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This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein... See more...
Aliases for NRAS Gene
Aliases for NRAS Gene
External Ids for NRAS Gene
- HGNC: 7989
- Entrez Gene: 4893
- Ensembl: ENSG00000213281
- OMIM: 164790
- UniProtKB: P01111
Previous GeneCards Identifiers for NRAS Gene
- GC01M115662
- GC01M114131
- GC01M114349
- GC01M114548
- GC01M114961
- GC01M115048
- GC01M115247
- GC01M113105
Summaries for NRAS Gene
-
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
-
Mutations in the RAS family of proteins have frequently been observed across cancer types. The amino acid positions G12, G13 and Q61 account for the overwhelming majority of these mutations. The isoforms, despite their raw similarity, also behave very differently when expressed in non-native tissue types, likely due to differences in the C-terminal hyper-variable regions. Mis-regulation of isoform expression has been shown to be a driving event in cancer, as well as missense mutations at the three hotspots previously mentioned. While highly recurrent in cancer, targeting these RAS mutants has also been very elusive, and has not yet become common practice in the clinic.
GeneCards Summary for NRAS Gene
NRAS (NRAS Proto-Oncogene, GTPase) is a Protein Coding gene. Diseases associated with NRAS include Ras-Associated Autoimmune Leukoproliferative Disorder and Melanocytic Nevus Syndrome, Congenital. Among its related pathways are Negative regulation of MAPK pathway and NGF Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is KRAS.
UniProtKB/Swiss-Prot Summary for NRAS Gene
-
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Additional gene information for NRAS Gene
- HGNC(7989)
- Entrez Gene(4893)
- Ensembl(ENSG00000213281)
- OMIM(164790)
- UniProtKB(P01111)
- Open Targets Platform(ENSG00000213281)
- Monarch Initiative
- Search for NRAS at DataMed
- Search for NRAS at HumanCyc
No data available for Tocris Summary , Rfam classification and piRNA Summary for NRAS Gene
Genomics for NRAS Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NRAS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NRAS on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NRAS
- Top Transcription factor binding sites by QIAGEN in the NRAS gene promoter:
-
- AP-1
- ATF-2
- c-Fos
- c-Jun
- MyoD
- STAT3
Genomic Locations for NRAS Gene
Genomic Locations for NRAS Gene
- chr1:114,704,469-114,716,771
- (GRCh38/hg38)
- Size:
- 12,303 bases
- Orientation:
- Minus strand
- chr1:115,247,085-115,259,515
- (GRCh37/hg19)
- Size:
- 12,431 bases
- Orientation:
- Minus strand
Genomic View for NRAS Gene
Genes around NRAS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.2 by HGNC
- 1p13.2 by Entrez Gene
- 1p13.2 by Ensembl
NRAS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NRAS Gene
Proteins for NRAS Gene
-
Protein details for NRAS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01111-RASN_HUMAN
- Recommended name:
- GTPase NRas
- Protein Accession:
- P01111
- Q14971
- Q15104
- Q15282
Protein attributes for NRAS Gene
- Size:
- 189 amino acids
- Molecular mass:
- 21229 Da
- Quaternary structure:
-
- Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (active GTP-bound form) with RASSF7 (PubMed:21278800).
- Miscellaneous:
-
- Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells and are implicated in a variety of human tumors.
Protein Expression for NRAS Gene
Post-translational modifications for NRAS Gene
- Palmitoylated by the ZDHHC9-GOLGA7 complex (PubMed:16000296). Depalmitoylated by ABHD17A, ABHD17B and ABHD17C (PubMed:26701913). A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi (PubMed:16000296, PubMed:15705808, PubMed:2661017, PubMed:26701913).
- Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).
- Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.
- Phosphorylation at Ser-89 by STK19 enhances NRAS-association with its downstream effectors.
