Aliases for NRG2 Gene
External Ids for NRG2 Gene
Previous GeneCards Identifiers for NRG2 Gene
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]
GeneCards Summary for NRG2 Gene
NRG2 (Neuregulin 2) is a Protein Coding gene. Diseases associated with NRG2 include Dysbaric Osteonecrosis and Charcot-Marie-Tooth Disease. Among its related pathways are RET signaling and Agrin Interactions at Neuromuscular Junction. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity. An important paralog of this gene is NRG1.
UniProtKB/Swiss-Prot Summary for NRG2 Gene
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.