Aliases for NREP Gene

Aliases for NREP Gene

  • Neuronal Regeneration Related Protein 2 3 5
  • Neuronal Protein 3.1 2 3 4
  • Neuronal Regeneration-Related Protein 3 4
  • Protein P311 3 4
  • C5orf13 3 4
  • P311 3 4
  • Neuronal Regeneration Related Protein Homolog (Rat) 2
  • Neuronal Regeneration Related Protein Homolog 3
  • Chromosome 5 Open Reading Frame 13 2
  • PRO1873 3
  • D4S114 3
  • PTZ17 3
  • SEZ17 3

External Ids for NREP Gene

Previous HGNC Symbols for NREP Gene

  • C5orf13

Previous GeneCards Identifiers for NREP Gene

  • GC05M110999

Summaries for NREP Gene

GeneCards Summary for NREP Gene

NREP (Neuronal Regeneration Related Protein) is a Protein Coding gene. Diseases associated with NREP include Rett Syndrome. Among its related pathways are MECP2 and Associated Rett Syndrome.

UniProtKB/Swiss-Prot Summary for NREP Gene

  • May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.

Gene Wiki entry for NREP Gene

Additional gene information for NREP Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NREP Gene

Genomics for NREP Gene

GeneHancer (GH) Regulatory Elements for NREP Gene

Promoters and enhancers for NREP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J111753 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 504.4 +241.2 241239 6.1 HNRNPK ZBTB40 EP300 CTCF TCF12 MYC POLR2G USF1 PHF8 ZFX NREP lnc-STARD4-4 ENSG00000214784 STARD4-AS1 BCLAF1P1 lnc-STARD4-3 RN7SKP57
GH05J112109 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 500.1 -111.2 -111237 5 JUND REST PKNOX1 IKZF1 NFATC3 ATF2 RXRA HNF4A PBX3 SPI1 lnc-NREP-7 NREP EPB41L4A CAMK4 piR-36746-028
GH05J111996 Enhancer 1 Ensembl ENCODE dbSUPER 500.7 -0.6 -604 4.1 JUND FOS REST OSR2 CREB1 ZNF263 CEBPG USF1 EZH2 ZFHX2 NREP STARD4 piR-50357-128 NREP-AS1 lnc-NREP-7
GH05J112145 Enhancer 1.2 FANTOM5 Ensembl ENCODE 4.2 -149.1 -149132 1.6 ZNF217 CTCF TEAD4 EP300 REST MEF2C RAD21 TRIM22 TEAD1 SMC3 piR-61945-412 EPB41L4A APC NREP piR-61532-249
GH05J111935 Enhancer 0.4 Ensembl dbSUPER 11 +62.2 62163 0.2 HLF NREP NREP-AS1 piR-30791-078 piR-58308-269 lnc-NREP-7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NREP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NREP

Genomic Locations for NREP Gene

Genomic Locations for NREP Gene
chr5:111,662,621-111,997,464
(GRCh38/hg38)
Size:
334,844 bases
Orientation:
Minus strand
chr5:110,998,318-111,333,161
(GRCh37/hg19)
Size:
334,844 bases
Orientation:
Minus strand

Genomic View for NREP Gene

Genes around NREP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NREP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NREP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NREP Gene

Proteins for NREP Gene

  • Protein details for NREP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16612-NREP_HUMAN
    Recommended name:
    Neuronal regeneration-related protein
    Protein Accession:
    Q16612
    Secondary Accessions:
    • B2RDN8
    • B7Z5D2
    • D3DSZ8

    Protein attributes for NREP Gene

    Size:
    68 amino acids
    Molecular mass:
    7909 Da
    Quaternary structure:
    • Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a decrease in TGFB autoinduction (By similarity). Interacts with FLNA.

    Alternative splice isoforms for NREP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NREP Gene

Post-translational modifications for NREP Gene

  • Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NREP Gene

Domains & Families for NREP Gene

Gene Families for NREP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NREP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NREP Gene

GenScript: Design optimal peptide antigens:
  • Protein p311 (NP311_HUMAN)
  • PRO1873 (Q9P187_HUMAN)
genes like me logo Genes that share domains with NREP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NREP Gene

Function for NREP Gene

Molecular function for NREP Gene

UniProtKB/Swiss-Prot Function:
May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.
UniProtKB/Swiss-Prot Induction:
Down-regulated in emphysematous lung compared to normal lung.

Phenotypes From GWAS Catalog for NREP Gene

Gene Ontology (GO) - Molecular Function for NREP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22365962
genes like me logo Genes that share ontologies with NREP: view
genes like me logo Genes that share phenotypes with NREP: view

Animal Models for NREP Gene

MGI Knock Outs for NREP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NREP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NREP Gene

Localization for NREP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NREP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NREP gene
Compartment Confidence
nucleus 4
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NREP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with NREP: view

Pathways & Interactions for NREP Gene

PathCards logo

SuperPathways for NREP Gene

genes like me logo Genes that share pathways with NREP: view

Pathways by source for NREP Gene

1 BioSystems pathway for NREP Gene

Gene Ontology (GO) - Biological Process for NREP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway IBA 21873635
GO:0031103 axon regeneration IBA 21873635
GO:0045664 regulation of neuron differentiation IBA 21873635
genes like me logo Genes that share ontologies with NREP: view

No data available for SIGNOR curated interactions for NREP Gene

Drugs & Compounds for NREP Gene

No Compound Related Data Available

Transcripts for NREP Gene

mRNA/cDNA for NREP Gene

11 REFSEQ mRNAs :
30 NCBI additional mRNA sequence :
23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NREP

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NREP Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - - -
SP15: - - - - -
SP16: - - - - - - - - -
SP17: - - - - - -
SP18: - - -
SP19: - - -

ExUns: 8g · 8h · 8i · 8j · 8k · 8l · 8m
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for NREP Gene

GeneLoc Exon Structure for
NREP

Expression for NREP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NREP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NREP Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.0) and Brain - Cerebellum (x8.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NREP

SOURCE GeneReport for Unigene cluster for NREP Gene:

Hs.36053

mRNA Expression by UniProt/SwissProt for NREP Gene:

Q16612-NREP_HUMAN
Tissue specificity: Expressed in lung (at protein level).

Evidence on tissue expression from TISSUES for NREP Gene

  • Nervous system(5)
  • Heart(4.7)
  • Skin(4.4)
  • Lung(3.3)
  • Eye(2.7)
  • Kidney(2.5)
  • Muscle(2.3)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with NREP: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NREP Gene

Orthologs for NREP Gene

This gene was present in the common ancestor of chordates.

Orthologs for NREP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NREP 31 30
  • 99.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia C10H5orf13 30
  • 88.73 (n)
NREP 31
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NREP 31 30
  • 86.76 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrep 30
  • 83.82 (n)
mouse
(Mus musculus)
Mammalia Nrep 17 31 30
  • 82.35 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.355 30
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7661 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4351 30
Species where no ortholog for NREP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NREP Gene

ENSEMBL:
Gene Tree for NREP (if available)
TreeFam:
Gene Tree for NREP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NREP: view image

Paralogs for NREP Gene

(1) SIMAP similar genes for NREP Gene using alignment to 5 proteins:

  • NREP_HUMAN
  • D6R982_HUMAN
  • D6R9Y7_HUMAN
  • D6REJ5_HUMAN
  • D6RIC9_HUMAN

Pseudogenes.org Pseudogenes for NREP Gene

genes like me logo Genes that share paralogs with NREP: view

No data available for Paralogs for NREP Gene

Variants for NREP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NREP Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs11559 - p.Glu43Gly

Additional dbSNP identifiers (rs#s) for NREP Gene

Structural Variations from Database of Genomic Variants (DGV) for NREP Gene

Variant ID Type Subtype PubMed ID
esv2730594 CNV deletion 23290073
esv3606277 CNV gain 21293372
esv3606278 CNV gain 21293372
esv3606280 CNV loss 21293372
esv3606281 CNV gain 21293372
nsv1073481 CNV deletion 25765185
nsv476416 CNV novel sequence insertion 20440878
nsv599367 CNV gain 21841781
nsv819569 CNV gain 19587683
nsv968233 CNV duplication 23825009
nsv968975 CNV duplication 23825009

Variation tolerance for NREP Gene

Residual Variation Intolerance Score: 67.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NREP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NREP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NREP Gene

Disorders for NREP Gene

MalaCards: The human disease database

(1) MalaCards diseases for NREP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rett syndrome
  • rtt
- elite association - COSMIC cancer census association via MalaCards
Search NREP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NREP

genes like me logo Genes that share disorders with NREP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NREP Gene

Publications for NREP Gene

  1. Identification of P311 as a potential gene regulating alveolar generation. (PMID: 16484684) Zhao L … Vu TH (American journal of respiratory cell and molecular biology 2006) 3 4 54
  2. Regulation of glioma cell migration by serine-phosphorylated P311. (PMID: 16229809) McDonough WS … Berens ME (Neoplasia (New York, N.Y.) 2005) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. P311 accelerates nerve regeneration of the axotomized facial nerve. (PMID: 15485502) Fujitani M … Yamashita T (Journal of neurochemistry 2004) 2 3 54

Products for NREP Gene

Sources for NREP Gene