NRG2 Gene (Protein Coding)

Neuregulin 2

GC05M139810
GIFtS:
41
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neur... See more...

Aliases for NRG2 Gene

Aliases for NRG2 Gene

  • Neuregulin 2 2 3 5
  • NTAK 2 3 4
  • Neural- And Thymus-Derived Activator For ErbB Kinases 2 3
  • Pro-Neuregulin-2, Membrane-Bound Isoform 3 4
  • Divergent Of Neuregulin-1 2 3
  • Pro-NRG2 3 4
  • HRG2 2 3
  • Don-1 2
  • DON1 3
  • NRG2 5

External Ids for NRG2 Gene

Previous GeneCards Identifiers for NRG2 Gene

  • GC05M139049
  • GC05M139210
  • GC05M139255
  • GC05M139207
  • GC05M134369

Summaries for NRG2 Gene

Entrez Gene Summary for NRG2 Gene

  • This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]

GeneCards Summary for NRG2 Gene

NRG2 (Neuregulin 2) is a Protein Coding gene. Diseases associated with NRG2 include Dysbaric Osteonecrosis and Charcot-Marie-Tooth Disease. Among its related pathways are RET signaling and Agrin Interactions at Neuromuscular Junction. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity. An important paralog of this gene is NRG1.

UniProtKB/Swiss-Prot Summary for NRG2 Gene

  • Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

Gene Wiki entry for NRG2 Gene

Additional gene information for NRG2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRG2 Gene

Genomics for NRG2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NRG2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRG2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRG2

Top Transcription factor binding sites by QIAGEN in the NRG2 gene promoter:
  • CREB
  • Egr-1
  • Egr-4
  • HEN1
  • Nkx2-5
  • Pax-5
  • SRF
  • SRF (504 AA)
  • USF-1
  • USF1

Genomic Locations for NRG2 Gene

Latest Assembly
chr5:139,846,779-140,043,675
(GRCh38/hg38)
Size:
196,897 bases
Orientation:
Minus strand

Previous Assembly
chr5:139,226,366-139,422,884
(GRCh37/hg19 by Entrez Gene)
Size:
196,519 bases
Orientation:
Minus strand

chr5:139,226,364-139,422,884
(GRCh37/hg19 by Ensembl)
Size:
196,521 bases
Orientation:
Minus strand

Genomic View for NRG2 Gene

Genes around NRG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRG2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NRG2 Gene

Proteins for NRG2 Gene

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  • Protein details for NRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14511-NRG2_HUMAN
    Recommended name:
    Pro-neuregulin-2, membrane-bound isoform
    Protein Accession:
    O14511

    Protein attributes for NRG2 Gene

    Size:
    850 amino acids
    Molecular mass:
    91679 Da
    Quaternary structure:
    • Interacts with ERBB3 and ERBB4.
    Miscellaneous:
    • [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for NRG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRG2 Gene

Protein Expression for NRG2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NRG2 Gene

  • Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
  • Extensive glycosylation precedes the proteolytic cleavage.
  • Glycosylation at Asn278, Asn52, Asn53, Thr333, Thr334, Asn346, and Asn147
  • Modification sites at PhosphoSitePlus

Other Protein References for NRG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NRG2 Gene

Domains & Families for NRG2 Gene

Gene Families for NRG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for NRG2 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Type I EGF
  • Neuregulin family signature

Suggested Antigen Peptide Sequences for NRG2 Gene

GenScript: Design optimal peptide antigens:
  • Pro-neuregulin-2, membrane-bound isoform (NRG2_HUMAN)
  • NRG2 protein (Q3MI86_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14511

UniProtKB/Swiss-Prot:

NRG2_HUMAN :
  • The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
  • Belongs to the neuregulin family.
Domain:
  • The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
  • ERBB receptor binding is elicited entirely by the EGF-like domain.
Family:
  • Belongs to the neuregulin family.
genes like me logo Genes that share domains with NRG2: view

