NRG3 Gene (Protein Coding)

Neuregulin 3

GC10P083672
GIFtS:
41
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apopt... See more...

Aliases for NRG3 Gene

Aliases for NRG3 Gene

  • Neuregulin 3 2 3 5
  • Pro-Neuregulin-3, Membrane-Bound Isoform 3 4
  • Pro-NRG3 3 4
  • Neuregulin-3-Like Polypeptide 3
  • HRG3 3
  • NRG3 5

External Ids for NRG3 Gene

Previous GeneCards Identifiers for NRG3 Gene

  • GC10U990072
  • GC10P083766
  • GC10P083299
  • GC10P083625
  • GC10P077483
  • GC10P081876
  • GC10P082102
  • GC10P082133
  • GC10P082165
  • GC10P083205
  • GC10P082030
  • GC10P081961

Summaries for NRG3 Gene

Entrez Gene Summary for NRG3 Gene

  • This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]

GeneCards Summary for NRG3 Gene

NRG3 (Neuregulin 3) is a Protein Coding gene. Diseases associated with NRG3 include Schizophrenia and Schizoaffective Disorder. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and receptor tyrosine kinase binding. An important paralog of this gene is NRG2.

UniProtKB/Swiss-Prot Summary for NRG3 Gene

  • Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.

Gene Wiki entry for NRG3 Gene

Additional gene information for NRG3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRG3 Gene

Genomics for NRG3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NRG3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10J081874 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +1.2 1211 4.8 KDM1A ZFX SP2 RAD21 CTCF CTBP1 EZH2 ZBTB26 ZNF513 SIN3A ENSG00000287358 NRG3 piR-38051-045
GH10J082799 Promoter 0.3 EPDnew 600 +924.5 924545 0.1 NRG3 piR-61945-053 piR-38716-015
GH10J082816 Promoter 0.3 EPDnew 600 +941.6 941562 0.1 NRG3 piR-61945-053 HSALNG0079275
GH10J081847 Enhancer 0.5 Ensembl ENCODE 12.1 -27.7 -27681 1 TEAD4 POU5F1 NRG3 piR-31470-057 lnc-DYDC1-2
GH10J081846 Enhancer 0.3 Ensembl 11.6 -29.4 -29389 0.4 ATF4 NRG3 piR-31470-057 lnc-DYDC1-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRG3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRG3

Top Transcription factor binding sites by QIAGEN in the NRG3 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-5
  • Gfi-1

Genomic Locations for NRG3 Gene

Genomic Locations for NRG3 Gene
chr10:81,875,190-82,989,979
(GRCh38/hg38)
Size:
1,114,790 bases
Orientation:
Plus strand
chr10:83,635,070-84,746,935
(GRCh37/hg19)
Size:
1,111,866 bases
Orientation:
Plus strand

Genomic View for NRG3 Gene

Genes around NRG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRG3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NRG3 Gene

Proteins for NRG3 Gene

Products:

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  • Protein details for NRG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56975-NRG3_HUMAN
    Recommended name:
    Pro-neuregulin-3, membrane-bound isoform
    Protein Accession:
    P56975
    Secondary Accessions:
    • A4D7U1
    • Q0PEH2
    • Q5VYH3

    Protein attributes for NRG3 Gene

    Size:
    720 amino acids
    Molecular mass:
    77901 Da
    Quaternary structure:
    • Interacts with ERBB4.

