Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct ta... See more...

Aliases for NRGN Gene

Aliases for NRGN Gene

  • Neurogranin 2 3 4 5
  • RC3 2 3 4
  • Neurogranin (Protein Kinase C Substrate, RC3) 2 3
  • Calmodulin-Binding Protein 3
  • Protein Kinase C Substrate 3
  • NRGN 5
  • Hng 3
  • Ng 4

External Ids for NRGN Gene

Previous GeneCards Identifiers for NRGN Gene

  • GC11P126610
  • GC11P126122
  • GC11P124643
  • GC11P124147
  • GC11P124114
  • GC11P124609
  • GC11P120552

Summaries for NRGN Gene

Entrez Gene Summary for NRGN Gene

  • Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]

GeneCards Summary for NRGN Gene

NRGN (Neurogranin) is a Protein Coding gene. Diseases associated with NRGN include Hypothyroidism and Jacobsen Syndrome. Gene Ontology (GO) annotations related to this gene include calmodulin binding.

UniProtKB/Swiss-Prot Summary for NRGN Gene

  • Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRGN Gene

Genomics for NRGN Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NRGN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRGN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRGN

Top Transcription factor binding sites by QIAGEN in the NRGN gene promoter:
  • c-Myc
  • CREB
  • deltaCREB
  • LCR-F1
  • LyF-1
  • Max1
  • S8
  • Spz1

Genomic Locations for NRGN Gene

Genomic Locations for NRGN Gene
chr11:124,739,942-124,747,210
(GRCh38/hg38)
Size:
7,269 bases
Orientation:
Plus strand
chr11:124,609,742-124,617,106
(GRCh37/hg19)
Size:
7,365 bases
Orientation:
Plus strand

Genomic View for NRGN Gene

Genes around NRGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRGN Gene

Proteins for NRGN Gene

  • Protein details for NRGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92686-NEUG_HUMAN
    Recommended name:
    Neurogranin
    Protein Accession:
    Q92686

    Protein attributes for NRGN Gene

    Size:
    78 amino acids
    Molecular mass:
    7618 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NRGN Gene

Post-translational modifications for NRGN Gene

  • Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRGN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NRGN Gene

Domains & Families for NRGN Gene

Gene Families for NRGN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NRGN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NRGN Gene

GenScript: Design optimal peptide antigens:
  • RC3 (NEUG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92686

UniProtKB/Swiss-Prot:

NEUG_HUMAN :
  • Neurogranin is intrinsically unstructured; however, upon binding with CaM, The IQ domain adopts a helical conformation.
  • Belongs to the neurogranin family.
Domain:
  • Neurogranin is intrinsically unstructured; however, upon binding with CaM, The IQ domain adopts a helical conformation.
Family:
  • Belongs to the neurogranin family.
genes like me logo Genes that share domains with NRGN: view

Function for NRGN Gene

Molecular function for NRGN Gene

UniProtKB/Swiss-Prot Function:
Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).
GENATLAS Biochemistry:
neurogranin,rat Ng/RC3 homolog gene encoding a brain-specific protein expressed in telencephalic neurons,target of thyroid hormone in brain (thyroid hormone-responsive element in the first intron)

Phenotypes From GWAS Catalog for NRGN Gene

Gene Ontology (GO) - Molecular Function for NRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0005516 calmodulin binding TAS --
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IBA --
GO:0016301 kinase activity IEA --
GO:0070300 phosphatidic acid binding IBA --
genes like me logo Genes that share ontologies with NRGN: view
genes like me logo Genes that share phenotypes with NRGN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRGN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRGN Gene

Localization for NRGN Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRGN gene
Compartment Confidence
cytosol 4
plasma membrane 3
extracellular 3
mitochondrion 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for NRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0012510 trans-Golgi network transport vesicle membrane IEA --
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with NRGN: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for NRGN Gene

Pathways & Interactions for NRGN Gene

PathCards logo

SuperPathways for NRGN Gene

No Data Available

SIGNOR curated interactions for NRGN Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10075657
GO:0007399 nervous system development TAS 10075657
GO:0008306 associative learning IEA --
GO:0016310 phosphorylation IEA --
GO:0021537 telencephalon development IEA --
genes like me logo Genes that share ontologies with NRGN: view

