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Aliases for NRBP1 Gene

Aliases for NRBP1 Gene

  • Nuclear Receptor Binding Protein 1 2 3 5
  • BCON3 3 4
  • NRBP 3 4
  • Myeloid Leukemia Factor 1 Adaptor Molecule 3
  • Multiple Domain Putative Nuclear Protein 3
  • Nuclear Receptor Binding Protein 2
  • Nuclear Receptor-Binding Protein 3
  • MUDPNP 3
  • MADM 3

External Ids for NRBP1 Gene

Previous HGNC Symbols for NRBP1 Gene

  • NRBP

Previous GeneCards Identifiers for NRBP1 Gene

  • GC02P027563
  • GC02P027504
  • GC02P027651

Summaries for NRBP1 Gene

GeneCards Summary for NRBP1 Gene

NRBP1 (Nuclear Receptor Binding Protein 1) is a Protein Coding gene. Diseases associated with NRBP1 include Dengue Virus. Among its related pathways are Gene Expression and Nuclear Receptor transcription pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is NRBP2.

UniProtKB/Swiss-Prot for NRBP1 Gene

  • May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.

Gene Wiki entry for NRBP1 Gene

Additional gene information for NRBP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRBP1 Gene

Genomics for NRBP1 Gene

GeneHancer (GH) Regulatory Elements for NRBP1 Gene

Promoters and enhancers for NRBP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I027427 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +2.0 2018 4.8 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 GC02M027429 NRBP1 SNX17 ZNF513 GCKR FNDC4 IFT172 RNU6-986P CCDC121 GPN1
GH02I027069 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 41.6 -351.3 -351296 14.9 CLOCK MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 MCM3 EMILIN1 OST4 CAD GTF3C2 SNX17 NRBP1 LOC105374363 GPN1 KHK TMEM214
GH02I027662 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 51.4 +235.9 235856 2.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SUPT7L SLC4A1AP IFT172 GTF3C2 CAD ZNF512 GPN1 NRBP1 EIF2B4 SNX17
GH02I026784 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 35.4 -641.7 -641682 2.3 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A CENPA ASXL2 EIF2B4 NRBP1 GPN1 GTF3C2 PPM1G ATRAID CAD GTF3C2-AS1
GH02I027049 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 33 -376.7 -376721 3.2 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 AGBL5-AS1 GC02P027055 PIR54422 PIR59385 TRY-GTA2-1 AGBL5 IFT172 SUPT7L ZNF512 CAD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NRBP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NRBP1 gene promoter:

Genomic Locations for NRBP1 Gene

Genomic Locations for NRBP1 Gene
chr2:27,427,790-27,442,259
(GRCh38/hg38)
Size:
14,470 bases
Orientation:
Plus strand
chr2:27,650,657-27,665,126
(GRCh37/hg19)

Genomic View for NRBP1 Gene

Genes around NRBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRBP1 Gene

Proteins for NRBP1 Gene

  • Protein details for NRBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHY1-NRBP_HUMAN
    Recommended name:
    Nuclear receptor-binding protein
    Protein Accession:
    Q9UHY1
    Secondary Accessions:
    • B3KV40
    • D6W558
    • Q53FZ5
    • Q96SU3

    Protein attributes for NRBP1 Gene

    Size:
    535 amino acids
    Molecular mass:
    59845 Da
    Quaternary structure:
    • Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm (By similarity).

neXtProt entry for NRBP1 Gene

Post-translational modifications for NRBP1 Gene

No data available for DME Specific Peptides for NRBP1 Gene

Domains & Families for NRBP1 Gene

Gene Families for NRBP1 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NRBP1 Gene

Suggested Antigen Peptide Sequences for NRBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHY1

UniProtKB/Swiss-Prot:

NRBP_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with NRBP1: view

Function for NRBP1 Gene

Molecular function for NRBP1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.

Phenotypes From GWAS Catalog for NRBP1 Gene

Gene Ontology (GO) - Molecular Function for NRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 11956649
GO:0005524 ATP binding IEA --
GO:0042803 protein homodimerization activity ISS --
genes like me logo Genes that share ontologies with NRBP1: view
genes like me logo Genes that share phenotypes with NRBP1: view

Animal Models for NRBP1 Gene

MGI Knock Outs for NRBP1:

Animal Model Products

CRISPR Products

miRNA for NRBP1 Gene

miRTarBase miRNAs that target NRBP1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NRBP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRBP1 Gene

Localization for NRBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRBP1 Gene

Cytoplasm, cell cortex. Endomembrane system. Cell projection, lamellipodium. Note=Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRBP1 gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA --
GO:0005938 cell cortex IEA --
GO:0012505 endomembrane system IDA,IEA 11956649
genes like me logo Genes that share ontologies with NRBP1: view

