Aliases for NRDE2 Gene
External Ids for NRDE2 Gene
Previous HGNC Symbols for NRDE2 Gene
Previous GeneCards Identifiers for NRDE2 Gene
GeneCards Summary for NRDE2 Gene
NRDE2 (NRDE-2, Necessary For RNA Interference, Domain Containing) is a Protein Coding gene. Diseases associated with NRDE2 include Hemophagocytic Lymphohistiocytosis, Familial, 1.
UniProtKB/Swiss-Prot Summary for NRDE2 Gene
Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217).