    Alternative splice isoforms for NRG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRG3 Gene

Protein Expression for NRG3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NRG3 Gene

  • Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
  • Extensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated.
  • Glycosylation at Thr276, Thr277, Thr278, Ser280, and Thr281
  • Modification sites at PhosphoSitePlus

Other Protein References for NRG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NRG3 Gene

Domains & Families for NRG3 Gene

Gene Families for NRG3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for NRG3 Gene

InterPro:
Blocks:
  • Type I EGF
ProtoNet:

Suggested Antigen Peptide Sequences for NRG3 Gene

GenScript: Design optimal peptide antigens:
  • Neuregulin 3 (B9EGV5_HUMAN)
  • Neuregulin 3 variant 1 (D9ZHP6_HUMAN)
  • Neuregulin 3 variant 3 (D9ZHP7_HUMAN)
  • Neuregulin 3 variant 4 (D9ZHP8_HUMAN)
  • Neuregulin 3 variant 5 (D9ZHP9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P56975

UniProtKB/Swiss-Prot:

NRG3_HUMAN :
  • The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
  • Belongs to the neuregulin family.
Domain:
  • The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
  • ERBB receptor binding is elicited entirely by the EGF-like domain.
Family:
  • Belongs to the neuregulin family.
genes like me logo Genes that share domains with NRG3: view

Function for NRG3 Gene

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Molecular function for NRG3 Gene

UniProtKB/Swiss-Prot Function:
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.

Phenotypes From GWAS Catalog for NRG3 Gene

Gene Ontology (GO) - Molecular Function for NRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA,IBA 21873635
GO:0008083 growth factor activity NAS 9275162
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity NAS 9275162
GO:0030971 receptor tyrosine kinase binding NAS 9275162
GO:0045499 chemorepellent activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with NRG3: view
genes like me logo Genes that share phenotypes with NRG3: view

Animal Models for NRG3 Gene

MGI Knock Outs for NRG3:
  • Nrg3 Nrg3<tm1.1Plet>

Animal Model Products

  • Taconic Biosciences Mouse Models for NRG3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRG3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRG3 Gene

Localization for NRG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRG3 Gene

[Pro-neuregulin-3, membrane-bound isoform]: Cell membrane. Single-pass type I membrane protein. Note=Does not seem to be active. {ECO:0000250}.
[Neuregulin-3]: Secreted.
[Isoform 3]: Cell membrane. Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRG3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 9275162
GO:0005615 extracellular space IBA 21873635
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane NAS 9275162
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NRG3: view

Pathways & Interactions for NRG3 Gene

PathCards logo

SuperPathways for NRG3 Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Apoptotic Pathways in Synovial Fibroblasts
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
3 Signaling by ERBB2
Downregulation of ERBB2 signaling
.59
Signaling by ERBB2
.59
SHC1 events in ERBB2 signaling
.43
ERBB2 Activates PTK6 Signaling
.01
ERBB2 Regulates Cell Motility
.01
GRB2 events in ERBB2 signaling
.01
PI3K events in ERBB2 signaling
.01
PI3K events in ERBB4 signaling
.01
SHC1 events in ERBB4 signaling
.01
4 GAB1 signalosome
Negative regulation of the PI3K/AKT network
.93
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
.93
PIP3 activates AKT signaling
.91
Role of LAT2/NTAL/LAB on calcium mobilization
.91
GAB1 signalosome
.89
PI3K/AKT activation
.89
Constitutive Signaling by Aberrant PI3K in Cancer
.75
PI3K/AKT Signaling in Cancer
.72
5 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
genes like me logo Genes that share pathways with NRG3: view

Pathways by source for NRG3 Gene

1 PharmGKB pathway for NRG3 Gene
1 KEGG pathway for NRG3 Gene
1 GeneGo (Thomson Reuters) pathway for NRG3 Gene
  • Development ERBB-family signaling
58 Qiagen pathways for NRG3 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

SIGNOR curated interactions for NRG3 Gene

Activates:

Gene Ontology (GO) - Biological Process for NRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 9275162
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA --
GO:0007389 pattern specification process IEA --
GO:0007399 nervous system development IEA --
GO:0021842 chemorepulsion involved in interneuron migration from the subpallium to the cortex IEA --
genes like me logo Genes that share ontologies with NRG3: view

Drugs & Compounds for NRG3 Gene

Products:

