubiquitination at Lys121, Lys184, and isoforms=2249
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NRM Gene

Domains & Families for NRM Gene

Gene Families for NRM Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for NRM Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IXM6

UniProtKB/Swiss-Prot:

NRM_HUMAN :
  • Belongs to the nurim family.
Family:
  • Belongs to the nurim family.
genes like me logo Genes that share domains with NRM: view

Function for NRM Gene

Phenotypes From GWAS Catalog for NRM Gene

Gene Ontology (GO) - Molecular Function for NRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NRM: view
genes like me logo Genes that share phenotypes with NRM: view

Animal Model Products

CRISPR Products

miRNA for NRM Gene

miRTarBase miRNAs that target NRM

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRM Gene

Localization for NRM Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRM Gene

Nucleus inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRM gene
Compartment Confidence
nucleus 5
plasma membrane 3
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IDA 10402458
GO:0005637 nuclear inner membrane IEA --
GO:0016020 membrane IDA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NRM: view

Pathways & Interactions for NRM Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NRM: view

No data available for Pathways by source and SIGNOR curated interactions for NRM Gene

Drugs & Compounds for NRM Gene

No Compound Related Data Available

Transcripts for NRM Gene

Unigene Clusters for NRM Gene

Nurim (nuclear envelope membrane protein):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRM Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - -
SP8:
SP9: - - -

Relevant External Links for NRM Gene

GeneLoc Exon Structure for
NRM
ECgene alternative splicing isoforms for
NRM

Expression for NRM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRM Gene

mRNA differential expression in normal tissues according to GTEx for NRM Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for NRM Gene

This gene is overexpressed in Nasal epithelium (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NRM Gene



Protein tissue co-expression partners for NRM Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NRM Gene:

NRM

SOURCE GeneReport for Unigene cluster for NRM Gene:

Hs.519993

Evidence on tissue expression from TISSUES for NRM Gene

  • Blood(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with NRM: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRM Gene

Orthologs for NRM Gene

This gene was present in the common ancestor of animals.

Orthologs for NRM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRM 33 34
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia NRM 34 33
  • 92.1 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NRM 34 33
  • 91.3 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nrm 16 34 33
  • 87.68 (n)
rat
(Rattus norvegicus)
Mammalia Nrm 33
  • 87.15 (n)
oppossum
(Monodelphis domestica)
Mammalia NRM 34
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRM 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489431 33
  • 58.3 (n)
zebrafish
(Danio rerio)
Actinopterygii nrm 33 34
  • 58.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7655 33 34
  • 50.18 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005818 33
  • 45.75 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToOne
Species where no ortholog for NRM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRM Gene

ENSEMBL:
Gene Tree for NRM (if available)
TreeFam:
Gene Tree for NRM (if available)

Paralogs for NRM Gene

No data available for Paralogs for NRM Gene

Variants for NRM Gene

Sequence variations from dbSNP and Humsavar for NRM Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1002322612 -- 30,691,176(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1004005392 -- 30,692,238(-) C/T upstream_transcript_variant
rs1004067064 -- 30,692,936(-) G/A upstream_transcript_variant
rs1005031678 -- 30,688,402(-) T/G 3_prime_UTR_variant, non_coding_transcript_variant
rs1005569430 -- 30,693,096(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NRM Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv2759413 CNV loss 17122850
esv3367670 CNV insertion 20981092
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv830626 CNV loss 17160897

Variation tolerance for NRM Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRM

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRM Gene

Disorders for NRM Gene

Additional Disease Information for NRM

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NRM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRM Gene

Publications for NRM Gene

  1. A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. (PMID: 10402458) Rolls MM … Rapoport TA (The Journal of cell biology 1999) 2 3 4 58
  2. The integral nuclear membrane protein nurim plays a role in the suppression of apoptosis. (PMID: 23092226) Chen H … Zhou R (Current molecular medicine 2012) 3 4 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  5. Early sorting of inner nuclear membrane proteins is conserved. (PMID: 17517639) Braunagel SC … Summers MD (Proceedings of the National Academy of Sciences of the United States of America 2007) 2 3 58

Products for NRM Gene

Sources for NRM Gene

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