Aliases for NRF1 Gene
Aliases for NRF1 Gene
External Ids for NRF1 Gene
- HGNC: 7996
- Entrez Gene: 4899
- Ensembl: ENSG00000106459
- OMIM: 600879
- UniProtKB: Q16656
Previous GeneCards Identifiers for NRF1 Gene
- GC07P127727
- GC07P128790
- GC07P128804
- GC07P128845
- GC07P129038
- GC07P129251
- GC07P123613
Summaries for NRF1 Gene
-
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]
GeneCards Summary for NRF1 Gene
NRF1 (Nuclear Respiratory Factor 1) is a Protein Coding gene. Diseases associated with NRF1 include Skin Carcinoma In Situ. Among its related pathways are Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway and Apelin signaling pathway. Gene Ontology (GO) annotations related to this gene include RNA polymerase II proximal promoter sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding.
UniProtKB/Swiss-Prot for NRF1 Gene
-
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRF1 Gene
Genomics for NRF1 Gene
GeneHancer (GH) Regulatory Elements for NRF1 Gene
Promoters and enhancers for NRF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around NRF1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NRF1 gene promoter:
-
- YY1
- aMEF-2
- MEF-2A
Regulatory Element Products
Genomic Locations for NRF1 Gene
Genomic Locations for NRF1 Gene
- chr7:129,611,702-129,757,082
- (GRCh38/hg38)
- Size:
- 145,381 bases
- Orientation:
- Plus strand
- chr7:129,251,555-129,396,922
- (GRCh37/hg19)
- Size:
- 145,368 bases
- Orientation:
- Plus strand
Genomic View for NRF1 Gene
Genes around NRF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q32.2 by Entrez Gene
- 7q32.2 by HGNC
- 7q32.2 by Ensembl
NRF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NRF1 Gene
Proteins for NRF1 Gene
-
Protein details for NRF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16656-NRF1_HUMAN
- Recommended name:
- Nuclear respiratory factor 1
- Protein Accession:
- Q16656
- A8K4C6
- B4DDV6
- Q15305
- Q96AN2
Protein attributes for NRF1 Gene
- Size:
- 503 amino acids
- Molecular mass:
- 53541 Da
- Quaternary structure:
-
- Homodimer. Binds DNA as a dimer. Interacts with PPRC1.
Protein Expression for NRF1 Gene
Post-translational modifications for NRF1 Gene
- Phosphorylation enhances DNA binding.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for NRF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for NRF1
- Novus Biologicals Antibodies for NRF1
-
Abcam antibodies for NRF1
- Invitrogen Antibodies for NRF1 (AFLGC-NRF1)
- GeneTex NRF1 Antibody for NRF1
-
Santa Cruz Biotechnology (SCBT) Antibodies for NRF1
- Sino Biological Antibodies for NRF1
Protein Products
-
OriGene Purified Proteins for NRF1
- Search Origene for MassSpec and Protein Over-expression Lysates for NRF1
- Origene Custom Protein Services for NRF1
- Search GeneTex for Proteins for NRF1
-
Abcam proteins for NRF1
Assay Products
No data available for DME Specific Peptides for NRF1 Gene
Domains & Families for NRF1 Gene
Gene Families for NRF1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NRF1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NRF1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q16656- Family:
-
- Belongs to the NRF1/Ewg family.
