Aliases for NRDE2 Gene

Aliases for NRDE2 Gene

  • NRDE-2, Necessary For RNA Interference, Domain Containing 2 3 5
  • Nuclear Exosome Regulator NRDE2 3 4
  • Protein NRDE2 Homolog 3 4
  • C14orf102 3 4
  • Chromosome 14 Open Reading Frame 102 2
  • UPF0614 Protein C14orf102 3

External Ids for NRDE2 Gene

Previous HGNC Symbols for NRDE2 Gene

  • C14orf102

Previous GeneCards Identifiers for NRDE2 Gene

  • GC14M090742
  • GC14M090296
  • GC14M090328
  • GC14M092323
  • GC14M092419
  • GC14M092446
  • GC14M090596
  • GC14M090602
  • GC14M090821
  • GC14M091095
  • GC14M091388
  • GC14M091674
  • GC14M091962
  • GC14M092224

Summaries for NRDE2 Gene

GeneCards Summary for NRDE2 Gene

NRDE2 (NRDE-2, Necessary For RNA Interference, Domain Containing) is a Protein Coding gene. Diseases associated with NRDE2 include Hemophagocytic Lymphohistiocytosis, Familial, 1.

UniProtKB/Swiss-Prot Summary for NRDE2 Gene

  • Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217).

Additional gene information for NRDE2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRDE2 Gene

Genomics for NRDE2 Gene

GeneHancer (GH) Regulatory Elements for NRDE2 Gene

Promoters and enhancers for NRDE2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRDE2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRDE2

Genomic Locations for NRDE2 Gene

Genomic Locations for NRDE2 Gene
chr14:90,267,860-90,332,137
(GRCh38/hg38)
Size:
64,278 bases
Orientation:
Minus strand
chr14:90,742,580-90,798,481
(GRCh37/hg19)
Size:
55,902 bases
Orientation:
Minus strand

Genomic View for NRDE2 Gene

Genes around NRDE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRDE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRDE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRDE2 Gene

Proteins for NRDE2 Gene

  • Protein details for NRDE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7Z3-NRDE2_HUMAN
    Recommended name:
    Nuclear exosome regulator NRDE2
    Protein Accession:
    Q9H7Z3
    Secondary Accessions:
    • B4DH71
    • Q4G0A7
    • Q9NWH6

    Protein attributes for NRDE2 Gene

    Size:
    1164 amino acids
    Molecular mass:
    132673 Da
    Quaternary structure:
    • Interacts with MTREX; the interaction is direct and stabilizes NRDE2.
    SequenceCaution:
    • Sequence=BAB14830.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NRDE2 Gene

neXtProt entry for NRDE2 Gene

Post-translational modifications for NRDE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NRDE2 Gene

Domains & Families for NRDE2 Gene

Gene Families for NRDE2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NRDE2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NRDE2 Gene

GenScript: Design optimal peptide antigens:
  • UPF0614 protein C14orf102 (CN102_HUMAN)
  • Chromosome 14 open reading frame 102, isoform CRA_b (Q0VFW7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H7Z3

UniProtKB/Swiss-Prot:

NRDE2_HUMAN :
  • The MID/MTR4-interacting domain is necessary and sufficient to mediate interaction with MTREX.
  • Belongs to the NRDE2 family.
Domain:
  • The MID/MTR4-interacting domain is necessary and sufficient to mediate interaction with MTREX.
Family:
  • Belongs to the NRDE2 family.
genes like me logo Genes that share domains with NRDE2: view

Function for NRDE2 Gene

Molecular function for NRDE2 Gene

UniProtKB/Swiss-Prot Function:
Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217).

Phenotypes From GWAS Catalog for NRDE2 Gene

Gene Ontology (GO) - Molecular Function for NRDE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI,IEA 30842217
genes like me logo Genes that share ontologies with NRDE2: view
genes like me logo Genes that share phenotypes with NRDE2: view

Animal Models for NRDE2 Gene

MGI Knock Outs for NRDE2:
  • Nrde2 Nrde2<tm2a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for NRDE2 Gene

miRTarBase miRNAs that target NRDE2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRDE2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRDE2 Gene

Localization for NRDE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRDE2 Gene

Nucleus speckle. Nucleus, nucleolus. Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRDE2 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRDE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005654 nucleoplasm IDA 30842217
GO:0005730 nucleolus IDA 30842217
GO:0016607 nuclear speck IDA 30842217
genes like me logo Genes that share ontologies with NRDE2: view

Pathways & Interactions for NRDE2 Gene

PathCards logo

SuperPathways for NRDE2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRDE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016246 RNA interference IBA 21873635
GO:0031048 chromatin silencing by small RNA IBA 21873635
GO:0046833 positive regulation of RNA export from nucleus IMP 30842217
GO:1902369 negative regulation of RNA catabolic process IMP 30842217
genes like me logo Genes that share ontologies with NRDE2: view

No data available for Pathways by source and SIGNOR curated interactions for NRDE2 Gene

Drugs & Compounds for NRDE2 Gene

No Compound Related Data Available

Transcripts for NRDE2 Gene

mRNA/cDNA for NRDE2 Gene

2 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRDE2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRDE2 Gene

No ASD Table

Relevant External Links for NRDE2 Gene

GeneLoc Exon Structure for
NRDE2

Expression for NRDE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NRDE2 Gene

Protein differential expression in normal tissues from HIPED for NRDE2 Gene

This gene is overexpressed in Heart (16.0), Lung (12.7), Neutrophil (9.1), and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NRDE2 Gene



Protein tissue co-expression partners for NRDE2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRDE2

SOURCE GeneReport for Unigene cluster for NRDE2 Gene:

Hs.528131

Evidence on tissue expression from TISSUES for NRDE2 Gene

  • Nervous system(4.2)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with NRDE2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRDE2 Gene

Orthologs for NRDE2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NRDE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRDE2 31 30
  • 99.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NRDE2 31 30
  • 82.87 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrde2 30
  • 82.68 (n)
mouse
(Mus musculus)
Mammalia Nrde2 17 31 30
  • 82.43 (n)
cow
(Bos Taurus)
Mammalia NRDE2 31 30
  • 81.52 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRDE2 31
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRDE2 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves C5H14ORF102 30
  • 67.61 (n)
NRDE2 31
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRDE2 31
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrde2 30
  • 60.77 (n)
Str.19178 30
zebrafish
(Danio rerio)
Actinopterygii LOC794348 30
  • 56.36 (n)
nrde2 31
  • 48 (a)
OneToOne
Dr.29156 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4429 30
worm
(Caenorhabditis elegans)
Secernentea nrde-2 31
  • 14 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G17712 30
  • 44.9 (n)
rice
(Oryza sativa)
Liliopsida Os02g0772500 30
  • 41.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
OneToMany
-- 31
  • 29 (a)
OneToMany
Species where no ortholog for NRDE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NRDE2 Gene

ENSEMBL:
Gene Tree for NRDE2 (if available)
TreeFam:
Gene Tree for NRDE2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NRDE2: view image

Paralogs for NRDE2 Gene

(2) SIMAP similar genes for NRDE2 Gene using alignment to 5 proteins:

  • NRDE2_HUMAN
  • E9PBK4_HUMAN
  • G3V338_HUMAN
  • H0YJT0_HUMAN
  • H0YJT6_HUMAN
genes like me logo Genes that share paralogs with NRDE2: view

No data available for Paralogs for NRDE2 Gene

Variants for NRDE2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRDE2 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
790147 Benign: not provided 90,288,593(-) C/T MISSENSE_VARIANT
rs3737035 - p.Asn1118Ser
rs59039343 - p.Glu928Lys
rs7140914 - p.Cys32Phe

Additional dbSNP identifiers (rs#s) for NRDE2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NRDE2 Gene

Variant ID Type Subtype PubMed ID
esv2652044 CNV insertion 19546169
esv2749005 CNV deletion 23290073
esv3383627 CNV duplication 20981092
esv3581385 CNV loss 25503493

Variation tolerance for NRDE2 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRDE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRDE2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRDE2 Gene

Disorders for NRDE2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NRDE2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hemophagocytic lymphohistiocytosis, familial, 1
  • fhl1
- elite association - COSMIC cancer census association via MalaCards
Search NRDE2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRDE2

genes like me logo Genes that share disorders with NRDE2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRDE2 Gene

Publications for NRDE2 Gene

  1. NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction. (PMID: 30842217) Wang J … Cheng H (Genes & development 2019) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 54
  4. ATG5 is required for B cell polarization and presentation of particulate antigens. (PMID: 30196744) Arbogast F … Gros F (Autophagy 2019) 3 54
  5. Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor. (PMID: 30538148) Jiao AL … Slack FJ (RNA (New York, N.Y.) 2019) 3 54

Products for NRDE2 Gene

Sources for NRDE2 Gene