-
Ubiquitination at Lys128 and Lys170
- NX_P01111 (NX_P01111-1)
- Modification sites at PhosphoSitePlus
Other Protein References for NRAS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences NRAS / N-ras Antibody (LS-B2501) and NRAS / N-ras Antibody (LS-B8261)
- G Biosciences Immunotagâ„¢ NRAS Antibody
- NSJ Bioreagents NRAS Antibody
- Creative Diagnostics Anti-HRAS monoclonal antibody, clone N448
- GeneTex Anti-N-RAS antibody
-
Custom Antibody ServicesOriGene Antibodies for NRAS
- Novus Biologicals Antibodies for NRAS
-
Abcam antibodies for NRAS
- Invitrogen Antibodies for NRAS (AFLGC-NRAS)
-
Custom Antibody ServicesProSci Antibodies for NRAS
-
Santa Cruz Biotechnology (SCBT) Antibodies for NRAS
- Sino Biological Antibodies for NRAS
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for NRAS
- Origene Custom Protein Services for NRAS
- Sino Biological Recombinant Proteins for NRAS
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for NRAS
Assay Products
- antibodies-online: Show 9 available GTPase NRas Elisa Kits ranked by validation data
- Compare Top GTPase NRas Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for NRAS
-
Abcam assays for NRAS
No data available for DME Specific Peptides for NRAS Gene
Domains & Families for NRAS Gene
Gene Families for NRAS Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Protein Domains for NRAS Gene
- InterPro:
- Blocks:
-
- Transforming protein P21 RAS signature
- Ras small GTPase, Ras type
- ProtoNet:
Suggested Antigen Peptide Sequences for NRAS Gene
- GenScript: Design optimal peptide antigens:
-
- Neuroblastoma RAS viral (V-ras) oncogene homolog, isoform CRA_a (Q5U091_HUMAN)
- N-ras protein (Q9UM97_HUMAN)
- Transforming protein N-Ras (RASN_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P01111- Family:
-
- Belongs to the small GTPase superfamily. Ras family.
Function for NRAS Gene
Molecular function for NRAS Gene
- UniProtKB/Swiss-Prot Function:
- Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
- GENATLAS Biochemistry:
- neuroblastoma Ras viral (v-ras) oncogene homolog
Phenotypes From GWAS Catalog for NRAS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003924 | GTPase activity | IBA,IDA | 30712867 |
| GO:0005515 | protein binding | IPI | 18641128 |
| GO:0005525 | GTP binding | IBA | 21873635 |
| GO:0019003 | GDP binding | IBA | 21873635 |
Phenotypes for NRAS Gene
- MGI mutant phenotypes for NRAS:
-
inferred from 12 alleles
- immune system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- pigmentation phenotype
- craniofacial phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for NRAS:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Moderately decreased NFAT1-GFP nuclear translocation
- Decreased shRNA abundance (Z-score < -2)
- Strongly decreased CFP-tsO45G cell surface transport
- Reduced mammosphere formation
- Decreased viability
- Increased transferrin (TF) endocytosis
- Downregulation of Wnt pathway after Wnt3A stimulation
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased cell elongation
- Decreased ionizing radiation sensitivity
- Increased homologous recombination repair frequency
- Increased shRNA abundance (Z-score > 2)
Animal Models for NRAS Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NRAS - Select products 50% OFF >
- * NRAS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NRAS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRAS
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRAS
miRNA for NRAS Gene
- miRTarBase miRNAs that target NRAS
-
- hsa-let-7a-5p (MIRT001854)
- hsa-let-7b-5p (MIRT003836)
- hsa-miR-20a-5p (MIRT003903)
- hsa-let-7c-5p (MIRT004531)
- hsa-miR-145-5p (MIRT007107)
- hsa-miR-148b-3p (MIRT007317)
- mmu-let-7b-5p (MIRT012218)
- mmu-miR-30e-5p (MIRT013351)
- hsa-miR-124-3p (MIRT023141)
- hsa-miR-98-5p (MIRT027862)
- hsa-miR-877-3p (MIRT037130)
- hsa-miR-214-3p (MIRT054716)
- hsa-miR-519c-5p (MIRT058802)
- hsa-miR-519b-5p (MIRT058803)
- hsa-miR-523-5p (MIRT058804)
- hsa-miR-518f-5p (MIRT058805)
- hsa-miR-526a (MIRT058806)
- hsa-miR-520c-5p (MIRT058807)