Function for NRF1 Gene
Molecular function for NRF1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
- GENATLAS Biochemistry:
- nuclear respiratory factor 1,involved in the regulation of mitochondrial biogenesis and in oxidative phosphorylation
Phenotypes From GWAS Catalog for NRF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 19674972 |
| GO:0001046 | core promoter sequence-specific DNA binding | ISS | -- |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IMP | 19674972 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IBA | -- |
Phenotypes for NRF1 Gene
- MGI mutant phenotypes for NRF1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NRF1:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Reduced mammosphere formation
- Increased Nanog expression
- Decreased viability
- no effect
- Decreased Aire reporter expression
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 50%
- Increased viability
Animal Models for NRF1 Gene
- MGI Knock Outs for NRF1:
-
- Nrf1 Nrf1<tm1Rcs>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NRF1
-
CRISPR Products
-
OriGene CRISPR knockouts for NRF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRF1
- genomics-online: gRNA clones - Search results for available NRF1 gene related products
- Applied Biological Materials CRISPR for NRF1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRF1
- GenScript: Design CRISPR guide RNA sequences for NRF1
miRNA for NRF1 Gene
- miRTarBase miRNAs that target NRF1
-
- hsa-mir-124-3p (MIRT022754)
- hsa-mir-320a (MIRT044600)
- hsa-mir-4772-5p (MIRT487476)
- hsa-mir-3127-5p (MIRT487477)
- hsa-mir-6823-5p (MIRT487478)
- hsa-mir-6798-5p (MIRT487479)
- hsa-mir-383-5p (MIRT487480)
- hsa-mir-4801 (MIRT487481)
- hsa-mir-4731-3p (MIRT487482)
- hsa-mir-377-3p (MIRT501760)
- hsa-mir-5579-3p (MIRT501761)
- hsa-mir-2115-5p (MIRT501762)
- hsa-mir-1277-5p (MIRT506404)
- hsa-mir-539-3p (MIRT506405)
- hsa-mir-485-3p (MIRT506406)
- hsa-mir-3924 (MIRT506407)
- hsa-mir-190a-3p (MIRT506408)
- hsa-mir-5011-5p (MIRT506409)
- hsa-mir-5580-3p (MIRT506410)
- hsa-mir-6780a-5p (MIRT511015)
- hsa-mir-6779-5p (MIRT511016)
- hsa-mir-3689c (MIRT511017)
- hsa-mir-3689b-3p (MIRT511018)
- hsa-mir-3689a-3p (MIRT511019)
- hsa-mir-30b-3p (MIRT511020)
- hsa-mir-1273h-5p (MIRT511021)
- hsa-mir-6799-5p (MIRT511022)
- hsa-mir-6883-5p (MIRT511023)
- hsa-mir-6785-5p (MIRT511024)
- hsa-mir-4728-5p (MIRT511025)
- hsa-mir-149-3p (MIRT511026)
- hsa-mir-7106-5p (MIRT511027)
- hsa-mir-1249-5p (MIRT511028)
- hsa-mir-6797-5p (MIRT511029)
- hsa-mir-765 (MIRT511030)
- hsa-mir-6133 (MIRT511031)
- hsa-mir-6130 (MIRT511032)
- hsa-mir-6129 (MIRT511033)
- hsa-mir-6127 (MIRT511034)
- hsa-mir-4510 (MIRT511035)
- hsa-mir-4419a (MIRT511036)
- hsa-mir-4487 (MIRT511037)
- hsa-mir-4756-5p (MIRT511038)
- hsa-mir-3192-5p (MIRT511039)
- hsa-mir-4739 (MIRT511040)
- hsa-mir-1321 (MIRT511041)
- hsa-mir-4779 (MIRT511042)
- hsa-mir-708-5p (MIRT511043)
- hsa-mir-3139 (MIRT511044)
- hsa-mir-28-5p (MIRT511045)
- hsa-mir-6083 (MIRT511046)
- hsa-mir-3912-5p (MIRT511047)
- hsa-mir-297 (MIRT511048)
- hsa-mir-223-5p (MIRT511049)
- hsa-mir-567 (MIRT511050)
- hsa-mir-511-3p (MIRT511051)
- hsa-mir-6834-3p (MIRT511052)
- hsa-mir-380-3p (MIRT511053)
- hsa-mir-4495 (MIRT511054)
- hsa-mir-379-3p (MIRT511055)
- hsa-mir-411-3p (MIRT511056)
- hsa-mir-7108-5p (MIRT535617)
- hsa-mir-588 (MIRT535618)
- hsa-mir-4701-5p (MIRT535619)
- hsa-mir-663b (MIRT535620)
- hsa-mir-7155-3p (MIRT535621)
- hsa-mir-3136-3p (MIRT535622)
- hsa-mir-33a-3p (MIRT721713)
- hsa-mir-3692-3p (MIRT721714)
- hsa-mir-6736-5p (MIRT721715)
- hsa-mir-4701-3p (MIRT721716)
- hsa-mir-1262 (MIRT721717)
- hsa-mir-183-3p (MIRT721718)
- hsa-mir-5701 (MIRT721719)
- hsa-mir-6776-5p (MIRT721720)
- hsa-mir-140-3p (MIRT721721)
- hsa-mir-944 (MIRT721722)
- hsa-mir-504-3p (MIRT733296)
Targeted motifs for NRF1 Gene