Function for NRG2 Gene

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  1. Animal Models for research
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  6. Cell Lines for research

Molecular function for NRG2 Gene

UniProtKB/Swiss-Prot Function:
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
GENATLAS Biochemistry:
neuregulin 2 multipotent epidermal growth factor-like factor with several splice variants,expressed in adult brain and developing heart,binding ERBB3 and ERBB4,involved in growth and differentiation of epithelial,neuronal,glial and other cell types

Phenotypes From GWAS Catalog for NRG2 Gene

Gene Ontology (GO) - Molecular Function for NRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA,IBA 21873635
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with NRG2: view
genes like me logo Genes that share phenotypes with NRG2: view

Animal Models for NRG2 Gene

MGI Knock Outs for NRG2:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRG2

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRG2 Gene

Localization for NRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRG2 Gene

[Pro-neuregulin-2, membrane-bound isoform]: Cell membrane. Single-pass type I membrane protein. Note=Does not seem to be active. {ECO:0000250}.
[Neuregulin-2]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRG2 gene
Compartment Confidence
plasma membrane 4
extracellular 4
nucleus 3
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NRG2: view

Pathways & Interactions for NRG2 Gene

PathCards logo

SuperPathways for NRG2 Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Apoptotic Pathways in Synovial Fibroblasts
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
3 Signaling by ERBB2
Downregulation of ERBB2 signaling
.59
Signaling by ERBB2
.59
SHC1 events in ERBB2 signaling
.43
Downregulation of ERBB2-ERBB3 signaling
.01
ERBB2 Activates PTK6 Signaling
.01
ERBB2 Regulates Cell Motility
.01
GRB2 events in ERBB2 signaling
.01
PI3K events in ERBB2 signaling
.01
PI3K events in ERBB4 signaling
.01
SHC1 events in ERBB4 signaling
.01
4 PI3K/AKT activation
Negative regulation of the PI3K/AKT network
.93
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
.93
PIP3 activates AKT signaling
.91
Role of LAT2/NTAL/LAB on calcium mobilization
.91
GAB1 signalosome
.89
PI3K/AKT activation
.89
Constitutive Signaling by Aberrant PI3K in Cancer
.75
PI3K/AKT Signaling in Cancer
.72
5 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
genes like me logo Genes that share pathways with NRG2: view

Pathways by source for NRG2 Gene

1 PharmGKB pathway for NRG2 Gene
1 GeneGo (Thomson Reuters) pathway for NRG2 Gene
  • Development ERBB-family signaling
58 Qiagen pathways for NRG2 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

SIGNOR curated interactions for NRG2 Gene

Activates:

Gene Ontology (GO) - Biological Process for NRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007165 signal transduction IEA,TAS 9168115
GO:0007399 nervous system development IEA --
GO:0035556 intracellular signal transduction IBA 21873635
GO:0038128 ERBB2 signaling pathway TAS --
genes like me logo Genes that share ontologies with NRG2: view

Drugs & Compounds for NRG2 Gene

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  1. Drug products for research

(2) Drugs for NRG2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NRG2: view

Transcripts for NRG2 Gene

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mRNA/cDNA for NRG2 Gene

7 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRG2

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for NRG2 Gene

No ASD Table

Relevant External Links for NRG2 Gene

GeneLoc Exon Structure for
NRG2

Expression for NRG2 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NRG2 Gene

mRNA expression in normal human tissues for NRG2 Gene
mRNA expression by BioGPS for NRG2 GenemRNA expression by GTEx for NRG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRG2 Gene

This gene is overexpressed in Brain - Cerebellum (x4.5) and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for NRG2 Gene

This gene is overexpressed in Lung (40.3) and Liver, secretome (23.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NRG2 Gene



Protein tissue co-expression partners for NRG2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRG2

SOURCE GeneReport for Unigene cluster for NRG2 Gene:

Hs.408515

mRNA Expression by UniProt/SwissProt for NRG2 Gene:

O14511-NRG2_HUMAN
Tissue specificity: Restricted to the cerebellum in the adult.