  1. Drug

(2) Drugs for NRG3 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iloperidone Approved Pharma Antagonist Dopamine (D2) and serotonin (5HT2) receptor antagonist 23
genes like me logo Genes that share compounds with NRG3: view

Transcripts for NRG3 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for NRG3 Gene

7 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRG3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRG3 Gene

No ASD Table

Relevant External Links for NRG3 Gene

GeneLoc Exon Structure for
NRG3

Expression for NRG3 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NRG3 Gene

mRNA expression in normal human tissues for NRG3 Gene
mRNA expression by GTEx for NRG3 GenemRNA expression by BioGPS for NRG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRG3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.1), Brain - Anterior cingulate cortex (BA24) (x6.5), Brain - Cortex (x6.1), Brain - Amygdala (x5.1), Brain - Hippocampus (x4.7), and Brain - Hypothalamus (x4.0).

Protein differential expression in normal tissues from HIPED for NRG3 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NRG3 Gene



Protein tissue co-expression partners for NRG3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRG3

SOURCE GeneReport for Unigene cluster for NRG3 Gene:

Hs.125119

mRNA Expression by UniProt/SwissProt for NRG3 Gene:

P56975-NRG3_HUMAN
Tissue specificity: Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for NRG3 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with NRG3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NRG3 Gene

Orthologs for NRG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRG3 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
 Mammalia NRG3 30 31
  • 93.85 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia NRG3 30 31
  • 91.08 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Nrg3 30 17 31
  • 90.12 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Nrg3 30
  • 88.62 (n)
Chimpanzee
(Pan troglodytes)
 Mammalia NRG3 31
  • 84 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia NRG3 31
  • 77 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves NRG3 30 31
  • 80.27 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia NRG3 31
  • 73 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia nrg3 30
  • 71.31 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.31978 30
Zebrafish
(Danio rerio)
 Actinopterygii LOC101882495 30
  • 53.27 (n)
NRG3 31
  • 23 (a)
 OneToOne
Species where no ortholog for NRG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NRG3 Gene

ENSEMBL:
Gene Tree for NRG3 (if available)
TreeFam:
Gene Tree for NRG3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NRG3: view image

Paralogs for NRG3 Gene

Paralogs for NRG3 Gene

(2) SIMAP similar genes for NRG3 Gene using alignment to 15 proteins:

  • NRG3_HUMAN
  • B9EGV5_HUMAN
  • D9ZHP6_HUMAN
  • D9ZHP7_HUMAN
  • D9ZHP8_HUMAN
  • D9ZHP9_HUMAN
  • D9ZHQ0_HUMAN
  • D9ZHQ1_HUMAN
  • D9ZHQ2_HUMAN
  • D9ZHQ3_HUMAN
  • D9ZHQ5_HUMAN
  • D9ZHQ6_HUMAN
  • D9ZHQ7_HUMAN
  • D9ZHQ8_HUMAN
  • R4GNI6_HUMAN
genes like me logo Genes that share paralogs with NRG3: view

Variants for NRG3 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRG3 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
691406 Uncertain Significance: Hirschsprung disease 81,878,019(+) C/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
691407 Uncertain Significance: Hirschsprung disease 82,985,284(+) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
691408 Uncertain Significance: Hirschsprung disease 82,985,500(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
716399 Benign: not provided 81,875,637(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
717976 Benign: not provided 82,958,962(+) C/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for NRG3 Gene

