Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-ne... See more...

Aliases for NRCAM Gene

Aliases for NRCAM Gene

  • Neuronal Cell Adhesion Molecule 2 3 4 5
  • NgCAM-Related Cell Adhesion Molecule 2 3 4
  • Neuronal Surface Protein Bravo 3 4
  • KIAA0343 2 4
  • Ng-CAM-Related 4
  • Nr-CAM 4
  • HBravo 4
  • NRCAM 5
  • Bravo 2

External Ids for NRCAM Gene

Previous GeneCards Identifiers for NRCAM Gene

  • GC07M106271
  • GC07M107334
  • GC07M107348
  • GC07M107382
  • GC07M107575
  • GC07M107788
  • GC07M102150

Summaries for NRCAM Gene

Entrez Gene Summary for NRCAM Gene

  • Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for NRCAM Gene

NRCAM (Neuronal Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with NRCAM include Masa Syndrome and Autism. Among its related pathways are L1CAM interactions and Developmental Biology. Gene Ontology (GO) annotations related to this gene include ankyrin binding and protein binding involved in heterotypic cell-cell adhesion. An important paralog of this gene is NFASC.

UniProtKB/Swiss-Prot Summary for NRCAM Gene

  • Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.

Gene Wiki entry for NRCAM Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRCAM Gene

Genomics for NRCAM Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NRCAM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J108453 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 254.7 +1.1 1067 3.5 ZNF600 ZNF223 ZNF10 ZIC2 ZBTB10 FEZF1 ZNF341 CTBP1 ZNF610 SP2 NRCAM HSALNG0060475 THAP5 ENSG00000273055 LAMB1 RPL7P32 RF00017-6026 LAMB4
GH07J108262 Promoter 0.4 EPDnew 250.1 +194.6 194579 0.1 MZF1 NRCAM HSALNG0060473-001 HSALNG0060473-002 HSALNG0060473-003 RF00066-174 LAMB4
GH07J108413 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +38.1 38119 10 BCLAF1 ZNF600 NCOR1 ZNF580 NFIC ZIC2 HES1 FEZF1 ZNF341 CTBP1 PNPLA8 THAP5 NRCAM DNAJB9 LAMB4 RF00017-6026
GH07J108489 Enhancer 0.9 Ensembl ENCODE 11.7 -32.3 -32281 1.6 IKZF1 ZNF316 NFE2 ZFP91 ATF1 SMARCA4 MAFG MAFK MAFF L3MBTL2 THAP5 PNPLA8 NRCAM piR-59133 piR-61532-301
GH07J108434 Enhancer 0.8 Ensembl ENCODE dbSUPER 11.9 +21.6 21642 1.8 TCF7L2 FOS ZNF512 RUNX3 THAP5 NRCAM PNPLA8 RF00017-6026 LAMB4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRCAM on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRCAM

Top Transcription factor binding sites by QIAGEN in the NRCAM gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • FOXD3
  • Nkx2-5
  • Nkx3-1
  • Nkx3-1 v1
  • Roaz

Genomic Locations for NRCAM Gene

Latest Assembly
chr7:108,147,623-108,456,720
(GRCh38/hg38)
Size:
309,098 bases
Orientation:
Minus strand

Previous Assembly
chr7:107,788,094-108,097,164
(GRCh37/hg19 by Entrez Gene)
Size:
309,071 bases
Orientation:
Minus strand

chr7:107,788,068-108,097,161
(GRCh37/hg19 by Ensembl)
Size:
309,094 bases
Orientation:
Minus strand

Genomic View for NRCAM Gene

Genes around NRCAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRCAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRCAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRCAM Gene

Proteins for NRCAM Gene

  • Protein details for NRCAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92823-NRCAM_HUMAN
    Recommended name:
    Neuronal cell adhesion molecule
    Protein Accession:
    Q92823
    Secondary Accessions:
    • A4D0S3
    • E9PDA4
    • O15051
    • O15179
    • Q14BM2
    • Q9UHI3
    • Q9UHI4

    Protein attributes for NRCAM Gene

    Size:
    1304 amino acids
    Molecular mass:
    143890 Da
    Quaternary structure:
    • Constituent of a NFASC/NRCAM/ankyrin-G complex. Detected in a complex with CNTN1 and PTPRB. Interacts with GLDN/gliomedin (By similarity). Interacts with MYOC (PubMed:23897819).
    SequenceCaution:
    • Sequence=AAC50765.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA20801.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NRCAM Gene

    Alternative splice isoforms for NRCAM Gene

neXtProt entry for NRCAM Gene

Post-translational modifications for NRCAM Gene

  • Glycosylation at Asn83, Asn223, Asn245, Asn251, Asn276, Asn314, Asn433, Asn507, Asn619, Asn716, Asn802, Asn858, Asn993, Asn1009, Asn1019, Asn1072, Asn1083, and Asn1115
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • NRCAM_HUMAN (821)