Evidence on tissue expression from TISSUES for NRG2 Gene

  • Nervous system(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with NRG2: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NRG2 Gene

Orthologs for NRG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRG2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia NRG2 29 30
  • 98.48 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Nrg2 29 16 30
  • 91.01 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Nrg2 29
  • 90.94 (n)
Dog
(Canis familiaris)
 Mammalia NRG2 29 30
  • 90.79 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia NRG2 29 30
  • 90.41 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia NRG2 30
  • 84 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia NRG2 30
  • 72 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves NRG2 29 30
  • 73.48 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia NRG2 30
  • 72 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii nrg2a 29 30
  • 66.83 (n)
 OneToMany
nrg2b 30
  • 54 (a)
 OneToMany
Species where no ortholog for NRG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NRG2 Gene

ENSEMBL:
Gene Tree for NRG2 (if available)
TreeFam:
Gene Tree for NRG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NRG2: view image
Alliance of Genome Resources:
Additional Orthologs for NRG2

Paralogs for NRG2 Gene

Paralogs for NRG2 Gene

(3) SIMAP similar genes for NRG2 Gene using alignment to 4 proteins:

  • NRG2_HUMAN
  • F5GZS7_HUMAN
  • F5H0N2_HUMAN
  • Q3MI86_HUMAN
genes like me logo Genes that share paralogs with NRG2: view

Variants for NRG2 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRG2 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs188534354 Likely Benign: not provided 140,043,017(-) C/T
NM_004883.3(NRG2):c.53G>A (p.Arg18Gln) 		MISSENSE
rs376804956 Likely Benign: not provided 140,042,646(-) C/T
NM_004883.3(NRG2):c.424G>A (p.Gly142Ser) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NRG2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NRG2 Gene

Variant ID Type Subtype PubMed ID
dgv10091n54 CNV loss 21841781
esv1004341 CNV deletion 20482838
esv2667289 CNV deletion 23128226
esv26674 CNV loss 19812545
esv2674763 CNV deletion 23128226
esv3303578 CNV mobile element insertion 20981092
esv3308333 CNV mobile element insertion 20981092
esv3327934 CNV insertion 20981092
esv3330122 CNV duplication 20981092
esv3347369 CNV duplication 20981092
esv3360693 CNV insertion 20981092
esv3566717 CNV deletion 23714750
esv3606944 CNV loss 21293372
esv3606946 CNV loss 21293372
nsv1074332 CNV deletion 25765185
nsv471051 CNV gain 18288195
nsv526406 CNV gain 19592680
nsv599821 CNV loss 21841781
nsv830506 CNV loss 17160897

Variation tolerance for NRG2 Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRG2
Leiden Open Variation Database (LOVD)
NRG2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRG2 Gene

Disorders for NRG2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NRG2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
dysbaric osteonecrosis
  • caisson disease of bone
charcot-marie-tooth disease
  • cmt - charcot-marie-tooth disease
tooth disease
  • teeth disease
- elite association - COSMIC cancer census association via MalaCards
Search NRG2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRG2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NRG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRG2 Gene

Publications for NRG2 Gene

  1. Fine mapping of new glaucoma locus GLC1M and exclusion of neuregulin 2 as the causative gene. (PMID: 17563728) Fan BJ … Pang CP (Molecular vision 2007) 3 22 40
  2. The human neuregulin-2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q. (PMID: 10369162) Ring HZ … Francke U (Human genetics 1999) 3 4 22
  3. A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4. (PMID: 9348101) Higashiyama S … Ishiguro H (Journal of biochemistry 1997) 3 4 22
  4. Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. (PMID: 9168115) Carraway KL … Lai C (Nature 1997) 2 3 22
  5. Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus. (PMID: 9199335) Busfield SJ … Gearing DP (Molecular and cellular biology 1997) 3 4 22

ExternalLinks

View latest publications for NRG2 gene in Mastermind

Products for NRG2 Gene

Sources for NRG2 Gene