Aliases for NRARP Gene
External Ids for NRARP Gene
Previous GeneCards Identifiers for NRARP Gene
GeneCards Summary for NRARP Gene
NRARP (NOTCH Regulated Ankyrin Repeat Protein) is a Protein Coding gene. Diseases associated with NRARP include Exudative Vitreoretinopathy 1. Among its related pathways are Notch Signaling Pathway (WikiPathways). An important paralog of this gene is ANKRD6.
UniProtKB/Swiss-Prot Summary for NRARP Gene
Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity).