NRAS Gene (Protein Coding)

NRAS Proto-Oncogene, GTPase

GC01M114704
GIFtS:
50
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein... See more...

Aliases for NRAS Gene

Aliases for NRAS Gene

  • NRAS Proto-Oncogene, GTPase 2 3 5
  • Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog 2 3
  • Neuroblastoma RAS Viral Oncogene Homolog 2 3
  • Transforming Protein N-Ras 3 4
  • GTPase NRas 3 4
  • N-Ras 2 3
  • V-Ras Neuroblastoma RAS Viral Oncogene Homolog 3
  • N-Ras Protein Part 4 3
  • EC 3.6.5.2 4
  • ALPS4 3
  • NRAS1 3
  • HRAS1 4
  • CMNS 3
  • NCMS 3
  • NRAS 5
  • NS6 3

External Ids for NRAS Gene

Previous GeneCards Identifiers for NRAS Gene

  • GC01M115662
  • GC01M114131
  • GC01M114349
  • GC01M114548
  • GC01M114961
  • GC01M115048
  • GC01M115247
  • GC01M113105

Summaries for NRAS Gene

Entrez Gene Summary for NRAS Gene

  • This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]

CIViC Summary for NRAS Gene

  • Mutations in the RAS family of proteins have frequently been observed across cancer types. The amino acid positions G12, G13 and Q61 account for the overwhelming majority of these mutations. The isoforms, despite their raw similarity, also behave very differently when expressed in non-native tissue types, likely due to differences in the C-terminal hyper-variable regions. Mis-regulation of isoform expression has been shown to be a driving event in cancer, as well as missense mutations at the three hotspots previously mentioned. While highly recurrent in cancer, targeting these RAS mutants has also been very elusive, and has not yet become common practice in the clinic.

GeneCards Summary for NRAS Gene

NRAS (NRAS Proto-Oncogene, GTPase) is a Protein Coding gene. Diseases associated with NRAS include Ras-Associated Autoimmune Leukoproliferative Disorder and Melanocytic Nevus Syndrome, Congenital. Among its related pathways are RET signaling and Apelin signaling pathway. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is KRAS.

UniProtKB/Swiss-Prot Summary for NRAS Gene

Gene Wiki entry for NRAS Gene

PharmGKB "VIP" Summary for NRAS Gene

Additional gene information for NRAS Gene

No data available for Tocris Summary , Rfam classification and piRNA Summary for NRAS Gene

Genomics for NRAS Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NRAS Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J114715 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.4 355 2.4 LARP7 SP1 ZNF207 NCOR1 MYC SIX5 ZNF592 POLR2A ATF3 BRCA1 NRAS TRIM33 TSPAN2 SIKE1 DENND2C CSDE1 RSBN1 piR-43107-020 AMPD1
GH01J114754 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.3 -40.0 -40014 4.8 SP1 ZNF207 ZNF600 NCOR1 MYC SIX5 ZNF580 ZNF592 POLR2A CEBPA TRIM33 CSDE1 lnc-SIKE1-2 SIKE1 RSBN1 AP4B1-AS1 TSPAN2 piR-58576 NRAS
GH01J114719 Enhancer 0.7 dbSUPER 0.7 -3.8 -3825 2.4 CEBPA ATF3 YY1 ZNF639 ZEB1 HOMEZ FOXA2 RXRA SAP130 RARA lnc-NRAS-1 AMPD1 CSDE1 SIKE1 NRAS HSALNG0006236
GH01J114745 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.3 -28.9 -28907 1.2 LARP7 ZBTB40 BATF MAFK JUNB CSDE1 ARID3A RUNX3 SIKE1 piR-58576 CSDE1 lnc-SIKE1-2 piR-53220 NRAS
GH01J114739 Enhancer 0.6 dbSUPER 0.4 -24.4 -24404 3.6 LARP7 ZNF316 NFE2 MAFG CSDE1 POLR2A MNT YBX1 NBN ZNF507 TRIM33 SIKE1 RSBN1 TSPAN2 piR-53220 piR-58576 lnc-SIKE1-2 CSDE1 NRAS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRAS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRAS

Top Transcription factor binding sites by QIAGEN in the NRAS gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • MyoD
  • STAT3

Genomic Locations for NRAS Gene

Latest Assembly
chr1:114,704,469-114,716,771
(GRCh38/hg38)
Size:
12,303 bases
Orientation:
Minus strand

Previous Assembly
chr1:115,247,090-115,259,392
(GRCh37/hg19 by Entrez Gene)
Size:
12,303 bases
Orientation:
Minus strand

chr1:115,247,090-115,259,515
(GRCh37/hg19 by Ensembl)
Size:
12,426 bases
Orientation:
Minus strand

Genomic View for NRAS Gene

Genes around NRAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRAS Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NRAS Gene

Proteins for NRAS Gene

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  • Protein details for NRAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01111-RASN_HUMAN
    Recommended name:
    GTPase NRas
    Protein Accession:
    P01111
    Secondary Accessions:
    • Q14971
    • Q15104
    • Q15282

    Protein attributes for NRAS Gene

    Size:
    189 amino acids
    Molecular mass:
    21229 Da
    Quaternary structure:
    • Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (active GTP-bound form) with RASSF7 (PubMed:21278800).
    Miscellaneous:
    • Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells and are implicated in a variety of human tumors.

    Three dimensional structures from OCA and Proteopedia for NRAS Gene

neXtProt entry for NRAS Gene

Protein Expression for NRAS Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NRAS Gene

  • Palmitoylated by the ZDHHC9-GOLGA7 complex (PubMed:16000296). Depalmitoylated by ABHD17A, ABHD17B and ABHD17C (PubMed:26701913). A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi (PubMed:16000296, PubMed:15705808, PubMed:2661017, PubMed:26701913).
  • Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).
  • Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.
  • Phosphorylation at Ser-89 by STK19 enhances NRAS-association with its downstream effectors.
  • (Microbial infection) Glucosylated at Thr-35 by P.sordellii toxin TcsL.
  • Glycosylation at Thr35
  • Ubiquitination at Lys128 and Lys170
  • Modification sites at PhosphoSitePlus

Other Protein References for NRAS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for NRAS

No data available for DME Specific Peptides for NRAS Gene

Domains & Families for NRAS Gene

Gene Families for NRAS Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for NRAS Gene

InterPro:
Blocks:
  • Transforming protein P21 RAS signature
  • Ras small GTPase, Ras type

Suggested Antigen Peptide Sequences for NRAS Gene

GenScript: Design optimal peptide antigens:
  • Neuroblastoma RAS viral (V-ras) oncogene homolog, isoform CRA_a (Q5U091_HUMAN)
  • N-ras protein (Q9UM97_HUMAN)
  • Transforming protein N-Ras (RASN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01111

UniProtKB/Swiss-Prot:

RASN_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with NRAS: view

Function for NRAS Gene

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  6. Cell Lines for research

Molecular function for NRAS Gene

UniProtKB/Swiss-Prot Function:
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000250|UniProtKB:P01116};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
GENATLAS Biochemistry:
neuroblastoma Ras viral (v-ras) oncogene homolog

Enzyme Numbers (IUBMB) for NRAS Gene

Phenotypes From GWAS Catalog for NRAS Gene

Gene Ontology (GO) - Molecular Function for NRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IBA,IDA 30712867
GO:0005515 protein binding IPI 18641128
GO:0005525 GTP binding IBA 21873635
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NRAS: view
genes like me logo Genes that share phenotypes with NRAS: view

Human Phenotype Ontology for NRAS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NRAS Gene

MGI Knock Outs for NRAS:
  • Nras Nras<tm1Mok>
  • Nras Nras<tm1Rak>
  • Nras Nras<tm1b(EUCOMM)Hmgu>

Animal Models for research

miRNA for NRAS Gene

miRTarBase miRNAs that target NRAS

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRAS

No data available for Transcription Factor Targets and HOMER Transcription for NRAS Gene