Other Protein References for NRCAM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NRCAM Gene

Domains & Families for NRCAM Gene

Gene Families for NRCAM Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NRCAM Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin I-set
  • Fibronectin type III repeat signature

Suggested Antigen Peptide Sequences for NRCAM Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ35011 fis, clone OCBBF2013149, highly similar to Neuronal cell adhesion molecule (B3KRX0_HUMAN)
  • NgCAM-related cell adhesion molecule (NRCAM_HUMAN)
  • NRCAM protein (Q14BM2_HUMAN)
  • NRCAM protein (Q14CA1_HUMAN)
  • NRCAM protein (Q4KMQ7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92823

UniProtKB/Swiss-Prot:

NRCAM_HUMAN :
  • Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
Family:
  • Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
genes like me logo Genes that share domains with NRCAM: view

Function for NRCAM Gene

Molecular function for NRCAM Gene

UniProtKB/Swiss-Prot Function:
Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.
GENATLAS Biochemistry:
neuron-glia-CAM-related cell-adhesion molecule,murine Nrcam homolog

Phenotypes From GWAS Catalog for NRCAM Gene

Gene Ontology (GO) - Molecular Function for NRCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 23897819
GO:0030506 ankyrin binding IDA 14602817
genes like me logo Genes that share ontologies with NRCAM: view
genes like me logo Genes that share phenotypes with NRCAM: view

Animal Models for NRCAM Gene

MGI Knock Outs for NRCAM:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRCAM

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRCAM Gene

Localization for NRCAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRCAM Gene

Cell membrane. Single-pass type I membrane protein. Cell projection, axon. Secreted. Note=Detected at nodes of Ranvier. {ECO:0000250 UniProtKB:Q810U4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRCAM gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane NAS 8812479
GO:0009897 external side of plasma membrane NAS 8812479
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NRCAM: view

Pathways & Interactions for NRCAM Gene

genes like me logo Genes that share pathways with NRCAM: view

Pathways by source for NRCAM Gene

1 Qiagen pathway for NRCAM Gene
  • WNT Signaling

SIGNOR curated interactions for NRCAM Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NRCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEP 11866539
GO:0001764 neuron migration NAS 11483367
GO:0007155 cell adhesion IEA --
GO:0007409 axonogenesis NAS 8812479
GO:0007411 axon guidance IEA --
genes like me logo Genes that share ontologies with NRCAM: view

Drugs & Compounds for NRCAM Gene

(2) Drugs for NRCAM Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for NRCAM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NRCAM: view

Transcripts for NRCAM Gene

mRNA/cDNA for NRCAM Gene

68 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRCAM

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for NRCAM Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^
SP1: -
SP2:
SP3:

ExUns: 26 ^ 27 ^ 28 ^ 29a · 29b
SP1: - -
SP2: - -
SP3:

Relevant External Links for NRCAM Gene

GeneLoc Exon Structure for
NRCAM

Expression for NRCAM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NRCAM Gene

mRNA differential expression in normal tissues according to GTEx for NRCAM Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.7), Brain - Anterior cingulate cortex (BA24) (x6.1), Brain - Cortex (x4.6), and Brain - Amygdala (x4.2).

Protein differential expression in normal tissues from HIPED for NRCAM Gene

This gene is overexpressed in Cerebrospinal fluid (33.8), Brain (7.9), and Frontal cortex (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NRCAM Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRCAM

SOURCE GeneReport for Unigene cluster for NRCAM Gene:

Hs.21422

mRNA Expression by UniProt/SwissProt for NRCAM Gene:

Q92823-NRCAM_HUMAN
Tissue specificity: Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.

Evidence on tissue expression from TISSUES for NRCAM Gene

  • Nervous system(5)
  • Liver(4.3)
  • Bone marrow(4.2)
  • Eye(2.7)
  • Adrenal gland(2.4)
  • Kidney(2)
genes like me logo Genes that share expression patterns with NRCAM: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRCAM Gene

Orthologs for NRCAM Gene

This gene was present in the common ancestor of animals.

Orthologs for NRCAM Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NRCAM 30
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia NRCAM 30
  • 93 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Nrcam 29 16 30
  • 88.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nrcam 29
  • 88.17 (n)
Dog
(Canis familiaris)
Mammalia NRCAM 30
  • 88 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NRCAM 30
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NRCAM 30
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NRCAM 29 30
  • 77.44 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NRCAM 30
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nrcam 29
  • 70.59 (n)
Zebrafish
(Danio rerio)
Actinopterygii nrcamb 30
  • 72 (a)
OneToMany
nrcama 29 30
  • 63.11 (n)
OneToMany
NRCAM (3 of 3) 30
  • 53 (a)
OneToMany
-- 29
Fruit Fly
(Drosophila melanogaster)
Insecta Nrg 29 30 31
  • 44.15 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000720 29
  • 43.06 (n)
Worm
(Caenorhabditis elegans)
Secernentea lad-2 29 30
  • 44.04 (n)
OneToMany
lad-1 31
  • 28 (a)
Y54G2A.25 31
  • 27 (a)
sax-7 30
  • 26 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 32 (a)
OneToOne
Species where no ortholog for NRCAM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NRCAM Gene

ENSEMBL:
Gene Tree for NRCAM (if available)
TreeFam:
Gene Tree for NRCAM (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NRCAM: view image
Alliance of Genome Resources:
Additional Orthologs for NRCAM

Paralogs for NRCAM Gene

(9) SIMAP similar genes for NRCAM Gene using alignment to 12 proteins:

  • NRCAM_HUMAN
  • C9J8B6_HUMAN
  • C9JF43_HUMAN
  • C9JH43_HUMAN
  • C9JUR7_HUMAN
  • C9JYY6_HUMAN
  • F8W775_HUMAN
  • H7C132_HUMAN
  • Q14CA1_HUMAN
  • Q4KMQ7_HUMAN
  • Q6QRP2_HUMAN
  • Q75ML9_HUMAN
genes like me logo Genes that share paralogs with NRCAM: view

Variants for NRCAM Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRCAM Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs1224811138 Likely Benign: not provided 108,160,353(-) T/C
NM_001037132.4(NRCAM):c.3598+8A>G
INTRON
rs142366452 Benign: not provided 108,207,588(-) T/G
NM_001037132.4(NRCAM):c.1147A>C (p.Arg383=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs145828112 Likely Benign: not provided 108,159,534(-) T/C
NM_001037132.4(NRCAM):c.3606A>G (p.Glu1202=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs145997635 Likely Benign: not provided 108,184,256(-) C/T
NM_001037132.4(NRCAM):c.2289G>A (p.Leu763=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs201534122 Uncertain Significance: Severe Myopia 108,182,814(-) G/C
NM_001037132.4(NRCAM):c.2411C>G (p.Ser804Cys)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NRCAM Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NRCAM Gene

Variant ID Type Subtype PubMed ID
dgv6549n100 CNV gain 25217958
esv1008394 CNV insertion 20482838
esv1688012 CNV deletion 17803354
esv1781344 CNV insertion 17803354
esv22031 CNV loss 19812545
esv2735001 CNV deletion 23290073
esv2761354 CNV gain 21179565
esv3360161 CNV insertion 20981092
nsv1030222 CNV gain 25217958
nsv1075989 CNV deletion 25765185
nsv1109908 CNV deletion 24896259
nsv1112461 CNV deletion 24896259
nsv365475 CNV deletion 16902084
nsv509220 CNV insertion 20534489
nsv5894 CNV insertion 18451855
nsv5895 CNV insertion 18451855
nsv831089 CNV loss 17160897
nsv831090 CNV loss 17160897
nsv957052 CNV deletion 24416366

Variation tolerance for NRCAM Gene

Residual Variation Intolerance Score: 5.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRCAM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRCAM
Leiden Open Variation Database (LOVD)
NRCAM

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRCAM Gene

Disorders for NRCAM Gene

MalaCards: The human disease database

(6) MalaCards diseases for NRCAM Gene - From: COP and GCD

Disorder Aliases PubMed IDs
masa syndrome
  • mental retardation, aphasia, shuffling gait, and adducted thumbs
autism
  • autistic disorder
autism spectrum disorder
  • asd
generalized epilepsy with febrile seizures plus
  • gefs+
early infantile epileptic encephalopathy
  • early infantile epileptic encephalopathy with burst-suppression
- elite association - COSMIC cancer census association via MalaCards
Search NRCAM in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRCAM

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NRCAM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRCAM Gene

Publications for NRCAM Gene

  1. Association analysis of the NrCAM gene in autism and in subsets of families with severe obsessive-compulsive or self-stimulatory behaviors. (PMID: 17106428) Sakurai T … Buxbaum JD (Psychiatric genetics 2006) 3 22 40
  2. Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31. (PMID: 8812479) Lane RP … Dreyer WJ (Genomics 1996) 2 3 4
  3. Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling. (PMID: 23897819) Kwon HS … Tomarev SI (The Journal of biological chemistry 2013) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  5. A genome-wide association study identifies multiple loci associated with mathematics ability and disability. (PMID: 20039944) Docherty SJ … Plomin R (Genes, brain, and behavior 2010) 3 40

Products for NRCAM Gene

  • Boster Bio Antibodies for NRCAM
  • Boster Bio ELISA Kits for NRCAM

Sources for NRCAM Gene