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The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008] See more...
Aliases for NRG4 Gene
Aliases for NRG4 Gene
External Ids for NRG4 Gene
- HGNC: 29862
- Entrez Gene: 145957
- Ensembl: ENSG00000169752
- OMIM: 610894
- UniProtKB: Q8WWG1
Previous GeneCards Identifiers for NRG4 Gene
- GC15M074022
- GC15M076233
- GC15M052990
Summaries for NRG4 Gene
-
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
GeneCards Summary for NRG4 Gene
NRG4 (Neuregulin 4) is a Protein Coding gene. Diseases associated with NRG4 include Her2-Receptor Positive Breast Cancer. Among its related pathways are RET signaling and Downstream signaling events of B Cell Receptor (BCR). Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity. An important paralog of this gene is NRG2.
UniProtKB/Swiss-Prot Summary for NRG4 Gene
-
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRG4 Gene
Genomics for NRG4 Gene
GeneHancer (GH) Regulatory Elements for NRG4 Gene
Promoters and enhancers for NRG4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NRG4 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRG4
- Top Transcription factor binding sites by QIAGEN in the NRG4 gene promoter:
-
- AML1a
- CUTL1
- E4BP4
- FOXJ2
- FOXJ2 (long isoform)
- HFH-1
- Hlf
- IRF-1
- Pax-4a
- TGIF
Genomic Locations for NRG4 Gene
Genomic Locations for NRG4 Gene
- chr15:75,935,969-76,059,795
- (GRCh38/hg38)
- Size:
- 123,827 bases
- Orientation:
- Minus strand
- chr15:76,228,310-76,352,136
- (GRCh37/hg19)
- Size:
- 123,827 bases
- Orientation:
- Minus strand
Genomic View for NRG4 Gene
Genes around NRG4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q24.2 by HGNC
- 15q24.2 by Entrez Gene
- 15q24.2 by Ensembl
NRG4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NRG4 Gene
Proteins for NRG4 Gene
-
Protein details for NRG4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WWG1-NRG4_HUMAN
- Recommended name:
- Pro-neuregulin-4, membrane-bound isoform
- Protein Accession:
- Q8WWG1
- A6NIE8
Protein attributes for NRG4 Gene
- Size:
- 115 amino acids
- Molecular mass:
- 12722 Da
- Quaternary structure:
-
- Interacts with ERBB4.
Post-translational modifications for NRG4 Gene
- Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
- Extensive glycosylation precedes the proteolytic cleavage.
-
Glycosylation at Asn39
- NX_Q8WWG1 (NX_Q8WWG1-1)
Other Protein References for NRG4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ NRG4 Antibody
- Creative Diagnostics Anti-NRG4 monoclonal antibody
- Creative Biolabs Mouse Anti-NRG4 Recombinant Antibody (CBFYH-2684)
-
Custom Antibody ServicesOriGene Antibodies for NRG4
- Novus Biologicals Antibodies for NRG4
-
Abcam antibodies for NRG4
- Invitrogen Antibodies for NRG4 (AFLGC-NRG4)
-
Biorbyt antibodies for NRG4
-
Santa Cruz Biotechnology (SCBT) Antibodies for NRG4
- Sino Biological Antibodies for NRG4
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for NRG4
- Origene Custom Protein Services for NRG4
- Sino Biological Recombinant Proteins for NRG4
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for NRG4
-
Signalway Proteins for NRG4
-
ProSci Proteins for NRG4
-
Abcam proteins for NRG4
Assay Products
- G Biosciences Immunotag™ Human NRG-4 (Neuregulin 4) ELISA
- Creative Diagnostics Human NRG4 ELISA KIT
- Aviva Systems Biology NRG4 ELISA Kit (Human) (OKCD01642)
- Novus Biologicals ELISA Kits for NRG4
-
Signalway ELISA kits for NRG4
No data available for DME Specific Peptides for NRG4 Gene
Domains & Families for NRG4 Gene
Gene Families for NRG4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for NRG4 Gene
- Blocks:
-
- Type I EGF
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NRG4 Gene
- GenScript: Design optimal peptide antigens:
-
- Pro-neuregulin-4, membrane-bound isoform (NRG4_HUMAN)
- Neuregulin 4 (Q0P6N4_HUMAN)
- Neuregulin 4 (Q0P6N5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8WWG1UniProtKB/Swiss-Prot:
NRG4_HUMAN :- The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
- Belongs to the neuregulin family.
