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The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
NRG1 (Neuregulin 1) is a Protein Coding gene. Diseases associated with NRG1 include Schizophrenia 6 and Lung Cancer. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity. An important paralog of this gene is NRG2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH08J032546 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 629.5 | +910.7 | 910661 | 7.7 | GATAD2A CTCF ZNF692 FOXA1 LARP7 ZSCAN4 RXRB PATZ1 RAD21 IRF2 | NRG1 ENSG00000286131 NRG1-IT3 | |
GH08J031640 | Promoter | 1.4 | EPDnew Ensembl CraniofacialAtlas | 600.7 | +0.5 | 479 | 1.8 | CTCF ZIC2 POLR2A EZH2 SCRT2 RAD21 ZBTB26 ZNF335 RCOR1 | NRG1 lnc-PURG-4 | |
GH08J031644 | Promoter | 0.5 | Ensembl | 600.7 | +1.7 | 1678 | 0.2 | EZH2 CTCF | NRG1 lnc-PURG-4 L13714-429 | |
GH08J032574 | Enhancer | 0.8 | ENCODE dbSUPER | 24.4 | +936.1 | 936086 | 0.2 | IKZF2 TRIM22 PKNOX1 DPF2 RELB RUNX3 GATAD2B ELF1 NBN IKZF1 | NRG1 ENSG00000286131 NRG1-IT3 | |
GH08J032554 | Enhancer | 0.7 | ENCODE | 29.4 | +914.9 | 914886 | 0.2 | CTCF REST SP1 JUND FOXA2 ATF3 FOS YY1 FOSL2 RAD21 | NRG1 ENSG00000286131 NRG1-IT3 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003712 | transcription coregulator activity | IDA | 15073182 |
GO:0005102 | signaling receptor binding | IEA,IBA | 21873635 |
GO:0005125 | cytokine activity | TAS | 10372964 |
GO:0005176 | ErbB-2 class receptor binding | IEA | -- |
GO:0005178 | integrin binding | IDA | 20682778 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
3 | Signaling by ERBB2 | ||
4 | GAB1 signalosome |
.89
|
|
5 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0000187 | activation of MAPK activity | IMP | 20682778 |
GO:0000902 | cell morphogenesis | IEA | -- |
GO:0003161 | cardiac conduction system development | IEA | -- |
GO:0003222 | ventricular trabecula myocardium morphogenesis | IDA | 17336907 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NRG1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NRG1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NRG1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nrg1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | NRG1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NRG1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Nrg1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NRG1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NRG1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100496613 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | nrg1-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | nrg1 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6383 30 |
|
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
712801 | Benign: not provided | 32,763,844(+) | C/T | SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT | |
730052 | Likely Benign: not provided | 32,760,370(+) | C/G | MISSENSE_VARIANT | |
739170 | Likely Benign: not provided | 32,763,859(+) | G/A | SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT | |
739457 | Likely Benign: not provided | 32,605,565(+) | G/A | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT | |
740327 | Likely Benign: not provided | 32,728,046(+) | A/G | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
schizophrenia 6 |
|
|
lung cancer |
|
|
mucinous lung adenocarcinoma |
|
|
schizophreniform disorder |
|
|
bipolar disorder |
|