No data available for Pathways by source for NRGN Gene

Drugs & Compounds for NRGN Gene

(8) Drugs for NRGN Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556

(8) Additional Compounds for NRGN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NRGN: view

Transcripts for NRGN Gene

mRNA/cDNA for NRGN Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRGN

Alternative Splicing Database (ASD) splice patterns (SP) for NRGN Gene

No ASD Table

Relevant External Links for NRGN Gene

GeneLoc Exon Structure for
NRGN

Expression for NRGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NRGN Gene

mRNA differential expression in normal tissues according to GTEx for NRGN Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x8.5), Brain - Cortex (x8.0), Brain - Frontal Cortex (BA9) (x7.5), Brain - Anterior cingulate cortex (BA24) (x5.7), Brain - Caudate (basal ganglia) (x5.1), and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for NRGN Gene

This gene is overexpressed in Platelet (19.9), Brain (16.0), Frontal cortex (8.0), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NRGN Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRGN

SOURCE GeneReport for Unigene cluster for NRGN Gene:

Hs.524116

mRNA Expression by UniProt/SwissProt for NRGN Gene:

Q92686-NEUG_HUMAN
Tissue specificity: In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease.

Evidence on tissue expression from TISSUES for NRGN Gene

  • Nervous system(5)
  • Blood(3.3)
  • Muscle(3)
  • Liver(2.9)
  • Heart(2.5)
  • Kidney(2.2)
  • Stomach(2.1)
  • Intestine(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with NRGN: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRGN Gene

Orthologs for NRGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRGN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NRGN 30 31
  • 100 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NRGN 31
  • 97 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Nrgn 31
  • 96 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NRGN 31
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia NRGN 31
  • 41 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NRGN 31
  • 72 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NRGN 31
  • 68 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii nrgna 31
  • 60 (a)
OneToOne
Species where no ortholog for NRGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NRGN Gene

ENSEMBL:
Gene Tree for NRGN (if available)
TreeFam:
Gene Tree for NRGN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NRGN: view image

Paralogs for NRGN Gene

(1) SIMAP similar genes for NRGN Gene using alignment to 1 proteins:

  • NEUG_HUMAN
genes like me logo Genes that share paralogs with NRGN: view

No data available for Paralogs for NRGN Gene

Variants for NRGN Gene

Additional dbSNP identifiers (rs#s) for NRGN Gene

Structural Variations from Database of Genomic Variants (DGV) for NRGN Gene

Variant ID Type Subtype PubMed ID
esv3627986 CNV gain 21293372
nsv556487 CNV loss 21841781
nsv952751 CNV deletion 24416366

Variation tolerance for NRGN Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRGN Gene

Human Gene Mutation Database (HGMD)
NRGN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRGN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRGN Gene

Disorders for NRGN Gene

MalaCards: The human disease database

(7) MalaCards diseases for NRGN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypothyroidism
  • thyroid deficiency
jacobsen syndrome
  • jbs
congenital hypothyroidism
  • endemic cretinism
alzheimer disease
  • ad
schizophrenia
  • sczd
- elite association - COSMIC cancer census association via MalaCards
Search NRGN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRGN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NRGN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRGN Gene

Publications for NRGN Gene

  1. Structure, organization, and chromosomal mapping of the human neurogranin gene (NRGN). (PMID: 9143500) Martínez de Arrieta C … Coloma A (Genomics 1997) 2 3 4 23
  2. Common variants conferring risk of schizophrenia. (PMID: 19571808) Stefansson H … Collier DA (Nature 2009) 3 23 41
  3. Association of the gene encoding neurogranin with schizophrenia in males. (PMID: 17140601) Ruano D … Palha JA (Journal of psychiatric research 2008) 3 23 41
  4. [Structure and chromosomal localization of human neurogranin gene]. (PMID: 9499372) Mertsalov IB … Tsetlin VI (Bioorganicheskaia khimiia 1997) 3 4 23
  5. [Cloning cDNA for human neurogranin]. (PMID: 8929222) Mertsalov IB … Tsetlin VI (Bioorganicheskaia khimiia 1996) 3 4 23

Products for NRGN Gene

Sources for NRGN Gene