- Domain:
-
- The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
- ERBB receptor binding is elicited entirely by the EGF-like domain.
- Family:
-
- Belongs to the neuregulin family.
Function for NRG4 Gene
Molecular function for NRG4 Gene
- UniProtKB/Swiss-Prot Function:
- Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).
Phenotypes From GWAS Catalog for NRG4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IBA,IEA | 21873635 |
| GO:0005515 | protein binding | IPI | 21516116 |
| GO:0008083 | growth factor activity | IEA | -- |
Phenotypes for NRG4 Gene
- MGI mutant phenotypes for NRG4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NRG4:
Animal Model Products
-
Taconic Biosciences Mouse Models for NRG4
CRISPR Products
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-
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRG4
- genomics-online: gRNA clones - Search for available Neuregulin 4 gRNA products
- Overview of 95 available Neuregulin 4 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRG4
miRNA for NRG4 Gene
- miRTarBase miRNAs that target NRG4
-
- hsa-mir-215-5p (MIRT024936)
- hsa-mir-192-5p (MIRT026870)
- hsa-mir-6788-5p (MIRT454377)
- hsa-mir-30c-2-3p (MIRT454378)
- hsa-mir-30c-1-3p (MIRT454379)
- hsa-mir-4276 (MIRT454380)
- hsa-mir-6881-5p (MIRT454381)
- hsa-mir-8085 (MIRT454382)
- hsa-mir-6731-5p (MIRT454383)
- hsa-mir-6878-5p (MIRT454384)
- hsa-mir-4644 (MIRT454385)
- hsa-mir-4306 (MIRT454386)
- hsa-mir-185-5p (MIRT454387)
- hsa-mir-5194 (MIRT454388)
- hsa-mir-6738-5p (MIRT454389)
- hsa-mir-1914-3p (MIRT454390)
- hsa-mir-6133 (MIRT454391)
- hsa-mir-6130 (MIRT454392)
- hsa-mir-6129 (MIRT454393)
- hsa-mir-6127 (MIRT454394)
- hsa-mir-4510 (MIRT454395)
- hsa-mir-4419a (MIRT454396)
- hsa-mir-194-3p (MIRT454397)
- hsa-mir-5693 (MIRT454398)
- hsa-mir-4756-5p (MIRT454399)
- hsa-mir-1321 (MIRT454400)
- hsa-mir-4739 (MIRT454401)
- hsa-mir-6873-5p (MIRT454402)
- hsa-mir-6856-5p (MIRT454403)
- hsa-mir-6758-5p (MIRT454404)
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for NRG4 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for NRG4
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Cell Line Products
-
Horizon Cell Lines for NRG4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRG4 Gene
Localization for NRG4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NRG4 Gene
- [Pro-neuregulin-4, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active. {ECO:0000250}.
- [Neuregulin-4]: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 4 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NRG4 Gene
Pathways & Interactions for NRG4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 3 | Signaling by ERBB2 | ||
| 4 | GAB1 signalosome |
.89
|
|
| 5 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
Pathways by source for NRG4 Gene
3 BioSystems pathways for NRG4 Gene
71 Reactome pathways for NRG4 Gene
1 KEGG pathway for NRG4 Gene
1 GeneGo (Thomson Reuters) pathway for NRG4 Gene
- Development ERBB-family signaling
58 Qiagen pathways for NRG4 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
Interacting Proteins for NRG4 Gene
Selected Interacting proteins:
Q8WWG1-NRG4_HUMAN
ENSP00000378367
for NRG4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NRG4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0035556 | intracellular signal transduction | IBA | 21873635 |
| GO:0038128 | ERBB2 signaling pathway | TAS | -- |
| GO:0051897 | positive regulation of protein kinase B signaling | TAS | -- |
Transcripts for NRG4 Gene
mRNA/cDNA for NRG4 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000394907 3212 bps (ENST00000394907.8)
- ENST00000461391 3406 bps (ENST00000461391.5)
- ENST00000472094 2368 bps (ENST00000472094.5)
- ENST00000498750 529 bps (ENST00000498750.5)
- ENST00000562114 1036 bps (ENST00000562114.5)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NRG4 - Select products 50% OFF >
- * NRG4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NRG4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRG4
- genomics-online: gRNA clones - Search for available Neuregulin 4 gRNA products
- Overview of 95 available Neuregulin 4 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRG4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NRG4
- Browse OriGene Inhibitory RNA Products For NRG4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRG4
- genomics-online: shRNA clones - Search for available Neuregulin 4 shRNA products
- Overview of 95 available Neuregulin 4 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for NRG4 - Select products 50% OFF >