HOMER Transcription Factor Regulatory Elements motif NRF1
- Consensus sequence: CTGCGCATGCGC Submotif: canonical Cell Type: MCF7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NRF1
- Browse OriGene Inhibitory RNA Products For NRF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRF1
- genomics-online: shRNA clones - Search results for available NRF1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for NRF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRF1
- genomics-online: cdna clones - Search results for available NRF1 gene related products
- orf clones - Search results for available NRF1 gene related products
- Applied Biological Materials Clones for NRF1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for NRF1 Gene
Localization for NRF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NRF1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 3 |
| peroxisome | 2 |
- Nucleoplasm (3)
- Cytosol (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
Pathways & Interactions for NRF1 Gene
Pathways by source for NRF1 Gene
2 BioSystems pathways for NRF1 Gene
8 Reactome pathways for NRF1 Gene
2 KEGG pathways for NRF1 Gene
1 Qiagen pathway for NRF1 Gene
1 Cell Signaling Technology pathway for NRF1 Gene
Interacting Proteins for NRF1 Gene
Selected Interacting proteins:
Q16656-NRF1_HUMAN
ENSP00000223190
for NRF1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for NRF1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006091 | generation of precursor metabolites and energy | TAS | 7629110 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 8034649 |
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
Drugs & Compounds for NRF1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Drug Products
Transcripts for NRF1 Gene
mRNA/cDNA for NRF1 Gene
- (4) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (106) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000477428 513 bps (uc064hxk.1)
- ENST00000454688 814 bps (uc064hxl.1)
- ENST00000223190 2424 bps (uc064hxm.1)
- ENST00000311967 2481 bps (uc003vpa.4)
- ENST00000393230 3523 bps (uc003vpb.4)
Unigene Clusters for NRF1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NRF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRF1
- genomics-online: gRNA clones - Search results for available NRF1 gene related products
- Applied Biological Materials CRISPR for NRF1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRF1
- GenScript: Design CRISPR guide RNA sequences for NRF1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NRF1
- Browse OriGene Inhibitory RNA Products For NRF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRF1
- genomics-online: shRNA clones - Search results for available NRF1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for NRF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRF1
- genomics-online: cdna clones - Search results for available NRF1 gene related products
- orf clones - Search results for available NRF1 gene related products
- Applied Biological Materials Clones for NRF1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||
| SP7: |
Expression for NRF1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- Double Negative 2 Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Negative 2 Thymocytes Thymus
-
Liver (Hepatobiliary System)
- Hepatoblasts Liver Bud
-
Epithelial Cells
- Hepatoblasts Liver Bud
This gene is overexpressed in CD8 Tcells (13.4), Blymphocyte (10.7), NK cells (9.2), and Placenta (8.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NRF1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of NRF1 Gene:
NRF1SOURCE GeneReport for Unigene cluster for NRF1 Gene:
Hs.654363mRNA Expression by UniProt/SwissProt for NRF1 Gene:
Q16656-NRF1_HUMAN
Tissue specificity:
Ubiquitously expressed with strongest expression in skeletal muscle.
