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This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apopt... See more...
Aliases for NRG3 Gene
Aliases for NRG3 Gene
External Ids for NRG3 Gene
- HGNC: 7999
- NCBI Entrez Gene: 10718
- Ensembl: ENSG00000185737
- OMIM®: 605533
- UniProtKB/Swiss-Prot: P56975
Previous GeneCards Identifiers for NRG3 Gene
- GC10U990072
- GC10P083766
- GC10P083299
- GC10P083625
- GC10P077483
- GC10P081876
- GC10P082102
- GC10P082133
- GC10P082165
- GC10P083205
- GC10P082030
- GC10P081961
- GC10P083672
- GC10P084191
Summaries for NRG3 Gene
-
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]
GeneCards Summary for NRG3 Gene
NRG3 (Neuregulin 3) is a Protein Coding gene. Diseases associated with NRG3 include Hirschsprung Disease 1 and Schizoaffective Disorder. Among its related pathways are RET signaling and Agrin Interactions at Neuromuscular Junction. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and receptor tyrosine kinase binding. An important paralog of this gene is NRG1.
UniProtKB/Swiss-Prot Summary for NRG3 Gene
-
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Additional gene information for NRG3 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRG3 Gene
Genomics for NRG3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NRG3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH10J081874 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE CraniofacialAtlas | 250.7 | +1.0 | 1011 | 4.4 | SIN3A ZNF513 CTBP1 SP2 CTCF ZFP36 ZFX RAD21 KDM1A EZH2 | ENSG00000287358 NRG3 piR-38051-045 | |
| GH10J082799 | Promoter | 0.3 | EPDnew | 250 | +924.5 | 924545 | 0.1 | HSALNG0079269 NRG3 HSALNG0079268 | ||
| GH10J082816 | Promoter | 0.3 | EPDnew | 250 | +941.6 | 941562 | 0.1 | NRG3 piR-61945-053 HSALNG0079269 HSALNG0079271 | ||
| GH10J081838 | Enhancer | 0.3 | Ensembl | 11.6 | -36.1 | -36089 | 0.2 | CTCF RAD21 | lnc-DYDC1-2 NRG3 piR-31470-057 | |
| GH10J081847 | Enhancer | 0.3 | ENCODE | 12.1 | -27.3 | -27330 | 0.2 | POU5F1 | NRG3 piR-31470-057 lnc-DYDC1-2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NRG3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRG3
- Top Transcription factor binding sites by QIAGEN in the NRG3 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-5
- Gfi-1
Genomic Locations for NRG3 Gene
Latest Assembly
- chr10:81,875,190-82,989,979
- (GRCh38/hg38)
- Size:
- 1,114,790 bases
- Orientation:
- Plus strand
Previous Assembly
- chr10:83,634,950-84,746,935
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 1,111,986 bases
- Orientation:
- Plus strand
Genomic View for NRG3 Gene
Genes around NRG3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q23.1 by HGNC
- 10q23.1 by Entrez Gene
- 10q23.1 by Ensembl
NRG3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NRG3 Gene
Proteins for NRG3 Gene
-
Protein details for NRG3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P56975-NRG3_HUMAN
- Recommended name:
- Pro-neuregulin-3, membrane-bound isoform
- Protein Accession:
- P56975
- A4D7U1
- Q0PEH2
- Q5VYH3
Protein attributes for NRG3 Gene
- Size:
- 720 amino acids
- Molecular mass:
- 77901 Da
- Quaternary structure:
-
- Interacts with ERBB4.
Protein Expression for NRG3 Gene
Post-translational modifications for NRG3 Gene
- Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
- Extensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated.
-
Glycosylation at Thr276, Thr277, Thr278, Ser280, and Thr281
- NX_P56975 (NX_P56975-1)
- Modification sites at PhosphoSitePlus
Other Protein References for NRG3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_011537474.1
- XP_011537475.1
- XP_011537477.1
- XP_011537480.1
- XP_016871062.1
- XP_016871063.1
- XP_016871064.1
- XP_016871065.1
- XP_016871066.1
- XP_016871067.1
- XP_016871068.1
- XP_016871069.1
- XP_016871071.1
- XP_016871072.1
- XP_016871073.1
- XP_024303549.1
- NP_001010848.2
- NP_001159444.1
- NP_001159445.1
- NP_001357010.1
- NP_001357011.1
- NP_001357012.1
- NP_001357013.1
Antibodies for research
- LifeSpan BioSciences NRG3 Antibody
- G Biosciences Immunotag™ NRG3 Antibody
- Novus Biologicals Antibodies for NRG3
-
Abcam antibodies for NRG3
- Invitrogen Antibodies for NRG3 (AFLGC-NRG3)
-
Boster Bio Antibodies for NRG3
-
Santa Cruz Biotechnology (SCBT) Antibodies for NRG3
- Sino Biological Antibodies for NRG3
Protein products for research
-
OriGene Purified Proteins for NRG3
- Search Origene for MassSpec and Protein Over-expression Lysates for NRG3
- Origene Custom Protein Services for NRG3
- Sino Biological Recombinant Proteins for NRG3
- Sino Biological Cell Lysates for NRG3
-
Abcam proteins for NRG3
Assay products for research
- G Biosciences Immunotag™ Human NRG-3 (Neuregulin 3) ELISA
- Novus Biologicals ELISA Kits for NRG3
No data available for DME Specific Peptides for NRG3 Gene
Domains & Families for NRG3 Gene
Gene Families for NRG3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for NRG3 Gene
- InterPro:
- Blocks:
-
- Type I EGF
Suggested Antigen Peptide Sequences for NRG3 Gene
- GenScript: Design optimal peptide antigens:
-
- Neuregulin 3 (B9EGV5_HUMAN)
- Neuregulin 3 variant 1 (D9ZHP6_HUMAN)
- Neuregulin 3 variant 3 (D9ZHP7_HUMAN)
- Neuregulin 3 variant 4 (D9ZHP8_HUMAN)
- Neuregulin 3 variant 5 (D9ZHP9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P56975UniProtKB/Swiss-Prot:
NRG3_HUMAN :- The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
- Belongs to the neuregulin family.
- Domain:
-
- The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
- ERBB receptor binding is elicited entirely by the EGF-like domain.
- Family:
-
- Belongs to the neuregulin family.
Function for NRG3 Gene
Molecular function for NRG3 Gene
- UniProtKB/Swiss-Prot Function:
- Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Phenotypes From GWAS Catalog for NRG3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IEA,IBA | 21873635 |
| GO:0008083 | growth factor activity | NAS | 9275162 |
| GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity | NAS | 9275162 |
| GO:0030971 | receptor tyrosine kinase binding | NAS | 9275162 |
| GO:0045499 | chemorepellent activity | IBA | 21873635 |
Phenotypes for NRG3 Gene
- MGI mutant phenotypes for NRG3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for NRG3:
Animal Models for NRG3 Gene
- MGI Knock Outs for NRG3:
-
- Nrg3 Nrg3<tm1.1Plet>
Animal Models for research
-
Taconic Biosciences Mouse Models for NRG3
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NRG3 - Starting at $85 >
- * NRG3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NRG3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRG3
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRG3
miRNA for NRG3 Gene
- miRTarBase miRNAs that target NRG3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NRG3
- Browse OriGene Inhibitory RNA Products For NRG3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRG3
Clone products for research
- Applied Biological Materials (abm): Clones for NRG3 - Starting at $45 >
- * NRG3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG221718
- MG221719
- MG221720
- MR221718
- MR221718L3
- MR221718L4
- MR221719
- MR221719L3
- MR221719L4
- MR221720
- MR221720L3
- MR221720L4
- RC224735
- RC224735L3
- RC224735L4
- RC228414
- RC228414L3
- RC228414L4
- RC228998
- RC228998L3
- RC228998L4
- RG224735
- RG228414
- RG228998
- MR221718L3V
- MR221718L4V
- MR221719L3V
- MR221719L4V
- MR221720L3V
- MR221720L4V
- RC224735L3V
- RC224735L4V
- RC228414L3V
- RC228414L4V
- RC228998L3V
- RC228998L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NRG3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRG3
Cell Lines for research
-
Horizon Cell Lines for NRG3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRG3 Gene
Localization for NRG3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NRG3 Gene
- [Pro-neuregulin-3, membrane-bound isoform]: Cell membrane. Single-pass type I membrane protein. Note=Does not seem to be active. {ECO:0000250}.
- [Neuregulin-3]: Secreted.
- [Isoform 3]: Cell membrane. Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Vesicles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | NAS | 9275162 |
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005887 | integral component of plasma membrane | NAS | 9275162 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for NRG3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 3 | Signaling by ERBB2 | ||
| 4 | PI3K/AKT activation |
.89
|
|
| 5 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
Pathways by source for NRG3 Gene
3 BioSystems pathways for NRG3 Gene
71 Reactome pathways for NRG3 Gene
1 PharmGKB pathway for NRG3 Gene
2 KEGG pathways for NRG3 Gene
1 GeneGo (Thomson Reuters) pathway for NRG3 Gene
- Development ERBB-family signaling
58 Qiagen pathways for NRG3 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
Interacting Proteins for NRG3 Gene
GPS-Prot Interaction Network for NRG3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001558 | regulation of cell growth | NAS | 9275162 |
| GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity | IEA | -- |
| GO:0007389 | pattern specification process | IEA | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0021842 | chemorepulsion involved in interneuron migration from the subpallium to the cortex | IEA | -- |
Drugs & Compounds for NRG3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Iloperidone | Approved | Pharma | Dopamine (D2) and serotonin (5HT2) receptor antagonist | 26 |
Transcripts for NRG3 Gene
mRNA/cDNA for NRG3 Gene
- 7 REFSEQ mRNAs :
- 23 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000372141 3811 nts (view in UCSC)
- ENST00000372142 3136 nts (view in UCSC)
- ENST00000404547 2163 nts (view in UCSC)
- ENST00000404576 1503 nts (view in UCSC)
- ENST00000537893 1174 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NRG3 - Starting at $85 >
- * NRG3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NRG3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRG3
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRG3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NRG3
- Browse OriGene Inhibitory RNA Products For NRG3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRG3
Clone products for research
- Applied Biological Materials (abm): Clones for NRG3 - Starting at $45 >
- * NRG3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG221718
- MG221719
- MG221720
- MR221718
- MR221718L3
- MR221718L4
- MR221719
- MR221719L3
- MR221719L4
- MR221720
- MR221720L3
- MR221720L4
- RC224735
- RC224735L3
- RC224735L4
- RC228414
- RC228414L3
- RC228414L4
- RC228998
- RC228998L3
- RC228998L4
- RG224735
- RG228414
- RG228998
- MR221718L3V
- MR221718L4V
- MR221719L3V
- MR221719L4V
- MR221720L3V
- MR221720L4V
- RC224735L3V
- RC224735L4V
- RC228414L3V
- RC228414L4V
- RC228998L3V
- RC228998L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NRG3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRG3
Relevant External Links for NRG3 Gene
- GeneLoc Exon Structure for
- NRG3
Expression for NRG3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Plasmacytoid Dendritic cells Peripheral Blood
- T Helper Cells Peripheral Blood
- Basophils Peripheral Blood
- Granulocyte-Monocyte Progenitor Cells Hematopoietic Bone Marrow
mRNA differential expression in normal tissues according to GTEx for NRG3 Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.1), Brain - Anterior cingulate cortex (BA24) (x6.5), Brain - Cortex (x6.1), Brain - Amygdala (x5.1), Brain - Hippocampus (x4.7), and Brain - Hypothalamus (x4.0).
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NRG3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRG3
SOURCE GeneReport for Unigene cluster for NRG3 Gene:
Hs.125119mRNA Expression by UniProt/SwissProt for NRG3 Gene:
P56975-NRG3_HUMAN
Tissue specificity:
Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.
Evidence on tissue expression from TISSUES for NRG3 Gene
- Nervous system(4.7)
Primer products for research
-
OriGene qPCR primer pairs for NRG3
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NRG3 Gene
Orthologs for NRG3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Cow (Bos Taurus) |
Mammalia | NRG3 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NRG3 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Nrg3 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Nrg3 29 |
|
||
| Chimpanzee (Pan troglodytes) |
Mammalia | NRG3 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | NRG3 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | NRG3 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NRG3 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nrg3 29 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.31978 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC101882495 29 |
|
||
| NRG3 30 |
|
OneToOne |
- Species where no ortholog for NRG3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for NRG3 Gene
- ENSEMBL:
- Gene Tree for NRG3 (if available)
- TreeFam:
- Gene Tree for NRG3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NRG3: view image
- Alliance of Genome Resources:
- Additional Orthologs for NRG3
Paralogs for NRG3 Gene
(2) SIMAP similar genes for NRG3 Gene using alignment to 15 proteins:
- NRG3_HUMAN
- B9EGV5_HUMAN
- D9ZHP6_HUMAN
- D9ZHP7_HUMAN
- D9ZHP8_HUMAN
- D9ZHP9_HUMAN
- D9ZHQ0_HUMAN
- D9ZHQ1_HUMAN
- D9ZHQ2_HUMAN
- D9ZHQ3_HUMAN
- D9ZHQ5_HUMAN
- D9ZHQ6_HUMAN
- D9ZHQ7_HUMAN
- D9ZHQ8_HUMAN
- R4GNI6_HUMAN
Variants for NRG3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRG3 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs117760740 | Benign: not provided | 82,985,521(+) |
C/G NM_001010848.4(NRG3):c.2007C>G (p.Pro669=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs138878772 | Benign: Hirschsprung disease; not provided | 82,985,465(+) |
G/A NM_001010848.4(NRG3):c.1951G>A (p.Glu651Lys) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
| rs139007511 | Benign: not provided | 82,979,025(+) |
G/A NM_001010848.4(NRG3):c.1488G>A (p.Pro496=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs143338524 | Benign: not provided | 82,958,962(+) |
C/G NM_001010848.4(NRG3):c.1171C>G (p.Gln391Glu) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
| rs143587502 | Likely Benign: not provided | 82,738,642(+) |
C/T NM_001010848.4(NRG3):c.1019C>T (p.Ser340Leu) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
19.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.74;
73.34% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NRG3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRG3 Gene
Disorders for NRG3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hirschsprung disease 1 |
|
|
| schizoaffective disorder |
|
|
| schizophrenia |
|
|
| disease of mental health |
|
|
Search NRG3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NRG3
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
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No data available for UniProtKB/Swiss-Prot and Genatlas for NRG3 Gene
Publications for NRG3 Gene
- Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. (PMID: 9275162) Zhang D … Godowski PJ (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22
- Neuregulin 3 genetic variations and susceptibility to schizophrenia in a Chinese population. (PMID: 18708184) Wang YC … Liou YJ (Biological psychiatry 2008) 3 22 40
- Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival. (PMID: 16478787) Carteron C … Cabedo H (Journal of cell science 2006) 3 4 22
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
- Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PMID: 20398908) Saus E … Estivill X (Journal of psychiatric research 2010) 3 40
ExternalLinks
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