- * NRG4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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- Sino Biological Human cDNA Clone for NRG4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRG4
Relevant External Links for NRG4 Gene
- GeneLoc Exon Structure for
- NRG4
Expression for NRG4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Motor Neurons (Nervous System)
- Neurons
- Spinal Cord (Nervous System)
-
Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for NRG4 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.2), Brain - Cerebellum (x5.3), and Pancreas (x4.2).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRG4
SOURCE GeneReport for Unigene cluster for NRG4 Gene:
Hs.732438Evidence on tissue expression from TISSUES for NRG4 Gene
- Liver(4.3)
- Nervous system(2.4)
Primer Products
-
OriGene qPCR primer pairs for NRG4
-
OriGene qPCR primer pairs and template standards for NRG4
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRG4 Gene
Orthologs for NRG4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NRG4 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NRG4 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nrg4 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Nrg4 17 31 30 |
|
||
| dog (Canis familiaris) |
Mammalia | NRG4 31 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | NRG4 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | NRG4 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NRG4 31 30 |
|
OneToOne |
- Species where no ortholog for NRG4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for NRG4 Gene
- ENSEMBL:
- Gene Tree for NRG4 (if available)
- TreeFam:
- Gene Tree for NRG4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NRG4: view image
Paralogs for NRG4 Gene
(9) SIMAP similar genes for NRG4 Gene using alignment to 7 proteins:
- NRG4_HUMAN
- E9PJI7_HUMAN
- F8W729_HUMAN
- H3BP63_HUMAN
- Q0P6N4_HUMAN
- Q0P6N5_HUMAN
- Q0P6N6_HUMAN
Variants for NRG4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRG4 Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 783718 | Benign: not provided | 75,961,970(-) | C/T | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2622n100 | CNV | gain | 25217958 |
| esv2749895 | CNV | deletion | 23290073 |
| esv2749898 | CNV | deletion | 23290073 |
| esv2749900 | CNV | deletion | 23290073 |
| esv3636933 | CNV | gain | 21293372 |
| nsv1108966 | CNV | deletion | 24896259 |
| nsv1116463 | OTHER | inversion | 24896259 |
| nsv518214 | CNV | loss | 19592680 |
| nsv518261 | CNV | loss | 19592680 |
| nsv569998 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.74;
33.04% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NRG4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRG4 Gene
Disorders for NRG4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| her2-receptor positive breast cancer |
|
|
Search NRG4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NRG4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NRG4 Gene
Publications for NRG4 Gene
- The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis. (PMID: 25401691) Wang GX … Lin JD (Nature medicine 2014) 2 3 54
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
- Characterization of the cell membrane-associated products of the Neuregulin 4 gene. (PMID: 17684490) Hayes NV … Gullick WJ (Oncogene 2008) 3 23 54
- Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer. (PMID: 17545517) Hayes NV … Gullick WJ (Clinical cancer research : an official journal of the American Association for Cancer Research 2007) 3 23 54
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
ExternalLinks
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- antibodies-online: Show 14 available Neuregulin 4 Antibodies ranked by validation data
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- Overview of 95 available Neuregulin 4 gene related products
- orf clones - Search for available Neuregulin 4 ORF products
- Overview of 95 available Neuregulin 4 gene related products
- genomics-online: gRNA clones - Search for available Neuregulin 4 gRNA products
- Overview of 95 available Neuregulin 4 gene related products
- genomics-online: primer clones - Search for available Neuregulin 4 Primer products
- Overview of 95 available Neuregulin 4 gene related products
- genomics-online: shRNA clones - Search for available Neuregulin 4 shRNA products
- Overview of 95 available Neuregulin 4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRG4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRG4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NRG4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRG4
- Biorbyt antibodies for NRG4
Sources for NRG4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody