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Aliases for NRARP Gene

Aliases for NRARP Gene

  • NOTCH Regulated Ankyrin Repeat Protein 2 3 5

External Ids for NRARP Gene

Previous GeneCards Identifiers for NRARP Gene

  • GC09M139315
  • GC09M140194
  • GC09M109653

Summaries for NRARP Gene

GeneCards Summary for NRARP Gene

NRARP (NOTCH Regulated Ankyrin Repeat Protein) is a Protein Coding gene. Among its related pathways are Notch signaling pathway (KEGG). An important paralog of this gene is PPP1R27.

UniProtKB/Swiss-Prot for NRARP Gene

  • Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity).

Additional gene information for NRARP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRARP Gene

Genomics for NRARP Gene

GeneHancer (GH) Regulatory Elements for NRARP Gene

Promoters and enhancers for NRARP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I137292 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 571.5 +1.9 1850 15.3 PKNOX1 FOXA2 ARNT ZFP64 SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 NRARP GC09M137300 EHMT1 DPH7 SDCCAG3 EXD3 NDOR1 INPP5E ANAPC2 MAN1B1
GH09I137309 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5 -13.5 -13531 12.7 HDGF PKNOX1 CLOCK ATF1 SMAD1 ARID4B SIN3A ZBTB7B ZNF48 GLIS2 EXD3 INPP5E DPH7 NOXA1 ARRDC1-AS1 NPDC1 SNAPC4 ANAPC2 MAN1B1 CCDC183-AS1
GH09I137405 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.7 -104.8 -104772 2.6 HDGF RB1 ARID4B SIN3A RAD21 ZNF335 ZNF121 GLIS2 EGR1 ZNF207 INPP5E EXD3 NOXA1 ARRDC1-AS1 DPH7 NRARP CACNA1B GC09M137332
GH09I137669 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 2.4 -368.4 -368389 2.5 HDGF FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 CBX5 EHMT1 NDOR1 MAN1B1 ZMYND19 NRARP SETP5 ENSG00000283411 GC09P137764 GC09M137538
GH09I137126 Enhancer 1.5 FANTOM5 Ensembl ENCODE 2.2 +173.5 173450 4.4 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 EHMT1 DPH7 SDCCAG3 ANAPC2 SNHG7 SEC16A NDOR1 UAP1L1 INPP5E EXD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NRARP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NRARP gene promoter:

Genomic Locations for NRARP Gene

Genomic Locations for NRARP Gene
chr9:137,299,631-137,302,251
(GRCh38/hg38)
Size:
2,621 bases
Orientation:
Minus strand
chr9:140,194,083-140,196,703
(GRCh37/hg19)

Genomic View for NRARP Gene

Genes around NRARP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRARP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRARP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRARP Gene

Proteins for NRARP Gene

  • Protein details for NRARP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6K4-NRARP_HUMAN
    Recommended name:
    Notch-regulated ankyrin repeat-containing protein
    Protein Accession:
    Q7Z6K4
    Secondary Accessions:
    • B8A4K5

    Protein attributes for NRARP Gene

    Size:
    114 amino acids
    Molecular mass:
    12492 Da
    Quaternary structure:
    • Interacts with LEF1.

neXtProt entry for NRARP Gene

Post-translational modifications for NRARP Gene

No Post-translational modifications

Other Protein References for NRARP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NRARP Gene

Domains & Families for NRARP Gene

Gene Families for NRARP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NRARP Gene

Suggested Antigen Peptide Sequences for NRARP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6K4

UniProtKB/Swiss-Prot:

NRARP_HUMAN :
  • Belongs to the NRARP family.
Family:
  • Belongs to the NRARP family.
genes like me logo Genes that share domains with NRARP: view

Function for NRARP Gene

Molecular function for NRARP Gene

UniProtKB/Swiss-Prot Function:
Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity).
UniProtKB/Swiss-Prot Induction:
In endothelial cells by Notch signaling.

