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Aliases for NRDC Gene

Aliases for NRDC Gene

  • Nardilysin Convertase 2 3 4 5
  • Nardilysin (N-Arginine Dibasic Convertase) 2 3
  • N-Arginine Dibasic Convertase 2 4
  • NRD Convertase 3 4
  • NRD1 3 4
  • EC 4
  • Nardilysin 3
  • HNRD1 3
  • HNRD2 3
  • NRD-C 4

External Ids for NRDC Gene

Previous HGNC Symbols for NRDC Gene

  • NRD1

Summaries for NRDC Gene

Entrez Gene Summary for NRDC Gene

  • This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for NRDC Gene

NRDC (Nardilysin Convertase) is a Protein Coding gene. Diseases associated with NRDC include Differentiating Neuroblastoma. An important paralog of this gene is IDE.

UniProtKB/Swiss-Prot for NRDC Gene

  • Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.

Gene Wiki entry for NRDC Gene

Additional gene information for NRDC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRDC Gene

Genomics for NRDC Gene

GeneHancer (GH) Regulatory Elements for NRDC Gene

Promoters and enhancers for NRDC Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J051874 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 661 +1.5 1470 5.3 CLOCK MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC NRDC ENSG00000266993 TUT4 PRPF38A KTI12 GAPDHP51 SLC25A6P3 TXNDC12-AS1 CC2D1B TXNDC12
GH01J051563 Enhancer 1.4 Ensembl ENCODE dbSUPER 15.7 +310.9 310919 9.3 HNRNPUL1 ATF1 PKNOX1 NEUROD1 SIN3A ATF7 FOS RUNX3 JUNB REST NRDC RNU6-1281P ENSG00000266993 CDKN2C EPS15 ENSG00000227070 RNU6-877P CALR4P OSBPL9 GC01P051545
GH01J051728 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.4 +149.0 149031 3.4 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 POLR2B CBX5 OSBPL9 GC01P051732 GC01P051733 ENSG00000266993 PRPF38A TXNDC12 TUT4 NRDC GPX7 KTI12
GH01J051642 Enhancer 1.2 FANTOM5 Ensembl ENCODE 14.5 +235.1 235136 3.4 PKNOX1 JUN ZNF384 CTBP1 ZNF366 POLR2A ZSCAN5C PRDM10 FOSL2 FOS NRDC OSBPL9 ENSG00000212624 RNU6-877P LOC105378719 GAPDHP51
GH01J051736 Enhancer 1 Ensembl ENCODE 10.6 +142.0 142019 0.6 HDAC1 HDGF PKNOX1 SMAD1 NFIB ARNT MZF1 FEZF1 ZBTB40 CHAMP1 PRPF38A NRDC GC01P051733 ENSG00000266993 OSBPL9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRDC on UCSC Golden Path with GeneCards custom track

Genomic Locations for NRDC Gene

Genomic Locations for NRDC Gene
89,747 bases
Minus strand
89,747 bases
Minus strand

Genomic View for NRDC Gene

Genes around NRDC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRDC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRDC Gene

Proteins for NRDC Gene

  • Protein details for NRDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NI41
    • O15241
    • O15242
    • Q5VUL0
    • Q96HB2
    • Q9NU57

    Protein attributes for NRDC Gene

    1150 amino acids
    Molecular mass:
    131572 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NRDC Gene


neXtProt entry for NRDC Gene

Post-translational modifications for NRDC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NRDC Gene

Domains & Families for NRDC Gene

Gene Families for NRDC Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M16 family.
  • Belongs to the peptidase M16 family.
genes like me logo Genes that share domains with NRDC: view

Function for NRDC Gene

Molecular function for NRDC Gene

UniProtKB/Swiss-Prot Function:
Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of polypeptides, preferably at -Xaa- -Arg-Lys-, and less commonly at -Arg- -Arg-Xaa-, in which Xaa is not Arg or Lys.

Enzyme Numbers (IUBMB) for NRDC Gene

Gene Ontology (GO) - Molecular Function for NRDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA,NAS 9581555
GO:0005515 protein binding IPI 18355445
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NRDC: view
genes like me logo Genes that share phenotypes with NRDC: view

Animal Models for NRDC Gene

MGI Knock Outs for NRDC:
  • Nrd1 Nrd1<tm1Eiin>

Animal Model Products

  • Taconic Biosciences Mouse Models for NRDC

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRDC Gene

Localization for NRDC Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRDC gene
Compartment Confidence
mitochondrion 5
cytosol 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NRDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 28017472
GO:0005829 cytosol TAS 12463163
GO:0009986 cell surface TAS 12463163
genes like me logo Genes that share ontologies with NRDC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NRDC Gene

Pathways & Interactions for NRDC Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS,IEA 9581555
GO:0007528 neuromuscular junction development TAS 9479496
GO:0008283 cell proliferation TAS 12463163
GO:0016477 cell migration TAS 15544571
GO:0043171 peptide catabolic process IBA --
genes like me logo Genes that share ontologies with NRDC: view

No data available for Pathways by source and SIGNOR curated interactions for NRDC Gene

Drugs & Compounds for NRDC Gene

(2) Drugs for NRDC Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NRDC: view

Transcripts for NRDC Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRDC Gene

No ASD Table

Relevant External Links for NRDC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NRDC Gene

NURSA nuclear receptor signaling pathways regulating expression of NRDC Gene:


mRNA Expression by UniProt/SwissProt for NRDC Gene:

Tissue specificity: Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues.

Evidence on tissue expression from TISSUES for NRDC Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Heart(4.3)
  • Skin(3)
  • Lung(2.9)
  • Muscle(2)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRDC Gene

Orthologs for NRDC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NRDC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NRD1 34 33
  • 99.59 (n)
(Bos Taurus)
Mammalia NRD1 34 33
  • 93.96 (n)
(Canis familiaris)
Mammalia NRD1 34 33
  • 93.6 (n)
(Mus musculus)
Mammalia Nrd1 16 34 33
  • 90.59 (n)
(Rattus norvegicus)
Mammalia Nrd1 33
  • 89.24 (n)
(Monodelphis domestica)
Mammalia NRD1 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia NRD1 34
  • 75 (a)
(Gallus gallus)
Aves NRD1 34 33
  • 75.63 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 70 (a)
-- 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nrd1 33
  • 66.27 (n)
(Danio rerio)
Actinopterygii NRD1 (1 of 2) 34
  • 69 (a)
si:dkey-193b15.9 33
  • 68 (n)
nrd1 34
  • 64 (a)
wufk24c07 33
fruit fly
(Drosophila melanogaster)
Insecta CG10588 34
  • 31 (a)
CG2025 34
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE23 34
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06900 33
  • 47.34 (n)
(Oryza sativa)
Liliopsida Os03g0336300 33
  • 47.87 (n)
Species where no ortholog for NRDC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRDC Gene

Gene Tree for NRDC (if available)
Gene Tree for NRDC (if available)
Evolutionary constrained regions (ECRs) for NRDC: view image

Paralogs for NRDC Gene

Paralogs for NRDC Gene

genes like me logo Genes that share paralogs with NRDC: view

Variants for NRDC Gene

Sequence variations from dbSNP and Humsavar for NRDC Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000009422 -- 51,843,977(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000039176 -- 51,832,498(-) T/C intron_variant
rs1000055976 -- 51,835,111(-) G/A intron_variant
rs1000137268 -- 51,846,176(-) G/A/T genic_upstream_transcript_variant, intron_variant
rs1000152468 -- 51,857,975(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NRDC Gene

Variant ID Type Subtype PubMed ID
dgv82n106 CNV deletion 24896259
esv1546529 CNV insertion 17803354
esv1684865 CNV insertion 17803354
esv2551965 CNV insertion 19546169
esv3349028 CNV insertion 20981092
esv3586044 CNV gain 21293372
nsv1110660 CNV insertion 24896259
nsv512738 CNV insertion 21212237
nsv519495 CNV loss 19592680
nsv829837 CNV loss 17160897
nsv956714 CNV insertion 24416366

Variation tolerance for NRDC Gene

Residual Variation Intolerance Score: 3.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRDC Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRDC Gene

Disorders for NRDC Gene

MalaCards: The human disease database

(1) MalaCards diseases for NRDC Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
differentiating neuroblastoma
- elite association - COSMIC cancer census association via MalaCards
Search NRDC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRDC

genes like me logo Genes that share disorders with NRDC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRDC Gene

Publications for NRDC Gene

  1. Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues. (PMID: 9479496) Fumagalli P … Taramelli R (Genomics 1998) 2 3 4 22 58
  2. Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family. (PMID: 9581555) Hospital V … Cohen P (The Biochemical journal 1997) 2 3 4 22 58
  3. Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines. (PMID: 11042131) Winter AG … Pierotti AR (The Biochemical journal 2000) 3 4 22 58
  4. Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases. (PMID: 18355445) Hiraoka Y … Nishi E (Biochemical and biophysical research communications 2008) 3 22 58
  5. Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons. (PMID: 17442499) Bernstein HG … Reiser G (Neuroscience 2007) 3 22 58

Products for NRDC Gene

Sources for NRDC Gene

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