Aliases for NRG4 Gene
External Ids for NRG4 Gene
Previous GeneCards Identifiers for NRG4 Gene
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
GeneCards Summary for NRG4 Gene
NRG4 (Neuregulin 4) is a Protein Coding gene. Diseases associated with NRG4 include Her2-Receptor Positive Breast Cancer. Among its related pathways are RET signaling and Downstream signaling events of B Cell Receptor (BCR). Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity. An important paralog of this gene is NRG2.
UniProtKB/Swiss-Prot Summary for NRG4 Gene
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).