Aliases for NRIP1 Gene
External Ids for NRIP1 Gene
Previous GeneCards Identifiers for NRIP1 Gene
Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]
GeneCards Summary for NRIP1 Gene
NRIP1 (Nuclear Receptor Interacting Protein 1) is a Protein Coding gene. Diseases associated with NRIP1 include Congenital Anomalies Of Kidney And Urinary Tract 3 and Cakut. Among its related pathways are Circadian rythm related genes and BMAL1-CLOCK,NPAS2 activates circadian gene expression. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and transcription corepressor activity.
UniProtKB/Swiss-Prot Summary for NRIP1 Gene
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549).