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The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008] See more...
Aliases for NRG4 Gene
Aliases for NRG4 Gene
External Ids for NRG4 Gene
- HGNC: 29862
- NCBI Entrez Gene: 145957
- Ensembl: ENSG00000169752
- OMIM®: 610894
- UniProtKB/Swiss-Prot: Q8WWG1
Previous GeneCards Identifiers for NRG4 Gene
- GC15M074022
- GC15M076233
- GC15M052990
Summaries for NRG4 Gene
-
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
GeneCards Summary for NRG4 Gene
NRG4 (Neuregulin 4) is a Protein Coding gene. Diseases associated with NRG4 include Type 2 Diabetes Mellitus. Among its related pathways are RET signaling and Agrin Interactions at Neuromuscular Junction. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity. An important paralog of this gene is NRG3.
UniProtKB/Swiss-Prot Summary for NRG4 Gene
-
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).
Additional gene information for NRG4 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRG4 Gene
Genomics for NRG4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NRG4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NRG4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRG4
- Top Transcription factor binding sites by QIAGEN in the NRG4 gene promoter:
-
- AML1a
- CUTL1
- E4BP4
- FOXJ2
- FOXJ2 (long isoform)
- HFH-1
- Hlf
- IRF-1
- Pax-4a
- TGIF
Genomic Locations for NRG4 Gene
Latest Assembly
- chr15:75,933,219-76,069,830
- (GRCh38/hg38)
- Size:
- 136,612 bases
- Orientation:
- Minus strand
Previous Assembly
- chr15:76,233,277-76,304,765
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 71,489 bases
- Orientation:
- Minus strand
Genomic View for NRG4 Gene
Genes around NRG4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q24.2 by HGNC
- 15q24.2 by Entrez Gene
- 15q24.2 by Ensembl
NRG4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NRG4 Gene
Proteins for NRG4 Gene
-
Protein details for NRG4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WWG1-NRG4_HUMAN
- Recommended name:
- Pro-neuregulin-4, membrane-bound isoform
- Protein Accession:
- Q8WWG1
- A6NIE8
Protein attributes for NRG4 Gene
- Size:
- 115 amino acids
- Molecular mass:
- 12722 Da
- Quaternary structure:
-
- Interacts with ERBB4.
Post-translational modifications for NRG4 Gene
- Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
- Extensive glycosylation precedes the proteolytic cleavage.
-
Glycosylation at Asn39
- NX_Q8WWG1 (NX_Q8WWG1-1)
Other Protein References for NRG4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ NRG4 Antibody
-
Custom Antibody ServicesOriGene Antibodies for NRG4
- Novus Biologicals Antibodies for NRG4
-
Abcam antibodies for NRG4
- Invitrogen Antibodies for NRG4 (AFLGC-NRG4)
-
Biorbyt antibodies for NRG4
-
Boster Bio Antibodies for NRG4
-
Custom Antibody ServicesProSci Antibodies for NRG4
-
Santa Cruz Biotechnology (SCBT) Antibodies for NRG4
- Sino Biological Antibodies for NRG4
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for NRG4
- Origene Custom Protein Services for NRG4
- Sino Biological Recombinant Proteins for NRG4
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for NRG4
-
ProSci Proteins for NRG4
-
Abcam proteins for NRG4
Assay products for research
- G Biosciences Immunotag™ Human NRG-4 (Neuregulin 4) ELISA
- Novus Biologicals ELISA Kits for NRG4
No data available for DME Specific Peptides for NRG4 Gene
Domains & Families for NRG4 Gene
Gene Families for NRG4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for NRG4 Gene
- InterPro:
- Blocks:
-
- Type I EGF
Suggested Antigen Peptide Sequences for NRG4 Gene
- GenScript: Design optimal peptide antigens:
-
- Pro-neuregulin-4, membrane-bound isoform (NRG4_HUMAN)
- Neuregulin 4 (Q0P6N4_HUMAN)
- Neuregulin 4 (Q0P6N5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8WWG1UniProtKB/Swiss-Prot:
NRG4_HUMAN :- The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
- Belongs to the neuregulin family.