Localization for NRAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRAS Gene

Cell membrane. Lipid-anchor. Cytoplasmic side. Golgi apparatus membrane. Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000269 PubMed:15705808, ECO:0000269 PubMed:26701913}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRAS gene
Compartment Confidence
plasma membrane 4
extracellular 4
cytosol 4
golgi apparatus 4
nucleus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IDA 21968647
GO:0005886 plasma membrane TAS --
GO:0016020 membrane HDA 19946888
GO:0070062 extracellular exosome HDA 20458337
genes like me logo Genes that share ontologies with NRAS: view

Pathways & Interactions for NRAS Gene

PathCards logo

SuperPathways for NRAS Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR3
.88
Signaling by FGFR3 in disease
.88
Signaling by FGFR3 point mutants in cancer
.88
FRS-mediated FGFR2 signaling
.85
SHC-mediated cascade-FGFR2
.85
Downstream signaling of activated FGFR2
.83
FRS-mediated FGFR1 signaling
.83
SHC-mediated cascade-FGFR1
.83
Downstream signaling of activated FGFR4
.81
FRS-mediated FGFR4 signaling
.81
Downstream signaling of activated FGFR1
.74
FRS-mediated FGFR3 signaling
.01
SHC-mediated cascade-FGFR3
.01
SHC-mediated cascade-FGFR4
.01
Signaling by FGFR3 fusions in cancer
.01
Signaling by FGFR4 in disease
.01
3 IL-2 Pathway
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
IL-4 Pathway
.34
4 Endometrial cancer
Colorectal cancer
.50
Endometrial cancer
.50
Chronic myeloid leukemia
.45
Thyroid cancer
.36
Prostate cancer
.32
Acute myeloid leukemia
.30
5 fMLP Pathway
CCR3 Pathway in Eosinophils
.44
VEGF and S-1P Signaling
.44
fMLP Pathway
.43
CXCR4 Pathway
.39
Alpha-Adrenergic Signaling
.38
Internalin Pathway
.31
genes like me logo Genes that share pathways with NRAS: view

Pathways by source for NRAS Gene

4 GeneGo (Thomson Reuters) pathways for NRAS Gene
  • Development EGFR signaling via small GTPases
  • Development EPO-induced MAPK pathway
  • G-protein signaling N-RAS regulation pathway
  • G-protein signaling Ras family GTPases in kinase cascades (scheme)
109 Qiagen pathways for NRAS Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Agrin Interactions at Neuromuscular Junction
  • Akt Signaling
1 Cell Signaling Technology pathway for NRAS Gene
2 GeneTex pathways for NRAS Gene

SIGNOR curated interactions for NRAS Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001938 positive regulation of endothelial cell proliferation IMP 23619365
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0007165 signal transduction IEA --
GO:0007265 Ras protein signal transduction TAS --
genes like me logo Genes that share ontologies with NRAS: view

Drugs & Compounds for NRAS Gene

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  1. Drug products for research

(60) Drugs for NRAS Gene - From: PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cetuximab Approved Pharma EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 902
Dabrafenib Approved, Investigational Pharma BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase 136
Trametinib Approved Pharma MEK 1/2 inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors 217
Fludarabine Approved Pharma DNA synthsis inhibitor 1633,1633
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 2791

(2) Additional Compounds for NRAS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) ApexBio Compounds for NRAS Gene

Compound Action Cas Number
Kobe0065 Ras inhibitor 436133-68-5
kobe2602 Ras inhibitor 454453-49-7
Salirasib Inhibitor of active Ras protein 162520-00-5
genes like me logo Genes that share compounds with NRAS: view

Drug products for research

Transcripts for NRAS Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
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mRNA/cDNA for NRAS Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRAS

Alternative Splicing Database (ASD) splice patterns (SP) for NRAS Gene

No ASD Table

Relevant External Links for NRAS Gene

GeneLoc Exon Structure for
NRAS

Expression for NRAS Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NRAS Gene

mRNA expression in normal human tissues for NRAS Gene
mRNA expression by GTEx for NRAS GenemRNA expression by BioGPS for NRAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NRAS Gene

