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Aliases for NRIP3 Gene

Aliases for NRIP3 Gene

  • Nuclear Receptor Interacting Protein 3 2 3 5
  • Sarcoma Antigen NY-SAR-105 3 4
  • C11orf14 3 4
  • Nuclear Receptor-Interacting Protein 3 3
  • Chromosome 11 Open Reading Frame 14 2
  • NY-SAR-105 3

External Ids for NRIP3 Gene

Previous HGNC Symbols for NRIP3 Gene

  • C11orf14

Previous GeneCards Identifiers for NRIP3 Gene

  • GC11M009043
  • GC11M008968
  • GC11M008960
  • GC11M008673

Summaries for NRIP3 Gene

GeneCards Summary for NRIP3 Gene

NRIP3 (Nuclear Receptor Interacting Protein 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is NRIP2.

Additional gene information for NRIP3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRIP3 Gene

Genomics for NRIP3 Gene

GeneHancer (GH) Regulatory Elements for NRIP3 Gene

Promoters and enhancers for NRIP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I009003 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.0 11 1.1 HDGF ATF1 RB1 MZF1 ZBTB40 POLR2B ATF7 CREM SMAD5 GTF2B LOC105376541 NRIP3 SNORA3B SCUBE2 TMEM9B RPL27A RPL21P97 AKIP1 GC11P008977
GH11I009004 Enhancer 0.3 ENCODE 550.8 -0.8 -760 0.2 EZH2 LOC105376541 NRIP3 TMEM9B MIR5691
GH11I009361 Enhancer 1.7 FANTOM5 Ensembl ENCODE 28.5 -359.5 -359467 4.9 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 SSRP1 DENND5A NRIP3 SNORA3B ZNF143 AKIP1 RPL21P97 RPL27A IPO7 TMEM41B TMEM9B
GH11I009273 Enhancer 1.1 FANTOM5 Ensembl ENCODE 26.3 -269.9 -269852 1.4 MEIS2 PKNOX1 CEBPG ATF4 ZNF366 POLR2A SCRT2 ZNF512 PRDM1 TRL-CAA5-1 DENND5A NRIP3 TMEM41B SCUBE2 ZNF143 IPO7 TMEM9B
GH11I009158 Enhancer 1 FANTOM5 Ensembl ENCODE 28.1 -156.0 -155985 2.2 FOSL1 ATF4 JUND JUN CEBPB CEBPG DENND5A NRIP3 SCUBE2 TMEM41B ZNF143 IPO7 TMEM9B RPL27A GC11M009222
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NRIP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NRIP3 gene promoter:

Genomic Locations for NRIP3 Gene

Genomic Locations for NRIP3 Gene
chr11:8,980,576-9,004,049
(GRCh38/hg38)
Size:
23,474 bases
Orientation:
Minus strand
chr11:9,002,123-9,025,596
(GRCh37/hg19)

Genomic View for NRIP3 Gene

Genes around NRIP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRIP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRIP3 Gene

Proteins for NRIP3 Gene

  • Protein details for NRIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ35-NRIP3_HUMAN
    Recommended name:
    Nuclear receptor-interacting protein 3
    Protein Accession:
    Q9NQ35
    Secondary Accessions:
    • Q86WD9

    Protein attributes for NRIP3 Gene

    Size:
    241 amino acids
    Molecular mass:
    26975 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NRIP3 Gene

Post-translational modifications for NRIP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRIP3 Gene

No data available for DME Specific Peptides for NRIP3 Gene

Domains & Families for NRIP3 Gene

Gene Families for NRIP3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NRIP3 Gene

Suggested Antigen Peptide Sequences for NRIP3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NRIP3: view

No data available for UniProtKB/Swiss-Prot for NRIP3 Gene

Function for NRIP3 Gene

Gene Ontology (GO) - Molecular Function for NRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NRIP3: view
genes like me logo Genes that share phenotypes with NRIP3: view

Animal Model Products

miRNA for NRIP3 Gene

miRTarBase miRNAs that target NRIP3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRIP3 Gene

Localization for NRIP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRIP3 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NRIP3 Gene

Pathways & Interactions for NRIP3 Gene

SuperPathways for NRIP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with NRIP3: view

No data available for Pathways by source and SIGNOR curated interactions for NRIP3 Gene

Drugs & Compounds for NRIP3 Gene

No Compound Related Data Available

Transcripts for NRIP3 Gene

Unigene Clusters for NRIP3 Gene

Nuclear receptor interacting protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRIP3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b
SP1: -
SP2: - - -
SP3: -
SP4:
SP5:

Relevant External Links for NRIP3 Gene

GeneLoc Exon Structure for
NRIP3
ECgene alternative splicing isoforms for
NRIP3

Expression for NRIP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRIP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRIP3 Gene

This gene is overexpressed in Brain - Hippocampus (x7.3), Brain - Cerebellum (x5.6), and Brain - Cerebellar Hemisphere (x5.4).

Protein differential expression in normal tissues from HIPED for NRIP3 Gene

This gene is overexpressed in Retina (41.6) and Platelet (27.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRIP3 Gene



Protein tissue co-expression partners for NRIP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NRIP3 Gene:

NRIP3

SOURCE GeneReport for Unigene cluster for NRIP3 Gene:

Hs.523467

Evidence on tissue expression from TISSUES for NRIP3 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with NRIP3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRIP3 Gene

Orthologs for NRIP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRIP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRIP3 33 34
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia NRIP3 34 33
  • 93.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NRIP3 34 33
  • 91.94 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrip3 33
  • 91.67 (n)
mouse
(Mus musculus)
Mammalia Nrip3 16 34 33
  • 91.39 (n)
oppossum
(Monodelphis domestica)
Mammalia NRIP3 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRIP3 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRIP3 34 33
  • 67.83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRIP3 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732611 33
  • 65.85 (n)
Species where no ortholog for NRIP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NRIP3 Gene

ENSEMBL:
Gene Tree for NRIP3 (if available)
TreeFam:
Gene Tree for NRIP3 (if available)

Paralogs for NRIP3 Gene

Paralogs for NRIP3 Gene

(1) SIMAP similar genes for NRIP3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NRIP3: view

Variants for NRIP3 Gene

Sequence variations from dbSNP and Humsavar for NRIP3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000142204 -- 8,980,623(-) C/A 3_prime_UTR_variant, non_coding_transcript_variant
rs1000345231 -- 8,983,570(-) G/A intron_variant
rs1000678136 -- 8,982,010(-) A/G 3_prime_UTR_variant, non_coding_transcript_variant
rs1001035623 -- 8,995,546(-) C/T intron_variant
rs1001160011 -- 8,982,356(-) G/A 3_prime_UTR_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NRIP3 Gene

Variant ID Type Subtype PubMed ID
esv2670495 CNV deletion 23128226
esv2759803 CNV gain 17122850
esv33264 CNV loss 17666407
esv3891928 CNV gain 25118596
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855
nsv832062 CNV loss 17160897

Variation tolerance for NRIP3 Gene

Residual Variation Intolerance Score: 78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRIP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRIP3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRIP3 Gene

Disorders for NRIP3 Gene

Additional Disease Information for NRIP3

No disorders were found for NRIP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRIP3 Gene

Publications for NRIP3 Gene

  1. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PMID: 11528127) Amid C … Schmidt ER (Cytogenetics and cell genetics 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Immunomic analysis of human sarcoma. (PMID: 12601173) Lee SY … Scanlan MJ (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for NRIP3 Gene

Sources for NRIP3 Gene

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