Aliases for NRG3 Gene
Aliases for NRG3 Gene
External Ids for NRG3 Gene
- HGNC: 7999
- Entrez Gene: 10718
- Ensembl: ENSG00000185737
- OMIM: 605533
- UniProtKB: P56975
Previous GeneCards Identifiers for NRG3 Gene
- GC10U990072
- GC10P083766
- GC10P083299
- GC10P083625
- GC10P077483
Summaries for NRG3 Gene
-
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]
GeneCards Summary for NRG3 Gene
NRG3 (Neuregulin 3) is a Protein Coding gene. Diseases associated with NRG3 include Schizophrenia. Among its related pathways are RET signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include receptor binding and receptor tyrosine kinase binding. An important paralog of this gene is NRG1.
UniProtKB/Swiss-Prot for NRG3 Gene
-
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Additional gene information for NRG3 Gene
- Monarch Initiative
- Search for NRG3 at DataMed
- Search for NRG3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRG3 Gene
Genomics for NRG3 Gene
GeneHancer (GH) Regulatory Elements for NRG3 Gene
Promoters and enhancers for NRG3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH10I081874 | Promoter/Enhancer | 1.5 | EPDnew Ensembl ENCODE | 550.8 | -0.3 | -316 | 0.8 | CTCF CTBP1 MXI1 SP2 ZBTB26 EZH2 | NRG3 LOC105378390 | |
| GH10I081876 | Enhancer | 0.5 | ENCODE | 550.8 | +1.2 | 1239 | 0.5 | SRF SIN3A CTBP2 EZH2 | NRG3 ENSG00000229458 | |
| GH10I081964 | Enhancer | 0.3 | FANTOM5 | 11.2 | +89.4 | 89372 | 0.4 | NRG3 ENSG00000229458 | ||
| GH10I081847 | Enhancer | 0.2 | ENCODE | 12 | -27.4 | -27449 | 0.2 | NRG3 LOC105378389 LOC105378390 | ||
| GH10I082352 | Enhancer | 0.2 | FANTOM5 | 1.9 | +477.6 | 477569 | 0 | NRG3 RNU6-441P PIR38961 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NRG3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for NRG3 Gene
Genomic Locations for NRG3 Gene
- chr10:81,875,309-82,987,179
- (GRCh38/hg38)
- Size:
- 1,111,871 bases
- Orientation:
- Plus strand
- chr10:83,635,070-84,746,935
- (GRCh37/hg19)
Genomic View for NRG3 Gene
Genes around NRG3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q23.1 by Ensembl
- 10q23.1 by Entrez Gene
- 10q23.1 by HGNC
NRG3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NRG3 Gene
Proteins for NRG3 Gene
-
Protein details for NRG3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P56975-NRG3_HUMAN
- Recommended name:
- Pro-neuregulin-3, membrane-bound isoform
- Protein Accession:
- P56975
- A4D7U1
- Q0PEH2
- Q5VYH3
Protein attributes for NRG3 Gene
- Size:
- 720 amino acids
- Molecular mass:
- 77901 Da
- Quaternary structure:
-
- Interacts with ERBB4.
Protein Expression for NRG3 Gene
Post-translational modifications for NRG3 Gene
- Extensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated.
- Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
- Glycosylation at isoforms=2, 4276, isoforms=2, 4277, isoforms=2, 4278, isoforms=2, 4280, and Thr281
- Modification sites at PhosphoSitePlus
Other Protein References for NRG3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam proteins for NRG3
Assay Products
-
Cloud-Clone Corp. Assay Kits for NRG3
No data available for DME Specific Peptides for NRG3 Gene
Domains & Families for NRG3 Gene
Gene Families for NRG3 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted membrane proteins
Protein Domains for NRG3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NRG3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P56975UniProtKB/Swiss-Prot:
NRG3_HUMAN :- The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
- Belongs to the neuregulin family.
- Domain:
-
- The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
- ERBB receptor binding is elicited entirely by the EGF-like domain.
- Family:
-
- Belongs to the neuregulin family.
Function for NRG3 Gene
Molecular function for NRG3 Gene
- UniProtKB/Swiss-Prot Function:
- Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Phenotypes From GWAS Catalog for NRG3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | receptor binding | IBA | -- |
| GO:0008083 | growth factor activity | NAS | 9275162 |
| GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity | NAS | 9275162 |
| GO:0030971 | receptor tyrosine kinase binding | NAS | 9275162 |
| GO:0045499 | chemorepellent activity | IEA | -- |
Phenotypes for NRG3 Gene
- MGI mutant phenotypes for NRG3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NRG3:
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miRNA for NRG3 Gene
- miRTarBase miRNAs that target NRG3
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRG3 Gene
Localization for NRG3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NRG3 Gene
- Pro-neuregulin-3, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active. {ECO:0000250}.
- Neuregulin-3: Secreted.
- Isoform 3: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | NAS | 9275162 |
| GO:0005615 | extracellular space | IBA | -- |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005887 | integral component of plasma membrane | NAS | 9275162 |
Pathways & Interactions for NRG3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 3 | Signaling by ERBB2 | ||
| 4 | PI3K/AKT activation |
.89
|
|
| 5 | GPCR Pathway |
.73
.62
|
.55
|
Pathways by source for NRG3 Gene
3 BioSystems pathways for NRG3 Gene
71 Reactome pathways for NRG3 Gene
1 PharmGKB pathway for NRG3 Gene
1 KEGG pathway for NRG3 Gene
1 GeneGo (Thomson Reuters) pathway for NRG3 Gene
Interacting Proteins for NRG3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001558 | regulation of cell growth | NAS | 9275162 |
| GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity | IEA | -- |
| GO:0007389 | pattern specification process | IEA | -- |
| GO:0010469 | regulation of receptor activity | IEA | -- |
| GO:0021842 | chemorepulsion involved in interneuron migration from the subpallium to the cortex | IEA | -- |
Drugs & Compounds for NRG3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Iloperidone | Approved | Pharma | Antagonist | Dopamine (D2) and serotonin (5HT2) receptor antagonist | 0 |
Transcripts for NRG3 Gene
mRNA/cDNA for NRG3 Gene
- (20) REFSEQ mRNAs :
- (21) Additional mRNA sequences :
- (46) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NRG3 Gene
- Neuregulin 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for NRG3
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRG3
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miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NRG3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for NRG3 (Neuregulin-3/NRG3)
Expression for NRG3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Plasmacytoid Dendritic cells Peripheral Blood
- T Helper Cells Peripheral Blood
- Basophils Peripheral Blood
- Granulocyte-Monocyte Progenitor Cells Hematopoietic Bone Marrow
mRNA differential expression in normal tissues according to GTEx for NRG3 Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.1), Brain - Anterior cingulate cortex (BA24) (x6.5), Brain - Cortex (x6.1), Brain - Amygdala (x5.1), Brain - Hippocampus (x4.7), and Brain - Hypothalamus (x4.0).
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRG3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of NRG3 Gene:
NRG3SOURCE GeneReport for Unigene cluster for NRG3 Gene:
Hs.125119mRNA Expression by UniProt/SwissProt for NRG3 Gene:
P56975-NRG3_HUMAN
Tissue specificity:
Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.
Evidence on tissue expression from TISSUES for NRG3 Gene
- Nervous system(4.7)
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-
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Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NRG3 Gene
Orthologs for NRG3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | NRG3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | NRG3 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Nrg3 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nrg3 33 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | NRG3 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | NRG3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NRG3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | NRG3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nrg3 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.31978 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101882495 33 |
|
||
| NRG3 34 |
|
OneToOne |
- Species where no ortholog for NRG3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for NRG3 Gene
(2) SIMAP similar genes for NRG3 Gene using alignment to 15 proteins:
Variants for NRG3 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000001725 | -- | 82,161,358(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000003079 | -- | 82,356,401(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000003199 | -- | 82,989,978(+) | G/A | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1000005643 | -- | 82,036,472(+) | T/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000006371 | -- | 82,663,619(+) | G/A | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
19.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.74;
73.34% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NRG3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRG3 Gene
Disorders for NRG3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| schizophrenia |
|
Search NRG3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NRG3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NRG3 Gene
Publications for NRG3 Gene
- Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. (PMID: 9275162) Zhang D … Godowski PJ (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 58
- Neuregulin 3 genetic variations and susceptibility to schizophrenia in a Chinese population. (PMID: 18708184) Wang YC … Liou YJ (Biological psychiatry 2008) 3 22 44 58
- Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival. (PMID: 16478787) Carteron C … Cabedo H (Journal of cell science 2006) 3 4 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 76 available Neuregulin 3 Antibodies ranked by validation data
- Compare Top Neuregulin 3 Antibodies
- antibodies-online: Search results for 15 available Neuregulin 3 Elisa Kits ranked by validation data
- Compare Top Neuregulin 3 Elisa Kits
- antibodies-online: Search results for 10 available Neuregulin 3 Proteins ranked by validation data
- Compare Top Neuregulin 3 Proteins
- Search GeneTex for Antibodies for NRG3
- Search GeneTex for Proteins for NRG3
- ViGene Biosciences adenoviral particle packaged cDNA for NRG3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for NRG3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for NRG3 gene
- Search ViGene Biosciences for NRG3
- Santa Cruz Biotechnology (SCBT) Antibodies for NRG3
- Search Santa Cruz Biotechnology (SCBT) for NRG3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NRG3
- Horizon Cell Lines for NRG3
- genomics-online: cdna clones - Search results for 95 available Neuregulin 3 gene related products
- Overview of 95 available Neuregulin 3 gene related products
- orf clones - Search results for 95 available Neuregulin 3 gene related products
- Overview of 95 available Neuregulin 3 gene related products
- genomics-online: gRNA clones - Search results for 95 available Neuregulin 3 gene related products
- Overview of 95 available Neuregulin 3 gene related products
- genomics-online: primer clones - Search results for 95 available Neuregulin 3 gene related products
- Overview of 95 available Neuregulin 3 gene related products
- genomics-online: shRNA clones - Search results for 95 available Neuregulin 3 gene related products
- Overview of 95 available Neuregulin 3 gene related products
Sources for NRG3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
