Aliases for NRGN Gene
External Ids for NRGN Gene
Previous GeneCards Identifiers for NRGN Gene
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]
GeneCards Summary for NRGN Gene
NRGN (Neurogranin) is a Protein Coding gene. Diseases associated with NRGN include Hypothyroidism and Jacobsen Syndrome. Gene Ontology (GO) annotations related to this gene include calmodulin binding.
UniProtKB/Swiss-Prot Summary for NRGN Gene
Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).