Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative ... See more...
Aliases for NRF1 Gene
Aliases for NRF1 Gene
External Ids for NRF1 Gene
- HGNC: 7996
- Entrez Gene: 4899
- Ensembl: ENSG00000106459
- OMIM: 600879
- UniProtKB: Q16656
Previous GeneCards Identifiers for NRF1 Gene
- GC07P127727
- GC07P128790
- GC07P128804
- GC07P128845
- GC07P129038
- GC07P129251
- GC07P123613
Summaries for NRF1 Gene
-
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]
GeneCards Summary for NRF1 Gene
NRF1 (Nuclear Respiratory Factor 1) is a Protein Coding gene. Diseases associated with NRF1 include Skin Carcinoma In Situ and Oncocytoma. Among its related pathways are Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include RNA polymerase II proximal promoter sequence-specific DNA binding and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific.
UniProtKB/Swiss-Prot Summary for NRF1 Gene
-
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Additional gene information for NRF1 Gene
- HGNC(7996)
- Entrez Gene(4899)
- Ensembl(ENSG00000106459)
- OMIM(600879)
- UniProtKB(Q16656)
- Open Targets Platform(ENSG00000106459)
- Search for NRF1 at DataMed
- Search for NRF1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRF1 Gene
Genomics for NRF1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NRF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NRF1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRF1
- Top Transcription factor binding sites by QIAGEN in the NRF1 gene promoter:
-
- aMEF-2
- MEF-2A
- YY1
Genomic Locations for NRF1 Gene
Genomic Locations for NRF1 Gene
- chr7:129,611,720-129,757,082
- (GRCh38/hg38)
- Size:
- 145,363 bases
- Orientation:
- Plus strand
- chr7:129,251,555-129,396,922
- (GRCh37/hg19)
- Size:
- 145,368 bases
- Orientation:
- Plus strand
Genomic View for NRF1 Gene
Genes around NRF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q32.2 by HGNC
- 7q32.2 by Entrez Gene
- 7q32.2 by Ensembl
NRF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NRF1 Gene
Proteins for NRF1 Gene
-
Protein details for NRF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16656-NRF1_HUMAN
- Recommended name:
- Nuclear respiratory factor 1
- Protein Accession:
- Q16656
- A8K4C6
- B4DDV6
- Q15305
- Q96AN2
Protein attributes for NRF1 Gene
- Size:
- 503 amino acids
- Molecular mass:
- 53541 Da
- Quaternary structure:
-
- Homodimer. Binds DNA as a dimer. Interacts with PPRC1.
Protein Expression for NRF1 Gene
Post-translational modifications for NRF1 Gene
- Phosphorylation enhances DNA binding.
-
Ubiquitination at Lys139
- NX_Q16656 (NX_Q16656-1)
- Modification sites at PhosphoSitePlus
Other Protein References for NRF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences NRF1 / NRF-1 Antibody (LS-B43) and NRF1 / NRF-1 Antibody (LS-B3511)
- NSJ Bioreagents NRF1 Antibody
- Creative Diagnostics Anti-NRF1 monoclonal antibody, clone 0F7-I9-C7
- GeneTex Anti-NRF1 antibody
-
Custom Antibody ServicesOriGene Antibodies for NRF1
- Novus Biologicals Antibodies for NRF1
-
Abcam antibodies for NRF1
- Invitrogen Antibodies for NRF1 (AFLGC-NRF1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for NRF1
- Sino Biological Antibodies for NRF1
Protein Products
- Creative Biomart Recombinant Human NRF1
-
OriGene Purified Proteins for NRF1
- Search Origene for MassSpec and Protein Over-expression Lysates for NRF1
- Origene Custom Protein Services for NRF1
-
Abcam proteins for NRF1
No data available for DME Specific Peptides for NRF1 Gene
Domains & Families for NRF1 Gene
Gene Families for NRF1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NRF1 Gene
- InterPro:
- Blocks:
-
- Transcription factor, MADS-box
- ProtoNet:
Suggested Antigen Peptide Sequences for NRF1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ57098, highly similar to Nuclear respiratory factor 1 (B4DDV6_HUMAN)
- Alpha palindromic-binding protein (NRF1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q16656- Family:
-
- Belongs to the NRF1/Ewg family.