- Domain:
-
- The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
- ERBB receptor binding is elicited entirely by the EGF-like domain.
- Family:
-
- Belongs to the neuregulin family.
Function for NRG4 Gene
Molecular function for NRG4 Gene
- UniProtKB/Swiss-Prot Function:
- Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).
Phenotypes From GWAS Catalog for NRG4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 21516116 |
| GO:0008083 | growth factor activity | IEA | -- |
Phenotypes for NRG4 Gene
- MGI mutant phenotypes for NRG4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NRG4:
Animal Models for research
-
Taconic Biosciences Mouse Models for NRG4
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NRG4 - Starting at $85 >
- * NRG4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NRG4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRG4
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRG4
miRNA for NRG4 Gene
- miRTarBase miRNAs that target NRG4
-
- hsa-miR-215-5p (MIRT024936)
- hsa-miR-192-5p (MIRT026870)
- hsa-miR-6788-5p (MIRT454377)
- hsa-miR-30c-2-3p (MIRT454378)
- hsa-miR-30c-1-3p (MIRT454379)
- hsa-miR-4276 (MIRT454380)
- hsa-miR-6881-5p (MIRT454381)
- hsa-miR-8085 (MIRT454382)
- hsa-miR-6731-5p (MIRT454383)
- hsa-miR-6878-5p (MIRT454384)
- hsa-miR-4644 (MIRT454385)
- hsa-miR-4306 (MIRT454386)
- hsa-miR-185-5p (MIRT454387)
- hsa-miR-5194 (MIRT454388)
- hsa-miR-6738-5p (MIRT454389)
- hsa-miR-1914-3p (MIRT454390)
- hsa-miR-6133 (MIRT454391)
- hsa-miR-6130 (MIRT454392)
- hsa-miR-6129 (MIRT454393)
- hsa-miR-6127 (MIRT454394)
- hsa-miR-4510 (MIRT454395)
- hsa-miR-4419a (MIRT454396)
- hsa-miR-194-3p (MIRT454397)
- hsa-miR-5693 (MIRT454398)
- hsa-miR-4756-5p (MIRT454399)
- hsa-miR-1321 (MIRT454400)
- hsa-miR-4739 (MIRT454401)
- hsa-miR-6873-5p (MIRT454402)
- hsa-miR-6856-5p (MIRT454403)
- hsa-miR-6758-5p (MIRT454404)
miRNA products for research
Inhibitory RNAs for research
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Clone products for research
- Applied Biological Materials (abm): Clones for NRG4 - Starting at $45 >
- * NRG4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for NRG4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRG4
Cell Lines for research
-
Horizon Cell Lines for NRG4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRG4 Gene
Localization for NRG4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NRG4 Gene
- [Pro-neuregulin-4, membrane-bound isoform]: Cell membrane. Single-pass type I membrane protein. Note=Does not seem to be active. {ECO:0000250}.
