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This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]
NRG2 (Neuregulin 2) is a Protein Coding gene. Diseases associated with NRG2 include Dysbaric Osteonecrosis and Charcot-Marie-Tooth Disease. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity. An important paralog of this gene is NRG1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IEA,IBA | 21873635 |
GO:0008083 | growth factor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
3 | Signaling by ERBB2 | ||
4 | GAB1 signalosome |
.89
|
|
5 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0007165 | signal transduction | TAS | 9168115 |
GO:0007399 | nervous system development | IEA | -- |
GO:0035556 | intracellular signal transduction | IBA | 21873635 |
GO:0038128 | ERBB2 signaling pathway | TAS | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NRG2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Nrg2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nrg2 30 |
|
||
Dog (Canis familiaris) |
Mammalia | NRG2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NRG2 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NRG2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NRG2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NRG2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NRG2 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | nrg2a 30 31 |
|
OneToMany | |
nrg2b 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv10091n54 | CNV | loss | 21841781 |
esv1004341 | CNV | deletion | 20482838 |
esv2667289 | CNV | deletion | 23128226 |
esv26674 | CNV | loss | 19812545 |
esv2674763 | CNV | deletion | 23128226 |
esv3303578 | CNV | mobile element insertion | 20981092 |
esv3308333 | CNV | mobile element insertion | 20981092 |
esv3327934 | CNV | insertion | 20981092 |
esv3330122 | CNV | duplication | 20981092 |
esv3347369 | CNV | duplication | 20981092 |
esv3360693 | CNV | insertion | 20981092 |
esv3566717 | CNV | deletion | 23714750 |
esv3606944 | CNV | loss | 21293372 |
esv3606946 | CNV | loss | 21293372 |
nsv1074332 | CNV | deletion | 25765185 |
nsv471051 | CNV | gain | 18288195 |
nsv526406 | CNV | gain | 19592680 |
nsv599821 | CNV | loss | 21841781 |
nsv830506 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
dysbaric osteonecrosis |
|
|
charcot-marie-tooth disease |
|
|