Evidence on tissue expression from TISSUES for NRF1 Gene
- Intestine(4.1)
- Muscle(2.5)
- Heart(2)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs for NRF1
-
OriGene qPCR primer pairs and template standards for NRF1
- genomics-online: primer clones - Search results for available NRF1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRF1 Gene
Orthologs for NRF1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NRF1 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | NRF1 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NRF1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NRF1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Nrf1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nrf1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | NRF1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | F 34 |
|
OneToOne | |
| NRF1 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | NRF1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nrf1 33 |
|
||
| Str.3769 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3115 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | nrf1 34 33 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | ewg 34 35 |
|
OneToOne |
- Species where no ortholog for NRF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for NRF1 Gene
- ENSEMBL:
- Gene Tree for NRF1 (if available)
- TreeFam:
- Gene Tree for NRF1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NRF1: view image
Paralogs for NRF1 Gene
No data available for Paralogs for NRF1 Gene
Variants for NRF1 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000005204 | -- | 129,742,466(+) | T/A | intron_variant | |
| rs1000009633 | -- | 129,756,534(+) | TCTGTCT/TCT | 3_prime_UTR_variant | |
| rs1000017301 | -- | 129,621,924(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000044458 | -- | 129,631,204(+) | T/G | intron_variant | |
| rs1000088967 | -- | 129,674,015(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv23078 | CNV | gain | 19812545 |
| esv2674051 | CNV | deletion | 23128226 |
| esv3542421 | CNV | deletion | 23714750 |
| esv3615004 | CNV | loss | 21293372 |
| esv3615005 | CNV | gain | 21293372 |
| nsv474317 | CNV | novel sequence insertion | 20440878 |
| nsv516024 | CNV | gain+loss | 19592680 |
| nsv5948 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.32;
7.15% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NRF1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NRF1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRF1 Gene
Disorders for NRF1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| skin carcinoma in situ |
|
|
Search NRF1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NRF1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NRF1 Gene
Publications for NRF1 Gene
- Genetic variation and association analyses of the nuclear respiratory factor 1 (nRF1) gene in Chinese patients with type 2 diabetes. (PMID: 18071027) Liu Y … Liu Y (Diabetes 2008) 3 22 44 58
- Association between polymorphisms in the nuclear respiratory factor 1 gene and type 2 diabetes mellitus in the Korean population. (PMID: 16082529) Cho YM … Lee HK (Diabetologia 2005) 3 22 44 58
- Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells. (PMID: 11340167) Andersson U … Scarpulla RC (Molecular and cellular biology 2001) 3 4 22 58
- Serine phosphorylation within a concise amino-terminal domain in nuclear respiratory factor 1 enhances DNA binding. (PMID: 9228045) Gugneja S … Scarpulla RC (The Journal of biological chemistry 1997) 3 4 22 58
- Structure, expression, and chromosomal assignment of the human gene encoding nuclear respiratory factor 1. (PMID: 7629110) Gopalakrishnan L … Scarpulla RC (The Journal of biological chemistry 1995) 3 4 22 58
Products for NRF1 Gene
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- Custom Antibody ServicesOriGene Antibodies for NRF1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NRF1
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- Browse OriGene miRNA Products For NRF1
- GenScript: Next-day shipping of latest version cDNA ORF clones for NRF1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for NRF1
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- GenScript: Design CRISPR guide RNA sequences for NRF1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
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- GenScript Custom Peptide Services for NRF1
- Sino Biological Human cDNA Clone for NRF1
- Browse Sino Biological Recombinant Proteins
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- Sino Biological Antibodies for NRF1
- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for NRF1
- Novus Biologicals lysates and proteins for NRF1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Abcam antibodies for NRF1
- Abcam proteins for NRF1
- Find your target
- Browse Primary Antibodies
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- Invitrogen Antibodies for NRF1 (AFLGC-NRF1)
- Cyagen custom Knockout/knockin (KOKI) mouse models for NRF1
- antibodies-online: Search results for 107 available NRF1 Antibodies ranked by validation data
- Compare Top NRF1 Antibodies
- antibodies-online: Search results for 12 available NRF1 Elisa Kits ranked by validation data
- Compare Top NRF1 Elisa Kits
- antibodies-online: Search results for 6 available NRF1 Proteins ranked by validation data
- Compare Top NRF1 Proteins
- GeneTex NRF1 Antibody for NRF1
- Search GeneTex for Proteins for NRF1
- Santa Cruz Biotechnology (SCBT) Antibodies for NRF1
- Search Santa Cruz Biotechnology (SCBT) for NRF1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NRF1
- genomics-online: cdna clones - Search results for available NRF1 gene related products
- orf clones - Search results for available NRF1 gene related products
- genomics-online: gRNA clones - Search results for available NRF1 gene related products
- genomics-online: primer clones - Search results for available NRF1 gene related products
- genomics-online: shRNA clones - Search results for available NRF1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRF1
- GeneCopoeia miRNA 3'UTR Target clone products for NRF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRF1
Sources for NRF1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt