Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NRBP2 Gene

Aliases for NRBP2 Gene

  • Nuclear Receptor Binding Protein 2 2 3 5
  • Nuclear Receptor-Binding Protein 2 3 4
  • Transformation-Related Gene 16 Protein 4
  • Transformation-Related Protein 16 3
  • Pp9320 3
  • TRG-16 4
  • TRG16 3

External Ids for NRBP2 Gene

Previous GeneCards Identifiers for NRBP2 Gene

  • GC08M144988
  • GC08M144917
  • GC08M140168
  • GC08M144919

Summaries for NRBP2 Gene

GeneCards Summary for NRBP2 Gene

NRBP2 (Nuclear Receptor Binding Protein 2) is a Protein Coding gene. Diseases associated with NRBP2 include Coloboma Of Macula. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NRBP1.

UniProtKB/Swiss-Prot for NRBP2 Gene

  • May regulate apoptosis of neural progenitor cells during their differentiation.

Additional gene information for NRBP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRBP2 Gene

Genomics for NRBP2 Gene

GeneHancer (GH) Regulatory Elements for NRBP2 Gene

Promoters and enhancers for NRBP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J143840 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 600.7 -0.3 -335 3 ZFX ZNF148 NKRF POLR2A ZNF639 GLIS2 ZBTB8A NRF1 BACH1 ZNF143 NRBP2 NAPRT ENSG00000285599 GC08P143837 GC08M143801
GH08J144002 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE 10.8 -168.4 -168427 16 ZNF473 SP1 ZKSCAN8 NKRF ZNF121 CEBPG ZNF687 NCOA3 IKZF1 MCM2 SPATC1 ZNF7 CPSF1 ZNF623 ZNF251 GPAA1 PLEC ZNF250 ENSG00000255182 VPS28
GH08J144455 Enhancer 1.3 Ensembl ENCODE 12.1 -616.2 -616248 3.2 ZNF473 HDGF MTA3 MNT CBFA2T2 ZNF148 MLLT1 GTF2F1 CSDE1 ZSCAN21 ZNF251 ZNF7 ZNF623 LRRC14 ZNF250 CPSF1 ZNF16 VPS28 ZNF517 GPAA1
GH08J143905 Enhancer 1.1 ENCODE dbSUPER 11.6 -65.3 -65284 1.5 ELF3 MYC TFE3 POLR2A SP5 ZNF384 KAT8 CREB1 ZBTB33 TARDBP ZNF7 ZNF250 PLEC VPS28 CPSF1 FBXL6 COMMD5 EPPK1 ADCK5 LRRC14
GH08J143994 Enhancer 1 Ensembl ENCODE 10.8 -156.2 -156227 6.4 CBFA2T2 MZF1 HDGF ZBED1 CREB1 PKNOX1 IKZF1 RFX1 GATAD2B ZIC2 PLEC GPAA1 EXOSC4 ENSG00000255224 MIR661 CYC1 MAF1 WDR97 SHARPIN NRBP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRBP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NRBP2 gene promoter:
  • AML1a
  • ATF6
  • Egr-3
  • FOXO4
  • LCR-F1
  • Sp1
  • Spz1
  • STAT5A
  • ZIC2

Genomic Locations for NRBP2 Gene

Genomic Locations for NRBP2 Gene
chr8:143,830,016-143,840,974
(GRCh38/hg38)
Size:
10,959 bases
Orientation:
Minus strand
chr8:144,915,755-144,924,200
(GRCh37/hg19)
Size:
8,446 bases
Orientation:
Minus strand

Genomic View for NRBP2 Gene

Genes around NRBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRBP2 Gene

Proteins for NRBP2 Gene

  • Protein details for NRBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSY0-NRBP2_HUMAN
    Recommended name:
    Nuclear receptor-binding protein 2
    Protein Accession:
    Q9NSY0
    Secondary Accessions:
    • B4DF59
    • Q2HIX8
    • Q597G7
    • Q8NCX8
    • Q8WYS5

    Protein attributes for NRBP2 Gene

    Size:
    501 amino acids
    Molecular mass:
    57803 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI13874.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAB70864.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for NRBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRBP2 Gene

Post-translational modifications for NRBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NRBP2 Gene

Domains & Families for NRBP2 Gene

Gene Families for NRBP2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NRBP2 Gene

Suggested Antigen Peptide Sequences for NRBP2 Gene

GenScript: Design optimal peptide antigens:
  • Nuclear receptor binding protein 2, isoform CRA_b (D3DWK9_HUMAN)
  • Transformation-related gene 16 protein (NRBP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NSY0

UniProtKB/Swiss-Prot:

NRBP2_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with NRBP2: view

Function for NRBP2 Gene

Molecular function for NRBP2 Gene

UniProtKB/Swiss-Prot Function:
May regulate apoptosis of neural progenitor cells during their differentiation.