Phenotypes From GWAS Catalog for NRARP Gene

genes like me logo Genes that share phenotypes with NRARP: view

Animal Models for NRARP Gene

MGI Knock Outs for NRARP:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRARP Gene

Localization for NRARP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRARP gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NRARP Gene

Pathways & Interactions for NRARP Gene

SuperPathways for NRARP Gene

SuperPathway Contained pathways
1 Notch signaling pathway (KEGG)
genes like me logo Genes that share pathways with NRARP: view

Pathways by source for NRARP Gene

1 R&D Systems pathway for NRARP Gene

SIGNOR curated interactions for NRARP Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for NRARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001569 branching involved in blood vessel morphogenesis IBA,IEA --
GO:0001938 positive regulation of endothelial cell proliferation IBA,IEA --
GO:0002040 sprouting angiogenesis IEA --
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA,IBA --
genes like me logo Genes that share ontologies with NRARP: view

Drugs & Compounds for NRARP Gene

No Compound Related Data Available

Transcripts for NRARP Gene

mRNA/cDNA for NRARP Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(92) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NRARP Gene

NOTCH-regulated ankyrin repeat protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRARP Gene

No ASD Table

Relevant External Links for NRARP Gene

GeneLoc Exon Structure for
NRARP
ECgene alternative splicing isoforms for
NRARP

Expression for NRARP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRARP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRARP Gene

This gene is overexpressed in Colon - Transverse (x6.7).

NURSA nuclear receptor signaling pathways regulating expression of NRARP Gene:

NRARP

SOURCE GeneReport for Unigene cluster for NRARP Gene:

Hs.732282

Evidence on tissue expression from TISSUES for NRARP Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with NRARP: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRARP Gene

Orthologs for NRARP Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRARP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRARP 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia NRARP 34 33
  • 96.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NRARP 33 34
  • 95.03 (n)
mouse
(Mus musculus)
Mammalia Nrarp 33 16 34
  • 93.86 (n)
rat
(Rattus norvegicus)
Mammalia Nrarp 33
  • 93.27 (n)
oppossum
(Monodelphis domestica)
Mammalia NRARP 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRARP 34 33
  • 88.89 (n)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nrarpb 34
  • 87 (a)
OneToMany
nrarpa 33 34
  • 84.52 (n)
Species where no ortholog for NRARP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRARP Gene

ENSEMBL:
Gene Tree for NRARP (if available)
TreeFam:
Gene Tree for NRARP (if available)

Paralogs for NRARP Gene

Variants for NRARP Gene

Sequence variations from dbSNP and Humsavar for NRARP Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000036321 -- 137,300,819(-) G/A 3_prime_UTR_variant
rs1000410163 -- 137,301,090(-) G/A 3_prime_UTR_variant
rs1000513361 -- 137,302,949(-) G/A upstream_transcript_variant
rs1001066487 -- 137,303,616(-) T/C upstream_transcript_variant
rs1001229715 -- 137,302,523(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NRARP Gene

Variant ID Type Subtype PubMed ID
nsv951207 CNV deletion 24416366
nsv825190 CNV gain 20364138
nsv825189 CNV gain 20364138
nsv825185 CNV gain 20364138
nsv524322 CNV loss 19592680
nsv1161918 CNV duplication 26073780
nsv1145274 CNV deletion 24896259
nsv1075289 CNV deletion 25765185
nsv1037407 CNV gain 25217958
esv3622026 OTHER inversion 21293372
esv2422220 CNV deletion 17116639
dgv13011n54 CNV loss 21841781
dgv13009n54 CNV loss 21841781

Variation tolerance for NRARP Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRARP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRARP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRARP Gene

Disorders for NRARP Gene

Additional Disease Information for NRARP

No disorders were found for NRARP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRARP Gene

Publications for NRARP Gene

  1. C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling. (PMID: 25985737) Zhu P … Fan Z (Nature communications 2015) 3 4 58
  2. The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice. (PMID: 21998026) Krebs LT … Gridley T (Genesis (New York, N.Y. : 2000) 2012) 2 3 58
  3. Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. (PMID: 19154719) Phng LK … Gerhardt H (Developmental cell 2009) 3 4 58
  4. Nrarp is a novel intracellular component of the Notch signaling pathway. (PMID: 11485984) Lamar E … Kintner C (Genes & development 2001) 2 3 58
  5. Overexpression of NOTCH-regulated Ankyrin Repeat Protein is associated with papillary thyroid carcinoma progression. (PMID: 28207739) Zhang M … Chu B (PloS one 2017) 3 58

Products for NRARP Gene

Sources for NRARP Gene

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