Structural Variations from Database of Genomic Variants (DGV) for NRG3 Gene

Variant ID Type Subtype PubMed ID
dgv1300n54 CNV gain 21841781
dgv1301n54 CNV gain 21841781
dgv1302n54 CNV loss 21841781
dgv1303n54 CNV loss 21841781
dgv1304n54 CNV loss 21841781
dgv1305n54 CNV loss 21841781
dgv1306n54 CNV loss 21841781
dgv1307n54 CNV loss 21841781
dgv1308n54 CNV loss 21841781
dgv1309n54 CNV loss 21841781
dgv1310n54 CNV gain 21841781
dgv153e214 CNV gain 21293372
dgv154e214 CNV loss 21293372
dgv155e214 CNV gain 21293372
dgv158e199 CNV deletion 23128226
dgv165n67 CNV loss 20364138
dgv259e212 CNV gain 25503493
dgv260e212 CNV loss 25503493
dgv261e212 CNV loss 25503493
dgv262e212 CNV loss 25503493
dgv263e212 CNV gain 25503493
dgv486n106 CNV deletion 24896259
dgv487n106 CNV deletion 24896259
dgv7n50 CNV loss 21212237
dgv942n100 CNV gain 25217958
dgv943n100 CNV loss 25217958
dgv944n100 CNV gain 25217958
dgv945n100 CNV gain 25217958
esv1006949 CNV deletion 20482838
esv1211637 CNV deletion 17803354
esv1370318 CNV deletion 17803354
esv1787554 CNV insertion 17803354
esv1981738 CNV deletion 18987734
esv22050 CNV loss 19812545
esv2287780 CNV deletion 18987734
esv2304405 CNV deletion 18987734
esv2421719 CNV deletion 20811451
esv2422053 CNV deletion 20811451
esv24251 CNV loss 19812545
esv2427309 CNV loss 19546169
esv24433 CNV loss 19812545
esv2526609 CNV deletion 19546169
esv2660411 CNV deletion 23128226
esv2665966 CNV deletion 23128226
esv2669227 CNV deletion 23128226
esv2671454 CNV deletion 23128226
esv2676643 CNV deletion 23128226
esv2678481 CNV deletion 23128226
esv2759771 CNV loss 17122850
esv2759772 CNV gain 17122850
esv2759773 CNV loss 17122850
esv2760161 CNV loss 21179565
esv2761613 CNV loss 21179565
esv2762875 CNV loss 21179565
esv2762876 CNV loss 21179565
esv2763991 CNV gain 21179565
esv2764180 CNV loss 21179565
esv28936 CNV loss 19812545
esv3262051 CNV deletion 24192839
esv33611 CNV loss 17666407
esv34368 CNV loss 17911159
esv3451380 CNV insertion 20981092
esv35106 CNV gain 17911159
esv3546576 CNV deletion 23714750
esv3546577 CNV deletion 23714750
esv3546579 CNV deletion 23714750
esv3546580 CNV deletion 23714750
esv3546583 CNV deletion 23714750
esv3577483 CNV gain 25503493
esv3577505 CNV gain 25503493
esv3579003 CNV loss 25503493
esv3579008 CNV loss 25503493
esv3579010 CNV loss 25503493
esv3579013 CNV loss 25503493
esv3579014 CNV loss 25503493
esv3579015 CNV loss 25503493
esv3579017 CNV loss 25503493
esv3579018 CNV loss 25503493
esv3579019 CNV loss 25503493
esv3579020 CNV loss 25503493
esv3623983 CNV loss 21293372
esv3623985 CNV loss 21293372
esv3623988 CNV loss 21293372
esv3623989 CNV loss 21293372
esv3623990 CNV loss 21293372
esv3623994 CNV loss 21293372
esv3623995 CNV loss 21293372
esv3623997 CNV loss 21293372
esv3624001 CNV loss 21293372
esv3624002 CNV loss 21293372
esv3624003 CNV loss 21293372
esv3624005 CNV loss 21293372
esv3624006 CNV loss 21293372
esv3891870 CNV loss 25118596
esv3891872 CNV loss 25118596
esv3891873 CNV gain 25118596
esv3891875 CNV loss 25118596
esv4025 CNV loss 18987735
esv5009 CNV loss 18987735
esv7990 CNV loss 19470904
nsv1038141 CNV loss 25217958
nsv1039464 CNV loss 25217958
nsv1049033 CNV loss 25217958
nsv1049314 CNV loss 25217958
nsv1050875 CNV loss 25217958
nsv1051317 CNV loss 25217958
nsv1053411 CNV gain 25217958
nsv1053827 CNV gain 25217958
nsv1054328 CNV loss 25217958