This gene is overexpressed in Brain (10.2), Peripheral blood mononuclear cells (9.0), and Bone (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NRAS Gene



Protein tissue co-expression partners for NRAS Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRAS

SOURCE GeneReport for Unigene cluster for NRAS Gene:

Hs.486502

Evidence on tissue expression from TISSUES for NRAS Gene

  • Nervous system(4.7)
  • Kidney(4.6)
  • Bone marrow(4.6)
  • Skin(3.5)
  • Intestine(3.3)
  • Liver(3.3)
  • Lymph node(2.9)
  • Blood(2.8)
  • Spleen(2.7)
  • Thyroid gland(2.7)
  • Lung(2.7)
  • Heart(2.5)
  • Stomach(2.5)
  • Muscle(2.4)
  • Pancreas(2.1)
  • Adrenal gland(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NRAS Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • scalp
  • skull
  • thyroid
  • tooth
Thorax:
  • aorta
  • breast
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • abdominal wall
  • intestine
  • kidney
  • large intestine
  • liver
  • spleen
  • stomach
Pelvis:
  • anus
  • pelvis
  • placenta
  • rectum
  • testicle
  • ureter
  • urethra
  • urinary bladder
  • uterus
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • lymph node
  • lymph vessel
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • spinal cord
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with NRAS: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NRAS Gene

Orthologs for NRAS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NRAS Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
 Mammalia N-RAS 30
  • 100 (a)
 OneToOne
NRAS 29
  • 95.77 (n)
Chimpanzee
(Pan troglodytes)
 Mammalia NRAS 29 30
  • 99.82 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia NRAS 30
  • 98 (a)
 OneToMany
-- 30
  • 84 (a)
 OneToMany
Cow
(Bos Taurus)
 Mammalia NRAS 29 30
  • 95.24 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Nras 29 16 30
  • 91.71 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Nras 29
  • 90.83 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia NRAS 30
  • 75 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves N-RAS 30
  • 97 (a)
 OneToOne
NRAS 29
  • 81.13 (n)
Lizard
(Anolis carolinensis)
 Reptilia NRAS 30
  • 94 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC549517 29
  • 78.48 (n)
Str.17112 29
African clawed frog
(Xenopus laevis)
 Amphibia Xl.895 29
Zebrafish
(Danio rerio)
 Actinopterygii nras 29 30
  • 78.72 (n)
 OneToOne
-- 29
Fruit Fly
(Drosophila melanogaster)
 Insecta Ras85D 30 31
  • 76 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea let-60 30
  • 76 (a)
 OneToMany
C08F8.7 31
  • 45 (a)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes RAS1 30
  • 36 (a)
 ManyToMany
RAS2 30
  • 35 (a)
 ManyToMany
Species where no ortholog for NRAS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NRAS Gene

ENSEMBL:
Gene Tree for NRAS (if available)
TreeFam:
Gene Tree for NRAS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NRAS: view image
Alliance of Genome Resources:
Additional Orthologs for NRAS

Paralogs for NRAS Gene

Paralogs for NRAS Gene

(95) SIMAP similar genes for NRAS Gene using alignment to 2 proteins:

  • RASN_HUMAN
  • Q5U091_HUMAN
genes like me logo Genes that share paralogs with NRAS: view

Variants for NRAS Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRAS Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
1003866 Uncertain Significance: Rasopathy 114,713,818(-) G/A
NM_002524.5(NRAS):c.272C>T (p.Ala91Val) 		MISSENSE
1010637 Uncertain Significance: Rasopathy 114,708,529(-) ACCTTGTTACATCACC
NM_002524.5(NRAS):c.539_*4+1del 		SPLICE_DONOR
848828 Uncertain Significance: Rasopathy 114,709,731(-) A/G
NM_002524.5(NRAS):c.291-3T>C 		INTRON
863509 Uncertain Significance: Rasopathy 114,713,938(-) C/T
NM_002524.5(NRAS):c.152G>A (p.Cys51Tyr) 		MISSENSE
874294 Likely Benign: Noonan syndrome 6 114,705,278(-) A/G
NM_002524.5(NRAS):c.*2816T>C 		THREE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NRAS Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NRAS Gene

