Aliases for NRG2 Gene
Aliases for NRG2 Gene
External Ids for NRG2 Gene
- HGNC: 7998
- Entrez Gene: 9542
- Ensembl: ENSG00000158458
- OMIM: 603818
- UniProtKB: O14511
Previous GeneCards Identifiers for NRG2 Gene
- GC05M139049
- GC05M139210
- GC05M139255
- GC05M139207
- GC05M134369
Summaries for NRG2 Gene
-
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]
GeneCards Summary for NRG2 Gene
NRG2 (Neuregulin 2) is a Protein Coding gene. Diseases associated with NRG2 include Charcot-Marie-Tooth Disease. Among its related pathways are RET signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include receptor binding and growth factor activity. An important paralog of this gene is NRG1.
UniProtKB/Swiss-Prot for NRG2 Gene
-
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
Additional gene information for NRG2 Gene
- Monarch Initiative
- Search for NRG2 at DataMed
- Search for NRG2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRG2 Gene
Genomics for NRG2 Gene
GeneHancer (GH) Regulatory Elements for NRG2 Gene
Promoters and enhancers for NRG2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NRG2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for NRG2 Gene
Genomic Locations for NRG2 Gene
- chr5:139,846,779-140,043,437
- (GRCh38/hg38)
- Size:
- 196,659 bases
- Orientation:
- Minus strand
- chr5:139,226,364-139,422,884
- (GRCh37/hg19)
Genomic View for NRG2 Gene
Genes around NRG2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.2 by Ensembl
- 5q31.2 by Entrez Gene
- 5q31.2 by HGNC
NRG2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NRG2 Gene
Proteins for NRG2 Gene
-
Protein details for NRG2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14511-NRG2_HUMAN
- Recommended name:
- Pro-neuregulin-2, membrane-bound isoform
- Protein Accession:
- O14511
Protein attributes for NRG2 Gene
- Size:
- 850 amino acids
- Molecular mass:
- 91679 Da
- Quaternary structure:
-
- Interacts with ERBB3 and ERBB4.
Protein Expression for NRG2 Gene
Post-translational modifications for NRG2 Gene
- Extensive glycosylation precedes the proteolytic cleavage.
- Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
- Glycosylation at isoforms=2, 3, 4, 5, 652, isoforms=2, 3, 4, 5, 653, Asn147, isoforms=2, 3, 4, 5, 6, 7, 8278, Thr333, and isoforms=2, 3, 4, 5, 6, 7, 8346
- Modification sites at PhosphoSitePlus
Other Protein References for NRG2 Gene
Antibody Products
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-
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-
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Protein Products
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-
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-
Abcam proteins for NRG2
Assay Products
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Cloud-Clone Corp. Assay Kits for NRG2
No data available for DME Specific Peptides for NRG2 Gene
Domains & Families for NRG2 Gene
Gene Families for NRG2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted membrane proteins
Protein Domains for NRG2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NRG2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O14511UniProtKB/Swiss-Prot:
NRG2_HUMAN :- The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
- Belongs to the neuregulin family.
- Domain:
-
- The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
- ERBB receptor binding is elicited entirely by the EGF-like domain.
- Family:
-
- Belongs to the neuregulin family.
Function for NRG2 Gene
Molecular function for NRG2 Gene
- GENATLAS Biochemistry:
- neuregulin 2 multipotent epidermal growth factor-like factor with several splice variants,expressed in adult brain and developing heart,binding ERBB3 and ERBB4,involved in growth and differentiation of epithelial,neuronal,glial and other cell types
- UniProtKB/Swiss-Prot Function:
- Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
Phenotypes From GWAS Catalog for NRG2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | TAS | -- |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005102 | receptor binding | TAS | 9168114 |
| GO:0008083 | growth factor activity | IEA | -- |
| GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | TAS | -- |
Phenotypes for NRG2 Gene
- MGI mutant phenotypes for NRG2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NRG2:
Animal Models for NRG2 Gene
- MGI Knock Outs for NRG2:
-
- Nrg2 tm1Bus
Animal Model Products
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-
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-
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miRNA for NRG2 Gene
- miRTarBase miRNAs that target NRG2
-
- hsa-mir-5089-5p (MIRT612705)
- hsa-mir-377-3p (MIRT612706)
- hsa-mir-4769-5p (MIRT612707)
- hsa-mir-4654 (MIRT612708)
- hsa-mir-8485 (MIRT612709)
- hsa-mir-136-5p (MIRT783763)
- hsa-mir-4297 (MIRT785659)
- hsa-mir-4724-5p (MIRT786532)
- hsa-mir-515-5p (MIRT787179)
- hsa-mir-519e-5p (MIRT787252)
- hsa-mir-5581-5p (MIRT787666)
- hsa-mir-6516-3p (MIRT788373)
- hsa-mir-96-3p (MIRT790022)
- hsa-mir-2861 (MIRT790209)
- hsa-mir-5001-3p (MIRT790667)
- hsa-mir-7851-3p (MIRT791130)
- hsa-mir-939-3p (MIRT791166)
miRNA Products
- Search ViGene Biosciences for NRG2
Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NRG2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NRG2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRG2 Gene
Localization for NRG2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NRG2 Gene
- Pro-neuregulin-2, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active. {ECO:0000250}.