- [Neuregulin-4]: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 4 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NRG4 Gene
Pathways & Interactions for NRG4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 3 | Signaling by ERBB2 | ||
| 4 | PI3K/AKT activation |
.89
|
|
| 5 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
Pathways by source for NRG4 Gene
3 BioSystems pathways for NRG4 Gene
71 Reactome pathways for NRG4 Gene
2 KEGG pathways for NRG4 Gene
1 GeneGo (Thomson Reuters) pathway for NRG4 Gene
- Development ERBB-family signaling
58 Qiagen pathways for NRG4 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
Interacting Proteins for NRG4 Gene
Selected Interacting proteins:
Q8WWG1-NRG4_HUMAN
ENSP00000378367
for NRG4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NRG4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0038128 | ERBB2 signaling pathway | TAS | -- |
| GO:0051897 | positive regulation of protein kinase B signaling | TAS | -- |
| GO:2000145 | regulation of cell motility | TAS | -- |
Transcripts for NRG4 Gene
mRNA/cDNA for NRG4 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000394907 3212 nts (view in UCSC)
- ENST00000461391 3406 nts (view in UCSC)
- ENST00000472094 2368 nts (view in UCSC)
- ENST00000498750 529 nts (view in UCSC)
- ENST00000562114 1036 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NRG4 - Starting at $85 >
- * NRG4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NRG4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRG4
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRG4
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NRG4
- Browse OriGene Inhibitory RNA Products For NRG4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRG4
Clone products for research
- Applied Biological Materials (abm): Clones for NRG4 - Starting at $45 >
- * NRG4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for NRG4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRG4
Relevant External Links for NRG4 Gene
- GeneLoc Exon Structure for
- NRG4
Expression for NRG4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Motor Neurons (Nervous System)
- Neurons
- Spinal Cord (Nervous System)
-
Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for NRG4 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.2), Brain - Cerebellum (x5.3), and Pancreas (x4.2).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRG4
SOURCE GeneReport for Unigene cluster for NRG4 Gene:
Hs.732438Evidence on tissue expression from TISSUES for NRG4 Gene
- Liver(4.4)
- Nervous system(3.2)
- Pancreas(2.4)
- Muscle(2.3)
Primer products for research
-
OriGene qPCR primer pairs for NRG4
-
OriGene qPCR primer pairs and template standards for NRG4
Gene Expression Assays for research
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRG4 Gene
Orthologs for NRG4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NRG4 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NRG4 29 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Nrg4 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Nrg4 29 16 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NRG4 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | NRG4 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NRG4 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | NRG4 29 30 |
|
OneToOne |
- Species where no ortholog for NRG4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for NRG4 Gene
- ENSEMBL:
- Gene Tree for NRG4 (if available)
- TreeFam:
- Gene Tree for NRG4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NRG4: view image
- Alliance of Genome Resources:
- Additional Orthologs for NRG4
Paralogs for NRG4 Gene
(9) SIMAP similar genes for NRG4 Gene using alignment to 7 proteins:
- NRG4_HUMAN
- E9PJI7_HUMAN
- F8W729_HUMAN
- H3BP63_HUMAN
- Q0P6N4_HUMAN
- Q0P6N5_HUMAN
- Q0P6N6_HUMAN
Variants for NRG4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRG4 Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs74024031 | Benign: not provided | 75,961,970(-) |
C/T NM_138573.4(NRG4):c.109G>A (p.Val37Ile) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2622n100 | CNV | gain | 25217958 |
| esv2749895 | CNV | deletion | 23290073 |
| esv2749898 | CNV | deletion | 23290073 |
| esv2749900 | CNV | deletion | 23290073 |
| esv3636933 | CNV | gain | 21293372 |
| nsv1108966 | CNV | deletion | 24896259 |
| nsv1116463 | OTHER | inversion | 24896259 |
| nsv518214 | CNV | loss | 19592680 |
| nsv518261 | CNV | loss | 19592680 |
| nsv569998 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.74;
33.04% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NRG4 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRG4 Gene
Disorders for NRG4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| type 2 diabetes mellitus |
|
|
Search NRG4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NRG4
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for NRG4 Gene
Publications for NRG4 Gene
- The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis. (PMID: 25401691) Wang GX … Lin JD (Nature medicine 2014) 2 3
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
- Characterization of the cell membrane-associated products of the Neuregulin 4 gene. (PMID: 17684490) Hayes NV … Gullick WJ (Oncogene 2008) 3 22
- Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer. (PMID: 17545517) Hayes NV … Gullick WJ (Clinical cancer research : an official journal of the American Association for Cancer Research 2007) 3 22
- Expression of HER3, HER4 and their ligand heregulin-4 is associated with better survival in bladder cancer patients. (PMID: 15583696) Memon AA … Nexo E (British journal of cancer 2004) 3 22
ExternalLinks
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- antibodies-online: Show 14 available Neuregulin 4 Antibodies ranked by validation data
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- antibodies-online: Show 21 available Neuregulin 4 Proteins ranked by validation data
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- Biorbyt antibodies for NRG4
Sources for NRG4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources