NRG1 Gene (Protein Coding)

Neuregulin 1

GC08P031639
GIFtS:
47
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significant... See more...

Aliases for NRG1 Gene

Aliases for NRG1 Gene

  • Neuregulin 1 2 3 5
  • GGF 2 3 4
  • NDF 2 3 4
  • Pro-Neuregulin-1, Membrane-Bound Isoform 3 4
  • Pro-NRG1 3 4
  • HRGA 3 4
  • SMDF 3 4
  • HGL 3 4
  • HRG 2 3
  • NRG1 Intronic Transcript 2 (Non-Protein Coding) 2
  • Heregulin, Alpha (45kD, ERBB2 P185-Activator) 3
  • Acetylcholine Receptor-Inducing Activity 3
  • Sensory And Motor Neuron Derived Factor 3
  • Neu Differentiation Factor 3
  • Glial Growth Factor 2 3
  • NRG1-IT2 3
  • MSTP131 3
  • MST131 3
  • ARIA 3
  • GGF2 3
  • HRG1 3
  • NRG1 5

External Ids for NRG1 Gene

Previous HGNC Symbols for NRG1 Gene

  • HGL
  • NRG1-IT2

Previous GeneCards Identifiers for NRG1 Gene

  • GC08P031402
  • GC08P032856
  • GC08P032463
  • GC08P031554
  • GC08P031617
  • GC08P030042

Summaries for NRG1 Gene

Entrez Gene Summary for NRG1 Gene

  • The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]

CIViC Summary for NRG1 Gene

GeneCards Summary for NRG1 Gene

NRG1 (Neuregulin 1) is a Protein Coding gene. Diseases associated with NRG1 include Schizophrenia 6 and Lung Cancer. Among its related pathways are RET signaling and Agrin Interactions at Neuromuscular Junction. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity. An important paralog of this gene is NRG2.

UniProtKB/Swiss-Prot Summary for NRG1 Gene

  • Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).

Gene Wiki entry for NRG1 Gene

Additional gene information for NRG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRG1 Gene

Genomics for NRG1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NRG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08J032546 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 279.5 +910.7 910661 7.7 ZNF654 CEBPA ATF3 YY1 TRIM22 ZEB1 CTCF FOXA2 RXRA SAP130 NRG1 HSALNG0064435 ENSG00000286131
GH08J031640 Promoter 1.4 EPDnew Ensembl CraniofacialAtlas 250.7 +0.7 679 2.2 ZIC2 CTCF EZH2 SMC3 RAD21 POLR2A ZNF335 SCRT2 ZBTB26 NRG1 lnc-PURG-4
GH08J032574 Enhancer 0.8 ENCODE dbSUPER 24.4 +936.1 936086 0.2 TRIM22 SPI1 MYC MAX POLR2A ELF1 IKZF1 BMI1 ZNF217 PKNOX1 NRG1 HSALNG0064435 ENSG00000286131
GH08J032554 Enhancer 0.7 ENCODE 29.4 +914.9 914886 0.2 ZNF654 JUND ATF3 YY1 CTCF FOXA2 RXRA RAD21 SMC3 STAT3 NRG1 HSALNG0064435 ENSG00000286131
GH08J032225 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 12.3 +588.7 588711 5.2 JUND CTCF MAFF RAD21 SMC3 MAFK JUN FOS EP300 HSALNG0064426 NRG1 RNA5SP262 lnc-WRN-8 ENSG00000286131
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRG1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRG1

Top Transcription factor binding sites by QIAGEN in the NRG1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB

Genomic Locations for NRG1 Gene

Latest Assembly
chr8:31,639,222-32,855,666
(GRCh38/hg38)
Size:
1,216,445 bases
Orientation:
Plus strand

Previous Assembly
chr8:31,496,761-32,631,564
(GRCh37/hg19 by Entrez Gene)
Size:
1,134,804 bases
Orientation:
Plus strand

chr8:31,496,902-32,622,548
(GRCh37/hg19 by Ensembl)
Size:
1,125,647 bases
Orientation:
Plus strand

Genomic View for NRG1 Gene

Genes around NRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRG1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NRG1 Gene

Proteins for NRG1 Gene

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  • Protein details for NRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02297-NRG1_HUMAN
    Recommended name:
    Pro-neuregulin-1, membrane-bound isoform
    Protein Accession:
    Q02297
    Secondary Accessions:
    • A5YAK4
    • A5YAK5
    • A8K1L2
    • B7Z4Z3
    • E9PHH4
    • O14667
    • P98202
    • Q02298
    • Q02299
    • Q07110
    • Q07111
    • Q12779
    • Q12780
    • Q12781
    • Q12782
    • Q12783
    • Q12784
    • Q15491
    • Q7RTV9
    • Q7RTW0
    • Q7RTW1
    • Q7RTW2
    • Q8NFN1
    • Q8NFN2
    • Q8NFN3
    • Q9UPE3

    Protein attributes for NRG1 Gene

    Size:
    640 amino acids
    Molecular mass:
    70392 Da
    Quaternary structure:
    • The cytoplasmic domain interacts with the LIM domain region of LIMK1 (By similarity). Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4 (PubMed:20682778).
    SequenceCaution:
    • Sequence=AAA19955.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAC51756.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 10]: Potential internal signal sequence at positions 76-100.

    Three dimensional structures from OCA and Proteopedia for NRG1 Gene

    Alternative splice isoforms for NRG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRG1 Gene

Protein Expression for NRG1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NRG1 Gene

  • Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
  • N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage (By similarity).
  • Glycosylation at Asn120, Asn126, and Asn164
  • Modification sites at PhosphoSitePlus

Other Protein References for NRG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

Protein products for research

No data available for DME Specific Peptides for NRG1 Gene

Domains & Families for NRG1 Gene

Gene Families for NRG1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for NRG1 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Neuregulin family signature

Suggested Antigen Peptide Sequences for NRG1 Gene

GenScript: Design optimal peptide antigens:
  • Neuregulin 1 variant fetal a IV 1 (A5YAK6_HUMAN)
  • Neuregulin 1 variant fetal b IV-beta 1a (A5YAK7_HUMAN)
  • Neuregulin 1 variant fetal c IV 2 (A5YAK8_HUMAN)
  • Neuregulin 1 type IV fetal A beta 1a (A6MW54_HUMAN)
  • Neuregulin 1 type IV fetal B beta 1a (A6MW55_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q02297

UniProtKB/Swiss-Prot:

NRG1_HUMAN :
  • The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
  • Belongs to the neuregulin family.
Domain:
  • The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
  • ERBB receptor binding is elicited entirely by the EGF-like domain.
Family:
  • Belongs to the neuregulin family.
genes like me logo Genes that share domains with NRG1: view

Function for NRG1 Gene

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  6. Cell Lines for research

Molecular function for NRG1 Gene

UniProtKB/Swiss-Prot Function:
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).
GENATLAS Biochemistry:
neuregulin 1 multipotent epidermal growth factor-like factor with several splice variants (44kDa),indirect NEU/ERBB2 p185 activator (see ERBB2)

Phenotypes From GWAS Catalog for NRG1 Gene

Gene Ontology (GO) - Molecular Function for NRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription coregulator activity IDA 15073182
GO:0005102 signaling receptor binding IEA,IBA 21873635
GO:0005125 cytokine activity TAS 10372964
GO:0005176 ErbB-2 class receptor binding IEA --
GO:0005178 integrin binding IDA 20682778
genes like me logo Genes that share ontologies with NRG1: view
genes like me logo Genes that share phenotypes with NRG1: view

Animal Models for research

  • Taconic Biosciences Mouse Models for NRG1

miRNA for NRG1 Gene

miRTarBase miRNAs that target NRG1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRG1

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRG1 Gene

Localization for NRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRG1 Gene

[Pro-neuregulin-1, membrane-bound isoform]: Cell membrane. Single-pass type I membrane protein. Note=Does not seem to be active.
[Neuregulin-1]: Secreted.
[Isoform 8]: Nucleus. Note=May be nuclear.
[Isoform 9]: Secreted. Note=Has a signal peptide.
[Isoform 10]: Membrane. Single-pass type I membrane protein. Note=May possess an internal uncleaved signal sequence.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRG1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NRG1: view

Pathways & Interactions for NRG1 Gene

PathCards logo

SuperPathways for NRG1 Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Apoptotic Pathways in Synovial Fibroblasts
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
3 Signaling by ERBB2
Downregulation of ERBB2 signaling
.59
Signaling by ERBB2
.59
SHC1 events in ERBB2 signaling
.43
Downregulation of ERBB2-ERBB3 signaling
.01
ERBB2 Activates PTK6 Signaling
.01
ERBB2 Regulates Cell Motility
.01
GRB2 events in ERBB2 signaling
.01
PI3K events in ERBB2 signaling
.01
PI3K events in ERBB4 signaling
.01
SHC1 events in ERBB4 signaling
.01
4 PI3K/AKT activation
Negative regulation of the PI3K/AKT network
.93
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
.93
PIP3 activates AKT signaling
.91
Role of LAT2/NTAL/LAB on calcium mobilization
.91
GAB1 signalosome
.89
PI3K/AKT activation
.89
Constitutive Signaling by Aberrant PI3K in Cancer
.75
PI3K/AKT Signaling in Cancer
.72
5 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
genes like me logo Genes that share pathways with NRG1: view

Pathways by source for NRG1 Gene

1 PharmGKB pathway for NRG1 Gene
4 GeneGo (Thomson Reuters) pathways for NRG1 Gene
  • Apoptosis and survival Role of CDK5 in neuronal death and survival
  • Development ERBB-family signaling
  • Development Ligand-independent activation of ESR1 and ESR2
  • Translation Non-genomic (rapid) action of Androgen Receptor
58 Qiagen pathways for NRG1 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
1 Cell Signaling Technology pathway for NRG1 Gene

SIGNOR curated interactions for NRG1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity IMP 20682778
GO:0000902 cell morphogenesis IEA --
GO:0003161 cardiac conduction system development IEA --
GO:0003222 ventricular trabecula myocardium morphogenesis IDA 17336907
genes like me logo Genes that share ontologies with NRG1: view

Drugs & Compounds for NRG1 Gene

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  1. Drug products for research

(45) Drugs for NRG1 Gene - From: PharmGKB, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pancrelipase Approved, Investigational Pharma 1288
antipsychotics Pharma 0
Antibodies Pharma 8474
Antibodies, Bispecific Pharma 189
Antibodies, Monoclonal Pharma 4203

(25) Additional Compounds for NRG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NRG1: view

Transcripts for NRG1 Gene

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mRNA/cDNA for NRG1 Gene

23 REFSEQ mRNAs :
55 NCBI additional mRNA sequence :
37 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRG1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for NRG1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for NRG1 Gene

GeneLoc Exon Structure for
NRG1

Expression for NRG1 Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NRG1 Gene

mRNA expression in normal human tissues for NRG1 Gene
mRNA expression by BioGPS for NRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NRG1 Gene

This gene is overexpressed in Pancreatic juice (58.5) and Liver (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NRG1 Gene



Protein tissue co-expression partners for NRG1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRG1

SOURCE GeneReport for Unigene cluster for NRG1 Gene:

Hs.453951

mRNA Expression by UniProt/SwissProt for NRG1 Gene:

Q02297-NRG1_HUMAN
Tissue specificity: Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific.

Evidence on tissue expression from TISSUES for NRG1 Gene

  • Nervous system(4.8)
  • Intestine(4.5)
  • Muscle(2.3)
  • Skin(2.3)
  • Kidney(2.2)
  • Heart(2.2)
  • Liver(2.2)
  • Thyroid gland(2.1)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with NRG1: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRG1 Gene

Orthologs for NRG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRG1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia NRG1 29 30
  • 99.55 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia NRG1 29 30
  • 91.69 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia NRG1 29 30
  • 90.64 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Nrg1 29
  • 89.06 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia NRG1 30
  • 88 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia NRG1 30
  • 85 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Nrg1 30
  • 67 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves NRG1 30
  • 64 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia NRG1 30
  • 73 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC100496613 29
  • 72.37 (n)
African clawed frog
(Xenopus laevis)
 Amphibia nrg1-A 29
Zebrafish
(Danio rerio)
 Actinopterygii nrg1 29 30
  • 60.13 (n)
 OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.6383 29
Species where no ortholog for NRG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NRG1 Gene

ENSEMBL:
Gene Tree for NRG1 (if available)
TreeFam:
Gene Tree for NRG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NRG1: view image
Alliance of Genome Resources:
Additional Orthologs for NRG1

Paralogs for NRG1 Gene

Paralogs for NRG1 Gene

(3) SIMAP similar genes for NRG1 Gene using alignment to 34 proteins:

  • NRG1_HUMAN
  • A5YAK6_HUMAN
  • A5YAK7_HUMAN
  • A5YAK8_HUMAN
  • A6MW54_HUMAN
  • A6MW55_HUMAN
  • A6MW56_HUMAN
  • B0FWZ3_HUMAN
  • B0FYA7_HUMAN
  • B0FYA8_HUMAN
  • B0FYA9_HUMAN
  • B5BU95_HUMAN
  • B7Z168_HUMAN
  • B7Z1E3_HUMAN
  • B9EK51_HUMAN
  • E3SFM9_HUMAN
  • E3SFN0_HUMAN
  • E5RHP6_HUMAN
  • E5RHQ1_HUMAN
  • E5RIG8_HUMAN
  • E7EX30_HUMAN
  • F8W9E3_HUMAN
  • H0YBA3_HUMAN
  • H0YCP0_HUMAN
  • H0YDC2_HUMAN
  • H7BXY2_HUMAN
  • Q6ICV5_HUMAN
  • Q6PK61_HUMAN
  • Q7RTV8_HUMAN
  • Q7RTW3_HUMAN
  • Q7RTW4_HUMAN
  • Q7RTW5_HUMAN
  • Q86WJ0_HUMAN
  • Q96IB3_HUMAN
genes like me logo Genes that share paralogs with NRG1: view

Variants for NRG1 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRG1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs115066329 Benign: not provided 32,763,844(+) C/T
NM_013956.5(NRG1):c.1380C>T (p.Pro460=) 		SYNONYMOUS_VARIANT,THREE_PRIME_UTR
rs1407040962 Uncertain Significance: not provided 32,760,384(+) C/T
NM_013956.5(NRG1):c.1261C>T (p.Arg421Ter) 		NONSENSE
rs142663418 Likely Benign: not provided 32,605,565(+) G/A
NM_013962.2(NRG1):c.927G>A (p.Lys309=) 		SYNONYMOUS_VARIANT,FIVE_PRIME_UTR
rs145358541 Likely Benign: not provided 32,763,859(+) G/A
NM_013956.5(NRG1):c.1395G>A (p.Thr465=) 		SYNONYMOUS_VARIANT,THREE_PRIME_UTR
rs147561043 Benign: not provided 32,595,868(+) G/A
NM_013962.2(NRG1):c.786G>A (p.Ser262=) 		SYNONYMOUS_VARIANT,FIVE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NRG1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NRG1 Gene

Variant ID Type Subtype PubMed ID
dgv1177n67 CNV loss 20364138
dgv3803n106 CNV deletion 24896259
esv1412340 CNV insertion 17803354
esv1484590 CNV insertion 17803354
esv1693112 CNV deletion 17803354
esv2167886 CNV deletion 18987734
esv2638529 CNV deletion 19546169
esv2657877 CNV deletion 23128226
esv2659448 CNV deletion 23128226
esv2663032 CNV deletion 23128226
esv2677557 CNV deletion 23128226
esv2736844 CNV deletion 23290073
esv2736845 CNV deletion 23290073
esv274992 CNV gain+loss 21479260
esv275121 CNV loss 21479260
esv275566 CNV loss 21479260
esv2761420 CNV loss 21179565
esv3344849 CNV insertion 20981092
esv3359497 CNV insertion 20981092
esv3390500 CNV insertion 20981092
esv3543307 CNV deletion 23714750
esv3572666 CNV loss 25503493
esv3572667 CNV loss 25503493
esv3572668 CNV loss 25503493
esv3572669 CNV loss 25503493
esv3572670 CNV loss 25503493
esv3576536 CNV gain 25503493
esv3576537 CNV gain 25503493
esv3616802 CNV gain 21293372
esv3616803 CNV loss 21293372
esv3616806 CNV loss 21293372
esv3616807 CNV loss 21293372
esv3616808 CNV loss 21293372
esv3616809 CNV loss 21293372
esv3616810 CNV gain 21293372
esv3616813 CNV loss 21293372
esv3891380 CNV gain 25118596
esv4933 CNV loss 18987735
esv8345 CNV gain 19470904
esv9668 CNV loss 19470904
esv991445 CNV deletion 20482838
nsv1016490 CNV gain 25217958
nsv1075128 CNV deletion 25765185
nsv1076078 CNV deletion 25765185
nsv1117817 CNV deletion 24896259
nsv1124334 CNV deletion 24896259
nsv1132138 CNV deletion 24896259
nsv1139933 CNV duplication 24896259
nsv1145984 CNV deletion 26484159
nsv397244 CNV deletion 16902084
nsv397271 CNV deletion 16902084
nsv398013 CNV deletion 16902084
nsv398284 CNV deletion 16902084
nsv465632 CNV gain 19166990
nsv465633 CNV loss 19166990
nsv470207 CNV gain 18288195
nsv474487 CNV novel sequence insertion 20440878
nsv510140 OTHER sequence alteration 20534489
nsv518140 CNV loss 19592680
nsv522780 CNV loss 19592680
nsv526564 CNV loss 19592680
nsv528531 CNV loss 19592680
nsv610880 CNV gain 21841781
nsv610881 CNV loss 21841781
nsv6142 CNV insertion 18451855
nsv831280 CNV loss 17160897
nsv831282 CNV gain 17160897
nsv957672 CNV deletion 24416366

Variation tolerance for NRG1 Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.88; 98.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRG1 Gene

Human Gene Mutation Database (HGMD)
NRG1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRG1
Leiden Open Variation Database (LOVD)
NRG1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRG1 Gene

Disorders for NRG1 Gene

MalaCards: The human disease database

(37) MalaCards diseases for NRG1 Gene - From: LNC, GTR, COP, and GCD

Disorder Aliases PubMed IDs
schizophrenia 6
  • sczd6
lung cancer
  • lung cancer, susceptibility to
mucinous lung adenocarcinoma
schizophreniform disorder
  • schizophreniform disorders
cannabis abuse
  • marijuana abuse
- elite association - COSMIC cancer census association via MalaCards
Search NRG1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NRG1_HUMAN
  • Note=A chromosomal aberration involving NRG1 produces gamma-heregulin. Translocation t(8;11) with TENM4. The translocation fuses the 5'-end of TENM4 to NRG1 (isoform 8). The product of this translocation was first thought to be an alternatively spliced isoform. Gamma-heregulin is a soluble activating ligand for the ERBB2-ERBB3 receptor complex and acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175). Not detected in breast carcinoma samples, including ductal, lobular, medullary, and mucinous histological types, neither in other breast cancer cell lines.

Additional Disease Information for NRG1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NRG1: view

No data available for Genatlas for NRG1 Gene

Publications for NRG1 Gene

  1. Identification of heregulin, a specific activator of p185erbB2. (PMID: 1350381) Holmes WE … Lewis GD (Science (New York, N.Y.) 1992) 2 3 4 22
  2. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PMID: 19367581) So HC … Sham PC (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 22 40
  3. Neuregulin-1 genotypes and eye movements in schizophrenia. (PMID: 19575259) Haraldsson HM … Petursson H (European archives of psychiatry and clinical neuroscience 2010) 3 22 40
  4. Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample. (PMID: 19937977) Réthelyi JM … Bitter I (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 22 40
  5. Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population. (PMID: 19394386) Okochi T … Iwata N (Progress in neuro-psychopharmacology & biological psychiatry 2009) 3 22 40

ExternalLinks

View latest publications for NRG1 gene in Mastermind

Products for NRG1 Gene