nsv1055074 CNV loss 25217958
nsv1113321 CNV deletion 24896259
nsv1121817 CNV deletion 24896259
nsv1141011 CNV deletion 24896259
nsv1141879 OTHER inversion 24896259
nsv1143511 CNV deletion 24896259
nsv1143644 CNV deletion 24896259
nsv1144504 CNV deletion 24896259
nsv1145797 CNV deletion 26484159
nsv1149299 CNV duplication 26484159
nsv24044 CNV deletion 16902084
nsv24927 CNV deletion 16902084
nsv436117 CNV deletion 17901297
nsv442196 CNV loss 18776908
nsv442197 CNV gain 18776908
nsv442198 CNV gain+loss 18776908
nsv467402 CNV loss 19166990
nsv467403 CNV gain 19166990
nsv474746 CNV novel sequence insertion 20440878
nsv507565 OTHER sequence alteration 20534489
nsv514578 CNV loss 21397061
nsv514579 CNV loss 21397061
nsv516167 CNV loss 19592680
nsv516182 CNV loss 19592680
nsv516267 CNV loss 19592680
nsv516930 CNV loss 19592680
nsv517505 CNV gain+loss 19592680
nsv517782 CNV loss 19592680
nsv518939 CNV loss 19592680
nsv526120 CNV loss 19592680
nsv527270 CNV loss 19592680
nsv527301 CNV loss 19592680
nsv527348 CNV loss 19592680
nsv551669 CNV gain 21841781
nsv551670 CNV loss 21841781
nsv551674 CNV gain 21841781
nsv551682 CNV gain+loss 21841781
nsv551689 CNV loss 21841781
nsv551692 CNV loss 21841781
nsv551704 CNV loss 21841781
nsv551705 CNV loss 21841781
nsv551706 CNV loss 21841781
nsv551730 CNV loss 21841781
nsv551731 CNV loss 21841781
nsv551732 CNV loss 21841781
nsv551733 CNV gain 21841781
nsv551736 CNV loss 21841781
nsv551737 CNV loss 21841781
nsv7398 CNV insertion 18451855
nsv7410 CNV insertion 18451855
nsv818776 CNV gain 17921354
nsv818779 CNV loss 17921354
nsv825483 CNV loss 20364138
nsv831925 CNV gain 17160897
nsv831927 CNV gain 17160897
nsv831928 CNV gain 17160897
nsv8711 CNV gain 18304495
nsv955649 CNV deletion 24416366
nsv956935 CNV deletion 24416366
nsv975065 CNV deletion 23825009

Variation tolerance for NRG3 Gene

Residual Variation Intolerance Score: 19.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.74; 73.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRG3 Gene

Human Gene Mutation Database (HGMD)
NRG3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRG3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRG3 Gene

Disorders for NRG3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NRG3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • sczd
schizoaffective disorder
  • schizo-affective psychosis
hirschsprung disease 1
  • hirschsprung disease, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search NRG3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRG3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NRG3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRG3 Gene

Publications for NRG3 Gene

  1. Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. (PMID: 9275162) Zhang D … Godowski PJ (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 23
  2. Neuregulin 3 genetic variations and susceptibility to schizophrenia in a Chinese population. (PMID: 18708184) Wang YC … Liou YJ (Biological psychiatry 2008) 3 23 41
  3. Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival. (PMID: 16478787) Carteron C … Cabedo H (Journal of cell science 2006) 3 4 23
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41

ExternalLinks

View latest publications for NRG3 gene in Mastermind

Products for NRG3 Gene

  • Signalway ELISA kits for NRG3
  • Signalway Proteins for NRG3

Sources for NRG3 Gene