Variant ID Type Subtype PubMed ID
esv28734 CNV loss 19812545
nsv946157 CNV duplication 23825009

Variation tolerance for NRAS Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 3.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRAS Gene

Human Gene Mutation Database (HGMD)
NRAS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRAS
Leiden Open Variation Database (LOVD)
NRAS

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRAS Gene

Disorders for NRAS Gene

MalaCards: The human disease database

(123) MalaCards diseases for NRAS Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search NRAS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RASN_HUMAN
  • Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. {ECO:0000269 PubMed:17332249}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Noonan syndrome 6 (NS6) [MIM:613224]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. {ECO:0000269 PubMed:19966803}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • RAS-associated autoimmune leukoproliferative disorder (RALD) [MIM:614470]: A disorder of apoptosis, characterized by chronic accumulation of non-malignant lymphocytes, defective lymphocyte apoptosis, and an increased risk for the development of hematologic malignancies. {ECO:0000269 PubMed:17517660}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Melanocytic nevus syndrome, congenital (CMNS) [MIM:137550]: A syndrome characterized by congenital pigmentary skin lesions which can occur at any site and can cover most of the body surface. These lesions may or may not be hairy. Congenital melanocytic nevi are associated with neuromelanosis (the presence of melanin-producing cells within the brain parenchyma or leptomeninges). Less commonly they are associated with malignant melanoma in childhood, both in the skin and the central nervous system. CMNS patients also tend to have a characteristic facial appearance, including wide or prominent forehead, periorbital fullness, small short nose with narrow nasal bridge, round face, full cheeks, prominent premaxilla, and everted lower lip. {ECO:0000269 PubMed:18633438, ECO:0000269 PubMed:23392294}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Melanosis, neurocutaneous (NCMS) [MIM:249400]: A rare congenital disease characterized by the presence of giant or multiple melanocytic nevi on the skin, foci of melanin-producing cells within the brain parenchyma, and infiltration of leptomeninges by abnormal melanin deposits. Neurologic abnormalities include seizures, hydrocephalus, arachnoid cysts, tumors, and syringomyelia. Some patients may develop malignant melanoma. {ECO:0000269 PubMed:23392294}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Keratinocytic non-epidermolytic nevus (KNEN) [MIM:162900]: Epidermal nevi of the common, non-organoid and non-epidermolytic type are benign skin lesions and may vary in their extent from a single (usually linear) lesion to widespread and systematized involvement. They may be present at birth or develop early during childhood. {ECO:0000269 PubMed:22499344}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Thyroid cancer, non-medullary, 2 (NMTC2) [MIM:188470]: A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms. {ECO:0000269 PubMed:12727991}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Additional Disease Information for NRAS

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NRAS: view

No data available for Genatlas for NRAS Gene

Publications for NRAS Gene

  1. Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. (PMID: 19047918) Yoshida N … Kojima S (Pediatric research 2009) 3 22 40 72
  2. Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS. (PMID: 23392294) Kinsler VA … Moore GE (The Journal of investigative dermatology 2013) 3 4 72
  3. Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma. (PMID: 20140953) Conway C … Newton-Bishop JA (Genes, chromosomes & cancer 2010) 3 22 40
  4. A restricted spectrum of NRAS mutations causes Noonan syndrome. (PMID: 19966803) Cirstea IC … Zenker M (Nature genetics 2010) 3 4 72
  5. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. (PMID: 18450602) Schlenk RF … German-Austrian Acute Myeloid Leukemia Study Group (The New England journal of medicine 2008) 3 22 40

ExternalLinks

View latest publications for NRAS gene in Mastermind

Products for NRAS Gene

  • Addgene plasmids for NRAS