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The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
NRG4 (Neuregulin 4) is a Protein Coding gene. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity. An important paralog of this gene is NRG1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IEA | -- |
GO:0005515 | protein binding | IPI | 21516116 |
GO:0008083 | growth factor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
3 | Signaling by ERBB2 | ||
4 | GAB1 signalosome |
.89
|
|
5 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0007399 | nervous system development | IEA | -- |
GO:0035556 | intracellular signal transduction | IBA | -- |
GO:0038128 | ERBB2 signaling pathway | TAS | -- |
GO:0048513 | animal organ development | IBA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NRG4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NRG4 30 |
|
||
Rat (Rattus norvegicus) |
Mammalia | Nrg4 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Nrg4 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NRG4 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NRG4 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NRG4 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NRG4 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
783718 | Benign: not provided | 75,961,970(-) | C/T | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2622n100 | CNV | gain | 25217958 |
esv2749895 | CNV | deletion | 23290073 |
esv2749898 | CNV | deletion | 23290073 |
esv2749900 | CNV | deletion | 23290073 |
esv3636933 | CNV | gain | 21293372 |
nsv1108966 | CNV | deletion | 24896259 |
nsv1116463 | OTHER | inversion | 24896259 |
nsv518214 | CNV | loss | 19592680 |
nsv518261 | CNV | loss | 19592680 |
nsv569998 | CNV | gain | 21841781 |
No disorders were found for NRG4 Gene.