Aliases for NRAS Gene
External Ids for NRAS Gene
Previous GeneCards Identifiers for NRAS Gene
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
Mutations in the RAS family of proteins have frequently been observed across cancer types. The amino acid positions G12, G13 and Q61 account for the overwhelming majority of these mutations. The isoforms, despite their raw similarity, also behave very differently when expressed in non-native tissue types, likely due to differences in the C-terminal hyper-variable regions. Mis-regulation of isoform expression has been shown to be a driving event in cancer, as well as missense mutations at the three hotspots previously mentioned. While highly recurrent in cancer, targeting these RAS mutants has also been very elusive, and has not yet become common practice in the clinic.
GeneCards Summary for NRAS Gene
NRAS (NRAS Proto-Oncogene, GTPase) is a Protein Coding gene. Diseases associated with NRAS include Ras-Associated Autoimmune Leukoproliferative Disorder and Melanocytic Nevus Syndrome, Congenital. Among its related pathways are Negative regulation of MAPK pathway and NGF Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is KRAS.
UniProtKB/Swiss-Prot Summary for NRAS Gene
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.