Pathways & Interactions for NRBP1 Gene

genes like me logo Genes that share pathways with NRBP1: view

Pathways by source for NRBP1 Gene

Gene Ontology (GO) - Biological Process for NRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006468 protein phosphorylation IEA,IBA --
GO:0006888 ER to Golgi vesicle-mediated transport IDA 11956649
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with NRBP1: view

No data available for SIGNOR curated interactions for NRBP1 Gene

Drugs & Compounds for NRBP1 Gene

No Compound Related Data Available

Transcripts for NRBP1 Gene

Unigene Clusters for NRBP1 Gene

Nuclear receptor binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NRBP1

Alternative Splicing Database (ASD) splice patterns (SP) for NRBP1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^
SP1: - - - -
SP2: - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - - -
SP9:
SP10: -
SP11:
SP12:
SP13: -

ExUns: 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:

Relevant External Links for NRBP1 Gene

GeneLoc Exon Structure for
NRBP1
ECgene alternative splicing isoforms for
NRBP1

Expression for NRBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRBP1 Gene

Protein differential expression in normal tissues from HIPED for NRBP1 Gene

This gene is overexpressed in Salivary gland (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NRBP1 Gene



Protein tissue co-expression partners for NRBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NRBP1 Gene:

NRBP1

SOURCE GeneReport for Unigene cluster for NRBP1 Gene:

Hs.515876

mRNA Expression by UniProt/SwissProt for NRBP1 Gene:

Q9UHY1-NRBP_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues examined with high levels in the testis.

Evidence on tissue expression from TISSUES for NRBP1 Gene

  • Nervous system(4.9)
  • Blood(4.2)
  • Pancreas(3.5)
  • Lung(2.9)
  • Skin(2.4)
  • Kidney(2.2)
  • Heart(2)
  • Liver(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with NRBP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRBP1 Gene

Orthologs for NRBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NRBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRBP1 33 34
  • 99.63 (n)
oppossum
(Monodelphis domestica)
Mammalia NRBP1 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRBP1 33 34
  • 95.83 (n)
cow
(Bos Taurus)
Mammalia NRBP1 33 34
  • 95.14 (n)
mouse
(Mus musculus)
Mammalia Nrbp1 33 16 34
  • 93.27 (n)
rat
(Rattus norvegicus)
Mammalia Nrbp1 33
  • 92.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NRBP1 34
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRBP1 33 34
  • 76.69 (n)
lizard
(Anolis carolinensis)
Reptilia NRBP1 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrbp1 33
  • 77.31 (n)
Str.6647 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6276 33
zebrafish
(Danio rerio)
Actinopterygii nrbp1 33 34
  • 73.7 (n)
Dr.13170 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9281 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007996 33
  • 59.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta Madm 33 34
  • 56.54 (n)
worm
(Caenorhabditis elegans)
Secernentea hpo-11 34
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5793 34
  • 48 (a)
OneToMany
Species where no ortholog for NRBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NRBP1 Gene

ENSEMBL:
Gene Tree for NRBP1 (if available)
TreeFam:
Gene Tree for NRBP1 (if available)

Paralogs for NRBP1 Gene

Paralogs for NRBP1 Gene

(2) SIMAP similar genes for NRBP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NRBP1: view

Variants for NRBP1 Gene

Sequence variations from dbSNP and Humsavar for NRBP1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs753734841 An ovarian mucinous carcinoma sample 27,440,906(+) C/T coding_sequence_variant, missense_variant
rs1000116662 -- 27,440,521(+) G/A intron_variant
rs1000286482 -- 27,437,022(+) CC/C intron_variant
rs1000431434 -- 27,432,522(+) G/A intron_variant
rs1000436881 -- 27,426,527(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NRBP1 Gene

Variant ID Type Subtype PubMed ID
nsv833614 CNV gain 17160897
nsv817684 CNV gain 17921354
nsv581244 CNV loss 21841781
nsv1116367 CNV deletion 24896259
esv3325195 CNV insertion 20981092

Variation tolerance for NRBP1 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRBP1 Gene

Disorders for NRBP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NRBP1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
dengue virus
  • dengue virus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search NRBP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRBP1

genes like me logo Genes that share disorders with NRBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRBP1 Gene

Publications for NRBP1 Gene

  1. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. (PMID: 11956649) De Langhe S … Heisterkamp N (International journal of molecular medicine 2002) 2 3 4 22 58
  2. The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structure. (PMID: 15084397) Chua JJ … Chow VT (Virus research 2004) 3 4 22 58
  3. Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein. (PMID: 10843813) Hooper JD … Antalis TM (Genomics 2000) 2 3 4 58
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  5. Adapter protein NRBP associates with Jab1 and negatively regulates AP-1 activity. (PMID: 17052710) Wang H … Wu J (FEBS letters 2006) 3 22 58

Products for NRBP1 Gene

  • Addgene plasmids for NRBP1

Sources for NRBP1 Gene

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