- hsa-miR-518e-5p (MIRT058809)
- hsa-miR-518d-5p (MIRT058810)
- hsa-miR-522-5p (MIRT058811)
- hsa-miR-519a-5p (MIRT058812)
- hsa-miR-4686 (MIRT058817)
- hsa-miR-2681-5p (MIRT058831)
- hsa-miR-2113 (MIRT179789)
- hsa-miR-3123 (MIRT246065)
- hsa-miR-3925-5p (MIRT246067)
- hsa-miR-4468 (MIRT332202)
- hsa-miR-543 (MIRT404771)
- hsa-miR-4480 (MIRT443333)
- hsa-miR-2276-3p (MIRT443334)
- hsa-miR-4772-3p (MIRT443335)
- hsa-miR-7109-3p (MIRT443336)
- hsa-miR-3662 (MIRT443337)
- hsa-miR-513a-5p (MIRT471919)
- hsa-miR-1193 (MIRT471920)
- hsa-miR-3613-3p (MIRT471921)
- hsa-miR-2392 (MIRT471922)
- hsa-miR-7161-5p (MIRT471923)
- hsa-miR-548u (MIRT471924)
- hsa-miR-27b-3p (MIRT471925)
- hsa-miR-27a-3p (MIRT471926)
- hsa-miR-6833-5p (MIRT471927)
- hsa-miR-218-5p (MIRT471928)
- hsa-miR-8068 (MIRT471929)
- hsa-miR-3190-3p (MIRT471930)
- hsa-miR-3650 (MIRT471931)
- hsa-miR-6077 (MIRT471932)
- hsa-miR-2467-3p (MIRT471933)
- hsa-miR-7-5p (MIRT471934)
- hsa-miR-7114-5p (MIRT471935)
- hsa-miR-4257 (MIRT471936)
- hsa-miR-548b-3p (MIRT471937)
- hsa-miR-1303 (MIRT501794)
- hsa-miR-3143 (MIRT501795)
- hsa-miR-4537 (MIRT501796)
- hsa-miR-520g-5p (MIRT501797)
- hsa-miR-2278 (MIRT501798)
- hsa-miR-219b-3p (MIRT511057)
- hsa-miR-922 (MIRT511058)
- hsa-miR-92b-3p (MIRT511059)
- hsa-miR-367-3p (MIRT511060)
- hsa-miR-32-5p (MIRT511061)
- hsa-miR-363-3p (MIRT511062)
- hsa-miR-25-3p (MIRT511063)
- hsa-miR-92a-3p (MIRT511064)
- hsa-miR-5585-3p (MIRT555957)
- hsa-miR-3160-5p (MIRT555958)
- hsa-miR-642b-3p (MIRT555959)
- hsa-miR-642a-3p (MIRT555960)
- hsa-miR-4774-5p (MIRT555961)
- hsa-miR-4490 (MIRT555962)
- hsa-miR-4719 (MIRT555963)
- hsa-miR-425-5p (MIRT555965)
- hsa-miR-944 (MIRT561844)
- mmu-miR-466q (MIRT577120)
- mmu-miR-1896 (MIRT582117)
- mmu-miR-129-5p (MIRT589417)
- mmu-miR-3064-5p (MIRT589418)
- mmu-miR-3085-3p (MIRT589419)
- mmu-miR-466c-3p (MIRT589420)
- mmu-miR-466m-3p (MIRT589421)
- mmu-miR-466o-3p (MIRT589422)
- mmu-miR-1b-5p (MIRT589423)
- mmu-miR-466p-3p (MIRT589424)
- mmu-miR-466b-3p (MIRT589425)
- mmu-miR-1898 (MIRT589426)
- hsa-miR-26a-5p (MIRT732062)
- hsa-miR-181a-5p (MIRT734574)
- hsa-miR-98-3p (MIRT734616)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NRAS
- Browse OriGene Inhibitory RNA Products For NRAS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRAS
Clone Products
- Applied Biological Materials (abm): Clones for NRAS - Select products 50% OFF >
- * NRAS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201859
- MR201859
- MR201859L1
- MR201859L2
- MR201859L3
- MR201859L4
- RC202681
- RC202681L1
- RC202681L2
- RC202681L3
- RC202681L4
- RG202681
- RR203820
- RR203820L3
- RR203820L4
- MR201859L1V
- MR201859L2V
- MR201859L3V
- MR201859L4V
- RC202681L1V
- RC202681L2V
- RC202681L3V
- RC202681L4V
- RR203820L3V
- RR203820L4V
- RC400137
- RC400138
- RC400139
- RC400140
- RC400141
- RC400142
- RC400143
- RC400144
- RC400145
- RC400146
- RC400147
- RC400148
- RC400149
- RC400150
- RC400151
- RC400152
- RC400153
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NRAS
- Addgene plasmids for NRAS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRAS
Cell Line Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NRAS Gene
Localization for NRAS Gene
Subcellular locations from UniProtKB/Swiss-Prot for NRAS Gene
- Cell membrane. Lipid-anchor. Cytoplasmic side. Golgi apparatus membrane. Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000269 PubMed:15705808, ECO:0000269 PubMed:26701913}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 4 |
| cytosol | 4 |
| golgi apparatus | 4 |
| nucleus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA | 21968647 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | HDA | 19946888 |
| GO:0070062 | extracellular exosome | HDA | 20458337 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NRAS Gene
Pathways & Interactions for NRAS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Downstream signaling of activated FGFR2 | ||
| 3 | IL-2 Pathway |
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
|
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
IL-4 Pathway
.34
|
| 4 | Endometrial cancer |
.36
.32
|
|
| 5 | fMLP Pathway |
CCR3 Pathway in Eosinophils
.44
VEGF and S-1P Signaling
.44
fMLP Pathway
.43
|
CXCR4 Pathway
.39
Alpha-Adrenergic Signaling
.38
Internalin Pathway
.31
|
Pathways by source for NRAS Gene
11 Sino Biological pathways for NRAS Gene
16 BioSystems pathways for NRAS Gene
110 Reactome pathways for NRAS Gene
6 PharmGKB pathways for NRAS Gene
76 KEGG pathways for NRAS Gene
4 GeneGo (Thomson Reuters) pathways for NRAS Gene
- Development EGFR signaling via small GTPases
- Development EPO-induced MAPK pathway
- G-protein signaling N-RAS regulation pathway
- G-protein signaling Ras family GTPases in kinase cascades (scheme)
5 Tocris pathways for NRAS Gene
109 Qiagen pathways for NRAS Gene
- 14-3-3 Induced Intracellular Signaling
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Agrin Interactions at Neuromuscular Junction
- Akt Signaling
1 Cell Signaling Technology pathway for NRAS Gene
2 GeneTex pathways for NRAS Gene
Interacting Proteins for NRAS Gene
Selected Interacting proteins:
P01111-RASN_HUMAN
ENSP00000358548
for NRAS Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for NRAS
SIGNOR curated interactions for NRAS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0001938 | positive regulation of endothelial cell proliferation | IMP | 23619365 |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007265 | Ras protein signal transduction | TAS | -- |
Drugs & Compounds for NRAS Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Trametinib | Approved | Pharma | MEK 1/2 inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors | 194 | ||
| Cetuximab | Approved | Pharma | EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors | 869 | ||
| Dabrafenib | Approved, Investigational | Pharma | BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase | 116 | ||
| Fludarabine | Approved | Pharma | DNA synthsis inhibitor | 1533,1533 | ||
| Carboplatin | Approved | Pharma | Antitumor agent that forms platinum-DNA adducts., Platinum | 2588 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(3) ApexBio Compounds for NRAS Gene
Transcripts for NRAS Gene
mRNA/cDNA for NRAS Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000369535 4326 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NRAS - Select products 50% OFF >
- * NRAS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NRAS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NRAS
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRAS
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NRAS
- Browse OriGene Inhibitory RNA Products For NRAS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NRAS
Clone Products
- Applied Biological Materials (abm): Clones for NRAS - Select products 50% OFF >
- * NRAS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201859
- MR201859
- MR201859L1
- MR201859L2
- MR201859L3
- MR201859L4
- RC202681
- RC202681L1
- RC202681L2
- RC202681L3
- RC202681L4
- RG202681
- RR203820
- RR203820L3
- RR203820L4
- MR201859L1V
- MR201859L2V
- MR201859L3V
- MR201859L4V
- RC202681L1V
- RC202681L2V
- RC202681L3V
- RC202681L4V
- RR203820L3V
- RR203820L4V
- RC400137
- RC400138
- RC400139
- RC400140
- RC400141
- RC400142
- RC400143
- RC400144
- RC400145
- RC400146
- RC400147
- RC400148
- RC400149
- RC400150
- RC400151
- RC400152
- RC400153
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NRAS
- Addgene plasmids for NRAS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NRAS
Relevant External Links for NRAS Gene
- GeneLoc Exon Structure for
- NRAS
Expression for NRAS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
This gene is overexpressed in Brain (10.2), Peripheral blood mononuclear cells (9.0), and Bone (8.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NRAS Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRAS
SOURCE GeneReport for Unigene cluster for NRAS Gene:
Hs.486502Evidence on tissue expression from TISSUES for NRAS Gene
- Nervous system(4.7)
- Bone marrow(4.7)
- Kidney(4.6)
- Skin(3.7)
- Intestine(3.5)
- Liver(3.4)
- Lymph node(3.1)
- Blood(3.1)
- Thyroid gland(2.9)
- Spleen(2.9)
- Lung(2.9)
- Heart(2.8)
- Muscle(2.7)
- Stomach(2.6)
- Pancreas(2.3)
- Adrenal gland(2.2)
- Eye(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for NRAS Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cerebellum
- cheek
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- scalp
- skull
- thyroid
- tooth
Thorax:
- aorta
- breast
- chest wall
- clavicle
- heart
- heart valve
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- abdominal wall
- intestine
- kidney
- large intestine
- liver
- spleen
- stomach
Pelvis:
- anus
- pelvis
- placenta
- rectum
- testicle
- ureter
- urethra
- urinary bladder
- uterus
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- nail
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- hair
- lymph node
- lymph vessel
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- spinal column
- spinal cord
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for NRAS
-
OriGene qPCR primer pairs and template standards for NRAS
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NRAS Gene
Orthologs for NRAS Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | N-RAS 31 |
|
OneToOne | |
| NRAS 30 |
|
||||
| Chimpanzee (Pan troglodytes) |
Mammalia | NRAS 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | NRAS 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | NRAS 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Nras 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Nras 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NRAS 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | N-RAS 31 |
|
OneToOne | |
| NRAS 30 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | NRAS 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC549517 30 |
|
||
| Str.17112 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.895 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | nras 30 31 |
|
OneToOne | |
| -- 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Ras85D 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | let-60 31 |
|
OneToMany | |
| C08F8.7 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RAS1 31 |
|
ManyToMany | |
| RAS2 31 |
|
ManyToMany |
- Species where no ortholog for NRAS was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for NRAS Gene
- ENSEMBL:
- Gene Tree for NRAS (if available)
- TreeFam:
- Gene Tree for NRAS (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NRAS: view image
Paralogs for NRAS Gene
Paralogs for NRAS Gene
(95) SIMAP similar genes for NRAS Gene using alignment to 2 proteins:
- RASN_HUMAN
- Q5U091_HUMAN
- N-ras
- c-bas/has
- KRAS
- HRAS
- RALA
- RAP1B
- RAP2A
- RIT2
- RALB
- RAP1A
- RIT1
- RRAS2
- RAP2C
- RAB1C
- RAB1B
- RRAS
- RAP2B
- DKFZp547A0616
- ERAS
- MRAS
- RAB1A
- RAB5C
- RAB13
- DIRAS1
- RERG
- RAB37
- RHEB
- RHEBL1
- RAB5B
- RAB3C
- RAB10
- RAB8B
- RAB5A
- RAB33B
- RAB26
- RAB19
- DIRAS2
- RASD2
- RAB8A
- RAB3D
- RAB33A
- RAB12
- GEM
- RASL11B
- RAB7B
- RAB7A
- RAB2B
- RAB2A
- REM2
- RASL12
- RASD1
- RAB9A
- RAB4B
- RAB4A
- RAB17
- DKFZp313C1541
- RAB30
- RASEF
- RAB3A
- RAB39B
- RAB35
- RAB25
- RAB11B
- RAB6A
- REM1
- RASL11A
- RAB7L1
- RAB6B
- RAB44
- RAB3B
- RAB31
- RAB22A
- RAB15
- RAB14
- RAB11A
- DIRAS3
- RAB41
- RAB27B
- RAB23
- RAB21
- RRAD
- RAB9B
- RAB43
- RAB39A
- CDC42
- RAB27A
- RAB18
- NKIRAS1
- NKIRAS2
- RHOQ
- RHOJ
- RHOC
- RHOG
- RHOA
- ARHG
Variants for NRAS Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NRAS Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 644733 | Uncertain Significance: Rasopathy | 114,708,544(-) | C/T | SYNONYMOUS_VARIANT | |
| 651614 | Uncertain Significance: Rasopathy | 114,709,699(-) | T/G | MISSENSE_VARIANT | |
| 658879 | Uncertain Significance: Rasopathy | 114,716,096(-) | T/C | MISSENSE_VARIANT | |
| 761147 | Likely Benign: not provided | 114,709,575(-) | G/A | SYNONYMOUS_VARIANT | |
| 762535 | Likely Benign: not provided | 114,716,116(-) | C/G | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.13;
3.05% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NRAS Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRAS Gene
Disorders for NRAS Gene
(109) MalaCards diseases for NRAS Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ras-associated autoimmune leukoproliferative disorder |
|
|
| melanocytic nevus syndrome, congenital |
|
|
| noonan syndrome 6 |
|
|
| melanosis, neurocutaneous |
|
|
| nevus, epidermal |
|
Search NRAS in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
RASN_HUMAN- Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. {ECO:0000269 PubMed:17332249}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Noonan syndrome 6 (NS6) [MIM:613224]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. {ECO:0000269 PubMed:19966803}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- RAS-associated autoimmune leukoproliferative disorder (RALD) [MIM:614470]: A disorder of apoptosis, characterized by chronic accumulation of non-malignant lymphocytes, defective lymphocyte apoptosis, and an increased risk for the development of hematologic malignancies. {ECO:0000269 PubMed:17517660}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Melanocytic nevus syndrome, congenital (CMNS) [MIM:137550]: A syndrome characterized by congenital pigmentary skin lesions which can occur at any site and can cover most of the body surface. These lesions may or may not be hairy. Congenital melanocytic nevi are associated with neuromelanosis (the presence of melanin-producing cells within the brain parenchyma or leptomeninges). Less commonly they are associated with malignant melanoma in childhood, both in the skin and the central nervous system. CMNS patients also tend to have a characteristic facial appearance, including wide or prominent forehead, periorbital fullness, small short nose with narrow nasal bridge, round face, full cheeks, prominent premaxilla, and everted lower lip. {ECO:0000269 PubMed:18633438, ECO:0000269 PubMed:23392294}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Melanosis, neurocutaneous (NCMS) [MIM:249400]: A rare congenital disease characterized by the presence of giant or multiple melanocytic nevi on the skin, foci of melanin-producing cells within the brain parenchyma, and infiltration of leptomeninges by abnormal melanin deposits. Neurologic abnormalities include seizures, hydrocephalus, arachnoid cysts, tumors, and syringomyelia. Some patients may develop malignant melanoma. {ECO:0000269 PubMed:23392294}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Keratinocytic non-epidermolytic nevus (KNEN) [MIM:162900]: Epidermal nevi of the common, non-organoid and non-epidermolytic type are benign skin lesions and may vary in their extent from a single (usually linear) lesion to widespread and systematized involvement. They may be present at birth or develop early during childhood. {ECO:0000269 PubMed:22499344}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Thyroid cancer, non-medullary, 2 (NMTC2) [MIM:188470]: A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms. {ECO:0000269 PubMed:12727991}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Additional Disease Information for NRAS
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for NRAS Gene
Publications for NRAS Gene
- Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma. (PMID: 20140953) Conway C … Newton-Bishop JA (Genes, chromosomes & cancer 2010) 3 23 41
- Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. (PMID: 19047918) Yoshida N … Kojima S (Pediatric research 2009) 3 23 41
- Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. (PMID: 18450602) Schlenk RF … German-Austrian Acute Myeloid Leukemia Study Group (The New England journal of medicine 2008) 3 23 41
- Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors. (PMID: 18615679) Agaram NP … Antonescu CR (Genes, chromosomes & cancer 2008) 3 23 41
- Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma. (PMID: 17507627) Thomas NE … Conway K (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007) 3 23 41
ExternalLinks
Products for NRAS Gene
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