Function for NRF1 Gene
Molecular function for NRF1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
- GENATLAS Biochemistry:
- nuclear respiratory factor 1,involved in the regulation of mitochondrial biogenesis and in oxidative phosphorylation
Phenotypes From GWAS Catalog for NRF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 19674972 |
| GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | IDA | 23525105 |
| GO:0001046 | core promoter sequence-specific DNA binding | IBA,ISS | -- |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IMP | 19674972 |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for NRF1 Gene
- MGI mutant phenotypes for NRF1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for NRF1:
-
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Increased gamma-H2AX phosphorylation
- Reduced mammosphere formation
- Increased Nanog expression
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased Aire reporter expression
Animal Models for NRF1 Gene
- MGI Knock Outs for NRF1:
-
- Nrf1 Nrf1<tm1Rcs>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NRF1 - Select products 50% OFF >
- * NRF1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NRF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRF1
miRNA for NRF1 Gene
- miRTarBase miRNAs that target NRF1
-
- hsa-miR-124-3p (MIRT022754)
- hsa-miR-320a (MIRT044600)
- mmu-miR-378a-3p (MIRT437441)
- hsa-miR-4772-5p (MIRT487476)
- hsa-miR-3127-5p (MIRT487477)
- hsa-miR-6823-5p (MIRT487478)
- hsa-miR-6798-5p (MIRT487479)
- hsa-miR-383-5p (MIRT487480)
- hsa-miR-4801 (MIRT487481)
- hsa-miR-4731-3p (MIRT487482)
- hsa-miR-377-3p (MIRT501760)
- hsa-miR-5579-3p (MIRT501761)
- hsa-miR-2115-5p (MIRT501762)
- hsa-miR-1277-5p (MIRT506404)
- hsa-miR-539-3p (MIRT506405)
- hsa-miR-485-3p (MIRT506406)
- hsa-miR-3924 (MIRT506407)
- hsa-miR-190a-3p (MIRT506408)
- hsa-miR-5011-5p (MIRT506409)
- hsa-miR-5580-3p (MIRT506410)
- hsa-miR-6780a-5p (MIRT511015)
- hsa-miR-6779-5p (MIRT511016)
- hsa-miR-3689c (MIRT511017)
- hsa-miR-3689b-3p (MIRT511018)
- hsa-miR-3689a-3p (MIRT511019)
- hsa-miR-30b-3p (MIRT511020)
- hsa-miR-1273h-5p (MIRT511021)
- hsa-miR-6799-5p (MIRT511022)
- hsa-miR-6883-5p (MIRT511023)
- hsa-miR-6785-5p (MIRT511024)
- hsa-miR-4728-5p (MIRT511025)
- hsa-miR-149-3p (MIRT511026)
- hsa-miR-7106-5p (MIRT511027)
- hsa-miR-1249-5p (MIRT511028)
- hsa-miR-6797-5p (MIRT511029)
- hsa-miR-765 (MIRT511030)
- hsa-miR-6133 (MIRT511031)
- hsa-miR-6130 (MIRT511032)
- hsa-miR-6129 (MIRT511033)
- hsa-miR-6127 (MIRT511034)
- hsa-miR-4510 (MIRT511035)
- hsa-miR-4419a (MIRT511036)
- hsa-miR-4487 (MIRT511037)
- hsa-miR-4756-5p (MIRT511038)
- hsa-miR-3192-5p (MIRT511039)
- hsa-miR-4739 (MIRT511040)
- hsa-miR-1321 (MIRT511041)
- hsa-miR-4779 (MIRT511042)
- hsa-miR-708-5p (MIRT511043)
- hsa-miR-3139 (MIRT511044)
- hsa-miR-28-5p (MIRT511045)
- hsa-miR-6083 (MIRT511046)
- hsa-miR-3912-5p (MIRT511047)
- hsa-miR-297 (MIRT511048)
- hsa-miR-223-5p (MIRT511049)
- hsa-miR-567 (MIRT511050)
- hsa-miR-511-3p (MIRT511051)
- hsa-miR-6834-3p (MIRT511052)
- hsa-miR-380-3p (MIRT511053)
- hsa-miR-4495 (MIRT511054)
- hsa-miR-379-3p (MIRT511055)
- hsa-miR-411-3p (MIRT511056)
- hsa-miR-7108-5p (MIRT535617)
- hsa-miR-588 (MIRT535618)
- hsa-miR-4701-5p (MIRT535619)
- hsa-miR-663b (MIRT535620)
- hsa-miR-7155-3p (MIRT535621)
- hsa-miR-3136-3p (MIRT535622)
- mmu-miR-466f-3p (MIRT577059)
- mmu-miR-466i-3p (MIRT577060)
- mmu-miR-362-3p (MIRT577061)
- mmu-miR-329-3p (MIRT577062)
- mmu-miR-467f (MIRT589399)
- mmu-miR-297b-5p (MIRT589400)
- mmu-miR-297a-5p (MIRT589401)
- mmu-miR-297c-5p (MIRT589402)
- mmu-miR-466n-3p (MIRT589403)
- mmu-miR-669f-3p (MIRT589404)
- mmu-miR-669m-3p (MIRT589405)
- mmu-miR-297b-3p (MIRT589406)
- mmu-miR-466d-3p (MIRT589407)
- mmu-miR-467g (MIRT589408)
- mmu-miR-466e-3p (MIRT589409)
- mmu-miR-466a-3p (MIRT589410)
- hsa-miR-33a-3p (MIRT721713)
- hsa-miR-3692-3p (MIRT721714)
- hsa-miR-6736-5p (MIRT721715)
- hsa-miR-4701-3p (MIRT721716)
- hsa-miR-1262 (MIRT721717)
- hsa-miR-183-3p (MIRT721718)
- hsa-miR-5701 (MIRT721719)
- hsa-miR-6776-5p (MIRT721720)
- hsa-miR-140-3p (MIRT721721)
- hsa-miR-944 (MIRT721722)
- hsa-miR-504-3p (MIRT733296)
Targeted motifs for NRF1 Gene
HOMER Transcription Factor Regulatory Elements motif NRF1
- Consensus sequence: CTGCGCATGCGC Submotif: canonical Cell Type: MCF7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NRF1
- Browse OriGene Inhibitory RNA Products For NRF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRF1
Clone Products
- Applied Biological Materials (abm): Clones for NRF1 - Select products 50% OFF >
- * NRF1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG208550
- MG226726
- MG226730
- MG226735
- MG226739
- MG226741
- MR208550
- MR208550L3
- MR208550L4
- MR226726
- MR226726L3
- MR226726L4
- MR226730
- MR226730L3
- MR226730L4
- MR226735
- MR226735L3
- MR226735L4
- MR226739
- MR226739L3
- MR226739L4
- MR226741
- MR226741L3
- MR226741L4
- RC217852
- RC217852L1
- RC217852L2
- RC217852L3
- RC217852L4
- RC220113
- RC220113L3
- RC220113L4
- RC237588
- RC238707
- RG217852
- RG220113
- RR204818
- RR204818L3
- RR204818L4
- MR208550L3V
- MR208550L4V
- MR226726L3V
- MR226726L4V
- MR226730L3V
- MR226730L4V
- MR226735L3V
- MR226735L4V
- MR226739L3V
- MR226739L4V
- MR226741L3V
- MR226741L4V
- RC217852L1V
- RC217852L2V
- RC217852L3V
- RC217852L4V
- RC220113L3V
- RC220113L4V
- RR204818L3V
- RR204818L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NRF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRF1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for NRF1 Gene
Localization for NRF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NRF1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| mitochondrion | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
- Cytosol (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,ISS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
Pathways & Interactions for NRF1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 2 | Mitochondrial Gene Expression | ||
| 3 | Metabolism |
.40
|
|
| 4 | Glucose / Energy Metabolism | ||
| 5 | Apelin signaling pathway | ||
Pathways by source for NRF1 Gene
2 BioSystems pathways for NRF1 Gene
8 Reactome pathways for NRF1 Gene
2 KEGG pathways for NRF1 Gene
1 Qiagen pathway for NRF1 Gene
- PGC1Alpha Pathway
1 Cell Signaling Technology pathway for NRF1 Gene
Interacting Proteins for NRF1 Gene
Selected Interacting proteins:
Q16656-NRF1_HUMAN
ENSP00000376924
for NRF1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for NRF1
SIGNOR curated interactions for NRF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006091 | generation of precursor metabolites and energy | TAS | 7629110 |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS,IBA | 21873635 |
| GO:0007005 | mitochondrion organization | TAS | -- |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IMP | 19674972 |
Drugs & Compounds for NRF1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Phosphoric acid | Approved | Pharma | 0 | |||
| Adenosine monophosphate | Approved, Investigational | Nutra | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
| heme | Pharma | Agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Drug Products
- Creative Biomart Recombinant Human NRF1
Transcripts for NRF1 Gene
mRNA/cDNA for NRF1 Gene
- 4 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000223190 2424 nts (view in UCSC)
- ENST00000311967 2481 nts (view in UCSC)
- ENST00000353868 3568 nts (view in UCSC)
- ENST00000393230 3523 nts (view in UCSC)
- ENST00000393232 3518 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NRF1 - Select products 50% OFF >
- * NRF1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NRF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRF1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NRF1
- Browse OriGene Inhibitory RNA Products For NRF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRF1
Clone Products
- Applied Biological Materials (abm): Clones for NRF1 - Select products 50% OFF >
- * NRF1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG208550
- MG226726
- MG226730
- MG226735
- MG226739
- MG226741
- MR208550
- MR208550L3
