Aliases for NRBF2 Gene

Aliases for NRBF2 Gene

  • Nuclear Receptor Binding Factor 2 2 3 5
  • Nuclear Receptor-Binding Factor 2 3 4
  • Comodulator Of PPAR And RXR 1 2 3
  • Comodulator Of PPAR And RXR 2 2 3
  • NRBF-2 3 4
  • COPR 3 4
  • Comodulator Of PPAR And RXR 4
  • COPR1 3
  • COPR2 3

External Ids for NRBF2 Gene

Previous GeneCards Identifiers for NRBF2 Gene

  • GC10P064237
  • GC10P064563
  • GC10P064893
  • GC10P058884

Summaries for NRBF2 Gene

GeneCards Summary for NRBF2 Gene

NRBF2 (Nuclear Receptor Binding Factor 2) is a Protein Coding gene. Among its related pathways are Autophagy - animal and Gene Expression.

UniProtKB/Swiss-Prot Summary for NRBF2 Gene

  • May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).
  • Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity).

Gene Wiki entry for NRBF2 Gene

Additional gene information for NRBF2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRBF2 Gene

Genomics for NRBF2 Gene

GeneHancer (GH) Regulatory Elements for NRBF2 Gene

Promoters and enhancers for NRBF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J063132 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 507.8 +1.1 1054 4.2 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 USF1 NRBF2 lnc-ADO-2 JMJD1C MRPL35P2
GH10J063463 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.5 +332.3 332321 3.9 EP300 HNRNPK ZSCAN5C SIN3A NRF1 POLR2G PHF8 ZFX ZNF10 ZBTB5 REEP3 JMJD1C-AS1 DBF4P1 JMJD1C NRBF2 MRPL35P2 ENSG00000224412
GH10J063260 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 8.7 +132.5 132517 11.1 ZBTB40 ZNF217 EP300 CTCF ZSCAN5C SIN3A TCF12 POLR2G NCOR1 GTF2E2 JMJD1C DBF4P1 JMJD1C-AS1 NRBF2 MRPL35P2 lnc-EGR2-6 piR-52079-028
GH10J063519 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 8.3 +388.6 388639 5.2 EP300 ZBTB40 SIN3A TCF12 NRF1 POLR2G USF1 PHF8 ZFX ZNF639 REEP3 JMJD1C NONHSAG006016.2 JMJD1C-AS1 NRBF2 L13714-042
GH10J063235 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 10.6 +103.6 103601 3.2 ZNF217 TCF12 JUND FOS EP300 MEF2C TRIM22 OSR2 BCL11A NCOR1 JMJD1C-AS1 NRBF2 REEP3 lnc-EGR2-5 lnc-NRBF2-2 lnc-EGR2-6 JMJD1C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRBF2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRBF2

Top Transcription factor binding sites by QIAGEN in the NRBF2 gene promoter:
  • AhR
  • aMEF-2
  • AP-4
  • Arnt
  • CUTL1
  • MEF-2A
  • NF-1
  • Nkx2-5
  • USF-1
  • USF1

Genomic Locations for NRBF2 Gene

Genomic Locations for NRBF2 Gene
chr10:63,133,247-63,155,031
(GRCh38/hg38)
Size:
21,785 bases
Orientation:
Plus strand
chr10:64,893,007-64,914,786
(GRCh37/hg19)
Size:
21,780 bases
Orientation:
Plus strand

Genomic View for NRBF2 Gene

Genes around NRBF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRBF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRBF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRBF2 Gene

Proteins for NRBF2 Gene

  • Protein details for NRBF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F24-NRBF2_HUMAN
    Recommended name:
    Nuclear receptor-binding factor 2
    Protein Accession:
    Q96F24
    Secondary Accessions:
    • A6PW36
    • B4DWS0
    • Q86UR2
    • Q96NP6
    • Q9H0S9
    • Q9H2I2

    Protein attributes for NRBF2 Gene

    Size:
    287 amino acids
    Molecular mass:
    32378 Da
    Quaternary structure:
    • Interacts with PPARA, PPARD and PPARG. Interacts with RARA, RARG and RXRA in the presence of bound ligand (PubMed:15610520). Interacts with SCOC (PubMed:22354037). Associates with the PI3K complex I (PI3KC3-C1); the direct binding partner in the complex is reported variably as PIK3R4 or ATG14 (PubMed:24785657).
    SequenceCaution:
    • Sequence=AAG44735.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NRBF2 Gene

    Alternative splice isoforms for NRBF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRBF2 Gene

Post-translational modifications for NRBF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRBF2 Gene

No data available for DME Specific Peptides for NRBF2 Gene

Domains & Families for NRBF2 Gene

Gene Families for NRBF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NRBF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NRBF2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52920, highly similar to Nuclear receptor-binding factor 2 (B4DWS0_HUMAN)
  • Comodulator of PPAR and RXR (NRBF2_HUMAN)
genes like me logo Genes that share domains with NRBF2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NRBF2 Gene

Function for NRBF2 Gene

Molecular function for NRBF2 Gene

UniProtKB/Swiss-Prot Function:
May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).
UniProtKB/Swiss-Prot Function:
Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity).

Phenotypes From GWAS Catalog for NRBF2 Gene

Gene Ontology (GO) - Molecular Function for NRBF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20562859
genes like me logo Genes that share ontologies with NRBF2: view
genes like me logo Genes that share phenotypes with NRBF2: view

Animal Model Products

CRISPR Products

miRNA for NRBF2 Gene

miRTarBase miRNAs that target NRBF2

Clone Products

  • Addgene plasmids for NRBF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRBF2 Gene

Localization for NRBF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRBF2 Gene

Nucleus. Cytoplasm. Cytoplasmic vesicle. Cytoplasmic vesicle, autophagosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRBF2 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRBF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005776 autophagosome IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with NRBF2: view

Pathways & Interactions for NRBF2 Gene

genes like me logo Genes that share pathways with NRBF2: view

Pathways by source for NRBF2 Gene

1 KEGG pathway for NRBF2 Gene

Gene Ontology (GO) - Biological Process for NRBF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006914 autophagy IMP 24785657
GO:0034976 response to endoplasmic reticulum stress IEA --
GO:0043550 regulation of lipid kinase activity IEA --
genes like me logo Genes that share ontologies with NRBF2: view

No data available for SIGNOR curated interactions for NRBF2 Gene

Drugs & Compounds for NRBF2 Gene

(2) Drugs for NRBF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for NRBF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NRBF2: view

Transcripts for NRBF2 Gene

mRNA/cDNA for NRBF2 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for NRBF2

Alternative Splicing Database (ASD) splice patterns (SP) for NRBF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -
SP3:

Relevant External Links for NRBF2 Gene

GeneLoc Exon Structure for
NRBF2

Expression for NRBF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NRBF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRBF2 Gene

This gene is overexpressed in Whole Blood (x7.7).

Protein differential expression in normal tissues from HIPED for NRBF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.2), Placenta (12.2), and Spleen (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NRBF2 Gene



Protein tissue co-expression partners for NRBF2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRBF2

SOURCE GeneReport for Unigene cluster for NRBF2 Gene:

Hs.449628

mRNA Expression by UniProt/SwissProt for NRBF2 Gene:

Q96F24-NRBF2_HUMAN
Tissue specificity: Detected in keratinocytes, liver and placenta (PubMed:15610520). Expressed in a subset of cells in pediatric medulloblastoma (PubMed:18619852).

Evidence on tissue expression from TISSUES for NRBF2 Gene

  • Blood(4.4)
  • Nervous system(4.4)
  • Spleen(4.3)
  • Lymph node(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with NRBF2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NRBF2 Gene

Orthologs for NRBF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRBF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRBF2 31 30
  • 99.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NRBF2 31 30
  • 92.45 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NRBF2 31 30
  • 89.9 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nrbf2 17 31 30
  • 85.08 (n)
rat
(Rattus norvegicus)
Mammalia Nrbf2 30
  • 84.85 (n)
oppossum
(Monodelphis domestica)
Mammalia NRBF2 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRBF2 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRBF2 31 30
  • 78.98 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRBF2 31
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrbf2 30
  • 66.78 (n)
zebrafish
(Danio rerio)
Actinopterygii nrbf2b 31 30
  • 60.9 (n)
OneToMany
NRBF2 (2 of 2) 31
  • 52 (a)
OneToMany
wufb26d03 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 24 (a)
OneToOne
Species where no ortholog for NRBF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRBF2 Gene

ENSEMBL:
Gene Tree for NRBF2 (if available)
TreeFam:
Gene Tree for NRBF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NRBF2: view image

Paralogs for NRBF2 Gene

genes like me logo Genes that share paralogs with NRBF2: view

No data available for Paralogs for NRBF2 Gene

Variants for NRBF2 Gene

Additional dbSNP identifiers (rs#s) for NRBF2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NRBF2 Gene

Variant ID Type Subtype PubMed ID
esv2677353 CNV deletion 23128226
nsv948033 CNV duplication 23825009

Variation tolerance for NRBF2 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRBF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRBF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRBF2 Gene

Disorders for NRBF2 Gene

Additional Disease Information for NRBF2

No disorders were found for NRBF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRBF2 Gene

Publications for NRBF2 Gene

  1. NRBF2 regulates macroautophagy as a component of Vps34 Complex I. (PMID: 24785657) Cao Y … Backer JM (The Biochemical journal 2014) 3 4 54
  2. Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels. (PMID: 25086043) Zhong Y … Wang QJ (The Journal of biological chemistry 2014) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Isolation and functional analysis of a keratinocyte-derived, ligand-regulated nuclear receptor comodulator. (PMID: 15610520) Flores AM … Aneskievich BJ (The Journal of investigative dermatology 2004) 3 4 54

Products for NRBF2 Gene

Sources for NRBF2 Gene