Phenotypes From GWAS Catalog for NRBP2 Gene

Gene Ontology (GO) - Molecular Function for NRBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NRBP2: view
genes like me logo Genes that share phenotypes with NRBP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NRBP2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRBP2

Clone Products

  • Applied Biological Materials (abm): Clones for NRBP2 - Now 50% OFF >
  • * NRBP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NRBP2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for NRBP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NRBP2 Gene

Localization for NRBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRBP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRBP2 gene
Compartment Confidence
cytosol 3
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NRBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,ISS --
GO:0012505 endomembrane system IBA 21873635
genes like me logo Genes that share ontologies with NRBP2: view

Pathways & Interactions for NRBP2 Gene

PathCards logo

SuperPathways for NRBP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IBA 21873635
GO:0006888 ER to Golgi vesicle-mediated transport IBA 21873635
GO:0007399 nervous system development IEA --
GO:0016242 negative regulation of macroautophagy IMP 22354037
GO:0030182 neuron differentiation ISS --
genes like me logo Genes that share ontologies with NRBP2: view

No data available for Pathways by source and SIGNOR curated interactions for NRBP2 Gene

Drugs & Compounds for NRBP2 Gene

No Compound Related Data Available

Transcripts for NRBP2 Gene

mRNA/cDNA for NRBP2 Gene

Unigene Clusters for NRBP2 Gene

Nuclear receptor binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRBP2

Clone Products

  • Applied Biological Materials (abm): Clones for NRBP2 - Now 50% OFF >
  • * NRBP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NRBP2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for NRBP2

Alternative Splicing Database (ASD) splice patterns (SP) for NRBP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
SP1: - - -
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8:

Relevant External Links for NRBP2 Gene

GeneLoc Exon Structure for
NRBP2
ECgene alternative splicing isoforms for
NRBP2

Expression for NRBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRBP2 Gene

Protein differential expression in normal tissues from HIPED for NRBP2 Gene

This gene is overexpressed in Spinal cord (22.1) and Frontal cortex (17.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NRBP2 Gene



Protein tissue co-expression partners for NRBP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NRBP2 Gene:

NRBP2

SOURCE GeneReport for Unigene cluster for NRBP2 Gene:

Hs.521926

Evidence on tissue expression from TISSUES for NRBP2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with NRBP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRBP2 Gene

Orthologs for NRBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NRBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRBP2 35 34
  • 99.2 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nrbp2 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRBP2 35 34
  • 89.29 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrbp2 34
  • 88.34 (n)
dog
(Canis familiaris)
Mammalia NRBP2 34 35
  • 88.15 (n)
oppossum
(Monodelphis domestica)
Mammalia NRBP2 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRBP2 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRBP2 34 35
  • 70.11 (n)
lizard
(Anolis carolinensis)
Reptilia NRBP2 35
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nrbp2 35 34
  • 66.74 (n)
OneToMany
NRBP2 (1 of 2) 35
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Madm 35
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hpo-11 35
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5793 35
  • 38 (a)
OneToMany
Species where no ortholog for NRBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NRBP2 Gene

ENSEMBL:
Gene Tree for NRBP2 (if available)
TreeFam:
Gene Tree for NRBP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NRBP2: view image

Paralogs for NRBP2 Gene

Paralogs for NRBP2 Gene

(2) SIMAP similar genes for NRBP2 Gene using alignment to 4 proteins:

  • NRBP2_HUMAN
  • D3DWK9_HUMAN
  • E9PR11_HUMAN
  • H0YCB1_HUMAN
genes like me logo Genes that share paralogs with NRBP2: view

Variants for NRBP2 Gene

Sequence variations from dbSNP and Humsavar for NRBP2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1064795388 likely-pathogenic, not provided 143,829,279(-) C/T downstream_transcript_variant
rs782172407 uncertain-significance, not specified 143,829,274(-) ACTTAC/AC downstream_transcript_variant
rs1000186951 -- 143,838,538(-) T/C intron_variant
rs1000541986 -- 143,829,341(-) C/T downstream_transcript_variant
rs1000757052 -- 143,833,693(-) T/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NRBP2 Gene

Variant ID Type Subtype PubMed ID
dgv3931n106 CNV deletion 24896259
nsv1077075 CNV deletion 25765185
nsv1161815 CNV deletion 26073780
nsv466009 CNV loss 19166990
nsv612896 CNV loss 21841781
nsv612897 CNV loss 21841781
nsv824782 CNV gain+loss 20364138
nsv950014 CNV deletion 24416366

Variation tolerance for NRBP2 Gene

Gene Damage Index Score: 3.71; 57.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRBP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRBP2 Gene

Disorders for NRBP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NRBP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
coloboma of macula
  • agenesis of macula
- elite association - COSMIC cancer census association via MalaCards
Search NRBP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRBP2

genes like me logo Genes that share disorders with NRBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRBP2 Gene

Publications for NRBP2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for NRBP2 Gene

Sources for NRBP2 Gene

Content
Loading form....