- MR208550L4
- MR226726
- MR226726L3
- MR226726L4
- MR226730
- MR226730L3
- MR226730L4
- MR226735
- MR226735L3
- MR226735L4
- MR226739
- MR226739L3
- MR226739L4
- MR226741
- MR226741L3
- MR226741L4
- RC217852
- RC217852L1
- RC217852L2
- RC217852L3
- RC217852L4
- RC220113
- RC220113L3
- RC220113L4
- RC237588
- RC238707
- RG217852
- RG220113
- RR204818
- RR204818L3
- RR204818L4
- MR208550L3V
- MR208550L4V
- MR226726L3V
- MR226726L4V
- MR226730L3V
- MR226730L4V
- MR226735L3V
- MR226735L4V
- MR226739L3V
- MR226739L4V
- MR226741L3V
- MR226741L4V
- RC217852L1V
- RC217852L2V
- RC217852L3V
- RC217852L4V
- RC220113L3V
- RC220113L4V
- RR204818L3V
- RR204818L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NRF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRF1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for NRF1 Gene
- GeneLoc Exon Structure for
- NRF1
Expression for NRF1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- Double Negative 2 Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Negative 2 Thymocytes Thymus
-
Liver (Hepatobiliary System)
- Hepatoblasts Liver Bud
-
Epithelial Cells
- Hepatoblasts Liver Bud
This gene is overexpressed in CD8 Tcells (13.4), Blymphocyte (10.7), NK cells (9.2), and Placenta (8.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NRF1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRF1
SOURCE GeneReport for Unigene cluster for NRF1 Gene:
Hs.654363mRNA Expression by UniProt/SwissProt for NRF1 Gene:
Q16656-NRF1_HUMAN
Tissue specificity:
Ubiquitously expressed with strongest expression in skeletal muscle.
Evidence on tissue expression from TISSUES for NRF1 Gene
- Intestine(4.4)
- Muscle(2.8)
- Heart(2.5)
- Liver(2.5)
- Nervous system(2.5)
- Blood(2.4)
- Skin(2.3)
- Kidney(2.2)
- Thyroid gland(2.1)
Primer Products
-
OriGene qPCR primer pairs for NRF1
-
OriGene qPCR primer pairs and template standards for NRF1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRF1 Gene
Orthologs for NRF1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NRF1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | NRF1 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NRF1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NRF1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Nrf1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Nrf1 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NRF1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | F 31 |
|
OneToOne | |
| NRF1 30 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | NRF1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nrf1 30 |
|
||
| Str.3769 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3115 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | nrf1 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | ewg 31 32 |
|
OneToOne |
- Species where no ortholog for NRF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for NRF1 Gene
- ENSEMBL:
- Gene Tree for NRF1 (if available)
- TreeFam:
- Gene Tree for NRF1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NRF1: view image
Paralogs for NRF1 Gene
No data available for Paralogs for NRF1 Gene
Variants for NRF1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRF1 Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 722654 | Benign: not provided | 129,657,483(+) | G/A | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 779428 | Benign: not provided | 129,671,445(+) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 782028 | Benign: not provided | 129,727,250(+) | C/T | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv23078 | CNV | gain | 19812545 |
| esv2674051 | CNV | deletion | 23128226 |
| esv3542421 | CNV | deletion | 23714750 |
| esv3615004 | CNV | loss | 21293372 |
| esv3615005 | CNV | gain | 21293372 |
| nsv474317 | CNV | novel sequence insertion | 20440878 |
| nsv516024 | CNV | gain+loss | 19592680 |
| nsv5948 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.32;
7.15% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NRF1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NRF1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRF1 Gene
Disorders for NRF1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| skin carcinoma in situ |
|
|
| oncocytoma |
|
|
| spastic entropion |
|
|
| cicatricial entropion |
|
|
| mitochondrial metabolism disease |
|
Search NRF1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NRF1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for NRF1 Gene
Publications for NRF1 Gene
- Genetic variation and association analyses of the nuclear respiratory factor 1 (nRF1) gene in Chinese patients with type 2 diabetes. (PMID: 18071027) Liu Y … Liu Y (Diabetes 2008) 3 23 41
- Association between polymorphisms in the nuclear respiratory factor 1 gene and type 2 diabetes mellitus in the Korean population. (PMID: 16082529) Cho YM … Lee HK (Diabetologia 2005) 3 23 41
- Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells. (PMID: 11340167) Andersson U … Scarpulla RC (Molecular and cellular biology 2001) 3 4 23
- Serine phosphorylation within a concise amino-terminal domain in nuclear respiratory factor 1 enhances DNA binding. (PMID: 9228045) Gugneja S … Scarpulla RC (The Journal of biological chemistry 1997) 3 4 23
- Structure, expression, and chromosomal assignment of the human gene encoding nuclear respiratory factor 1. (PMID: 7629110) Gopalakrishnan L … Scarpulla RC (The Journal of biological chemistry 1995) 3 4 23
ExternalLinks
Products for NRF1 Gene
- Custom Antibody ServicesOriGene Antibodies for NRF1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NRF1
- Search Origene for MassSpec and Protein Over-expression Lysates for NRF1
- Origene Custom Protein Services for NRF1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NRF1
- Browse OriGene Inhibitory RNA Products For NRF1
- OriGene qPCR primer pairs for NRF1
- OriGene qPCR primer pairs and template standards for NRF1
- OriGene CRISPR knockouts for NRF1
- MG208550
- MG226726
- MG226730
- MG226735
- MG226739
- MG226741
- MR208550
- MR208550L3
- MR208550L4
- MR226726
- MR226726L3
- MR226726L4
- MR226730
- MR226730L3
- MR226730L4
- MR226735
- MR226735L3
- MR226735L4
- MR226739
- MR226739L3
- MR226739L4
- MR226741
- MR226741L3
- MR226741L4
- RC217852
- RC217852L1
- RC217852L2
- RC217852L3
- RC217852L4
- RC220113
- RC220113L3
- RC220113L4
- RC237588
- RC238707
- RG217852
- RG220113
- RR204818
- RR204818L3
- RR204818L4
- MR208550L3V
- MR208550L4V
- MR226726L3V
- MR226726L4V
- MR226730L3V
- MR226730L4V
- MR226735L3V
- MR226735L4V
- MR226739L3V
- MR226739L4V
- MR226741L3V
- MR226741L4V
- RC217852L1V
- RC217852L2V
- RC217852L3V
- RC217852L4V
- RC220113L3V
- RC220113L4V
- RR204818L3V
- RR204818L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NRF1
- Sino Biological Human cDNA Clone for NRF1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for NRF1
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for NRF1
- Novus Biologicals proteins and lysates for NRF1
- Novus Biologicals ELISA Kits for NRF1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for NRF1
- Abcam proteins for NRF1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for NRF1 (AFLGC-NRF1)
- VectorBuilder Custom and pre-made DNA vectors for NRF1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for NRF1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for NRF1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for NRF1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for NRF1
- antibodies-online: Show 43 available NRF1 Antibodies ranked by validation data
- Compare Top NRF1 Antibodies
- antibodies-online: Show 18 available NRF1 Elisa Kits ranked by validation data
- Compare Top NRF1 Elisa Kits
- antibodies-online: Show 8 available NRF1 Proteins ranked by validation data
- Compare Top NRF1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for NRF1
- Search Santa Cruz Biotechnology (SCBT) for NRF1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NRF1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRF1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NRF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRF1
- Signalway ELISA kits for NRF1