The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010] See more...

Aliases for NRK Gene

Aliases for NRK Gene

  • Nik Related Kinase 2 3 5
  • Nik-Related Protein Kinase 3 4
  • EC 2.7.11.1 4 50
  • DKFZp686A17109 2
  • EC 2.7.11 50
  • NESK 3
  • NRK 5

External Ids for NRK Gene

Previous GeneCards Identifiers for NRK Gene

  • GC0XP103839
  • GC0XP104872
  • GC0XP105067
  • GC0XP094691

Summaries for NRK Gene

Entrez Gene Summary for NRK Gene

  • The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]

GeneCards Summary for NRK Gene

NRK (Nik Related Kinase) is a Protein Coding gene. Diseases associated with NRK include Hypermobility Syndrome and Sotos Syndrome 1. Among its related pathways are TNF signaling and NAD metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K4.

UniProtKB/Swiss-Prot Summary for NRK Gene

  • May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).

Gene Wiki entry for NRK Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRK Gene

Genomics for NRK Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NRK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ105820 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 260 +1.3 1256 4.8 TAF1 BHLHE40 SP1 L3MBTL2 ZNF24 ZNF143 CTCF CEBPB EZH2 NRK piR-57195-273 SERPINA7
GH0XJ105781 Enhancer 0.2 ENCODE 13 -39.9 -39939 0.2 NRK RF00017-7984 MK280144-723 HSALNG0139375-001 HSALNG0139375-002 TEX13A
GH0XJ105745 Enhancer 0.6 Ensembl ENCODE 0.2 -75.8 -75812 0.9 CTBP1 SMARCE1 DPF2 RFX5 FOS piR-37340 LOC105373303 RF00017-7984 HSALNG0139375-001 HSALNG0139375-002 NRK TEX13A
GH0XJ105702 Enhancer 0.8 Ensembl ENCODE 0.1 -120.6 -120572 2.1 ZNF217 CEBPB CTCF EP300 CTBP1 RAD21 CUX1 TCF7L2 ZBTB40 SMARCE1 piR-55036-118 piR-37340 LOC105373303 RF00017-7984 HSALNG0139375-001 HSALNG0139375-002 NRK TEX13A
GH0XJ105765 Enhancer 0.3 Ensembl 0.2 -55.8 -55848 0.6 CTCF RAD21 LOC105373303 RF00017-7984 piR-37340 HSALNG0139375-001 HSALNG0139375-002 NRK TEX13A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRK on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRK

Top Transcription factor binding sites by QIAGEN in the NRK gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • FOXO4
  • MZF-1

Genomic Locations for NRK Gene

Latest Assembly
chrX:105,821,942-105,958,610
(GRCh38/hg38)
Size:
136,669 bases
Orientation:
Plus strand

Previous Assembly
chrX:105,066,532-105,202,602
(GRCh37/hg19 by Entrez Gene)
Size:
136,071 bases
Orientation:
Plus strand

chrX:105,066,536-105,202,602
(GRCh37/hg19 by Ensembl)
Size:
136,067 bases
Orientation:
Plus strand

Genomic View for NRK Gene

Genes around NRK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRK Gene

Proteins for NRK Gene

  • Protein details for NRK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2Y5-NRK_HUMAN
    Recommended name:
    Nik-related protein kinase
    Protein Accession:
    Q7Z2Y5
    Secondary Accessions:
    • Q32ND6
    • Q5H9K2
    • Q6ZMP2

    Protein attributes for NRK Gene

    Size:
    1582 amino acids
    Molecular mass:
    178479 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NRK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRK Gene

Selected DME Specific Peptides for NRK Gene

Q7Z2Y5:
  • FIGTPYWMAPEV
  • VIHRDIKGQNVLLT
  • GITAIEMAEGAPPLC
  • LNLLITISG
  • WMAPEVI
  • GTPYWMAPE

Post-translational modifications for NRK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NRK Gene

Gene Families for NRK Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NRK Gene

Suggested Antigen Peptide Sequences for NRK Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50079, highly similar to Homo sapiens Nik related kinase (NRK), mRNA (B7Z1I7_HUMAN)
  • Nik related kinase, isoform CRA_a (D3DUX0_HUMAN)
  • Nik-related protein kinase (NRK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z2Y5

UniProtKB/Swiss-Prot:

NRK_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with NRK: view

Function for NRK Gene

Molecular function for NRK Gene

UniProtKB/Swiss-Prot Function:
May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

Enzyme Numbers (IUBMB) for NRK Gene

Phenotypes From GWAS Catalog for NRK Gene

Gene Ontology (GO) - Molecular Function for NRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IBA 21873635
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with NRK: view
genes like me logo Genes that share phenotypes with NRK: view

Animal Models for NRK Gene

MGI Knock Outs for NRK:
  • Nrk Nrk<tm1Mkom>

miRNA for NRK Gene

miRTarBase miRNAs that target NRK

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRK Gene

Localization for NRK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRK gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NRK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NRK Gene

Pathways & Interactions for NRK Gene

PathCards logo

SuperPathways for NRK Gene

SuperPathway Contained pathways
1 NAD metabolism
2 TNF signaling
genes like me logo Genes that share pathways with NRK: view

Pathways by source for NRK Gene

2 BioSystems pathways for NRK Gene

Gene Ontology (GO) - Biological Process for NRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IBA 21873635
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IBA --
GO:0016310 phosphorylation IEA --
GO:0031098 stress-activated protein kinase signaling cascade IBA 21873635
genes like me logo Genes that share ontologies with NRK: view

No data available for SIGNOR curated interactions for NRK Gene

Drugs & Compounds for NRK Gene

No Compound Related Data Available

Transcripts for NRK Gene

mRNA/cDNA for NRK Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRK

Alternative Splicing Database (ASD) splice patterns (SP) for NRK Gene

No ASD Table

Relevant External Links for NRK Gene

GeneLoc Exon Structure for
NRK

Expression for NRK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NRK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRK Gene

This gene is overexpressed in Ovary (x16.2) and Adrenal Gland (x10.2).

Protein differential expression in normal tissues from HIPED for NRK Gene

This gene is overexpressed in Plasma (57.9) and Placenta (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NRK Gene



Protein tissue co-expression partners for NRK Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRK

SOURCE GeneReport for Unigene cluster for NRK Gene:

Hs.209527

Evidence on tissue expression from TISSUES for NRK Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with NRK: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRK Gene

Orthologs for NRK Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRK Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NRK 29 30
  • 99.55 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NRK 29 30
  • 90.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NRK 29 30
  • 89.26 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Nrk 29 16 30
  • 79.03 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nrk 29
  • 76.46 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia NRK 30
  • 19 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 18 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-81j8.6 30
  • 16 (a)
ManyToMany
Species where no ortholog for NRK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NRK Gene

ENSEMBL:
Gene Tree for NRK (if available)
TreeFam:
Gene Tree for NRK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NRK: view image
Alliance of Genome Resources:
Additional Orthologs for NRK

Paralogs for NRK Gene

(20) SIMAP similar genes for NRK Gene using alignment to 5 proteins:

  • NRK_HUMAN
  • B7Z1I7_HUMAN
  • D3DUX0_HUMAN
  • F5H049_HUMAN
  • L0R517_HUMAN
genes like me logo Genes that share paralogs with NRK: view

Variants for NRK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRK Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs144119374 Benign: not provided 105,908,954(+) G/A
NM_198465.4(NRK):c.1313G>A (p.Arg438Gln)
MISSENSE
rs188996722 Benign: not provided 105,934,337(+) A/G
NM_198465.4(NRK):c.3392A>G (p.Asn1131Ser)
MISSENSE
rs192589373 Benign: not provided 105,915,745(+) C/T
NM_198465.4(NRK):c.2365C>T (p.Pro789Ser)
MISSENSE
rs200616257 Likely Benign: not provided 105,945,966(+) T/C
NM_198465.4(NRK):c.4154T>C (p.Val1385Ala)
MISSENSE
rs369253049 Likely Benign: not provided 105,955,558(+) A/G
NM_198465.4(NRK):c.4707A>G (p.Thr1569=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NRK Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NRK Gene

Variant ID Type Subtype PubMed ID
esv2140378 CNV deletion 18987734
esv2482028 CNV deletion 19546169
esv2636339 CNV deletion 19546169
esv2660063 CNV deletion 23128226
esv2676289 CNV deletion 23128226
esv2740368 CNV deletion 23290073
esv2752312 CNV gain 17911159
esv3559168 CNV deletion 23714750
esv4419 CNV loss 18987735
nsv1124512 CNV deletion 24896259
nsv1141075 CNV deletion 24896259
nsv521259 CNV gain 19592680

Variation tolerance for NRK Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.15; 87.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRK Gene

Human Gene Mutation Database (HGMD)
NRK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRK
Leiden Open Variation Database (LOVD)
NRK

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRK Gene

Disorders for NRK Gene

MalaCards: The human disease database

(2) MalaCards diseases for NRK Gene - From: COP

Disorder Aliases PubMed IDs
hypermobility syndrome
  • benign joint hypermobility
sotos syndrome 1
  • sotos1
- elite association - COSMIC cancer census association via MalaCards
Search NRK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRK

genes like me logo Genes that share disorders with NRK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRK Gene

Publications for NRK Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Identification of a novel therapeutic candidate, NRK, in primary cancer-associated fibroblasts of lung adenocarcinoma microenvironment. (PMID: 33387038) Wei T … Yang J (Journal of cancer research and clinical oncology 2021) 3
  5. TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity. (PMID: 31797533) Li Z … Zhang W (EMBO reports 2020) 3

Products for NRK Gene

Sources for NRK Gene