- Neuregulin-2: Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 4 |
| nucleus | 3 |
| cytosol | 2 |
| peroxisome | 1 |
- Nucleoli (3)
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA | -- |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for NRG2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 3 | Signaling by ERBB2 | ||
| 4 | PI3K/AKT activation |
.89
|
|
| 5 | GPCR Pathway |
.73
.62
|
.55
|
Pathways by source for NRG2 Gene
3 BioSystems pathways for NRG2 Gene
73 Reactome pathways for NRG2 Gene
1 PharmGKB pathway for NRG2 Gene
2 KEGG pathways for NRG2 Gene
1 GeneGo (Thomson Reuters) pathway for NRG2 Gene
Interacting Proteins for NRG2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0007165 | signal transduction | TAS | 9168114 |
| GO:0010469 | regulation of receptor activity | IEA | -- |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IEA | -- |
| GO:0035556 | intracellular signal transduction | IBA | -- |
Transcripts for NRG2 Gene
mRNA/cDNA for NRG2 Gene
- (13) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (38) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for NRG2
- genomics-online: gRNA clones - Search results for 89 available Neuregulin 2 gene related products
- Overview of 89 available Neuregulin 2 gene related products
- Applied Biological Materials CRISPR for NRG2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRG2
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miRNA Products
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Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 89 available Neuregulin 2 gene related products
- Overview of 89 available Neuregulin 2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for NRG2
- VectorBuilder custom plasmid, inducible vectors for NRG2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NRG2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NRG2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for NRG2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
-
Epithelial Cells
- Basal Keratinocytes Embryonic Epidermis
-
Hair
- Basal Keratinocytes Embryonic Epidermis
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for NRG2 Gene
This gene is overexpressed in Brain - Cerebellum (x4.5) and Brain - Cerebellar Hemisphere (x4.3).
This gene is overexpressed in Lung (40.3) and Liver, secretome (23.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRG2 Gene
NURSA nuclear receptor signaling pathways regulating expression of NRG2 Gene:
NRG2SOURCE GeneReport for Unigene cluster for NRG2 Gene:
Hs.408515mRNA Expression by UniProt/SwissProt for NRG2 Gene:
O14511-NRG2_HUMAN
Tissue specificity:
Restricted to the cerebellum in the adult.
Evidence on tissue expression from TISSUES for NRG2 Gene
- Nervous system(4.3)
- Lung(4.1)
Primer Products
-
OriGene qPCR primer pairs for NRG2
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NRG2 Gene
Orthologs for NRG2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NRG2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Nrg2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nrg2 33 |
|
||
| dog (Canis familiaris) |
Mammalia | NRG2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | NRG2 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | NRG2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | NRG2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NRG2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | NRG2 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | nrg2a 33 34 |
|
||
| nrg2b 34 |
|
OneToMany |
- Species where no ortholog for NRG2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for NRG2 Gene
(3) SIMAP similar genes for NRG2 Gene using alignment to 4 proteins:
Variants for NRG2 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000013397 | -- | 139,973,057(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000016829 | -- | 139,992,881(-) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000022435 | -- | 139,947,282(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000025322 | -- | 140,019,077(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000059033 | -- | 139,878,941(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10091n54 | CNV | loss | 21841781 |
| esv1004341 | CNV | deletion | 20482838 |
| esv2667289 | CNV | deletion | 23128226 |
| esv26674 | CNV | loss | 19812545 |
| esv2674763 | CNV | deletion | 23128226 |
| esv3303578 | CNV | mobile element insertion | 20981092 |
| esv3308333 | CNV | mobile element insertion | 20981092 |
| esv3327934 | CNV | insertion | 20981092 |
| esv3330122 | CNV | duplication | 20981092 |
| esv3347369 | CNV | duplication | 20981092 |
| esv3360693 | CNV | insertion | 20981092 |
| esv3566717 | CNV | deletion | 23714750 |
| esv3606944 | CNV | loss | 21293372 |
| esv3606946 | CNV | loss | 21293372 |
| nsv1074332 | CNV | deletion | 25765185 |
| nsv471051 | CNV | gain | 18288195 |
| nsv526406 | CNV | gain | 19592680 |
| nsv599821 | CNV | loss | 21841781 |
| nsv830506 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.01;
60.23% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NRG2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NRG2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRG2 Gene
Disorders for NRG2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| charcot-marie-tooth disease |
|
|
Search NRG2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NRG2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NRG2 Gene
Publications for NRG2 Gene
- Fine mapping of new glaucoma locus GLC1M and exclusion of neuregulin 2 as the causative gene. (PMID: 17563728) Fan BJ … Pang CP (Molecular vision 2007) 3 22 44 58
- The human neuregulin-2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q. (PMID: 10369162) Ring HZ … Francke U (Human genetics 1999) 3 4 22 58
- Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus. (PMID: 9199335) Busfield SJ … Gearing DP (Molecular and cellular biology 1997) 3 4 22 58
- A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4. (PMID: 9348101) Higashiyama S … Ishiguro H (Journal of biochemistry 1997) 3 4 22 58
- Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. (PMID: 9168115) Carraway KL … Lai C (Nature 1997) 2 3 22 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 45 available Neuregulin 2 Antibodies ranked by validation data
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- Overview of 89 available Neuregulin 2 gene related products
- genomics-online: gRNA clones - Search results for 89 available Neuregulin 2 gene related products
- Overview of 89 available Neuregulin 2 gene related products
- genomics-online: primer clones - Search results for 89 available Neuregulin 2 gene related products
- Overview of 89 available Neuregulin 2 gene related products
- genomics-online: shRNA clones - Search results for 89 available Neuregulin 2 gene related products
- Overview of 89 available Neuregulin 2 gene related products
Sources for NRG2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
